JP2011510650A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011510650A5 JP2011510650A5 JP2010544810A JP2010544810A JP2011510650A5 JP 2011510650 A5 JP2011510650 A5 JP 2011510650A5 JP 2010544810 A JP2010544810 A JP 2010544810A JP 2010544810 A JP2010544810 A JP 2010544810A JP 2011510650 A5 JP2011510650 A5 JP 2011510650A5
- Authority
- JP
- Japan
- Prior art keywords
- hla
- drb4
- fosb
- areg
- ctls1
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 24
- 108090000623 proteins and genes Proteins 0.000 claims 23
- -1 LOC96610 Proteins 0.000 claims 22
- 102100028636 HLA class II histocompatibility antigen, DR beta 4 chain Human genes 0.000 claims 17
- 108010040960 HLA-DRB4 Chains Proteins 0.000 claims 17
- 102100038778 Amphiregulin Human genes 0.000 claims 16
- 101000809450 Homo sapiens Amphiregulin Proteins 0.000 claims 16
- 101000931462 Homo sapiens Protein FosB Proteins 0.000 claims 16
- 102100020847 Protein FosB Human genes 0.000 claims 16
- 101001035752 Homo sapiens Hydroxycarboxylic acid receptor 3 Proteins 0.000 claims 13
- 101001096330 Homo sapiens Retinoid-binding protein 7 Proteins 0.000 claims 13
- 101000659879 Homo sapiens Thrombospondin-1 Proteins 0.000 claims 13
- 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 claims 13
- 102100039356 Hydroxycarboxylic acid receptor 3 Human genes 0.000 claims 13
- 102100037879 Retinoid-binding protein 7 Human genes 0.000 claims 13
- 102100036034 Thrombospondin-1 Human genes 0.000 claims 13
- 102100039390 Toll-like receptor 7 Human genes 0.000 claims 13
- GXAFMKJFWWBYNW-OWHBQTKESA-N 2-[3-[(1r)-1-[(2s)-1-[(2s)-3-cyclopropyl-2-(3,4,5-trimethoxyphenyl)propanoyl]piperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acid Chemical compound C1=C(OC)C(OC)=CC=C1CC[C@H](C=1C=C(OCC(O)=O)C=CC=1)OC(=O)[C@H]1N(C(=O)[C@@H](CC2CC2)C=2C=C(OC)C(OC)=C(OC)C=2)CCCC1 GXAFMKJFWWBYNW-OWHBQTKESA-N 0.000 claims 11
- 102100032045 E3 ubiquitin-protein ligase AMFR Human genes 0.000 claims 11
- 102100039621 Epithelial-stromal interaction protein 1 Human genes 0.000 claims 11
- 102100022633 Fructose-2,6-bisphosphatase Human genes 0.000 claims 11
- 102100028971 HLA class I histocompatibility antigen, C alpha chain Human genes 0.000 claims 11
- 108010052199 HLA-C Antigens Proteins 0.000 claims 11
- 101000879661 Homo sapiens Chitotriosidase-1 Proteins 0.000 claims 11
- 101000776154 Homo sapiens E3 ubiquitin-protein ligase AMFR Proteins 0.000 claims 11
- 101000814134 Homo sapiens Epithelial-stromal interaction protein 1 Proteins 0.000 claims 11
- 101000823467 Homo sapiens Fructose-2,6-bisphosphatase Proteins 0.000 claims 11
- 101001011442 Homo sapiens Interferon regulatory factor 5 Proteins 0.000 claims 11
- 101000840293 Homo sapiens Interferon-induced protein 44 Proteins 0.000 claims 11
- 101001082058 Homo sapiens Interferon-induced protein with tetratricopeptide repeats 2 Proteins 0.000 claims 11
- 101001128500 Homo sapiens Marginal zone B- and B1-cell-specific protein Proteins 0.000 claims 11
- 101001094028 Homo sapiens Phosphatase and actin regulator 2 Proteins 0.000 claims 11
- 101000693269 Homo sapiens Sphingosine 1-phosphate receptor 3 Proteins 0.000 claims 11
- 101000801255 Homo sapiens Tumor necrosis factor receptor superfamily member 17 Proteins 0.000 claims 11
- 102100030131 Interferon regulatory factor 5 Human genes 0.000 claims 11
- 102100029607 Interferon-induced protein 44 Human genes 0.000 claims 11
- 102100027303 Interferon-induced protein with tetratricopeptide repeats 2 Human genes 0.000 claims 11
- 102000003812 Interleukin-15 Human genes 0.000 claims 11
- 108090000172 Interleukin-15 Proteins 0.000 claims 11
- 102100031826 Marginal zone B- and B1-cell-specific protein Human genes 0.000 claims 11
- 102100035266 Phosphatase and actin regulator 2 Human genes 0.000 claims 11
- 102100025747 Sphingosine 1-phosphate receptor 3 Human genes 0.000 claims 11
