JP2011504932A5 - - Google Patents

Info

Publication number

JP2011504932A5

JP2011504932A5 JP2010536148A JP2010536148A JP2011504932A5 JP 2011504932 A5 JP2011504932 A5 JP 2011504932A5 JP 2010536148 A JP2010536148 A JP 2010536148A JP 2010536148 A JP2010536148 A JP 2010536148A JP 2011504932 A5 JP2011504932 A5 JP 2011504932A5

Authority

JP

Japan

Prior art keywords

lymphocyte

interleukin

lymphocytes

primary cell

mitogen

Prior art date

2008-11-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 210000001744 T-lymphocyte Anatomy 0.000 claims 9
• 238000000034 method Methods 0.000 claims 8
• 210000004027 cell Anatomy 0.000 claims 3
• LOGFVTREOLYCPF-KXNHARMFSA-N (2s,3r)-2-[[(2r)-1-[(2s)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoic acid Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CCCCN LOGFVTREOLYCPF-KXNHARMFSA-N 0.000 claims 2
• 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims 2
• 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims 2
• 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 2
• 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 2
• 108010074328 Interferon-gamma Proteins 0.000 claims 2
• 102000003777 Interleukin-1 beta Human genes 0.000 claims 2
• 108090000193 Interleukin-1 beta Proteins 0.000 claims 2
• 102000004889 Interleukin-6 Human genes 0.000 claims 2
• 108090001005 Interleukin-6 Proteins 0.000 claims 2
• 102000004890 Interleukin-8 Human genes 0.000 claims 2
• 108090001007 Interleukin-8 Proteins 0.000 claims 2
• 108010047620 Phytohemagglutinins Proteins 0.000 claims 2
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
• 230000006907 apoptotic process Effects 0.000 claims 2
• 229940100601 interleukin-6 Drugs 0.000 claims 2
• 229940096397 interleukin-8 Drugs 0.000 claims 2
• XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 claims 2
• 239000003226 mitogen Substances 0.000 claims 2
• 230000001885 phytohemagglutinin Effects 0.000 claims 2
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
• 102100037850 Interferon gamma Human genes 0.000 claims 1
• 102000008070 Interferon-gamma Human genes 0.000 claims 1
• 230000003115 biocidal effect Effects 0.000 claims 1
• 210000004369 blood Anatomy 0.000 claims 1
• 239000008280 blood Substances 0.000 claims 1
• 230000001120 cytoprotective effect Effects 0.000 claims 1
• 229940044627 gamma-interferon Drugs 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 238000011275 oncology therapy Methods 0.000 claims 1
• 230000002085 persistent effect Effects 0.000 claims 1