JP2011506273A5 - - Google Patents
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- Publication number
- JP2011506273A5 JP2011506273A5 JP2010534461A JP2010534461A JP2011506273A5 JP 2011506273 A5 JP2011506273 A5 JP 2011506273A5 JP 2010534461 A JP2010534461 A JP 2010534461A JP 2010534461 A JP2010534461 A JP 2010534461A JP 2011506273 A5 JP2011506273 A5 JP 2011506273A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- group
- formula
- compound
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010016654 Fibrosis Diseases 0.000 claims description 9
- 230000004761 fibrosis Effects 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 5
- 210000004185 liver Anatomy 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims 18
- 150000001413 amino acids Chemical class 0.000 claims 5
- 238000003384 imaging method Methods 0.000 claims 5
- 235000001014 amino acid Nutrition 0.000 claims 4
- 125000005647 linker group Chemical group 0.000 claims 4
- 239000004475 Arginine Substances 0.000 claims 3
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 3
- 239000004472 Lysine Substances 0.000 claims 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 3
- 235000003704 aspartic acid Nutrition 0.000 claims 3
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 3
- 235000018417 cysteine Nutrition 0.000 claims 3
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 3
- 235000018977 lysine Nutrition 0.000 claims 3
- 230000002285 radioactive effect Effects 0.000 claims 3
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 229910021645 metal ion Inorganic materials 0.000 claims 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 2
- NMDDZEVVQDPECF-LURJTMIESA-N (2s)-2,7-diaminoheptanoic acid Chemical compound NCCCCC[C@H](N)C(O)=O NMDDZEVVQDPECF-LURJTMIESA-N 0.000 claims 1
- IYKLZBIWFXPUCS-VIFPVBQESA-N (2s)-2-(naphthalen-1-ylamino)propanoic acid Chemical compound C1=CC=C2C(N[C@@H](C)C(O)=O)=CC=CC2=C1 IYKLZBIWFXPUCS-VIFPVBQESA-N 0.000 claims 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 claims 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- NTWVQPHTOUKMDI-YFKPBYRVSA-N N-Methyl-arginine Chemical compound CN[C@H](C(O)=O)CCCN=C(N)N NTWVQPHTOUKMDI-YFKPBYRVSA-N 0.000 claims 1
- 229920000954 Polyglycolide Polymers 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000000732 arylene group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 210000000746 body region Anatomy 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000000470 constituent Substances 0.000 claims 1
- -1 cycloalkyl alanine Chemical compound 0.000 claims 1
- 125000002993 cycloalkylene group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000003352 fibrogenic effect Effects 0.000 claims 1
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000005549 heteroarylene group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 238000011503 in vivo imaging Methods 0.000 claims 1
- 229910052755 nonmetal Inorganic materials 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 230000005298 paramagnetic effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 claims 1
- 229920001515 polyalkylene glycol Polymers 0.000 claims 1
- 239000004633 polyglycolic acid Substances 0.000 claims 1
- 239000004626 polylactic acid Substances 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 150000003573 thiols Chemical class 0.000 claims 1
- 210000004024 hepatic stellate cell Anatomy 0.000 description 4
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 3
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 3
- 210000002744 extracellular matrix Anatomy 0.000 description 3
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 210000003995 blood forming stem cell Anatomy 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 102000006495 integrins Human genes 0.000 description 1
- 108010044426 integrins Proteins 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98884007P | 2007-11-19 | 2007-11-19 | |
| GB0722650.9 | 2007-11-19 | ||
| GBGB0722650.9A GB0722650D0 (en) | 2007-11-19 | 2007-11-19 | Novel imaging method |
| US60/988,840 | 2007-11-19 | ||
| PCT/EP2008/065824 WO2009071444A2 (en) | 2007-11-19 | 2008-11-19 | Novel imaging method |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011506273A JP2011506273A (ja) | 2011-03-03 |
| JP2011506273A5 true JP2011506273A5 (https=) | 2014-01-09 |
| JP5709522B2 JP5709522B2 (ja) | 2015-04-30 |
Family
ID=38896533
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010534461A Expired - Fee Related JP5709522B2 (ja) | 2007-11-19 | 2008-11-19 | 新規イメージング法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8834843B2 (https=) |
| EP (1) | EP2219681A2 (https=) |
| JP (1) | JP5709522B2 (https=) |
| CN (1) | CN101951964B (https=) |
| BR (1) | BRPI0820430A2 (https=) |
| GB (1) | GB0722650D0 (https=) |
| RU (1) | RU2505316C2 (https=) |
| WO (1) | WO2009071444A2 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2571486C1 (ru) * | 2014-11-05 | 2015-12-20 | Общество с ограниченной ответственностью "ДИАМЕД" | Способ визуализации воспалений |
| WO2020250854A1 (ja) * | 2019-06-11 | 2020-12-17 | 富士フイルム株式会社 | 環状ペプチド、細胞足場材、細胞分離材、及び培地 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003006491A2 (en) | 2001-07-10 | 2003-01-23 | Amersham Health As | Peptide-based compounds for targeting intergin receptors |
| US20040223912A1 (en) * | 2003-05-07 | 2004-11-11 | Montalto Michael Christopher | Compositions and methods for non-invasive imaging of soluble beta-amyloid |
| GB0317815D0 (en) * | 2003-07-30 | 2003-09-03 | Amersham Health As | Imaging agents |
| EP1667668B1 (en) * | 2003-10-01 | 2008-07-02 | MERCK PATENT GmbH | Alfavbeta3 and alfavbeta6 integrin antagonists as antifibrotic agents |
| ES2358745T3 (es) * | 2004-11-22 | 2011-05-13 | Ge Healthcare As | Agentes de contraste para señalar matriz extracelular. |
| CN101272808B (zh) | 2005-01-06 | 2012-03-21 | 通用电气医疗集团股份有限公司 | 光学成像 |
| EP1877100A2 (en) | 2005-04-25 | 2008-01-16 | GE Healthcare AS | Liposomes |
| WO2007035843A2 (en) * | 2005-09-21 | 2007-03-29 | Dask Technologies, Llc | Methods and compositions for organ and tissue functionality |
| GB0524987D0 (en) * | 2005-12-08 | 2006-01-18 | Ge Healthcare Ltd | Novel imaging agents for fibrosis |
| WO2007148074A1 (en) | 2006-06-21 | 2007-12-27 | Hammersmith Imanet Limited | Chemical methods and apparatus |
-
2007
- 2007-11-19 GB GBGB0722650.9A patent/GB0722650D0/en not_active Ceased
-
2008
- 2008-11-19 JP JP2010534461A patent/JP5709522B2/ja not_active Expired - Fee Related
- 2008-11-19 BR BRPI0820430-6A patent/BRPI0820430A2/pt not_active IP Right Cessation
- 2008-11-19 EP EP08856281A patent/EP2219681A2/en not_active Withdrawn
- 2008-11-19 RU RU2010119187/15A patent/RU2505316C2/ru not_active IP Right Cessation
- 2008-11-19 CN CN200880117542.XA patent/CN101951964B/zh not_active Expired - Fee Related
- 2008-11-19 US US12/742,984 patent/US8834843B2/en not_active Expired - Fee Related
- 2008-11-19 WO PCT/EP2008/065824 patent/WO2009071444A2/en not_active Ceased
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