JP2011514337A - 糖ガラス化ウィルス様粒子（ｖｌｐ） - Google Patents
糖ガラス化ウィルス様粒子（ｖｌｐ） Download PDFInfo
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- JP2011514337A JP2011514337A JP2010547860A JP2010547860A JP2011514337A JP 2011514337 A JP2011514337 A JP 2011514337A JP 2010547860 A JP2010547860 A JP 2010547860A JP 2010547860 A JP2010547860 A JP 2010547860A JP 2011514337 A JP2011514337 A JP 2011514337A
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- sugar glass
- sugar
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16023—Virus like particles [VLP]
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- Pharmacology & Pharmacy (AREA)
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- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
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- General Chemical & Material Sciences (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3124308P | 2008-02-25 | 2008-02-25 | |
| PCT/US2009/035122 WO2009108689A1 (en) | 2008-02-25 | 2009-02-25 | Sugar glassified virus like particles (vlps) |
Publications (2)
| Publication Number | Publication Date |
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| JP2011514337A true JP2011514337A (ja) | 2011-05-06 |
| JP2011514337A5 JP2011514337A5 (cg-RX-API-DMAC7.html) | 2012-04-05 |
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| JP2010547860A Pending JP2011514337A (ja) | 2008-02-25 | 2009-02-25 | 糖ガラス化ウィルス様粒子（ｖｌｐ） |
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| EP (1) | EP2254554A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2011514337A (cg-RX-API-DMAC7.html) |
| CN (1) | CN102014873A (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0908861A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2716546A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2010009351A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2010139478A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009108689A1 (cg-RX-API-DMAC7.html) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017502962A (ja) * | 2013-12-31 | 2017-01-26 | インフェクシャス ディズィーズ リサーチ インスティチュート | 単一バイアルのワクチン製剤 |
| JP2017507165A (ja) * | 2013-12-16 | 2017-03-16 | マサチューセッツ インスティテュート オブ テクノロジー | マイクロモールド成形された、または３次元印刷されたパルス放出ワクチン製剤 |
| WO2025058011A1 (ja) * | 2023-09-13 | 2025-03-20 | 国立大学法人大阪大学 | 経鼻投与用組成物 |
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| US11446374B2 (en) | 2008-12-09 | 2022-09-20 | Novavax, Inc. | Modified RSV F proteins and methods of their use |
| EP3067064B1 (en) | 2008-12-09 | 2020-05-13 | Novavax, Inc. | Modified rsv f proteins and methods of their use |
| WO2011090712A2 (en) * | 2009-12-28 | 2011-07-28 | Ligocyte Pharmaceuticals, Inc. | Methods for stabilizing influenza antigen enveloped virus-based virus-like particle solutions |
| GB201002419D0 (en) * | 2010-02-12 | 2010-03-31 | Isis Innovation | Stable live vaccine formulations |
| CN103269716B (zh) * | 2010-12-02 | 2015-05-27 | 昂科利蒂克斯生物科技公司 | 冻干病毒制剂 |
| CA2819246C (en) | 2010-12-02 | 2023-04-25 | Oncolytics Biotech Inc. | Liquid viral formulations |
| JP6050811B2 (ja) * | 2011-06-24 | 2016-12-21 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | アルミニウムアジュバントを含むｈｐｖワクチン製剤およびその産生方法 |
| SG10201602434UA (en) * | 2011-09-30 | 2016-05-30 | Novavax Inc | Recombinant nanoparticle rsv f vaccine for respiratory syncytial virus |
| US20130089638A1 (en) * | 2011-10-11 | 2013-04-11 | Mead Johnson Nutrition Company | Compositions Comprising Maltotriose And Methods Of Using Same To Inhibit Damage Caused By Dehydration Processes |
| EP3041504B1 (en) | 2013-09-03 | 2021-08-25 | Georgia Tech Research Corporation | Thermally stable vaccine formulations and microneedles |
| MX2016007786A (es) | 2013-12-16 | 2017-03-03 | Massachusetts Inst Technology | Formulaciones de sal de micronutrientes fortificadas. |
| EP3139952A1 (en) * | 2014-05-06 | 2017-03-15 | The Regents of the University of Colorado, a body corporate | Compositions, methods and uses for thermally stable human papillomavirus formulations |
| US11273127B2 (en) * | 2014-05-06 | 2022-03-15 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and uses for thermally stable multi-targeted antigens |
| AU2016315478B2 (en) | 2015-09-03 | 2023-07-13 | Novavax, Inc. | Vaccine compositions having improved stability and immunogenicity |
