JP2011509074A5 - - Google Patents
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- JP2011509074A5 JP2011509074A5 JP2010538832A JP2010538832A JP2011509074A5 JP 2011509074 A5 JP2011509074 A5 JP 2011509074A5 JP 2010538832 A JP2010538832 A JP 2010538832A JP 2010538832 A JP2010538832 A JP 2010538832A JP 2011509074 A5 JP2011509074 A5 JP 2011509074A5
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- JP
- Japan
- Prior art keywords
- formula
- groups
- compound
- sensitive
- transport
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims 8
- 150000002430 hydrocarbons Chemical group 0.000 claims 6
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 230000000975 bioactive effect Effects 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical class C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 claims 2
- MWPLVEDNUUSJAV-UHFFFAOYSA-N anthracene Chemical class C1=CC=CC2=CC3=CC=CC=C3C=C21 MWPLVEDNUUSJAV-UHFFFAOYSA-N 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical class C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 125000000524 functional group Chemical group 0.000 claims 2
- 125000003367 polycyclic group Chemical group 0.000 claims 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000371 Esterases Proteins 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 125000005598 acylhydrazone group Chemical group 0.000 claims 1
- 150000003797 alkaloid derivatives Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000012620 biological material Substances 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 125000001295 dansyl group Chemical class [H]C1=C([H])C(N(C([H])([H])[H])C([H])([H])[H])=C2C([H])=C([H])C([H])=C(C2=C1[H])S(*)(=O)=O 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 230000020477 pH reduction Effects 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 125000002345 steroid group Chemical group 0.000 claims 1
- 0 C*(C)C(C)(C)C(C)(C)*C(C)(C)C(C)(C)NC(C)(C)* Chemical compound C*(C)C(C)(C)C(C)(C)*C(C)(C)C(C)(C)NC(C)(C)* 0.000 description 2
- FGALPHNSQJNSNG-UHFFFAOYSA-N CC(C)(C)C(C)(C)N Chemical compound CC(C)(C)C(C)(C)N FGALPHNSQJNSNG-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0708861A FR2925491B1 (fr) | 2007-12-19 | 2007-12-19 | Nouvelle classe de lipides cationiques pour le transport d'agents actifs dans les cellules |
| PCT/FR2008/001755 WO2009106713A2 (fr) | 2007-12-19 | 2008-12-16 | Nouvelle classe de lipides cationiques pour le transport d'agents actifs dans les cellules |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011509074A JP2011509074A (ja) | 2011-03-24 |
| JP2011509074A5 true JP2011509074A5 (https=) | 2012-01-19 |
Family
ID=39731919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010538832A Pending JP2011509074A (ja) | 2007-12-19 | 2008-12-16 | 活性剤を細胞内に輸送するためのカチオン性脂質の新規なクラス |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9107931B2 (https=) |
| EP (1) | EP2285772B1 (https=) |
| JP (1) | JP2011509074A (https=) |
| CA (1) | CA2708988C (https=) |
| FR (1) | FR2925491B1 (https=) |
| WO (1) | WO2009106713A2 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2851280C (en) | 2011-10-11 | 2021-05-18 | The Brigham And Women's Hospital, Inc. | Micrornas in neurodegenerative disorders |
| EP2831034B1 (en) | 2012-03-28 | 2019-07-31 | University of Central Florida Research Foundation, Inc. | Anti-metastatic agents predicated upon polyamine-macrocyclic conjugates |
| CA2868463C (en) | 2012-03-28 | 2021-01-19 | University Of Central Florida Research Foundation, Inc. | Polyamine transport selective therapeutic agents with enhanced stability |
| US9603799B2 (en) | 2013-03-15 | 2017-03-28 | Htd Biosystems Inc. | Liposomal vaccine adjuvants and methods of making and using same |
| US20140271815A1 (en) * | 2013-03-15 | 2014-09-18 | Aryo Sorayya | Heat-and freeze-stable vaccines and methods of making and using same |
| US8853278B1 (en) | 2013-05-22 | 2014-10-07 | Curza Global, Llc | Compositions comprising a biocidal polyamine |
| US9439433B2 (en) | 2013-05-22 | 2016-09-13 | Curza Global, Llc | Compositions and methods comprising a biocidal polyamine |
| US20160110406A1 (en) * | 2014-10-16 | 2016-04-21 | Microsoft Technology Licensing, Llc | Validation of data across multiple data stores |
| EP3218012A1 (en) | 2014-11-10 | 2017-09-20 | ethris GmbH | Induction of osteogenesis by delivering bmp encoding rna |
| CA2975371C (en) * | 2015-01-30 | 2024-02-13 | Nof Corporation | Cationic lipid for nucleic acid delivery |
| WO2017186711A1 (en) | 2016-04-25 | 2017-11-02 | Invivogen | Novel complexes of immunostimulatory compounds, and uses thereof |
| AU2017341769B2 (en) | 2016-10-13 | 2021-11-11 | Carnot, Llc | N-Acylethanolamide derivatives and uses thereof |
