JP2011502502A - 核酸のハイブリッド形成における修飾塩基を含むオリゴヌクレオチドの使用 - Google Patents

核酸のハイブリッド形成における修飾塩基を含むオリゴヌクレオチドの使用 Download PDF

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JP2011502502A
JP2011502502A JP2010532630A JP2010532630A JP2011502502A JP 2011502502 A JP2011502502 A JP 2011502502A JP 2010532630 A JP2010532630 A JP 2010532630A JP 2010532630 A JP2010532630 A JP 2010532630A JP 2011502502 A JP2011502502 A JP 2011502502A
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nucleic acid
modified oligonucleotide
nucleobases
target nucleic
modified
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JP2011502502A5 (enExample
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カレルソン,マティ
トルベ,エルッキ
オルスペルト,アラン
サルミエント,セシリア
サールマ,マルト
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バルティック テクロノジー デヴェロプメント,リミテッド
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111General methods applicable to biologically active non-coding nucleic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/33Chemical structure of the base
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/35Nature of the modification
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    • C12N2320/00Applications; Uses
    • C12N2320/50Methods for regulating/modulating their activity
    • C12N2320/51Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333Saccharide [e.g., DNA, etc.]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
JP2010532630A 2007-11-05 2008-11-05 核酸のハイブリッド形成における修飾塩基を含むオリゴヌクレオチドの使用 Pending JP2011502502A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98555207P 2007-11-05 2007-11-05
PCT/FI2008/050635 WO2009060124A2 (en) 2007-11-05 2008-11-05 Use of oligonucleotides with modified bases in hybridization of nucleic acids

Publications (2)

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JP2011502502A true JP2011502502A (ja) 2011-01-27
JP2011502502A5 JP2011502502A5 (enExample) 2011-07-21

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JP2010532630A Pending JP2011502502A (ja) 2007-11-05 2008-11-05 核酸のハイブリッド形成における修飾塩基を含むオリゴヌクレオチドの使用

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US (1) US20110152346A1 (enExample)
EP (1) EP2217705A2 (enExample)
JP (1) JP2011502502A (enExample)
CN (1) CN101983241A (enExample)
AU (1) AU2008324068A1 (enExample)
BR (1) BRPI0819193A2 (enExample)
CA (1) CA2704560A1 (enExample)
MX (1) MX2010004984A (enExample)
WO (1) WO2009060124A2 (enExample)
ZA (1) ZA201003235B (enExample)

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JP2016533717A (ja) * 2013-10-11 2016-11-04 アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. C9orf72発現を調節するための組成物
JP2021184720A (ja) * 2015-04-16 2021-12-09 アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals, Inc. C9orf72発現を調節するための組成物

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EP2508530A1 (en) 2011-03-28 2012-10-10 Rheinische Friedrich-Wilhelms-Universität Bonn Purification of triphosphorylated oligonucleotides using capture tags
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US10806146B2 (en) 2011-09-13 2020-10-20 Monsanto Technology Llc Methods and compositions for weed control
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CN103958686A (zh) 2011-09-13 2014-07-30 孟山都技术公司 用于杂草控制的方法和组合物
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CA2848576A1 (en) 2011-09-13 2013-03-21 Monsanto Technology Llc Methods and compositions for weed control comprising topical application of 4-hydroxyphenyl-pyruvate-dioxygenase (hppd)-inhibiting polynucleotides
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