JP2011239701A5 - - Google Patents

Info

Publication number

JP2011239701A5

JP2011239701A5 JP2010112588A JP2010112588A JP2011239701A5 JP 2011239701 A5 JP2011239701 A5 JP 2011239701A5 JP 2010112588 A JP2010112588 A JP 2010112588A JP 2010112588 A JP2010112588 A JP 2010112588A JP 2011239701 A5 JP2011239701 A5 JP 2011239701A5

Authority

JP

Japan

Prior art keywords

cells

dendritic

dendritic cell

preparing

csf

Prior art date

2010-05-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 210000004443 dendritic cell Anatomy 0.000 claims description 17
• 238000000034 method Methods 0.000 claims description 9
• 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims description 6
• 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims description 6
• 210000001744 T-lymphocyte Anatomy 0.000 claims description 5
• 108090000978 Interleukin-4 Proteins 0.000 claims description 3
• 210000004027 cell Anatomy 0.000 claims description 3
• 210000005259 peripheral blood Anatomy 0.000 claims description 3
• 239000011886 peripheral blood Substances 0.000 claims description 3
• 238000002360 preparation method Methods 0.000 claims description 3
• 210000004700 fetal blood Anatomy 0.000 claims description 2
• 210000001165 lymph node Anatomy 0.000 claims description 2
• 238000012258 culturing Methods 0.000 claims 4
• 239000008194 pharmaceutical composition Substances 0.000 claims 4
• 210000000601 blood cell Anatomy 0.000 claims 3
• 210000005087 mononuclear cell Anatomy 0.000 claims 3
• 238000002054 transplantation Methods 0.000 claims 3
• 208000023275 Autoimmune disease Diseases 0.000 claims 1
• 208000035473 Communicable disease Diseases 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
• 208000026935 allergic disease Diseases 0.000 claims 1
• 238000002617 apheresis Methods 0.000 claims 1
• 210000001185 bone marrow Anatomy 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1
• 238000002560 therapeutic procedure Methods 0.000 claims 1
• 230000000770 proinflammatory effect Effects 0.000 description 2
• 210000000130 stem cell Anatomy 0.000 description 2
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
• -1 IL-1β Proteins 0.000 description 1
• 108090001005 Interleukin-6 Proteins 0.000 description 1
• 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
• XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 description 1
• 229960002986 dinoprostone Drugs 0.000 description 1
• 244000005700 microbiome Species 0.000 description 1
• 210000001616 monocyte Anatomy 0.000 description 1
• XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 description 1
• 230000004936 stimulating effect Effects 0.000 description 1
• 230000000638 stimulation Effects 0.000 description 1