JP2011513419A - ピロロトリアジンキナーゼ阻害剤 - Google Patents

ピロロトリアジンキナーゼ阻害剤 Download PDF

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Publication number
JP2011513419A
JP2011513419A JP2010549840A JP2010549840A JP2011513419A JP 2011513419 A JP2011513419 A JP 2011513419A JP 2010549840 A JP2010549840 A JP 2010549840A JP 2010549840 A JP2010549840 A JP 2010549840A JP 2011513419 A JP2011513419 A JP 2011513419A
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JP
Japan
Prior art keywords
substituted
cancer
compound
pharmaceutically acceptable
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2010549840A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011513419A5 (enExample
Inventor
アペンダー・ベラパーシ
ドラトライ・エム・ビアス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of JP2011513419A publication Critical patent/JP2011513419A/ja
Publication of JP2011513419A5 publication Critical patent/JP2011513419A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2010549840A 2008-03-06 2009-03-04 ピロロトリアジンキナーゼ阻害剤 Pending JP2011513419A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3417108P 2008-03-06 2008-03-06
PCT/US2009/035975 WO2009111531A1 (en) 2008-03-06 2009-03-04 Pyrrolotriazine kinase inhibitors

Publications (2)

Publication Number Publication Date
JP2011513419A true JP2011513419A (ja) 2011-04-28
JP2011513419A5 JP2011513419A5 (enExample) 2012-03-15

Family

ID=40578742

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010549840A Pending JP2011513419A (ja) 2008-03-06 2009-03-04 ピロロトリアジンキナーゼ阻害剤

Country Status (5)

Country Link
US (1) US8212031B2 (enExample)
EP (1) EP2262806A1 (enExample)
JP (1) JP2011513419A (enExample)
CN (1) CN102015719A (enExample)
WO (1) WO2009111531A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2344504B1 (en) 2008-10-08 2014-06-04 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
WO2011049625A1 (en) 2009-10-20 2011-04-28 Mansour Samadpour Method for aflatoxin screening of products
MX352661B (es) 2009-11-05 2017-12-04 Rhizen Pharmaceuticals S A Star Moduladores novedosos de benzopiran cinasa.
JP6118314B2 (ja) 2011-05-04 2017-04-19 ライゼン・ファーマシューティカルズ・エスアー タンパク質キナーゼのモジュレーターとしての新規化合物
AU2013285081B2 (en) 2012-07-04 2017-01-12 Rhizen Pharmaceuticals Sa Selective PI3K delta inhibitors
US9050345B2 (en) 2013-03-11 2015-06-09 Bristol-Myers Squibb Company Pyrrolotriazines as potassium ion channel inhibitors
WO2015081783A1 (zh) * 2013-12-06 2015-06-11 江苏奥赛康药业股份有限公司 吡咯并[2,1-f][1,2,4]三嗪类衍生物及其制备方法和用途
CN111018860B (zh) * 2018-10-10 2022-06-10 中国药科大学 吡咯并三嗪类化合物及其应用
CN110950871B (zh) * 2019-12-25 2022-05-17 陕西师范大学 2-取代-4-芳氨基吡唑并三嗪衍生物及制备抗肿瘤药物的应用
JP2025512935A (ja) 2022-04-08 2025-04-22 シャイ・セラピューティクス・エルエルシー がん、炎症性疾患、ｒａｓ病、及び線維性疾患の処置のためのｒａｓスーパーファミリータンパク質と相互作用する化合物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008005956A2 (en) * 2006-07-07 2008-01-10 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
WO2008021924A1 (en) * 2006-08-09 2008-02-21 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1620437T3 (da) * 2003-04-29 2009-08-24 Pfizer Ltd 5,7-diaminopyrazolo-4,3-d-pyrimidiner, der er anvendelige til behandling af hypertension
WO2008131050A1 (en) 2007-04-18 2008-10-30 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
EP2344504B1 (en) * 2008-10-08 2014-06-04 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008005956A2 (en) * 2006-07-07 2008-01-10 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
WO2008021924A1 (en) * 2006-08-09 2008-02-21 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors

Also Published As

Publication number Publication date
EP2262806A1 (en) 2010-12-22
US20110003821A1 (en) 2011-01-06
US8212031B2 (en) 2012-07-03
WO2009111531A1 (en) 2009-09-11
CN102015719A (zh) 2011-04-13

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