JP2011507556A5 - - Google Patents
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- JP2011507556A5 JP2011507556A5 JP2009542394A JP2009542394A JP2011507556A5 JP 2011507556 A5 JP2011507556 A5 JP 2011507556A5 JP 2009542394 A JP2009542394 A JP 2009542394A JP 2009542394 A JP2009542394 A JP 2009542394A JP 2011507556 A5 JP2011507556 A5 JP 2011507556A5
- Authority
- JP
- Japan
- Prior art keywords
- cannula
- electrode
- processor
- sensing
- analytes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 47
- 239000008103 glucose Substances 0.000 claims description 47
- 238000003780 insertion Methods 0.000 claims description 40
- 230000037431 insertion Effects 0.000 claims description 40
- 238000007920 subcutaneous administration Methods 0.000 claims description 39
- 239000007788 liquid Substances 0.000 claims description 38
- 239000012530 fluid Substances 0.000 claims description 27
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 24
- 239000008280 blood Substances 0.000 claims description 20
- 210000004369 blood Anatomy 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 20
- 238000011282 treatment Methods 0.000 claims description 19
- 230000001225 therapeutic effect Effects 0.000 claims description 17
- 102000004877 Insulin Human genes 0.000 claims description 14
- 108090001061 Insulin Proteins 0.000 claims description 13
- 229940125396 insulin Drugs 0.000 claims description 12
- 230000008569 process Effects 0.000 claims description 8
- 238000004159 blood analysis Methods 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 239000012491 analyte Substances 0.000 description 51
- 238000010586 diagram Methods 0.000 description 30
- 241001631457 Cannula Species 0.000 description 14
- 230000006870 function Effects 0.000 description 11
- 108090000790 Enzymes Proteins 0.000 description 9
- 102000004190 Enzymes Human genes 0.000 description 9
- 229940088598 enzyme Drugs 0.000 description 9
- 238000012544 monitoring process Methods 0.000 description 9
- 230000000149 penetrating effect Effects 0.000 description 8
- 239000000523 sample Substances 0.000 description 8
- 239000003153 chemical reaction reagent Substances 0.000 description 7
- 210000003722 extracellular fluid Anatomy 0.000 description 7
- 239000010410 layer Substances 0.000 description 7
- 238000005259 measurement Methods 0.000 description 7
- 238000012545 processing Methods 0.000 description 7
- 238000003860 storage Methods 0.000 description 7
- 239000012528 membrane Substances 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 5
- 238000004891 communication Methods 0.000 description 5
- 206010012601 diabetes mellitus Diseases 0.000 description 5
- 238000009792 diffusion process Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 238000006911 enzymatic reaction Methods 0.000 description 4
- 238000001802 infusion Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 230000007246 mechanism Effects 0.000 description 4
- 239000011241 protective layer Substances 0.000 description 4
- 108010015776 Glucose oxidase Proteins 0.000 description 3
- 239000004366 Glucose oxidase Substances 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 239000004020 conductor Substances 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000009977 dual effect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 229940116332 glucose oxidase Drugs 0.000 description 3
- 235000019420 glucose oxidase Nutrition 0.000 description 3
- 210000000496 pancreas Anatomy 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
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- 210000001519 tissue Anatomy 0.000 description 3
- 238000004448 titration Methods 0.000 description 3
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- 238000004873 anchoring Methods 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 238000004040 coloring Methods 0.000 description 2
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- 230000001276 controlling effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 238000003487 electrochemical reaction Methods 0.000 description 2
- 238000007772 electroless plating Methods 0.000 description 2
- 201000001421 hyperglycemia Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 230000002572 peristaltic effect Effects 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000010076 replication Effects 0.000 description 2
- 238000004544 sputter deposition Methods 0.000 description 2
- 200000000007 Arterial disease Diseases 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 208000013016 Hypoglycemia Diseases 0.000 description 1
- 208000018262 Peripheral vascular disease Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 238000004082 amperometric method Methods 0.000 description 1
- 238000003928 amperometric titration Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000000835 electrochemical detection Methods 0.000 description 1
- 238000006056 electrooxidation reaction Methods 0.000 description 1
- 238000001952 enzyme assay Methods 0.000 description 1
- 210000001508 eye Anatomy 0.000 description 1
- 230000008713 feedback mechanism Effects 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 150000002303 glucose derivatives Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 238000002657 hormone replacement therapy Methods 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 230000003914 insulin secretion Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 210000004153 islets of langerhan Anatomy 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 238000010295 mobile communication Methods 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
