JP2011509157A - 骨造成および保存のためのインプラントペレットおよび方法 - Google Patents
骨造成および保存のためのインプラントペレットおよび方法 Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0003—Not used, see subgroups
- A61C8/0004—Consolidating natural teeth
- A61C8/0006—Periodontal tissue or bone regeneration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
- A61C8/0013—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy with a surface layer, coating
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
- A61C8/0016—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy polymeric material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2/2803—Bones for mandibular reconstruction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C2008/0084—Provisional implants or abutments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2002/3092—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth having an open-celled or open-pored structure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
- A61F2002/30957—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using a positive or a negative model, e.g. moulds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00185—Ceramics or ceramic-like structures based on metal oxides
- A61F2310/00203—Ceramics or ceramic-like structures based on metal oxides containing alumina or aluminium oxide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00185—Ceramics or ceramic-like structures based on metal oxides
- A61F2310/00239—Ceramics or ceramic-like structures based on metal oxides containing zirconia or zirconium oxide ZrO2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00329—Glasses, e.g. bioglass
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/00976—Coating or prosthesis-covering structure made of proteins or of polypeptides, e.g. of bone morphogenic proteins BMP or of transforming growth factors TGF
- A61F2310/00982—Coating made of collagen
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
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Abstract
Description
この出願は、2008年1月9日に出願された米国仮出願61/006,372の優先権を主張する。その出願は参照され、その全体が本出願明細書に組み入れられる。
本明細書に記載された実施態様は歯科外科のための方法およびデバイスに関し、特には骨保存(bone preservation)および/または骨造成(bone augmentation)を行なうためのデバイスおよび方法に関する。
抜歯されたかまたは他の原因で失われた歯が、直ちにグラフトされるかまたはインプラントで置き換えられなかつた時には、歯槽骨またはあご骨の萎縮が時間とともに生じる。
従って、長期間の間、部分的に歯のなくなった状態で放置した人には、しっかりと義歯を支持できない萎縮した顎堤(alveolar ridge)が残っている。更に、歯のなくなった人は審美性が低下し、咀嚼能力が危険にさらされ、好ましくない状態での口内健康状態を残したまま修復されなければならない。
ここに記載される実施態様はペレットと呼ばれるデバイスを含み、これは歯茎の新鮮な抜歯場所内に置かれるか、既存の骨組織上に乗せられる。ペレットは、歯槽内での骨形成(保存または造成)を促進するために設計される。ペレットは、あご骨の欠損に対応する様々な長さ、幅および形であることができる。ペレットは、ポリマーコーティングまたは、ポリマーと他のバイオマテリアル(分解性または非分解性の)から成る複合コーティングの組み合わせを有する1つ以上の生物学的適合性材料を有する。1つ以上の生物学的適合性材料は、骨誘導(osteoinduction)または骨伝導(osteoconduction)による骨成長環境を向上するように設計された、固体、マトリックスまたはメッシュ状の構造内に配置されるか組み立てられる。挿入の後、ペレットは、保存および/または造成用の新しい骨成長形成を促進する。時間とともに、一体化された骨組織(それは成長骨とペレットの間に得られた一体化されたものである)が発達する。一旦適切な骨成長が生じたならば、一体化された骨構造は補綴を支持するか、または開口部を作成するために穴を開けられることができ、それはインプラントデバイスと適合できる。したがって、得られる基礎は、骨組織の保存および/または造成に起因して、補綴またはインプラントデバイスのために向上された支持、固着およびアンカー強度を提供できる。
本明細書で議論された実施態様は骨成長を維持し造成するための技術とペレットを提供し、特には顎堤悪化を減少させて補綴の支持を向上することによく適する。以下の記載では、多数の具体的な詳細、たとえば材料タイプ、寸法、特定の組織などの詳細が、本発明についての完全な理解を提供するために述べられる。生物医学的な技術分野における通常の知識を有する技術者には、本発明がこれらの詳細の多くがなくても実行できることが理解される。他の例では、本発明を不明瞭にしないようにするために、公知の装置、方法および生化学過程は詳細には記載されない。
Claims (16)
- 以下を含む、骨造成および保存を行なうためのペレット:
所望の領域に新しい骨成長を引き起こすための内部材料;および
前記内部材料上のポリマーコーティング。 - 前記のペレットは円筒状である、請求項1記載のペレット。
- 前記の内部材料はバイオセラミック材料である、請求項1記載のペレット。
- 前記のポリマーコーティングが生体吸収性のポリマーである、請求項1記載のペレット。
- 前記ペレットが歯槽堤(edentulous ridge)内に置かれ、前記ペレットが該歯槽堤の保存を促進する、請求項1記載のペレット。
- 前記のペレットが歯槽堤内に置かれ、前記ペレットが該歯槽堤の造成を促進する、請求項1記載のペレット。
- 前記の内部の材料は第一の材料および第二の材料を含む複合材料を含む、請求項1記載のペレット。
- 前記の第一の材料はバイオセラミック材料を含む、請求項7記載のペレット。
- 前記の第二の材料は骨形態形成蛋白質材料を含む、請求項7記載のペレット。
- 前記の内部の材料は、前記の内部の材料を通って新しい骨が成長することを許容するように構成された織物、メッシュ状物に形成される、請求項1記載のペレット。
- 以下を含む、骨造成を行なう方法:
第一の材料およびポリマーコーティングを含むペレットを形成すること;
除去部位に前記のペレットを挿入すること;および
前記の除去部位にオステオインテグレイトされた骨構造を形成すること。 - 前記のオステオインテグレイトされた骨構造に穴を開けて骨内に空間を形成すること;および
前記の骨内の空間にインプラントデバイスを挿入すること、をさらに含む、請求項11記載の方法。 - 前記の骨内の空間に前記のインプラントデバイスをしっかりと取り付けることをさらに含む、請求項12記載の方法。
- 以下を含む、あご骨の顎堤に堤造成を行なう方法:
あご骨の顎堤の歯肉組織中に切り口を作成すること;
造成が望まれる領域で切り込みにペレットを挿入すること;
縫合して切り込みを閉じること;および
