JP2011502998A

JP2011502998A - ウイルス感染の治療および予防

ウイルス感染の治療および予防 Download PDF

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Publication number: JP2011502998A
Authority: JP; Japan
Prior art keywords: substituted; unsubstituted; compound; inhibitor; compounds
Prior art date: 2007-11-01
Legal status : Pending

Application number

JP2010532306A

Other languages

English (en)

Japanese (ja)

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JP2011502998A5 (enExample

Inventor

ミン・ルオ

ヤン・チェン

Original Assignee

ザユーエイビーリサーチファウンデイション

Priority date

2007-11-01

Filing date

2008-10-31

Publication date

2011-01-27

2008-10-31 Application filed by ザユーエイビーリサーチファウンデイション filed Critical ザユーエイビーリサーチファウンデイション

2011-01-27 Publication of JP2011502998A publication Critical patent/JP2011502998A/ja

2011-12-15 Publication of JP2011502998A5 publication Critical patent/JP2011502998A5/ja

Status Pending legal-status Critical Current

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230000009385 viral infection Effects 0.000 title claims abstract description 31
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230000002265 prevention Effects 0.000 title abstract description 11
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238000000034 method Methods 0.000 claims abstract description 91
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241000700605 Viruses Species 0.000 claims description 44
239000003112 inhibitor Substances 0.000 claims description 40
125000001072 heteroaryl group Chemical group 0.000 claims description 39
229910052717 sulfur Inorganic materials 0.000 claims description 37
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 35
229910052760 oxygen Inorganic materials 0.000 claims description 34
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 32
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MCGSCOLBFJQGHM-SCZZXKLOSA-N abacavir Chemical compound C=12N=CN([C@H]3C=C[C@@H](CO)C3)C2=NC(N)=NC=1NC1CC1 MCGSCOLBFJQGHM-SCZZXKLOSA-N 0.000 claims description 19
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GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 claims description 8
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RYMCFYKJDVMSIR-RNFRBKRXSA-N apricitabine Chemical compound O=C1N=C(N)C=CN1[C@@H]1S[C@H](CO)OC1 RYMCFYKJDVMSIR-RNFRBKRXSA-N 0.000 claims description 7
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