JP2011507868A5 - - Google Patents

Info

Publication number

JP2011507868A5

JP2011507868A5 JP2010539618A JP2010539618A JP2011507868A5 JP 2011507868 A5 JP2011507868 A5 JP 2011507868A5 JP 2010539618 A JP2010539618 A JP 2010539618A JP 2010539618 A JP2010539618 A JP 2010539618A JP 2011507868 A5 JP2011507868 A5 JP 2011507868A5

Authority

JP

Japan

Prior art keywords

ylidene

oxepin

fluoro

methyl

ylidenemethyl

Prior art date

2008-12-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 150000003839 salts Chemical class 0.000 claims 6
• 150000001875 compounds Chemical class 0.000 claims 5
• 239000004202 carbamide Substances 0.000 claims 4
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
• 239000003085 diluting agent Substances 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• 239000001257 hydrogen Substances 0.000 claims 2
• 229910052739 hydrogen Inorganic materials 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 239000000546 pharmaceutical excipient Substances 0.000 claims 2
• 208000011580 syndromic disease Diseases 0.000 claims 2
• JTHNQIXDIRAZEV-ODZAUARKSA-N (Z)-but-2-enedioic acid cyanamide Chemical compound NC#N.OC(=O)\C=C/C(O)=O JTHNQIXDIRAZEV-ODZAUARKSA-N 0.000 claims 1
• 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
• 208000007342 Diabetic Nephropathies Diseases 0.000 claims 1
• 206010019280 Heart failures Diseases 0.000 claims 1
• 206010020571 Hyperaldosteronism Diseases 0.000 claims 1
• 206010020772 Hypertension Diseases 0.000 claims 1
• 208000019025 Hypokalemia Diseases 0.000 claims 1
• XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
• AVBKPMYSFQPJOU-AUEPDCJTSA-N [5-[(e)-(3-fluoro-6h-benzo[c][1]benzoxepin-11-ylidene)methyl]-1-(1-methylazetidin-3-yl)benzimidazol-2-yl]cyanamide Chemical compound C1N(C)CC1N1C(=N/C#N)/NC2=CC(\C=C/3C4=CC=C(F)C=C4OCC4=CC=CC=C4\3)=CC=C21 AVBKPMYSFQPJOU-AUEPDCJTSA-N 0.000 claims 1
• FMRCXWHCSOZFKE-WADMIHMQSA-N [5-[(e)-(3-fluoro-6h-benzo[c][1]benzoxepin-11-ylidene)methyl]-1-[(3s,4s)-4-hydroxy-1-methylpyrrolidin-3-yl]benzimidazol-2-yl]cyanamide Chemical compound C1N(C)C[C@H](O)[C@H]1N1C(=N/C#N)/NC2=CC(\C=C/3C4=CC=C(F)C=C4OCC4=CC=CC=C4\3)=CC=C21 FMRCXWHCSOZFKE-WADMIHMQSA-N 0.000 claims 1
• YDFMYWUDVADGFG-SZNQACNXSA-N [5-[(e)-(3-fluoro-6h-benzo[c][1]benzoxepin-11-ylidene)methyl]-1-[(3s,4s)-4-hydroxy-1-methylpyrrolidin-3-yl]benzimidazol-2-yl]urea Chemical compound C1N(C)C[C@H](O)[C@H]1N1C(=N/C(N)=O)/NC2=CC(\C=C/3C4=CC=C(F)C=C4OCC4=CC=CC=C4\3)=CC=C21 YDFMYWUDVADGFG-SZNQACNXSA-N 0.000 claims 1
• 206010003119 arrhythmia Diseases 0.000 claims 1
• 230000006793 arrhythmia Effects 0.000 claims 1
• 208000020832 chronic kidney disease Diseases 0.000 claims 1
• 208000033679 diabetic kidney disease Diseases 0.000 claims 1
• 125000001153 fluoro group Chemical group F* 0.000 claims 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
• 230000002107 myocardial effect Effects 0.000 claims 1
• ATYBXHSAIOKLMG-UHFFFAOYSA-N oxepin Chemical compound O1C=CC=CC=C1 ATYBXHSAIOKLMG-UHFFFAOYSA-N 0.000 claims 1
• 208000024896 potassium deficiency disease Diseases 0.000 claims 1
• 201000009395 primary hyperaldosteronism Diseases 0.000 claims 1