JP2011502979A5 - - Google Patents

Download PDF

Info

Publication number
JP2011502979A5
JP2011502979A5 JP2010531606A JP2010531606A JP2011502979A5 JP 2011502979 A5 JP2011502979 A5 JP 2011502979A5 JP 2010531606 A JP2010531606 A JP 2010531606A JP 2010531606 A JP2010531606 A JP 2010531606A JP 2011502979 A5 JP2011502979 A5 JP 2011502979A5
Authority
JP
Japan
Prior art keywords
orn
group
cancer
triphosphate
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010531606A
Other languages
English (en)
Japanese (ja)
Other versions
JP5753382B2 (ja
JP2011502979A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/IB2008/002940 external-priority patent/WO2009060281A2/en
Publication of JP2011502979A publication Critical patent/JP2011502979A/ja
Publication of JP2011502979A5 publication Critical patent/JP2011502979A5/ja
Application granted granted Critical
Publication of JP5753382B2 publication Critical patent/JP5753382B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2010531606A 2007-11-06 2008-10-30 修飾されたオリゴリン酸基を含有する免疫賦活オリゴリボヌクレオチドアナログ Expired - Fee Related JP5753382B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US204907P 2007-11-06 2007-11-06
US61/002,049 2007-11-06
PCT/IB2008/002940 WO2009060281A2 (en) 2007-11-06 2008-10-30 Immune stimulatory oligoribonucleotide analogs containing modified oligophosphate moieties

Publications (3)

Publication Number Publication Date
JP2011502979A JP2011502979A (ja) 2011-01-27
JP2011502979A5 true JP2011502979A5 (https=) 2015-02-19
JP5753382B2 JP5753382B2 (ja) 2015-07-22

Family

ID=40626260

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010531606A Expired - Fee Related JP5753382B2 (ja) 2007-11-06 2008-10-30 修飾されたオリゴリン酸基を含有する免疫賦活オリゴリボヌクレオチドアナログ

Country Status (10)

Country Link
US (2) US8349812B2 (https=)
EP (1) EP2207787B1 (https=)
JP (1) JP5753382B2 (https=)
AU (1) AU2008326187B2 (https=)
CA (1) CA2704853C (https=)
DK (1) DK2207787T3 (https=)
ES (1) ES2530215T3 (https=)
HR (1) HRP20150131T1 (https=)
PT (1) PT2207787E (https=)
WO (1) WO2009060281A2 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030129251A1 (en) * 2000-03-10 2003-07-10 Gary Van Nest Biodegradable immunomodulatory formulations and methods for use thereof
MXPA05013658A (es) * 2003-06-11 2006-03-02 Hybridon Inc Oligonucleotidos inmunomoduladores estabilizados.
AU2004275876B2 (en) * 2003-09-25 2011-03-31 Coley Pharmaceutical Gmbh Nucleic acid-lipophilic conjugates
ES2911034T3 (es) 2006-08-08 2022-05-17 Univ Bonn Rheinische Friedrich Wilhelms Estructura y uso de oligonucleótidos 5' fosfato
CN101820908A (zh) * 2007-10-09 2010-09-01 科利制药公司 包含改性糖部分的免疫刺激寡核苷酸类似物
WO2009141146A1 (en) * 2008-05-21 2009-11-26 Gunther Hartmann 5' triphosphate oligonucleotide with blunt end and uses thereof
WO2012079115A1 (en) * 2010-12-14 2012-06-21 Commonwealth Scientific And Industrial Research Organisation Immunostimulatory oligonucleotides
EP2508530A1 (en) 2011-03-28 2012-10-10 Rheinische Friedrich-Wilhelms-Universität Bonn Purification of triphosphorylated oligonucleotides using capture tags
EP2712870A1 (en) 2012-09-27 2014-04-02 Rheinische Friedrich-Wilhelms-Universität Bonn Novel RIG-I ligands and methods for producing them
US20140287023A1 (en) * 2013-02-11 2014-09-25 Mcgill University 5'-triphosphate oligoribonucleotides
WO2014169049A1 (en) 2013-04-09 2014-10-16 Duke University 2' fluoro-modified rnas as immunostimulators
EP3362563A1 (en) 2015-10-14 2018-08-22 Bio-Path Holdings, Inc. P-ethoxy nucleic acids for liposomal formulation
JP7132911B2 (ja) 2016-09-16 2022-09-07 バイオ-パス ホールディングス, インコーポレイテッド リポソームアンチセンスオリゴヌクレオチドとの併用療法
US11382966B2 (en) 2017-03-24 2022-07-12 Rigontec Gmbh Method for designing RIG-I ligands
CN110709515A (zh) 2017-04-03 2020-01-17 杜克大学 用于差异性诱导细胞死亡和干扰素表达的组合物和方法
IL269608B2 (en) * 2017-04-19 2024-06-01 Bio Path Holdings Inc Compositions comprising p-ethoxy nucleic acids for stat3 inhibition for use in treating cancer or autoimmune disease
EP3612160A4 (en) 2017-04-19 2021-01-20 Bio-Path Holdings, Inc. P-ETHOXY NUCLEIC ACIDS FOR BCL2 INHIBITION
EP3990635A1 (en) 2019-06-27 2022-05-04 Rigontec GmbH Design method for optimized rig-i ligands
KR20230013266A (ko) * 2020-05-19 2023-01-26 허드슨 인스티튜트 오브 메디컬 리서치 올리고뉴클레오티드
AU2024321134A1 (en) * 2023-08-10 2026-02-19 Harness Therapeutics Limited Functional nucleic acid

