JP2011505810A - ヒト化抗ヒトｃｄ３４抗体、その調製方法および使用 - Google Patents

ヒト化抗ヒトｃｄ３４抗体、その調製方法および使用 Download PDF

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JP2011505810A
JP2011505810A JP2010537235A JP2010537235A JP2011505810A JP 2011505810 A JP2011505810 A JP 2011505810A JP 2010537235 A JP2010537235 A JP 2010537235A JP 2010537235 A JP2010537235 A JP 2010537235A JP 2011505810 A JP2011505810 A JP 2011505810A
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antibody
human
cells
variable region
fragment
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JP2011505810A5 (https=
Inventor
クオ，ヤジュン
チエン，ウェイツゥ
ホウ，シェン
リ，ボフア
ワン，ハオ
マ，ジン
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シャンハイ グオジアン バイオ−テック インスティチュート
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Priority claimed from CN 200710094456 external-priority patent/CN101245108B/zh
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Publication of JP2011505810A publication Critical patent/JP2011505810A/ja
Publication of JP2011505810A5 publication Critical patent/JP2011505810A5/ja
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57505—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the blood, e.g. leukaemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders
    • G01N2800/245—Transplantation related diseases, e.g. graft versus host disease

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2010537235A 2007-12-13 2008-12-03 ヒト化抗ヒトｃｄ３４抗体、その調製方法および使用 Ceased JP2011505810A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN 200710094456 CN101245108B (zh) 2007-12-13 2007-12-13 抗人cd34抗体、其制备方法及用途
CN200810043016 2008-01-08
PCT/CN2008/001963 WO2009079922A1 (en) 2007-12-13 2008-12-03 Humanized anti-cd34 monoclonal antibody, the preparation and uses thereof

Publications (2)

Publication Number Publication Date
JP2011505810A true JP2011505810A (ja) 2011-03-03
JP2011505810A5 JP2011505810A5 (https=) 2012-01-26

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JP2010537235A Ceased JP2011505810A (ja) 2007-12-13 2008-12-03 ヒト化抗ヒトｃｄ３４抗体、その調製方法および使用

Country Status (6)

Country Link
US (1) US20100311955A1 (https=)
EP (1) EP2233501B1 (https=)
JP (1) JP2011505810A (https=)
BR (1) BRPI0821211A2 (https=)
CA (1) CA2708407A1 (https=)
WO (1) WO2009079922A1 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2686418A4 (en) 2011-03-17 2015-04-22 Minerva Biotechnologies Corp METHOD FOR THE PRODUCTION OF PLURIPOTENTAL STEM CELLS
US8785603B2 (en) 2011-05-20 2014-07-22 Siemens Healthcare Diagnostics Inc. Antibodies to 25-hydroxyvitamin D2 and D3 and uses thereof
TWI443107B (zh) 2011-12-29 2014-07-01 Ind Tech Res Inst 人源化之抗人類細胞表面抗原ｃｄ３４之單株抗體及其應用
DK3105252T3 (da) 2014-02-12 2019-10-14 Michael Uhlin Bispecifikke antistoffer til anvendelse ved stamcelletransplantation
US10604586B2 (en) 2016-05-09 2020-03-31 Industrial Technology Research Institute Humanized monoclonal antibody and uses thereof
CN109265547B (zh) * 2018-07-23 2022-07-26 中国科学院微生物研究所 一种抗cd47抗体及其应用
CN111879923A (zh) * 2020-08-06 2020-11-03 深圳科隆生物新材料有限公司 一种可消除hama效应的试剂盒
WO2023133595A2 (en) 2022-01-10 2023-07-13 Sana Biotechnology, Inc. Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
EP4466019A4 (en) * 2022-01-21 2026-01-07 Marengo Therapeutics Inc MULTIFUNCTIONAL MOLECULES COMPRISING A G6B BINDER AND/OR A CD34 BINDER AND THEIR USES
WO2024040194A1 (en) 2022-08-17 2024-02-22 Capstan Therapeutics, Inc. Conditioning for in vivo immune cell engineering
WO2024081820A1 (en) 2022-10-13 2024-04-18 Sana Biotechnology, Inc. Viral particles targeting hematopoietic stem cells
WO2024119157A1 (en) 2022-12-02 2024-06-06 Sana Biotechnology, Inc. Lipid particles with cofusogens and methods of producing and using the same
KR20260016952A (ko) 2023-05-23 2026-02-04 사나 바이오테크놀로지, 인크. 탠덤 퓨소젠 및 관련 지질 입자
WO2025006799A1 (en) 2023-06-27 2025-01-02 Capstan Therapeutics, Inc. Extracorporeal and ex vivo engineering of select cell populations from peripheral blood
CN116970650B (zh) * 2023-09-22 2023-12-08 深圳华大生命科学研究院 一种包膜蛋白组合、含其的靶向病毒载体及制备方法
WO2025184529A1 (en) 2024-03-01 2025-09-04 Sana Biotechnology, Inc. Viral particles with fusogen display and related compositions and methods
CN118501458B (zh) * 2024-05-08 2025-09-30 广东省第二人民医院（广东省卫生应急医院） 一种外周血细胞外囊泡表面多种免疫标志物联合检测的试剂盒及方法
CN120098129B (zh) * 2025-03-03 2026-04-03 安徽医科大学第一附属医院 一种具有信号蛋白标签的cd34生物融合酶抗体及应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11332594A (ja) * 1998-05-26 1999-12-07 Asahi Chem Ind Co Ltd Ｃｄ４陽性細胞の分離装置および分離方法
JPH11332578A (ja) * 1998-05-25 1999-12-07 Asahi Chem Ind Co Ltd 細胞の分離装置及び分離方法
US20070207210A1 (en) * 2004-05-12 2007-09-06 Brown Larry R Protein Microspheres Retaining Pharmacokinetic and Pharmacodynamic Properties