- 102100030951 Tissue factor pathway inhibitor Human genes 0.000 claims 11
- 102100033726 Tumor necrosis factor receptor superfamily member 17 Human genes 0.000 claims 11
- 108010013555 lipoprotein-associated coagulation inhibitor Proteins 0.000 claims 11
- 102100037328 Chitotriosidase-1 Human genes 0.000 claims 10
- 101001054838 Homo sapiens Immunoglobulin lambda variable 1-44 Proteins 0.000 claims 10
- 102100026921 Immunoglobulin lambda variable 1-44 Human genes 0.000 claims 10
- 206010040047 Sepsis Diseases 0.000 claims 5
- 210000004369 blood Anatomy 0.000 claims 5
- 239000008280 blood Substances 0.000 claims 5
- 239000000523 sample Substances 0.000 claims 5
- 230000004768 organ dysfunction Effects 0.000 claims 4
- 230000003828 downregulation Effects 0.000 claims 3
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 3
- 230000003827 upregulation Effects 0.000 claims 3
- 206010053159 Organ failure Diseases 0.000 claims 2
- 101800004937 Protein C Proteins 0.000 claims 2
- 102100036546 Salivary acidic proline-rich phosphoprotein 1/2 Human genes 0.000 claims 2
- 101800001700 Saposin-D Proteins 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 210000000265 leukocyte Anatomy 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 229940127557 pharmaceutical product Drugs 0.000 claims 2
- 238000004393 prognosis Methods 0.000 claims 2
- 229960000856 protein c Drugs 0.000 claims 2
- 108020004463 18S ribosomal RNA Proteins 0.000 claims 1
- 101150028074 2 gene Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 206010040070 Septic Shock Diseases 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 230000009286 beneficial effect Effects 0.000 claims 1
- 229940088598 enzyme Drugs 0.000 claims 1
- 210000003714 granulocyte Anatomy 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 210000005087 mononuclear cell Anatomy 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 230000036303 septic shock Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08290090A EP2085486A1 (en) | 2008-02-01 | 2008-02-01 | Methods and kits for the rapid determination of patients at high risk of death during septic shock |
| US4391408P | 2008-04-10 | 2008-04-10 | |
| PCT/IB2009/000292 WO2009095786A2 (en) | 2008-02-01 | 2009-01-30 | Methods and kits for the rapid determination of patients at high risk of death during septic shock |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011510650A JP2011510650A (ja) | 2011-04-07 |
| JP2011510650A5 true JP2011510650A5 (enExample) | 2012-03-08 |
Family
ID=39590402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010544810A Pending JP2011510650A (ja) | 2008-02-01 | 2009-01-30 | 敗血症性ショックの間に死亡する危険が高い患者を迅速に決定する方法及びキット |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20110190143A1 (enExample) |
| EP (2) | EP2085486A1 (enExample) |
| JP (1) | JP2011510650A (enExample) |
| CA (1) | CA2713839A1 (enExample) |
| WO (1) | WO2009095786A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010049818A1 (en) * | 2008-10-28 | 2010-05-06 | Assistance Publique - Hopitaux De Paris | Methods and kits for the rapid determination of patients at high risk of death during severe sepsis and septic shock |
| US8283131B2 (en) | 2008-10-28 | 2012-10-09 | Assistance Publique-Hopitaux De Paris | Methods and kits for the rapid determination of patients at high risk of death during severe sepsis and septic shock |
| JP2013536678A (ja) * | 2010-09-03 | 2013-09-26 | コンファルマ・フランス | リアルタイム定量ｐｃｒによる残留宿主細胞ｄｎａの定量 |
| US9938557B2 (en) | 2010-09-16 | 2018-04-10 | The General Hospital Corporation | Red blood cell dynamics for administering treatment for iron-deficiency anemia |
| WO2012068519A2 (en) * | 2010-11-19 | 2012-05-24 | Sirius Genomics Inc. | Markers associated with response to activated protein c administration, and uses thereof |