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3534017A (en) 1967-03-14 1970-10-13 Kyowa Hakko Kogyo Kk Process for the preparation of nucleoside-5'-diphosphates and triphosphates and mono- and oligo-nucleotidyl-nucleoside-5'-diphosphates and triphosphates
FR1566530A (https=) 1967-03-14 1969-05-09
US4469863A (en) 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
US5023243A (en) 1981-10-23 1991-06-11 Molecular Biosystems, Inc. Oligonucleotide therapeutic agent and method of making same
DE3280400D1 (de) 1981-10-23 1992-06-04 Molecular Biosystems Inc Oligonukleotides heilmittel und dessen herstellungsverfahren.
FR2567892B1 (fr) * 1984-07-19 1989-02-17 Centre Nat Rech Scient Nouveaux oligonucleotides, leur procede de preparation et leurs applications comme mediateurs dans le developpement des effets des interferons
JP3507486B2 (ja) 1991-03-15 2004-03-15 アムジエン・インコーポレーテツド 顆粒球コロニー刺激因子の肺内投与
US5451569A (en) 1994-04-19 1995-09-19 Hong Kong University Of Science And Technology R & D Corporation Limited Pulmonary drug delivery system
US6111095A (en) * 1995-06-07 2000-08-29 Merck & Co., Inc. Capped synthetic RNA, analogs, and aptamers
US6770748B2 (en) 1997-03-07 2004-08-03 Takeshi Imanishi Bicyclonucleoside and oligonucleotide analogue
DE19935303A1 (de) * 1999-07-28 2001-02-08 Aventis Pharma Gmbh Oligonukleotide zur Inhibierung der Expression von humanem eg5
US6268790B1 (en) 2000-03-24 2001-07-31 Trw Inc. Anti-theft method and apparatus
WO2003008432A1 (en) 2001-07-16 2003-01-30 Isis Pharmaceuticals, Inc. Process for the preparation of alpha modified nucleoside triphosphates and compounds therefrom
WO2003072757A2 (en) 2002-02-28 2003-09-04 Biota, Inc. Nucleotide mimics and their prodrugs
EP3006043B1 (en) * 2002-04-04 2019-05-29 Zoetis Belgium S.A. Immunostimulatory g,u-containing oligoribonucleotides
JP2007526253A (ja) * 2004-02-19 2007-09-13 コーリー ファーマシューティカル グループ,インコーポレイテッド 免疫刺激性ウイルスrnaオリゴヌクレオチド
EP1819364A4 (en) * 2004-12-08 2010-12-29 3M Innovative Properties Co COMPOSITIONS, IMMUNOMODULATORY COMBINATIONS AND ASSOCIATED METHODS
US20060178334A1 (en) 2005-02-04 2006-08-10 City Of Hope Double-stranded and single-stranded RNA molecules with 5 ' triphosphates and their use for inducing interferon
EP1924284A1 (en) 2005-09-14 2008-05-28 Hartmann, Gunther Compositions comprising immunostimulatory rna oligonucleotides and methods for producing said rna oligonucleotides
WO2007038720A2 (en) * 2005-09-27 2007-04-05 Coley Pharmaceutical Gmbh Modulation of tlr-mediated immune responses using adaptor oligonucleotides
KR20080065656A (ko) * 2005-10-12 2008-07-14 캔써 리서치 테크놀로지 리미티드 면역질환을 치료하기 위한 방법 및 조성물
DK2405002T3 (en) * 2006-02-15 2015-01-05 Adiutide Pharmaceuticals Gmbh Compositions and methods for oligonukleotidformuleringer
KR101221589B1 (ko) * 2006-04-07 2013-01-15 이데라 파마슈티칼즈, 인코포레이티드 Tlr7 및 tlr8에 대한 안정화된 면역 조절성 rna〔simra〕 화합물
EP1920775B1 (en) 2006-10-10 2012-12-19 Gunther Prof. Dr. Hartmann 5'Triphosphate oligonucleotide induces anti-viral response

Similar Documents

Publication Publication Date Title
JP5753382B2 (ja) 修飾されたオリゴリン酸基を含有する免疫賦活オリゴリボヌクレオチドアナログ
JP2011502979A5 (https=)
CN102517292B (zh) 免疫刺激性寡核糖核苷酸
JP5414961B2 (ja) 免疫刺激性核酸
US9186399B2 (en) Immune stimulatory oligonucleotide analogs containing modified sugar moieties
JP2006508693A5 (https=)
EP2104738A2 (en) Oligoribonucleotides and uses thereof
JP5755827B2 (ja) 強化された免疫刺激活性を有するリン酸が修飾されたオリゴヌクレオチド類似体
AU2008288241B2 (en) RNA sequence motifs in the context of defined internucleotide linkages inducing specific immune modulatory profiles
CN101331229B (zh) 免疫刺激性寡核糖核苷酸
HK1133043A (en) Oligoribonucleotides and uses thereof
HK1143741B (en) Rna sequence motifs in the context of defined internucleotide linkages inducing specific immune modulatory profiles
HK1143314A (en) Immune stimulatory oligonucleotide analogs containing modified sugar moieties