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
KR20010043797A (ko) * 1998-05-25 2001-05-25 아사히 메디칼 가부시키가이샤 세포 분리 장치 및 분리 방법
AU2001274931B2 (en) * 2000-05-23 2006-03-30 Nexell Therapeutics, Inc. Reagents for cell selection and methods of use
CN101245108B (zh) * 2007-12-13 2013-04-10 上海抗体药物国家工程研究中心有限公司 抗人cd34抗体、其制备方法及用途

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11332578A (ja) * 1998-05-25 1999-12-07 Asahi Chem Ind Co Ltd 細胞の分離装置及び分離方法
JPH11332594A (ja) * 1998-05-26 1999-12-07 Asahi Chem Ind Co Ltd Ｃｄ４陽性細胞の分離装置および分離方法
US20070207210A1 (en) * 2004-05-12 2007-09-06 Brown Larry R Protein Microspheres Retaining Pharmacokinetic and Pharmacodynamic Properties

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JPN6013045111; ＯＴＴＯ，Ｍ．　ｅｔ　ａｌ．: 'Ｓｅｌｅｃｔｉｏｎ　ｏｆ　ｓｔｅｍ　ｃｅｌｌｓ　ｂｙ　ｕｓｉｎｇ　ａｎｔｉｂｏｄｉｅｓ　ｔｈａｔ　ｔａｒｇｅｔ　ｄｉｆｆｅｒｅｎｔ　ＣＤ３４　ｅｐｉｔｏｐｅｓ　ｙｉｅｌｄｓ　ｄｉｆｆｅｒｅｎｔ　ｐａｔ' Ｓｔｅｍ　Ｃｅｌｌｓ Ｖｏｌ．２５，　Ｎｏ．２, 200702, ｐｐ．５３７-４２ *
JPN6013045112; ＨＯＵ，Ｓ．　ｅｔ　ａｌ．: 'Ｈｕｍａｎｉｚａｔｉｏｎ　ｏｆ　ａｎ　ａｎｔｉ-ＣＤ３４　ｍｏｎｏｃｌｏｎａｌ　ａｎｔｉｂｏｄｙ　ｂｙ　ｃｏｍｐｌｅｍｅｎｔａｒｉｔｙ-ｄｅｔｅｒｍｉｎｉｎｇ　ｒｅｇｉｏｎ　ｇｒａｆｔｉｎｇ　ｂａｓｅ' Ｊ．　Ｂｉｏｃｈｅｍ． Ｖｏｌ．１４４，　Ｎｏ．１, 200807, ｐｐ．１１５-２０ *
JPN6013045114; ＱＩＡＮ，Ｗ．　ｅｔ　ａｌ．: 'Ｄｅｖｅｌｏｐｍｅｎｔ　ｏｆ　ｎｅｗ　ｖｅｒｓｉｏｎｓ　ｏｆ　ａｎｔｉ-ｈｕｍａｎ　ＣＤ３４　ｍｏｎｏｃｌｏｎａｌ　ａｎｔｉｂｏｄｉｅｓ　ｗｉｔｈ　ｐｏｔｅｎｔｉａｌｌｙ　ｒｅｄｕｃｅｄ　ｉｍｍｕｎｏ' Ｂｉｏｃｈｅｍ．　Ｂｉｏｐｈｙｓ．　Ｒｅｓ．　Ｃｏｍｍｕｎ． Ｖｏｌ．３６７，　Ｎｏ．２, 20080307, ｐｐ．４９７-５０２ *

Also Published As

Publication number Publication date
BRPI0821211A2 (pt) 2015-06-16
WO2009079922A1 (en) 2009-07-02
US20100311955A1 (en) 2010-12-09
EP2233501A1 (en) 2010-09-29
EP2233501A4 (en) 2010-12-01
EP2233501B1 (en) 2012-07-11
CA2708407A1 (en) 2009-07-02

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