JP2011509676A - ヒトTh17細胞の選択的分化、同定および調節 - Google Patents

ヒトTh17細胞の選択的分化、同定および調節 Download PDF

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JP2011509676A
JP2011509676A JP2010543306A JP2010543306A JP2011509676A JP 2011509676 A JP2011509676 A JP 2011509676A JP 2010543306 A JP2010543306 A JP 2010543306A JP 2010543306 A JP2010543306 A JP 2010543306A JP 2011509676 A JP2011509676 A JP 2011509676A
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cells
cell
tgf
podoplanin
blt1
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JP2011509676A5 (enExample
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ビジェイ ケー. クヘロー,
デイビッド イー. アンダーソン,
エステル ベッテリー,
デイビッド ハフラー,
モハメド オウッカ,
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The Brigham and Women's Hospital Inc
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JP2010543306A 2008-01-18 2009-01-21 ヒトTh17細胞の選択的分化、同定および調節 Pending JP2011509676A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US654108P 2008-01-18 2008-01-18
US3182408P 2008-02-27 2008-02-27
PCT/US2009/031477 WO2009092087A2 (en) 2008-01-18 2009-01-21 Selective differentiation, identification, and modulation of human th17 cells

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JP2011509676A true JP2011509676A (ja) 2011-03-31
JP2011509676A5 JP2011509676A5 (enExample) 2013-02-28

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US (1) US20110245107A1 (enExample)
EP (1) EP2238241B1 (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019112446A (ja) * 2013-07-23 2019-07-11 バイオコン・リミテッド Cd6結合パートナーの使用およびそれに基づく方法

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6702949B2 (en) 1997-10-24 2004-03-09 Microdiffusion, Inc. Diffuser/emulsifier for aquaculture applications
US8609148B2 (en) 2006-10-25 2013-12-17 Revalesio Corporation Methods of therapeutic treatment of eyes
US8445546B2 (en) 2006-10-25 2013-05-21 Revalesio Corporation Electrokinetically-altered fluids comprising charge-stabilized gas-containing nanostructures
EP2086668B1 (en) 2006-10-25 2016-11-16 Revalesio Corporation Mixing device and method
AU2007308840C1 (en) 2006-10-25 2014-09-25 Revalesio Corporation Methods of therapeutic treatment of eyes and other human tissues using an oxygen-enriched solution
US8784897B2 (en) 2006-10-25 2014-07-22 Revalesio Corporation Methods of therapeutic treatment of eyes
US8784898B2 (en) * 2006-10-25 2014-07-22 Revalesio Corporation Methods of wound care and treatment
WO2008115290A2 (en) 2006-10-25 2008-09-25 Revalesio Corporation Methods of wound care and treatment
US10125359B2 (en) 2007-10-25 2018-11-13 Revalesio Corporation Compositions and methods for treating inflammation
US20100310609A1 (en) * 2007-10-25 2010-12-09 Revalesio Corporation Compositions and methods for treatment of neurodegenerative diseases
US20100004189A1 (en) * 2007-10-25 2010-01-07 Revalesio Corporation Compositions and methods for treating cystic fibrosis
US20100008997A1 (en) * 2007-10-25 2010-01-14 Revalesio Corporation Compositions and methods for treating asthma and other lung disorders
US9523090B2 (en) * 2007-10-25 2016-12-20 Revalesio Corporation Compositions and methods for treating inflammation
US9745567B2 (en) 2008-04-28 2017-08-29 Revalesio Corporation Compositions and methods for treating multiple sclerosis
US20100303871A1 (en) * 2007-10-25 2010-12-02 Revalesio Corporation Compositions and methods for modulating cellular membrane-mediated intracellular signal transduction
EP2285347A4 (en) 2008-05-01 2011-09-21 Revalesio Corp COMPOSITIONS AND METHODS OF TREATING DISORDERS OF THE DIGESTION SYSTEM
US20100098687A1 (en) * 2008-10-22 2010-04-22 Revalesio Corporation Compositions and methods for treating thymic stromal lymphopoietin (tslp)-mediated conditions
US8815292B2 (en) 2009-04-27 2014-08-26 Revalesio Corporation Compositions and methods for treating insulin resistance and diabetes mellitus
EP2460880B1 (en) * 2009-07-29 2014-11-19 Sysmex Corporation Marker and reagent for detection of human il-17-producing helper t cells, and method for detection of human il-17-producing helper t cells
EP2459184A1 (en) * 2009-07-31 2012-06-06 The Brigham and Women's Hospital, Inc. Modulation of sgk1 expression in th17 cells to modulate th17-mediated immune responses
JP5481677B2 (ja) * 2009-12-10 2014-04-23 シャープ株式会社 生体内に蓄積した粒子の分析方法
NZ604063A (en) 2010-05-07 2015-01-30 Revalesio Corp Compositions and methods for enhancing physiological performance and recovery time
EP2578232A4 (en) * 2010-06-02 2013-11-20 Dainippon Sumitomo Pharma Co TREATMENT FOR AUTOIMMUN DISEASES AND ALLERGIC DISEASES
FR2960882B1 (fr) * 2010-06-04 2012-11-16 Hospices Civils Lyon Co-culture de cellules mononucleees et de cellules mesenchymateuses pour l'obtention de cellules productrices d'il-17
AU2011289172B2 (en) 2010-08-12 2015-09-24 Revalesio Corporation Compositions and methods for treatment of taupathy
EP2696849A4 (en) * 2011-04-13 2014-10-29 Revalesio Corp COMPOSITIONS AND METHODS FOR INHIBITING AND / OR MODULATING EFFECTOR CELLS IN INFLAMMABLE NEURODEGENERATIVE ILLNESSES
CA2840270C (en) * 2011-06-22 2023-09-26 Apellis Pharmaceuticals, Inc. Methods of treating chronic disorders with complement inhibitors
WO2014134351A2 (en) 2013-02-27 2014-09-04 The Broad Institute, Inc. T cell balance gene expression, compositions of matters and methods of use thereof
HK1225742A1 (zh) 2013-08-22 2017-09-15 Acceleron Pharma, Inc. TGF-β受体II型变体及其用途
WO2017024171A1 (en) 2015-08-04 2017-02-09 Acceleron Pharma Inc. Methods for treating myeloproliferative disorders
US12241053B2 (en) 2015-10-09 2025-03-04 The Brigham And Women's Hospital, Inc. Modulation of novel immune checkpoint targets
LT3628049T (lt) 2017-05-04 2023-08-25 Acceleron Pharma Inc. Tgf-beta ii tipo receptoriaus sulieti baltymai ir jų panaudojimo būdai
WO2020102623A1 (en) * 2018-11-15 2020-05-22 The University Of Toledo Materials and methods for the prevention of rheumatoid arthritis
US12630603B2 (en) 2020-02-20 2026-05-19 Kite Pharma, Inc. Chimeric antigen receptor T cell therapy
WO2022040504A2 (en) * 2020-08-21 2022-02-24 Georgetown University Stem cell-like memory t cells and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007149814A1 (en) * 2006-06-19 2007-12-27 Wyeth Methods of modulating il-22 and il-17

