JP2011502979A5 - - Google Patents

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Publication number
JP2011502979A5
JP2011502979A5 JP2010531606A JP2010531606A JP2011502979A5 JP 2011502979 A5 JP2011502979 A5 JP 2011502979A5 JP 2010531606 A JP2010531606 A JP 2010531606A JP 2010531606 A JP2010531606 A JP 2010531606A JP 2011502979 A5 JP2011502979 A5 JP 2011502979A5
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JP
Japan
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orn
group
cancer
triphosphate
subject
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JP2010531606A
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English (en)
Japanese (ja)
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JP5753382B2 (ja
JP2011502979A (ja
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Priority claimed from PCT/IB2008/002940 external-priority patent/WO2009060281A2/en
Publication of JP2011502979A publication Critical patent/JP2011502979A/ja
Publication of JP2011502979A5 publication Critical patent/JP2011502979A5/ja
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Publication of JP5753382B2 publication Critical patent/JP5753382B2/ja
Expired - Fee Related legal-status Critical Current
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JP2010531606A 2007-11-06 2008-10-30 修飾されたオリゴリン酸基を含有する免疫賦活オリゴリボヌクレオチドアナログ Expired - Fee Related JP5753382B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US204907P 2007-11-06 2007-11-06
US61/002,049 2007-11-06
PCT/IB2008/002940 WO2009060281A2 (en) 2007-11-06 2008-10-30 Immune stimulatory oligoribonucleotide analogs containing modified oligophosphate moieties

Publications (3)

Publication Number Publication Date
JP2011502979A JP2011502979A (ja) 2011-01-27
JP2011502979A5 true JP2011502979A5 (https=) 2015-02-19
JP5753382B2 JP5753382B2 (ja) 2015-07-22

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ID=40626260

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010531606A Expired - Fee Related JP5753382B2 (ja) 2007-11-06 2008-10-30 修飾されたオリゴリン酸基を含有する免疫賦活オリゴリボヌクレオチドアナログ

Country Status (10)

Country Link
US (2) US8349812B2 (https=)
EP (1) EP2207787B1 (https=)
JP (1) JP5753382B2 (https=)
AU (1) AU2008326187B2 (https=)
CA (1) CA2704853C (https=)
DK (1) DK2207787T3 (https=)
ES (1) ES2530215T3 (https=)
HR (1) HRP20150131T1 (https=)
PT (1) PT2207787E (https=)
WO (1) WO2009060281A2 (https=)

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CA2536139A1 (en) * 2003-09-25 2005-04-07 Coley Pharmaceutical Group, Inc. Nucleic acid-lipophilic conjugates
EP3342415B1 (en) 2006-08-08 2022-01-26 Rheinische Friedrich-Wilhelms-Universität Bonn Structure and use of 5' phosphate oligonucleotides
RU2010112771A (ru) * 2007-10-09 2011-11-20 Коули Фармасьютикал ГмбХ (DE) Иммуностимулирующие аналоги олигонуклеотидов, содержащие модифицированные сахарные группировки
EP2297323A1 (en) * 2008-05-21 2011-03-23 Hartmann, Gunther 5' triphosphate oligonucleotide with blunt end and uses thereof
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EP2508530A1 (en) 2011-03-28 2012-10-10 Rheinische Friedrich-Wilhelms-Universität Bonn Purification of triphosphorylated oligonucleotides using capture tags
EP2712870A1 (en) * 2012-09-27 2014-04-02 Rheinische Friedrich-Wilhelms-Universität Bonn Novel RIG-I ligands and methods for producing them
WO2014124433A1 (en) * 2013-02-11 2014-08-14 Oregon Health & Science University 5'-triphosphate oligoribonucleotides
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AU2017325971A1 (en) 2016-09-16 2019-04-11 Bio-Path Holdings, Inc. Combination therapy with liposomal antisense oligonucleotides
US11382966B2 (en) 2017-03-24 2022-07-12 Rigontec Gmbh Method for designing RIG-I ligands
CN110709515A (zh) 2017-04-03 2020-01-17 杜克大学 用于差异性诱导细胞死亡和干扰素表达的组合物和方法
EA201992485A1 (ru) * 2017-04-19 2020-02-17 Байо-Пат Холдингз, Инк. Р-этокси нуклеиновые кислоты для ингибирования stat3
EA201992490A1 (ru) 2017-04-19 2020-03-03 Байо-Пат Холдингз, Инк. Р-этокси нуклеиновые кислоты для ингибирования bcl2
WO2020260547A1 (en) 2019-06-27 2020-12-30 Rigontec Gmbh Design method for optimized rig-i ligands
CN115916978A (zh) * 2020-05-19 2023-04-04 哈德森医学研究所 寡核苷酸
KR20260051070A (ko) * 2023-08-10 2026-04-15 하네스 테라퓨틱스 리미티드 기능적 핵산

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