JP2011509156A - 血管移植片の開存性を促進するための組成物および方法 - Google Patents

血管移植片の開存性を促進するための組成物および方法 Download PDF

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JP2011509156A
JP2011509156A JP2010542335A JP2010542335A JP2011509156A JP 2011509156 A JP2011509156 A JP 2011509156A JP 2010542335 A JP2010542335 A JP 2010542335A JP 2010542335 A JP2010542335 A JP 2010542335A JP 2011509156 A JP2011509156 A JP 2011509156A
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Prior art keywords
polymer
vascular graft
poly
graft
conduit
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JP2010542335A
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Japanese (ja)
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JP2011509156A5 (cg-RX-API-DMAC10.html
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クリストファー ブレウアー,
セミス キリアキデス,
ジェイソン ロー,
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Yale University
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Yale University
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Publication of JP2011509156A publication Critical patent/JP2011509156A/ja
Publication of JP2011509156A5 publication Critical patent/JP2011509156A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/195—Chemokines, e.g. RANTES
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/426—Immunomodulating agents, i.e. cytokines, interleukins, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A61L2300/604—Biodegradation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Polymers & Plastics (AREA)
JP2010542335A 2008-01-08 2009-01-08 血管移植片の開存性を促進するための組成物および方法 Pending JP2011509156A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1040608P 2008-01-08 2008-01-08
PCT/US2009/030407 WO2009089324A1 (en) 2008-01-08 2009-01-08 Compositions and methods for promoting patency of vascular grafts

Publications (2)

Publication Number Publication Date
JP2011509156A true JP2011509156A (ja) 2011-03-24
JP2011509156A5 JP2011509156A5 (cg-RX-API-DMAC10.html) 2013-02-21