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3710795A (en) 1970-09-29 1973-01-16 Alza Corp Drug-delivery device with stretched, rate-controlling membrane
US5262564A (en) 1992-10-30 1993-11-16 Octamer, Inc. Sulfinic acid adducts of organo nitroso compounds useful as retroviral inactivating agents anti-retroviral agents and anti-tumor agents
US6905827B2 (en) 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
EP2130919A1 (en) 2001-11-05 2009-12-09 ZymoGenetics, Inc. IL-21 antagonists
US7622443B2 (en) * 2002-04-26 2009-11-24 California Institute Of Technology Method for inhibiting pro-angiogenic activities of endothelial cells selectively at a site of neoangiogenesis in a mammal by administration of the extracellular domain of D1-1 polypeptides
MXPA05000655A (es) 2002-07-15 2006-02-22 Harvard College Metodos y composiciones para modular el desarrollo y la funcion de las celulas t helper (th).
ES2389258T3 (es) 2003-06-17 2012-10-24 Millennium Pharmaceuticals, Inc. Composiciones y métodos para inhibir TGF-s
GB0410103D0 (en) * 2004-05-06 2004-06-09 Biolipox Ab New method
EP1771204A4 (en) * 2004-07-01 2008-08-13 Univ New York COMPOSITIONS AND METHOD FOR MODULATING ROR-GAMMA-T
WO2008100328A2 (en) * 2006-07-13 2008-08-21 Burnham Institute For Medical Research METHODS AND COMPOSITIONS FOR TARGETING gC1qR/p32
US8288357B2 (en) * 2007-03-23 2012-10-16 Korea University Research & Business Foundation Use of inhibitors of leukotriene B4 receptor BLT2 for treating human cancers
US20110136113A1 (en) * 2008-08-27 2011-06-09 Sysmex Corporation Marker for detecting il-17-producing helper t cell, and method for detecting il-17-producing helper t cell

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007149814A1 (en) * 2006-06-19 2007-12-27 Wyeth Methods of modulating il-22 and il-17

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
JPN6013038627; IVANOV,I.I. et al.: 'Transcriptional regulation of Th17 cell differentiation.' Semin. Immunol. Vol.19, No.6, 200712, pp.409-17 *
JPN6013038627; Seminars Immunol. Vol.19,, 2007, p.409-417 *
JPN6013038628; Nature Vol.448, 2007, p.480-483 *
JPN6013038628; NURIEVA,R. et al.: 'Essential autocrine regulation by IL-21 in the generation of inflammatory T cells.' Nature Vol.448, No.7152, 20070726, pp.480-3 *
JPN6013038629; Pancreas Vol.31, No.2, 2005, p.148-155 *
JPN6013038629; QU,P. et al.: 'Expression of CCL21 and 5'-Nase on pancreatic lymphatics in nonobese diabetic mice.' Pancreas Vol.31, No.2, 200508, pp.148-55 *
JPN6013038630; IVOS Vol.47, No.4, 2006, p.1543-1549 *
JPN6013038630; LIAO,T. et al.: 'Blockade of the interaction of leukotriene b4 with its receptor prevents development of autoimmune u' Invest. Ophthalmol. Vis. Sci. Vol.47, No.4, 200604, pp.1543-9 *
JPN6014022971; WILSON,N.J. et al.: 'Development, cytokine profile and function of human interleukin 17-producing helper T cells.' Nat. Immunol. Vol.8, No.9, 200709, pp.950-7 *
JPN6014022972; YANG,L. et al.: 'IL-21 and TGF-beta are required for differentiation of human T(H)17 cells.' Nature Vol.454, No.7202, 20080717, pp.350-2 *
JPN6014022975; MIYAMOTO,Y. et al.: 'Podoplanin is an inflammatory protein upregulated in Th17 cells in SKG arthritic joints.' Mol. Immunol. Vol.54, No.2, 201306, pp.199-207 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019112446A (ja) * 2013-07-23 2019-07-11 バイオコン・リミテッド Cd6結合パートナーの使用およびそれに基づく方法

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WO2009092087A2 (en) 2009-07-23
EP2238241A2 (en) 2010-10-13

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