| WO2017041083A1 (en) * | 2015-09-04 | 2017-03-09 | Inventprise, Llc | Vlp stabilized vaccine compositions |
| ES3028362T3 (en) | 2017-07-24 | 2025-06-19 | Novavax Inc | Methods and compositions for treating respiratory disease |
| SG11202009206QA (en) | 2018-03-19 | 2020-10-29 | Novavax Inc | Multivalent influenza nanoparticle vaccines |
| US12318436B2 (en) | 2019-05-25 | 2025-06-03 | Access To Advanced Health Institute | Composition and method for spray drying an adjuvant vaccine emulsion |
| IL298019A (en) | 2020-05-13 | 2023-01-01 | Massachusetts Inst Technology | Compositions of polymeric microdevices and their use in cancer immunotherapy |
| CN115350281B (zh) * | 2022-09-20 | 2026-01-02 | 华派生物技术(集团)股份有限公司 | 一种病毒样颗粒疫苗冻干保护剂及其制备方法 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002504090A (ja) * | 1997-03-18 | 2002-02-05 | クアドラント ホールディングス ケンブリッジ リミテッド | 液体調合物における安定な粒子 |
| WO2006017246A2 (en) * | 2004-07-12 | 2006-02-16 | Sd Pharmaceuticals, Inc. | Compositions for delivering highly water soluble drugs |
| JP2006518761A (ja) * | 2003-02-24 | 2006-08-17 | ファーマシューティカル プロダクションズ， インコーポレイテッド | 経粘膜薬物送達システム |
| WO2006085082A1 (en) * | 2005-02-09 | 2006-08-17 | Stabilitech Ltd. | A desiccated product |
| WO2006088336A1 (en) * | 2005-02-21 | 2006-08-24 | Lg Life Sciences, Ltd. | Sustained release composition of protein drug |
| JP2007535514A (ja) * | 2004-04-30 | 2007-12-06 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 乾燥方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6290991B1 (en) * | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
-
2009
- 2009-02-25 MX MX2010009351A patent/MX2010009351A/es unknown
- 2009-02-25 RU RU2010139478/15A patent/RU2010139478A/ru not_active Application Discontinuation
- 2009-02-25 WO PCT/US2009/035122 patent/WO2009108689A1/en not_active Ceased
- 2009-02-25 JP JP2010547860A patent/JP2011514337A/ja active Pending
- 2009-02-25 CA CA2716546A patent/CA2716546A1/en not_active Abandoned
- 2009-02-25 EP EP09713904A patent/EP2254554A1/en not_active Withdrawn
- 2009-02-25 CN CN2009801146099A patent/CN102014873A/zh active Pending
- 2009-02-25 BR BRPI0908861A patent/BRPI0908861A2/pt not_active IP Right Cessation
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002504090A (ja) * | 1997-03-18 | 2002-02-05 | クアドラント ホールディングス ケンブリッジ リミテッド | 液体調合物における安定な粒子 |
| JP2006518761A (ja) * | 2003-02-24 | 2006-08-17 | ファーマシューティカル プロダクションズ， インコーポレイテッド | 経粘膜薬物送達システム |
| JP2007535514A (ja) * | 2004-04-30 | 2007-12-06 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 乾燥方法 |
| WO2006017246A2 (en) * | 2004-07-12 | 2006-02-16 | Sd Pharmaceuticals, Inc. | Compositions for delivering highly water soluble drugs |
| WO2006085082A1 (en) * | 2005-02-09 | 2006-08-17 | Stabilitech Ltd. | A desiccated product |
| WO2006088336A1 (en) * | 2005-02-21 | 2006-08-24 | Lg Life Sciences, Ltd. | Sustained release composition of protein drug |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017507165A (ja) * | 2013-12-16 | 2017-03-16 | マサチューセッツ インスティテュート オブ テクノロジー | マイクロモールド成形された、または３次元印刷されたパルス放出ワクチン製剤 |
| US10300136B2 (en) | 2013-12-16 | 2019-05-28 | Massachusetts Institute Of Technology | Micromolded or 3-D printed pulsatile release vaccine formulations |
| JP2020055818A (ja) * | 2013-12-16 | 2020-04-09 | マサチューセッツ インスティテュート オブ テクノロジー | マイクロモールド成形された、または３次元印刷されたパルス放出ワクチン製剤 |
| US10960073B2 (en) | 2013-12-16 | 2021-03-30 | Tokitae Llc | Micromolded or 3-D printed pulsatile release vaccine formulations |
| JP2021120413A (ja) * | 2013-12-16 | 2021-08-19 | マサチューセッツ インスティテュート オブ テクノロジー | マイクロモールド成形された、または３次元印刷されたパルス放出ワクチン製剤 |
| JP2023075311A (ja) * | 2013-12-16 | 2023-05-30 | マサチューセッツ インスティテュート オブ テクノロジー | マイクロモールド成形された、または３次元印刷されたパルス放出ワクチン製剤 |
| US11975069B2 (en) | 2013-12-16 | 2024-05-07 | Massachusetts Institute Of Technology | Micromolded or 3-D printed pulsatile release vaccine formulations |
| JP2017502962A (ja) * | 2013-12-31 | 2017-01-26 | インフェクシャス ディズィーズ リサーチ インスティチュート | 単一バイアルのワクチン製剤 |
| WO2025058011A1 (ja) * | 2023-09-13 | 2025-03-20 | 国立大学法人大阪大学 | 経鼻投与用組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102014873A (zh) | 2011-04-13 |
| CA2716546A1 (en) | 2009-09-03 |
| WO2009108689A1 (en) | 2009-09-03 |
| BRPI0908861A2 (pt) | 2018-02-06 |
| EP2254554A1 (en) | 2010-12-01 |
| RU2010139478A (ru) | 2012-05-20 |
| MX2010009351A (es) | 2011-03-04 |
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