該領域内にオステオインテグレイトされた骨構造を形成すること。 - オステオインテグレイトされた骨構造が形成された後に、該領域内に穴を開けること;
前記の開口部内にインプラントを配置すること;および
前記顎堤へ前記のインプラントをしっかりと取り付けること、をさらに含む、請求項14記載の方法。 - オステオインテグレイトされた骨構造が形成された後に、前記の領域の上に補綴を配置することをさらに含む、請求項14記載の方法。
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Application Number | Priority Date | Filing Date | Title |
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US637208P | 2008-01-09 | 2008-01-09 | |
PCT/US2009/030428 WO2009089340A1 (en) | 2008-01-09 | 2009-01-08 | Implant pellets and methods for performing bone augmentation and preservation |
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JP2011509157A true JP2011509157A (ja) | 2011-03-24 |
JP2011509157A5 JP2011509157A5 (ja) | 2012-02-23 |
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US (3) | US8128706B2 (ja) |
EP (1) | EP2234559A1 (ja) |
JP (1) | JP2011509157A (ja) |
KR (1) | KR20100130178A (ja) |
AU (1) | AU2009204183A1 (ja) |
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JP2011509157A (ja) | 2008-01-09 | 2011-03-24 | イノベイテイブ ヘルス テクノロジーズ エルエルシー | 骨造成および保存のためのインプラントペレットおよび方法 |
US11179298B2 (en) * | 2008-01-09 | 2021-11-23 | Innovative Health Technologies, Llc | Implant pellets and methods for performing bone augmentation and preservation |
US9259320B2 (en) | 2008-08-26 | 2016-02-16 | Andy Boiangiu | Apparatus and method for bone augmentation |
US9861482B2 (en) | 2008-08-26 | 2018-01-09 | Andy Boiangiu | Dental bone implant and implant method |
DE202009018865U1 (de) * | 2009-08-21 | 2014-02-06 | Philipp Streckbein | Block aus Knochen - Knochenersatzmaterial |
GB0918484D0 (en) * | 2009-10-22 | 2009-12-09 | Depuy Int Ltd | A medical implant device |
US8470046B2 (en) | 2011-04-25 | 2013-06-25 | Warsaw Orthopedic, Inc. | Bone augmentation device and method |
US9381112B1 (en) | 2011-10-06 | 2016-07-05 | William Eric Sponsell | Bleb drainage device, ophthalmological product and methods |
US8632489B1 (en) | 2011-12-22 | 2014-01-21 | A. Mateen Ahmed | Implantable medical assembly and methods |
US9801700B1 (en) * | 2014-11-17 | 2017-10-31 | Janusz Liberkowski | Dental prosthesis with sealed attachment interface and cleaning fluid access thereto |
CN110430838B (zh) * | 2016-12-08 | 2022-03-08 | 王茜 | 一种具有完整胶原蛋白外壳的骨移植塞及其制备方法 |
KR102190291B1 (ko) * | 2017-04-28 | 2020-12-14 | 한국전기연구원 | 3d 프린팅용 은 잉크 및 이를 이용한 3d 프린팅 방법 |
US20200146737A1 (en) * | 2017-06-14 | 2020-05-14 | Osteoagra Llc | Method, composition, and apparatus for stabilization of vertebral bodies |
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- 2009-01-08 CA CA2711847A patent/CA2711847C/en active Active
- 2009-01-08 AU AU2009204183A patent/AU2009204183A1/en not_active Abandoned
- 2009-01-08 KR KR1020107017693A patent/KR20100130178A/ko not_active Application Discontinuation
- 2009-01-08 EP EP09700423A patent/EP2234559A1/en not_active Withdrawn
-
2012
- 2012-01-31 US US13/362,807 patent/US9301816B2/en active Active
-
2016
- 2016-04-04 US US15/090,201 patent/US9814544B2/en active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS6434372A (en) * | 1987-07-31 | 1989-02-03 | Toa Nenryo Kogyo Kk | Filler for bone depleted part and void part |
JPH10151188A (ja) * | 1996-11-21 | 1998-06-09 | Yamanouchi Pharmaceut Co Ltd | 骨形成用移植体 |
US6143036A (en) * | 1997-12-18 | 2000-11-07 | Comfort Biomedical, Inc. | Bone augmentation for prosthetic implants and the like |
US20070248933A1 (en) * | 2003-10-10 | 2007-10-25 | Dentigenix Inc. | Methods for treating dental conditions using tissue scaffolds |
WO2007079053A2 (en) * | 2005-12-28 | 2007-07-12 | Dentsply International Inc. | Light-curable bone growth material for treating dental bone defects |
Also Published As
Publication number | Publication date |
---|---|
AU2009204183A1 (en) | 2009-07-16 |
EP2234559A1 (en) | 2010-10-06 |
US8128706B2 (en) | 2012-03-06 |
US9814544B2 (en) | 2017-11-14 |
US20120129133A1 (en) | 2012-05-24 |
WO2009089340A1 (en) | 2009-07-16 |
US20090176193A1 (en) | 2009-07-09 |
CA2711847C (en) | 2018-05-08 |
US9301816B2 (en) | 2016-04-05 |
US20160213449A1 (en) | 2016-07-28 |
CA2711847A1 (en) | 2009-07-16 |
KR20100130178A (ko) | 2010-12-10 |
BRPI0906702A2 (pt) | 2015-06-30 |
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