| CA3037046A1 (en) | 2016-10-31 | 2018-05-03 | University Of Massachusetts | Targeting microrna-101-3p in cancer therapy |
| CA3058813A1 (en) | 2017-04-05 | 2018-10-11 | University Of Utah Research Foundation | Compositions and methods comprising a triaryl polyamine |
| CN118949075A (zh) | 2019-02-14 | 2024-11-15 | 埃泽瑞斯公司 | 纤毛疾病的治疗 |
| EP4553084A3 (en) | 2020-11-04 | 2025-11-26 | Ethris GmbH | Use of ifn-lambda mrna for treating viral infections |
| WO2024121160A1 (en) | 2022-12-05 | 2024-06-13 | Ethris Gmbh | Regulator(s) of energy homeostasis-encoding rna molecule(s) with increased translation efficiency |
| EP4480943A1 (en) * | 2023-06-22 | 2024-12-25 | Oz Biosciences | New class of lipids for delivering active ingredients into cells |
| IT202300015291A1 (it) | 2023-07-20 | 2025-01-20 | Fond Riccardo Terzi E Silvio Albini | Sistema di rilascio comprendente nanoparticelle lipidiche o polimeriche comprendenti ormoni tiroidei |
| WO2025097659A1 (en) * | 2023-11-08 | 2025-05-15 | Longuide Biopharma Corporation | Lipids and lipid nanoparticle formulations |
| WO2025209467A1 (en) * | 2024-04-01 | 2025-10-09 | Longuide Biopharma Corporation | Lipids and lipid nanoparticle formulations |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1351368A (fr) * | 1960-12-05 | 1964-02-07 | Merck & Co Inc | Composés d'isocyanates organiques et leur procédé de fabrication |
| CH448122A (de) * | 1963-10-14 | 1967-12-15 | Hoffmann La Roche | Verfahren zur Herstellung von Estern |
| JPS6039716B2 (ja) * | 1982-02-02 | 1985-09-07 | ライオン株式会社 | カチオン性界面活性剤組成物 |
| US4749694A (en) * | 1984-04-26 | 1988-06-07 | Merck & Co., Inc. | Novel lysine esters used as absorption |
| WO1987002367A2 (en) * | 1985-10-18 | 1987-04-23 | The Upjohn Company | Cyclic hydrocarbons with an aminoalkyl sidechain |
| EP0320976A1 (en) * | 1987-12-18 | 1989-06-21 | Ajinomoto Co., Inc. | Arginine derivatives and cosmetic compositions comprising the same |
| AU666416B2 (en) * | 1993-01-29 | 1996-02-08 | Tanabe Seiyaku Co., Ltd. | Ellipticine derivative and process for preparing the same |
| GB9326518D0 (en) * | 1993-12-29 | 1994-03-02 | Sandoz Ltd | Organic compounds |
| US5939401A (en) * | 1994-12-09 | 1999-08-17 | Genzyme Corporation | Cationic amphiphile compositions for intracellular delivery of therapeutic molecules |
| US5948767A (en) * | 1994-12-09 | 1999-09-07 | Genzyme Corporation | Cationic amphiphile/DNA complexes |
| US6071890A (en) * | 1994-12-09 | 2000-06-06 | Genzyme Corporation | Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy |
| US5719131A (en) * | 1994-12-09 | 1998-02-17 | Genzyme Corporation | Cationic amphiphiles containing dialkylamine lipophilic groups for intracellular delivery of therapeutic molecules |
| JPH08239398A (ja) * | 1995-03-03 | 1996-09-17 | Sogo Yatsukou Kk | 水不溶性、自己支持性透明ｄｎａ・脂質複合体フィルムおよびその製造方法 |
| EP0775751A3 (en) * | 1995-11-22 | 1998-06-10 | F. Hoffmann-La Roche Ag | Cell transfection |
| EP0784984B1 (en) * | 1996-01-17 | 2003-07-02 | F. Hoffmann-La Roche Ag | Transfection competent molecules |
| ATE244021T1 (de) * | 1996-01-17 | 2003-07-15 | Hoffmann La Roche | Transfektionskompetente moleküle |
| EP1046394A3 (en) * | 1999-04-19 | 2001-10-10 | ImaRx Pharmaceutical Corp. | Novel compositions useful for delivering compounds into a cell |
| DE60115667T2 (de) * | 2000-09-05 | 2006-08-24 | Centelion | Säureempfindliche verbindungen, deren herstellung und verwendungen |
| GB0106041D0 (en) * | 2001-03-12 | 2001-05-02 | Cancer Res Ventures Ltd | Lipids and liposomes |
| WO2003005965A2 (en) * | 2001-07-11 | 2003-01-23 | Musc Foundation For Research Development | Modulators of ceramidase and methods of use based thereon |
| EP1575976A4 (en) * | 2001-11-02 | 2006-08-23 | Insert Therapeutics Inc | METHODS AND COMPOSITIONS FOR THE THERAPEUTIC USE OF RNA INTERFERENCE |
| US20060148734A1 (en) * | 2002-03-27 | 2006-07-06 | Patrick Camilleri | Diaminoacid-aminoacid-polyamine based gemini surfactant compounds |
| JP4875612B2 (ja) * | 2005-04-27 | 2012-02-15 | 真司 武岡 | カチオン性アミノ酸型脂質 |
| WO2007079394A2 (en) * | 2005-12-30 | 2007-07-12 | Revance Therapeutics, Inc. | Arginine heteromers for topical administration |
-
2007
- 2007-12-19 FR FR0708861A patent/FR2925491B1/fr active Active
-
2008
- 2008-12-16 JP JP2010538832A patent/JP2011509074A/ja active Pending
- 2008-12-16 EP EP08872753.2A patent/EP2285772B1/fr active Active
- 2008-12-16 CA CA2708988A patent/CA2708988C/fr active Active
- 2008-12-16 WO PCT/FR2008/001755 patent/WO2009106713A2/fr not_active Ceased
-
2011
- 2011-02-16 US US13/028,940 patent/US9107931B2/en active Active
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