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US (3) US9855370B2 (cg-RX-API-DMAC10.html)
JP (1) JP2011509156A (cg-RX-API-DMAC10.html)
WO (1) WO2009089324A1 (cg-RX-API-DMAC10.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9855370B2 (en) 2008-01-08 2018-01-02 Yale University Compositions and methods for promoting patency of vascular grafts
WO2013003157A1 (en) * 2011-06-28 2013-01-03 Yale University Cell-free tissued engineered vascular grafts
US10195252B2 (en) 2012-08-03 2019-02-05 University of Pittsburgh—of the Commonwealth System of Higher Education Recruitment of mensenchymal cells using controlled release systems
WO2015148775A1 (en) * 2014-03-27 2015-10-01 Board Of Regents, The University Of Texas System Compositions and methods for growing autologous biological tissue
WO2017100782A1 (en) * 2015-12-11 2017-06-15 Research Institute At Nationwide Children's Hospital Systems and methods for optimized patent specific tissue engineering vascular grafts
US20200054790A1 (en) * 2017-05-02 2020-02-20 The Johns Hopkins University Implantable vascular grafts
WO2021097419A1 (en) * 2019-11-15 2021-05-20 Research Institute At Nationwide Children's Hospital Systems and methods producing seeded grafts
CN119454907A (zh) * 2025-01-09 2025-02-18 浙江大学 Vegf-c156s在制备减轻静脉移植物狭窄的药物中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003506401A (ja) * 1999-08-06 2003-02-18 ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム 薬剤放出生分解性繊維インプラント
US20030082148A1 (en) * 2001-10-31 2003-05-01 Florian Ludwig Methods and device compositions for the recruitment of cells to blood contacting surfaces in vivo
WO2007059253A2 (en) * 2005-11-15 2007-05-24 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5459128A (en) * 1993-11-12 1995-10-17 Dana-Farber Cancer Institute Human monocyte chemoattractant protein-1 (MCP-1) derivatives
US5716394A (en) 1994-04-29 1998-02-10 W. L. Gore & Associates, Inc. Blood contact surfaces using extracellular matrix synthesized in vitro
US6774278B1 (en) 1995-06-07 2004-08-10 Cook Incorporated Coated implantable medical device
US5922554A (en) 1995-10-30 1999-07-13 The Regents Of The University Of California Inhibition of cellular uptake of cholesterol
EP0880586A1 (en) 1996-02-01 1998-12-02 The University Of Florida Lyst1 and lyst2 gene compositions and methods of use
GB9716657D0 (en) * 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds
AU3214099A (en) 1998-04-03 1999-10-25 Curagen Corporation Lyst protein complexes and lyst interacting proteins
US6984400B2 (en) 1998-07-14 2006-01-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of treating restenosis using bisphosphonate nanoparticles
US7008645B2 (en) 1998-07-14 2006-03-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of inhibiting restenosis using bisphosphonates
US6184226B1 (en) 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
FR2785812B1 (fr) * 1998-11-16 2002-11-29 Commissariat Energie Atomique Protheses bioactives, notamment a proprietes immunosuppressives, antistenose et antithrombose, et leur fabrication
US7763580B2 (en) 1999-01-05 2010-07-27 University Of Utah Research Foundation Methods for treating conditions associated with the accumulation of excess extracellular matrix
GB9902455D0 (en) * 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
AU4798000A (en) 1999-04-09 2000-11-14 Smithkline Beecham Corporation Triarylimidazoles
US20020125613A1 (en) 2001-03-08 2002-09-12 Cominsky Kenneth D. Mandrel fabrication for cobond assembly
US6660034B1 (en) * 2001-04-30 2003-12-09 Advanced Cardiovascular Systems, Inc. Stent for increasing blood flow to ischemic tissues and a method of using the same
CA2449978A1 (en) * 2001-06-15 2002-12-27 Johns Hopkins Singapore Pte Ltd Biofunctional fibers
US20030064965A1 (en) 2001-10-02 2003-04-03 Jacob Richter Method of delivering drugs to a tissue using drug-coated medical devices
KR20040051618A (ko) 2001-10-25 2004-06-18 위스콘신 얼럼나이 리서어치 화운데이션 단백질 티로신 키나아제 저해제로 피복되거나 함침된 혈관스텐트 또는 이식물 및 그를 사용하는 방법
US20040063654A1 (en) 2001-11-02 2004-04-01 Davis Mark E. Methods and compositions for therapeutic use of RNA interference
GB0217786D0 (en) 2002-07-31 2002-09-11 Glaxo Group Ltd Compounds
US20050163821A1 (en) * 2002-08-02 2005-07-28 Hsing-Wen Sung Drug-eluting Biodegradable Stent and Delivery Means
EP1542724A4 (en) * 2002-08-19 2005-10-19 Abgenix Inc ANTIBODIES AGAINST THE MONOCYTE 1 CHIMIOATTRACTIVE PROTEIN (MCP-1) AND USES THEREOF
US7405299B2 (en) 2002-11-27 2008-07-29 Eli Lilly And Company Compounds as pharmaceutical agents
WO2004073504A2 (en) * 2003-02-20 2004-09-02 Proteon Therapeutics, Llc Methods for the treatment and prevention of diseases of biological conduits
DE602004015429D1 (de) 2003-03-11 2008-09-11 Pfizer Prod Inc Pyrazinverbindungen als inhibitoren des transforming growth factor (tgf)
