JP2011507933A5 - - Google Patents
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- Publication number
- JP2011507933A5 JP2011507933A5 JP2010540130A JP2010540130A JP2011507933A5 JP 2011507933 A5 JP2011507933 A5 JP 2011507933A5 JP 2010540130 A JP2010540130 A JP 2010540130A JP 2010540130 A JP2010540130 A JP 2010540130A JP 2011507933 A5 JP2011507933 A5 JP 2011507933A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- targeting agent
- use according
- cell
- bound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 claims 40
- 230000008685 targeting Effects 0.000 claims 35
- 239000000427 antigen Substances 0.000 claims 31
- 102000036639 antigens Human genes 0.000 claims 31
- 108091007433 antigens Proteins 0.000 claims 31
- 239000003795 chemical substances by application Substances 0.000 claims 31
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 239000012636 effector Substances 0.000 claims 5
- 230000009919 sequestration Effects 0.000 claims 5
- 239000003463 adsorbent Substances 0.000 claims 4
- 210000004369 blood Anatomy 0.000 claims 4
- 239000008280 blood Substances 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 4
- 229940127121 immunoconjugate Drugs 0.000 claims 3
- 229940124549 vasodilator Drugs 0.000 claims 3
- 239000003071 vasodilator agent Substances 0.000 claims 3
- 210000000601 blood cell Anatomy 0.000 claims 2
- 231100000433 cytotoxic Toxicity 0.000 claims 2
- 230000001472 cytotoxic effect Effects 0.000 claims 2
- 229960001389 doxazosin Drugs 0.000 claims 2
- RUZYUOTYCVRMRZ-UHFFFAOYSA-N doxazosin Chemical compound C1OC2=CC=CC=C2OC1C(=O)N(CC1)CCN1C1=NC(N)=C(C=C(C(OC)=C2)OC)C2=N1 RUZYUOTYCVRMRZ-UHFFFAOYSA-N 0.000 claims 2
- 230000014759 maintenance of location Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229960001289 prazosin Drugs 0.000 claims 2
- IENZQIKPVFGBNW-UHFFFAOYSA-N prazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1=CC=CO1 IENZQIKPVFGBNW-UHFFFAOYSA-N 0.000 claims 2
- 230000009885 systemic effect Effects 0.000 claims 2
- VCKUSRYTPJJLNI-UHFFFAOYSA-N terazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1CCCO1 VCKUSRYTPJJLNI-UHFFFAOYSA-N 0.000 claims 2
- 229960001693 terazosin Drugs 0.000 claims 2
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000002919 epithelial cell Anatomy 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 210000002216 heart Anatomy 0.000 claims 1
- 210000003494 hepatocyte Anatomy 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 238000002616 plasmapheresis Methods 0.000 claims 1
- 230000001172 regenerating effect Effects 0.000 claims 1
- 238000011285 therapeutic regimen Methods 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
- 238000011269 treatment regimen Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1663007P | 2007-12-26 | 2007-12-26 | |
| US1661307P | 2007-12-26 | 2007-12-26 | |
| PCT/EP2008/068268 WO2009080831A1 (en) | 2007-12-26 | 2008-12-23 | Method of decreasing cytotoxic side-effects and improving efficacy of immunoconjugates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014241327A Division JP2015038158A (ja) | 2007-12-26 | 2014-11-28 | 免疫複合体の細胞傷害性副作用の低減及び有効性の改善方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011507933A JP2011507933A (ja) | 2011-03-10 |
| JP2011507933A5 true JP2011507933A5 (cg-RX-API-DMAC7.html) | 2012-02-16 |
Family
ID=40459778
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010540130A Pending JP2011507933A (ja) | 2007-12-26 | 2008-12-23 | 免疫複合体の細胞傷害性副作用の低減及び有効性の改善方法 |
| JP2014241327A Pending JP2015038158A (ja) | 2007-12-26 | 2014-11-28 | 免疫複合体の細胞傷害性副作用の低減及び有効性の改善方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014241327A Pending JP2015038158A (ja) | 2007-12-26 | 2014-11-28 | 免疫複合体の細胞傷害性副作用の低減及び有効性の改善方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9011864B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2238169A1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2011507933A (cg-RX-API-DMAC7.html) |
| AR (1) | AR069979A1 (cg-RX-API-DMAC7.html) |
| TW (1) | TWI524897B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009080831A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060045877A1 (en) * | 2004-08-30 | 2006-03-02 | Goldmakher Viktor S | Immunoconjugates targeting syndecan-1 expressing cells and use thereof |
| US9221914B2 (en) * | 2007-12-26 | 2015-12-29 | Biotest Ag | Agents targeting CD138 and uses thereof |
| PL2242772T3 (pl) * | 2007-12-26 | 2015-05-29 | Biotest Ag | Immunokonjugaty nakierowane na CD138 i ich zastosowanie |
| PL2240516T3 (pl) * | 2007-12-26 | 2015-12-31 | Biotest Ag | Sposoby i środki do ulepszania nakierowania na komórki nowotworowe z ekspresją CD138 |
| AU2013201618B2 (en) * | 2009-05-06 | 2016-06-02 | Biotest Ag | Uses of immunoconjugates targeting CD138 |