| WO2013119871A1 (en) | 2012-02-07 | 2013-08-15 | Children's Hospital Medical Center | A multi-biomarker-based outcome risk stratification model for pediatric septic shock |
| WO2013119869A1 (en) | 2012-02-07 | 2013-08-15 | Children's Hospital Medical Center | A multi-biomarker-based outcome risk stratification model for adult septic shock |
| WO2015073665A1 (en) * | 2013-11-13 | 2015-05-21 | The General Hospital Corporation | Methods and assays relating to the treatment of infection |
| EP3074536B1 (en) | 2013-11-25 | 2019-06-19 | Children's Hospital Medical Center | Temporal pediatric sepsis biomarker risk model |
| WO2015135071A1 (en) * | 2014-03-14 | 2015-09-17 | Hancock Robert E W | Diagnostic for sepsis |
| US20170108487A1 (en) * | 2014-06-05 | 2017-04-20 | The General Hospital Corporation | Predicting morbidity associated with red blood cell volume variance |
| US10261068B2 (en) | 2015-06-04 | 2019-04-16 | Children's Hospital Medical Center | Persevere-II: redefining the pediatric sepsis biomarker risk model with septic shock phenotype |
| WO2017106461A1 (en) | 2015-12-15 | 2017-06-22 | The General Hospital Corporation | Methods of estimating blood glucose and related systems |
| US11293852B2 (en) | 2016-04-07 | 2022-04-05 | The General Hospital Corporation | White blood cell population dynamics |
| WO2019173647A1 (en) * | 2018-03-08 | 2019-09-12 | University Of Notre Dame Du Lac | Products for assessing colorectal cancer molecular subtype and risk of recurrence and for determining and adminstering treatment protocols based thereon |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7267945B2 (en) * | 2001-03-26 | 2007-09-11 | Applera Corporation | Methods of determining the presence of polynucleotides employing amplification |
| FR2881437B1 (fr) * | 2005-01-31 | 2010-11-19 | Biomerieux Sa | Procede pour le diagnostic/pronostic d'un syndrome septique |
-
2008
- 2008-02-01 EP EP08290090A patent/EP2085486A1/en not_active Withdrawn
-
2009
- 2009-01-30 EP EP09705033A patent/EP2245194A2/en not_active Withdrawn
- 2009-01-30 US US12/865,536 patent/US20110190143A1/en not_active Abandoned
- 2009-01-30 WO PCT/IB2009/000292 patent/WO2009095786A2/en not_active Ceased
- 2009-01-30 CA CA2713839A patent/CA2713839A1/en not_active Abandoned
- 2009-01-30 JP JP2010544810A patent/JP2011510650A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011510650A5 (enExample) | ||
| JP2016525355A5 (enExample) | ||
| US20210230695A1 (en) | Biomarker detection in pulmonary hypertension | |
| EP2406402A2 (en) | Method to assess human allograft status from microrna expression levels | |
| CN107338324B (zh) | 用于诊断不明原因复发性流产的血清lncRNA标志物、引物组及应用和试剂盒 | |
| US20210404002A1 (en) | Quantitative Algorithm for Endometriosis | |
| CN119776488A (zh) | 一种心力衰竭的生物标志物及其应用 | |
| CN105400882A (zh) | 一种适用于后纵韧带骨化诊断的血清miRNA标志物及应用 | |
| WO2012094366A1 (en) | Circulating mirnas as biomarkers for coronary artery disease | |
| WO2023206854A1 (zh) | 预测缺血性脑卒中发病风险的dna羟甲基化标志物及试剂盒 | |
| US20220220559A1 (en) | Cell-free mirna biomarkers for prognosis and diagnosis of neurodegenerative diseases | |
| EP3164508B1 (en) | Genes and gene signatures for diagnosis and treatment of melanoma | |
| US20200199680A1 (en) | MIRNA in Gulf War Illness | |
| EP2505667B1 (en) | Device and method for analysis of kidney failure | |
| CN115418397B (zh) | 一种用于扩张型心肌病辅助诊断的生物标志物及其应用 | |
| KR102083956B1 (ko) | 다발성 골수종 환자에서 레날리도마이드 및 덱사메타손의 치료에 대한 예후 예측용 바이오 마커 | |
| KR101673148B1 (ko) | 운동 민감도 예측용 바이오마커 | |
| Rowe et al. | Genetics, fitness, and left ventricular remodelling: The current state of play | |
| CN203307347U (zh) | 高血压相关基因位点检测试剂盒 | |
| KR102070969B1 (ko) | 통증 판별용 마커 | |
| CN110806482B (zh) | 用于判断临床治疗对膜性肾病疗效的标志物 | |
| TW202019483A (zh) | 乾癬性關節炎的診斷及治療、與其之套組 | |
| WO2023068220A1 (ja) | 予測方法及びバイオマーカー | |
| KR101673162B1 (ko) | 운동 민감도 예측용 바이오마커 | |
| CN102134585A (zh) | 血浆miR-208a在急性心梗诊断早期标志物中的应用 |