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- 238000003918 potentiometric titration Methods 0.000 description 1
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- 239000011780 sodium chloride Substances 0.000 description 1
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87694506P | 2006-12-22 | 2006-12-22 | |
| PCT/IL2007/001579 WO2008078319A1 (en) | 2006-12-22 | 2007-12-20 | Fluid delivery with in vivo electrochemical analyte sensing |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011507556A JP2011507556A (ja) | 2011-03-10 |
| JP2011507556A5 true JP2011507556A5 (enExample) | 2011-04-21 |
| JP5624322B2 JP5624322B2 (ja) | 2014-11-12 |
Family
ID=39247973
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009542394A Expired - Fee Related JP5624322B2 (ja) | 2006-12-22 | 2007-12-20 | 生体内電気化学的分析対象物感知を伴った液体供給 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9028409B2 (enExample) |
| EP (2) | EP2124726A1 (enExample) |
| JP (1) | JP5624322B2 (enExample) |
| CN (2) | CN101563022B (enExample) |
| AU (1) | AU2007337685A1 (enExample) |
| WO (1) | WO2008078319A1 (enExample) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20190357827A1 (en) | 2003-08-01 | 2019-11-28 | Dexcom, Inc. | Analyte sensor |
| EP2121076B1 (de) | 2006-12-29 | 2017-04-05 | F. Hoffmann-La Roche AG | Extrakorporal tragbare infusionsvorrichtung |
| FI3375470T3 (fi) * | 2007-04-10 | 2024-03-20 | Hoffmann La Roche | Laitteisto ja menetelmä nesteen pumppaamiseen |
| EP1987761B1 (de) * | 2007-05-03 | 2019-10-23 | F. Hoffmann-La Roche AG | Schlauchförmiger Sensor zum Nachweis eines Analyten |
| US8002752B2 (en) | 2007-06-25 | 2011-08-23 | Medingo, Ltd. | Protector apparatus |
| EP2173408A1 (en) * | 2007-06-27 | 2010-04-14 | Medingo Ltd. | Tubing for fluid delivery device |
| DK2173407T3 (da) * | 2007-07-02 | 2020-04-27 | Hoffmann La Roche | Anordning til indgivelse af lægemiddel |
| EP4098177A1 (en) | 2007-10-09 | 2022-12-07 | DexCom, Inc. | Integrated insulin delivery system with continuous glucose sensor |
| US20100256593A1 (en) * | 2007-11-21 | 2010-10-07 | Ofer Yodfat | Analyte Monitoring and Fluid Dispensing System |
| US9199031B2 (en) * | 2007-12-26 | 2015-12-01 | Ofer Yodfat | Maintaining glycemic control during exercise |
| ES2680896T3 (es) * | 2007-12-26 | 2018-09-11 | F. Hoffmann-La Roche Ag | Sistema para el control glucémico |
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| WO2009125398A2 (en) | 2008-04-09 | 2009-10-15 | Medingo Ltd. | Systems, devices and methods for fluid delivery |
| EP2277123B1 (en) | 2008-04-29 | 2019-08-07 | Roche Diabetes Care GmbH | A method for selecting bolus doses and bolus delivery patterns in a drug delivery device |
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| DK2506914T3 (en) | 2009-11-30 | 2018-12-10 | Hoffmann La Roche | ANALYSIS MONITORING AND FLUID SUBMISSION SYSTEM |
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| RU2585138C2 (ru) | 2010-04-28 | 2016-05-27 | Кимберли-Кларк Ворлдвайд, Инк. | Медицинские устройства для доставки кирнк |
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| CN103261433A (zh) * | 2010-12-09 | 2013-08-21 | 雅培糖尿病护理股份有限公司 | 具有包括小型感测斑点的感测表面的分析物传感器 |
| ES2847578T3 (es) | 2011-04-15 | 2021-08-03 | Dexcom Inc | Calibración avanzada de sensor de analito y detección de errores |
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| CN104039382B (zh) | 2011-10-27 | 2018-01-12 | 金伯利-克拉克环球有限公司 | 高粘度生物活性剂的经皮递送 |
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| CA3077720A1 (en) | 2017-10-24 | 2019-05-02 | Dexcom, Inc. | Pre-connected analyte sensors |
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| CN114269244A (zh) * | 2019-06-14 | 2022-04-01 | 太平洋糖尿病科技公司 | 用于连续葡萄糖监测的输注装置 |
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| CN112237661B (zh) * | 2019-07-19 | 2022-10-11 | 上海移宇科技股份有限公司 | 输注检测于一体的单边驱动医疗装置 |
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| JP2023540905A (ja) * | 2020-08-23 | 2023-09-27 | パシフィック・ダイアビーツ・テクノロジーズ・インコーポレイテッド | インスリン保存剤の悪影響を最小限にすることによるインスリン送達カテーテル近傍でのグルコースの測定：代替配位子および酸化還元メディエーター金属 |
| US20240115799A1 (en) * | 2021-01-05 | 2024-04-11 | Medtrum Technologies Inc. | Skin patch drug infusion device |
| US20230145155A1 (en) * | 2021-10-29 | 2023-05-11 | Cercacor Laboratories, Inc. | Implantable micro-electrochemical cell |
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-
2007
- 2007-12-20 WO PCT/IL2007/001579 patent/WO2008078319A1/en not_active Ceased
- 2007-12-20 EP EP07849605A patent/EP2124726A1/en not_active Withdrawn
- 2007-12-20 AU AU2007337685A patent/AU2007337685A1/en not_active Abandoned
- 2007-12-20 CN CN200780046642.3A patent/CN101563022B/zh not_active Expired - Fee Related
- 2007-12-20 EP EP13158027.6A patent/EP2601883A1/en not_active Withdrawn
- 2007-12-20 CN CN201210150258.0A patent/CN102743179B/zh not_active Expired - Fee Related
- 2007-12-20 JP JP2009542394A patent/JP5624322B2/ja not_active Expired - Fee Related
- 2007-12-21 US US11/963,481 patent/US9028409B2/en not_active Expired - Fee Related
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