JP2011513468A - 新規なｎ−置換テトラヒドロイソキノリン／イソインドリンヒドロキサム酸化合物 - Google Patents

新規なｎ−置換テトラヒドロイソキノリン／イソインドリンヒドロキサム酸化合物 Download PDF

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JP2011513468A
JP2011513468A JP2010550202A JP2010550202A JP2011513468A JP 2011513468 A JP2011513468 A JP 2011513468A JP 2010550202 A JP2010550202 A JP 2010550202A JP 2010550202 A JP2010550202 A JP 2010550202A JP 2011513468 A JP2011513468 A JP 2011513468A
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carboxamide
hydroxy
tetrahydroisoquinoline
disease
diseases
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JP2011513468A5 (enExample
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マイアー，トマス
ベッケルス，トマス
ヘスリンガー，クリスティアン
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４エスツェー アクチェンゲゼルシャフト
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Heart & Thoracic Surgery (AREA)
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  • Diabetes (AREA)
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JP2010550202A 2008-03-13 2009-03-12 新規なｎ−置換テトラヒドロイソキノリン／イソインドリンヒドロキサム酸化合物 Pending JP2011513468A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08004661A EP2100879A1 (en) 2008-03-13 2008-03-13 Novel N-substituted tetrahydroisoquinoline/isoindoline hydroxamic acid compounds
PCT/EP2009/052924 WO2009112550A1 (en) 2008-03-13 2009-03-12 Novel n-substituted tetrahydroisoquinoline/isoindoline hydroxamic acid compounds

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Publication Number Publication Date
JP2011513468A true JP2011513468A (ja) 2011-04-28
JP2011513468A5 JP2011513468A5 (enExample) 2014-02-27

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Country Status (4)

Country Link
US (1) US8575193B2 (enExample)
EP (2) EP2100879A1 (enExample)
JP (1) JP2011513468A (enExample)
WO (1) WO2009112550A1 (enExample)

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JP2012530703A (ja) * 2009-06-22 2012-12-06 ミレニアム ファーマシューティカルズ， インコーポレイテッド 置換ヒドロキサム酸およびその使用
JP2018531959A (ja) * 2015-10-27 2018-11-01 タイペイ メディカル ユニバーシティ 線維症疾患の治療及び／又は予防用インドリン誘導体

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WO2011106627A1 (en) 2010-02-26 2011-09-01 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
WO2011130163A1 (en) 2010-04-12 2011-10-20 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
US8513421B2 (en) 2010-05-19 2013-08-20 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
US8471026B2 (en) 2010-08-26 2013-06-25 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
WO2012031993A1 (en) * 2010-09-09 2012-03-15 F. Hoffmann-La Roche Ag Novel n-hydroxy-benzamides for the treatment of cancer
CN103200936B (zh) * 2010-09-09 2015-03-11 霍夫曼-拉罗奇有限公司 用于治疗癌症的新n-羟基苯甲酰胺类化合物
WO2012054332A1 (en) 2010-10-18 2012-04-26 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
US8778931B2 (en) * 2010-12-22 2014-07-15 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
WO2013041407A1 (en) * 2011-09-19 2013-03-28 Cellzome Ag Hydroxamic acids as hdac6 inhibitors
PH12014500249A1 (en) * 2011-09-19 2022-11-23 Alfasigma Spa New thio derivatives bearing lactams as potent hdac inhibitors and their uses as medicaments
EP2771321A4 (en) * 2011-10-28 2015-04-08 Chong Kun Dang Pharm Corp HYDROXAMATE DERIVATIVES FOR HDAC INHIBITORS AND PHARMACEUTICAL COMPOSITIONS THEREWITH
CN104812898B (zh) 2012-05-25 2018-01-30 博格有限责任公司 通过调节热休克蛋白质(HSP)90‑β治疗代谢综合征的方法
US10167258B2 (en) 2013-12-13 2019-01-01 The Board Of Regents Of The University Of Texas System Inhibitors of mitochondrial pyruvate dehydrogenase kinase isoforms 1-4 and uses thereof
WO2015188198A2 (en) 2014-06-06 2015-12-10 Berg Llc Methods of treating a metabolic syndrome by modulating heat shock protein (hsp) 90-beta
AR103598A1 (es) 2015-02-02 2017-05-24 Forma Therapeutics Inc Ácidos bicíclicos[4,6,0]hidroxámicos como inhibidores de hdac
AU2016215432B2 (en) 2015-02-02 2020-07-30 Valo Early Discovery, Inc. 3-alkyl-4-amido-bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors
EP3472131B1 (en) 2016-06-17 2020-02-19 Forma Therapeutics, Inc. 2-spiro-5- and 6-hydroxamic acid indanes as hdac inhibitors
WO2018075959A1 (en) 2016-10-20 2018-04-26 Forma Therapeutics, Inc. Methods using hdac11 inhibitors
WO2018095260A1 (en) * 2016-11-28 2018-05-31 National Institute Of Biological Sciences, Beijing Dihydroxyphenyl Sulfonylisoindoline Derivatives
WO2018165520A1 (en) 2017-03-10 2018-09-13 Vps-3, Inc. Metalloenzyme inhibitor compounds
CA3097696A1 (en) * 2018-04-20 2019-10-24 Valo Early Discovery, Inc. Isoindolines as hdac inhibitors
US11535607B2 (en) 2018-04-20 2022-12-27 Valo Health, Inc. Isoindolines as HDAC inhibitors
CN108752316B (zh) * 2018-07-18 2020-07-10 云南大学 四氢异喹啉-2-甲基苯并咪唑盐类化合物及其制备方法和应用
US12215382B2 (en) * 2019-03-01 2025-02-04 The General Hospital Corporation Liver protective MARC variants and uses thereof
JP2022543106A (ja) * 2019-07-30 2022-10-07 エイコニゾ セラピューティクス，インコーポレーテッド Ｈｄａｃ６インヒビターおよびそれらの使用
CN111808102B (zh) * 2020-08-03 2021-12-31 南通大学 一种3-甲氧基-6,7-二氢-5H-吡咯并[3,4-b]吡啶盐酸盐及其合成方法
TW202246212A (zh) * 2021-03-26 2022-12-01 大陸商北京加科思新藥研發有限公司 用作sting激動劑的新型化合物及其用途

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JP2018531959A (ja) * 2015-10-27 2018-11-01 タイペイ メディカル ユニバーシティ 線維症疾患の治療及び／又は予防用インドリン誘導体

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