ES2389258T3 (es) 2003-06-17 2012-10-24 Millennium Pharmaceuticals, Inc. Composiciones y métodos para inhibir TGF-s
US20080206219A1 (en) 2003-08-08 2008-08-28 The Regencts Of The University Of California Novel Indications for Transforming Growth Factor-Beta Regulators
AU2004277302B2 (en) 2003-09-29 2010-08-26 Hemoteq Ag Biocompatible, biostable coating of medical surfaces
CA2536042A1 (en) * 2003-11-10 2005-06-02 Angiotech International Ag Medical implants and anti-scarring agents
US6997989B2 (en) * 2003-12-08 2006-02-14 Boston Scientific Scimed, Inc. Medical implant processing chamber
ES2346226T3 (es) 2003-12-30 2010-10-13 Augustinus Bader Uso de la eritropoyetina para la regeneracion de tejido hepatico.
DE602005020754D1 (de) 2004-03-31 2010-06-02 Cook Inc Transplantatmaterial und gefässprothese mit extrazellulärer kollagenmatrix und dessen herstellungsverfahren
US7763065B2 (en) 2004-07-21 2010-07-27 Reva Medical, Inc. Balloon expandable crush-recoverable stent device
JP5144000B2 (ja) 2004-08-25 2013-02-13 太陽化学株式会社 形質転換増殖因子β抑制用組成物
JP2008511631A (ja) 2004-08-31 2008-04-17 バイオジェン・アイデック・エムエイ・インコーポレイテッド TGF−βインヒビターとしてのピリミジニルイミダゾール
WO2006099332A2 (en) 2005-03-11 2006-09-21 Wake Forest University Health Sciences Production of tissue engineered digits and limbs
US20060217437A1 (en) 2005-03-17 2006-09-28 Burmester James K TGF-beta modulators and methods for using the same
CN101553244B (zh) 2006-07-21 2013-01-02 普罗米克斯有限公司 内膜增生和相关病状的治疗
WO2008039521A2 (en) * 2006-09-26 2008-04-03 Nmt Medical, Inc. Method for modifying a medical implant surface for promoting tissue growth
EP2527345B1 (en) 2006-10-16 2015-12-16 Thesan Pharmaceuticals, Inc. Therapeutic pyrazolyl thienopyridines
US7959942B2 (en) 2006-10-20 2011-06-14 Orbusneich Medical, Inc. Bioabsorbable medical device with coating
US20100076544A1 (en) 2007-01-30 2010-03-25 Erika Hoffmann Biodegradable vascular support
KR100932688B1 (ko) 2007-07-06 2009-12-21 한국과학기술연구원 인공혈관용 이중막 구조의 튜브형 다공성 스캐폴드 및 그의제조방법
US20090043378A1 (en) * 2007-08-10 2009-02-12 Medtronic Vascular, Inc. Biocompatible Polymer System for Extended Drug Release
US8277832B2 (en) 2007-10-10 2012-10-02 The University Of Kansas Microsphere-based materials with predefined 3D spatial and temporal control of biomaterials, porosity and/or bioactive signals
US7824601B1 (en) 2007-11-14 2010-11-02 Abbott Cardiovascular Systems Inc. Process of making a tubular implantable medical device
US9855370B2 (en) 2008-01-08 2018-01-02 Yale University Compositions and methods for promoting patency of vascular grafts
US20100092534A1 (en) * 2008-10-10 2010-04-15 Medtronic Vascular, Inc. Combination Local Delivery Using a Stent
US20100129414A1 (en) 2008-11-24 2010-05-27 Medtronic Vascular, Inc. Bioactive Agent Delivery Using Liposomes in Conjunction With Stent Deployment
RU2440128C1 (ru) 2010-05-17 2012-01-20 Государственное образовательное учреждение дополнительного профессионального образования "Санкт-Петербургская медицинская академия последипломного образования Федерального агентства по здравоохранению и социальному развитию" (ГОУ ДПО СПбМАПО Росздрава) Способ комплексной патогенетической терапии острых форм вирусного гепатита в и микст-гепатитов (в+с, в+d, в+с+d)
CN102884172B (zh) 2010-05-17 2016-01-20 耶鲁大学 用于将细胞种植到三维支架上的系统
US9090863B2 (en) 2010-05-17 2015-07-28 Pall Corporation System for seeding cells onto three dimensional scaffolds
US20130013083A1 (en) 2011-01-06 2013-01-10 Humacyte Tissue-Engineered Constructs
US10227568B2 (en) 2011-03-22 2019-03-12 Nanofiber Solutions, Llc Fiber scaffolds for use in esophageal prostheses
WO2013003157A1 (en) 2011-06-28 2013-01-03 Yale University Cell-free tissued engineered vascular grafts
CN105209678A (zh) 2013-03-15 2015-12-30 纳米纤维解决方案股份有限公司 用于植入的生物相容的纤维织物
WO2014197790A1 (en) 2013-06-06 2014-12-11 University Of Maryland, College Park Compositions and methods for making biodegradable structures
WO2017100782A1 (en) 2015-12-11 2017-06-15 Research Institute At Nationwide Children's Hospital Systems and methods for optimized patent specific tissue engineering vascular grafts

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003506401A (ja) * 1999-08-06 2003-02-18 ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム 薬剤放出生分解性繊維インプラント
US20030082148A1 (en) * 2001-10-31 2003-05-01 Florian Ludwig Methods and device compositions for the recruitment of cells to blood contacting surfaces in vivo
WO2007059253A2 (en) * 2005-11-15 2007-05-24 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN6013035706; J. Pediatric Surgery, 2007, Vol.42, pp.198-202 *

Also Published As

Publication number Publication date
WO2009089324A1 (en) 2009-07-16
US9855370B2 (en) 2018-01-02
US12186455B2 (en) 2025-01-07
US20220226542A1 (en) 2022-07-21
US20100303889A1 (en) 2010-12-02
US20180193529A1 (en) 2018-07-12

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