| JP2012526079A (ja) * | 2009-05-06 | 2012-10-25 | バイオテスト・アクチエンゲゼルシヤフト | Cd138を標的とする免疫複合体の使用 |
| EP2589609A1 (en) | 2011-11-03 | 2013-05-08 | Pierre Fabre Medicament | Antigen binding protein and its use as addressing product for the treatment of cancer |
| WO2013083817A1 (en) | 2011-12-08 | 2013-06-13 | Biotest Ag | Uses of immunoconjugates targeting cd138 |
| US9353150B2 (en) | 2012-12-04 | 2016-05-31 | Massachusetts Institute Of Technology | Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment |
| CN105339498A (zh) * | 2013-03-07 | 2016-02-17 | 贝勒医学院 | 癌症中靶向cd138 |
| US10208125B2 (en) | 2013-07-15 | 2019-02-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Anti-mucin 1 binding agents and uses thereof |
| CN106029696B (zh) | 2013-12-17 | 2020-07-28 | 基因泰克公司 | 抗cd3抗体及使用方法 |
| CA2954934C (en) | 2014-06-30 | 2023-09-26 | Glykos Finland Oy | Drug derivative and conjugates |
| CA2983456A1 (en) * | 2015-06-12 | 2016-12-15 | Immunomedics, Inc. | Disease therapy with chimeric antigen receptor (car) constructs and t cells (car-t) or nk cells (car-nk) expressing car constructs |
| JP2018526972A (ja) | 2015-06-16 | 2018-09-20 | ジェネンテック, インコーポレイテッド | 抗cd3抗体及び使用方法 |
| PE20240218A1 (es) | 2015-06-16 | 2024-02-16 | Genentech Inc | Anticuerpos madurados por afinidad y humanizados para fcrh5 |
| US10918627B2 (en) | 2016-05-11 | 2021-02-16 | Massachusetts Institute Of Technology | Convergent and enantioselective total synthesis of Communesin analogs |
| US11466094B2 (en) | 2016-11-15 | 2022-10-11 | Genentech, Inc. | Dosing for treatment with anti-CD20/anti-CD3 bispecific antibodies |
| CN110234348B (zh) | 2016-12-16 | 2024-06-25 | 蓝鳍生物医药公司 | 抗-含cub结构域蛋白1(cdcp1)抗体、抗体药物缀合物及其使用方法 |
| WO2018209239A1 (en) | 2017-05-11 | 2018-11-15 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
| MX2020003783A (es) | 2017-10-02 | 2021-01-08 | Visterra Inc | Moleculas de anticuerpo de cd138 y sus usos. |
| US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
| CN118772288A (zh) | 2018-02-08 | 2024-10-15 | 豪夫迈·罗氏有限公司 | 双特异性抗原结合分子和使用方法 |
| SG11202110702WA (en) * | 2019-04-29 | 2021-11-29 | Immunogen Inc | Therapeutic combinations comprising anti-cd123 immunoconjugates |
| US11535634B2 (en) | 2019-06-05 | 2022-12-27 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
| US12338291B2 (en) | 2019-06-17 | 2025-06-24 | Visterra, Inc. | Humanized antibody molecules to CD138 and uses thereof |
| AR120741A1 (es) | 2019-12-13 | 2022-03-16 | Genentech Inc | Anticuerpos anti-ly6g6d y métodos de uso |
| JP7716473B2 (ja) | 2020-11-04 | 2025-07-31 | ジェネンテック, インコーポレイテッド | 抗cd20/抗cd3二重特異性抗体の皮下投薬 |
| WO2022098638A2 (en) | 2020-11-04 | 2022-05-12 | Genentech, Inc. | Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies |
| WO2022182415A1 (en) | 2021-02-24 | 2022-09-01 | Massachusetts Institute Of Technology | Himastatin derivatives, and processes of preparation thereof, and uses thereof |
| CA3218578A1 (en) | 2021-05-14 | 2022-11-17 | Carol Elaine O'hear | Methods for treatment of cd20-positive proliferative disorder with mosunetuzumab and polatuzumab vedotin |
| WO2023201291A1 (en) | 2022-04-13 | 2023-10-19 | Genentech, Inc. | Pharmaceutical compositions of mosunetuzumab and methods of use |
| GB202313214D0 (en) * | 2023-08-30 | 2023-10-11 | Iksuda Therapeutics Ltd | Co-administration of antibody-drug conjugate |
Family Cites Families (84)
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| CN103554261B (zh) * | 2003-07-21 | 2017-03-01 | 伊缪诺金公司 | Ca6抗原特异性细胞毒性偶联物及其应用方法 |
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| US20060045877A1 (en) * | 2004-08-30 | 2006-03-02 | Goldmakher Viktor S | Immunoconjugates targeting syndecan-1 expressing cells and use thereof |
| NZ586780A (en) | 2005-03-23 | 2012-02-24 | Genmab As | Antibodies against CD38 for treatment of multiple myeloma |
| US20060233814A1 (en) * | 2005-04-15 | 2006-10-19 | Immunogen Inc. | Elimination of heterogeneous or mixed cell population in tumors |
| JP2009518025A (ja) | 2005-12-06 | 2009-05-07 | ドマンティス リミテッド | 細胞表面標的に対して結合特異性を有する二重特異性リガンドおよびその使用方法 |
| EP2015772A2 (de) | 2006-05-03 | 2009-01-21 | Elke Pogge Von Strandmann | Mittel zur behandlung von malignen erkrankungen |
-
2008
- 2008-12-23 JP JP2010540130A patent/JP2011507933A/ja active Pending
- 2008-12-23 AR ARP080105722A patent/AR069979A1/es unknown
- 2008-12-23 EP EP08864283A patent/EP2238169A1/en not_active Ceased
- 2008-12-23 US US12/342,180 patent/US9011864B2/en not_active Expired - Fee Related
- 2008-12-23 WO PCT/EP2008/068268 patent/WO2009080831A1/en not_active Ceased
- 2008-12-24 TW TW097150429A patent/TWI524897B/zh not_active IP Right Cessation
-
2014
- 2014-11-28 JP JP2014241327A patent/JP2015038158A/ja active Pending
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