JP2011513468A - 新規なｎ−置換テトラヒドロイソキノリン／イソインドリンヒドロキサム酸化合物 - Google Patents

新規なｎ−置換テトラヒドロイソキノリン／イソインドリンヒドロキサム酸化合物 Download PDF

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JP2011513468A
JP2011513468A JP2010550202A JP2010550202A JP2011513468A JP 2011513468 A JP2011513468 A JP 2011513468A JP 2010550202 A JP2010550202 A JP 2010550202A JP 2010550202 A JP2010550202 A JP 2010550202A JP 2011513468 A JP2011513468 A JP 2011513468A
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carboxamide
hydroxy
tetrahydroisoquinoline
disease
diseases
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JP2011513468A5 (enExample
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マイアー，トマス
ベッケルス，トマス
ヘスリンガー，クリスティアン
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４エスツェー アクチェンゲゼルシャフト
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Bioinformatics & Cheminformatics (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
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JP2010550202A 2008-03-13 2009-03-12 新規なｎ−置換テトラヒドロイソキノリン／イソインドリンヒドロキサム酸化合物 Pending JP2011513468A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08004661A EP2100879A1 (en) 2008-03-13 2008-03-13 Novel N-substituted tetrahydroisoquinoline/isoindoline hydroxamic acid compounds
PCT/EP2009/052924 WO2009112550A1 (en) 2008-03-13 2009-03-12 Novel n-substituted tetrahydroisoquinoline/isoindoline hydroxamic acid compounds

Publications (2)

Publication Number Publication Date
JP2011513468A true JP2011513468A (ja) 2011-04-28
JP2011513468A5 JP2011513468A5 (enExample) 2014-02-27

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Country Status (4)

Country Link
US (1) US8575193B2 (enExample)
EP (2) EP2100879A1 (enExample)
JP (1) JP2011513468A (enExample)
WO (1) WO2009112550A1 (enExample)

Cited By (2)

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JP2012530703A (ja) * 2009-06-22 2012-12-06 ミレニアム ファーマシューティカルズ， インコーポレイテッド 置換ヒドロキサム酸およびその使用
JP2018531959A (ja) * 2015-10-27 2018-11-01 タイペイ メディカル ユニバーシティ 線維症疾患の治療及び／又は予防用インドリン誘導体

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WO2011106627A1 (en) 2010-02-26 2011-09-01 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
WO2011130163A1 (en) 2010-04-12 2011-10-20 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
US8513421B2 (en) 2010-05-19 2013-08-20 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
WO2012027564A1 (en) 2010-08-26 2012-03-01 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
BR112013005609A2 (pt) 2010-09-09 2019-09-24 F. Hoffmann - La Roche Ag composto de fórmula (i), composição, uso de um composto e novos compostos, processos, método e usos
WO2012054332A1 (en) 2010-10-18 2012-04-26 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
WO2012088015A2 (en) * 2010-12-22 2012-06-28 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
EP2758371B1 (en) * 2011-09-19 2016-06-15 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. New thio derivatives bearing lactams as potent hdac inhibitors and their uses as medicaments
WO2013041407A1 (en) * 2011-09-19 2013-03-28 Cellzome Ag Hydroxamic acids as hdac6 inhibitors
WO2013062344A1 (en) * 2011-10-28 2013-05-02 Chong Kun Dang Pharmaceutical Corp. Hydroxamate derivatives for hdac inhibitor, and the pharmaceutical composition comprising thereof
EA201492184A1 (ru) 2012-05-25 2015-07-30 Берг Ллк Способы лечения метаболического синдрома путем модулирования белка теплового шока (hsp) 90-бета
US10167258B2 (en) 2013-12-13 2019-01-01 The Board Of Regents Of The University Of Texas System Inhibitors of mitochondrial pyruvate dehydrogenase kinase isoforms 1-4 and uses thereof
WO2015188198A2 (en) 2014-06-06 2015-12-10 Berg Llc Methods of treating a metabolic syndrome by modulating heat shock protein (hsp) 90-beta
TW201629026A (zh) 2015-02-02 2016-08-16 佛瑪治療公司 作為ｈｄａｃ抑制劑的３－烷基雙環［４，５，０］異羥肟酸
WO2016126726A1 (en) 2015-02-02 2016-08-11 Forma Therapeutics, Inc. Bicyclic [4,6,0] hydroxamic acids as hdac6 inhibitors
US10555935B2 (en) 2016-06-17 2020-02-11 Forma Therapeutics, Inc. 2-spiro-5- and 6-hydroxamic acid indanes as HDAC inhibitors
TW201821105A (zh) 2016-10-20 2018-06-16 美商弗瑪治療公司 使用ｈｄａｃ１１抑制劑之方法
WO2018095260A1 (en) * 2016-11-28 2018-05-31 National Institute Of Biological Sciences, Beijing Dihydroxyphenyl Sulfonylisoindoline Derivatives
US10357493B2 (en) 2017-03-10 2019-07-23 Selenity Therapeutics (Bermuda), Ltd. Metalloenzyme inhibitor compounds
CN112292370A (zh) * 2018-04-20 2021-01-29 瓦洛早期发现股份有限公司 作为hdac抑制剂的异吲哚啉
US11535607B2 (en) 2018-04-20 2022-12-27 Valo Health, Inc. Isoindolines as HDAC inhibitors
CN108752316B (zh) * 2018-07-18 2020-07-10 云南大学 四氢异喹啉-2-甲基苯并咪唑盐类化合物及其制备方法和应用
US12215382B2 (en) * 2019-03-01 2025-02-04 The General Hospital Corporation Liver protective MARC variants and uses thereof
CN114727974A (zh) * 2019-07-30 2022-07-08 艾科尼佐治疗股份有限公司 Hdac6抑制剂及其用途
CN111808102B (zh) * 2020-08-03 2021-12-31 南通大学 一种3-甲氧基-6,7-二氢-5H-吡咯并[3,4-b]吡啶盐酸盐及其合成方法
WO2022169985A1 (en) 2021-02-03 2022-08-11 Eikonizo Therapeutics, Inc. Hdac6 inhibitors and uses thereof
CN117242056A (zh) * 2021-03-26 2023-12-15 北京加科思新药研发有限公司 用作sting激动剂的新型化合物及其用途

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JP2018531959A (ja) * 2015-10-27 2018-11-01 タイペイ メディカル ユニバーシティ 線維症疾患の治療及び／又は予防用インドリン誘導体

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