JP2011185855A - Method of manufacturing flat biometry sheet, and product of the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a method of manufacturing a flat biometry sheet employing a method of printing a large sheet and then cutting it to form respective products, and to provide the products. <P>SOLUTION: The flat biometry sheet includes a mounting sheet and an enzyme reaction region. A conductive circuit formed by evaporation is disposed on the mounting sheet, and mutually conductive measuring electrode terminal and electrode circuit terminal are disposed at the front end and rear end of the conductive circuit, respectively. The enzyme reaction region is connected to the front end of the measuring electrode terminal. The manufacturing method includes: (1) a process of using a plastic film as the mounting sheet and forming a shadow mask by printing; (2) a process of forming a conductive plated layer by evaporation on the mounting sheet on which the shadow mask is printed; (3) a process of removing the conductive plated layer covering the shadow mask by a physical method and exposing the conductive circuit; (4) a process of disposing enzyme in the enzyme reaction region; and (5) a process of sticking an upper lid film. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to a method for producing a planar biometric sheet and its product, and in particular, is a sheet for measuring the physiological state of a biological fluid, such as blood glucose, cholesterol, or urine in the blood of a human body. The present invention relates to a planar biometric sheet that has high stability and accuracy and can achieve a significant cost reduction in the manufacturing process.

  The extension of the average life expectancy of modern people is closely related to the development of modern medical science and technology. Many of the hidden symptoms can be detected in advance by medical device testing, so early prevention and early treatment can be performed. Taking human body blood sugar as an example, taking a small amount of blood from the human body, first letting the blood react with the enzyme region that reacts with blood sugar in the reaction sheet, and then analyzing it with a blood glucose measuring device Thus, the blood sugar level of the human body can be measured. Thereby, the user can cope with early symptoms of abnormal blood glucose levels early, and can be prevented from getting worse and becoming a serious disease.

  1 and 2 show the configuration of a conventional blood sugar reaction sheet. In the conventional reaction sheet 90, a single plastic film (for example, polyimide) is used as the substrate 100, a conductive graphite material is used, and a carbon ink is screen-printed, or the surface of the substrate 100 is coated with copper. Conductive circuits 93 that are mutually conductive are formed by photolithography and etching that cover the foil. The conductive circuit 93 includes a front-stage measurement electrode terminal 931 and a rear-stage electrode circuit terminal 932. The front ends of the measurement electrode terminals 931 are connected to an enzyme reaction region 92 (provided with an enzyme) and a siphon channel 91, respectively. Further, the upper cover film 96 is covered, the electrode circuit terminals 932 are exposed, and finally, an appropriate size is cut.

  In use, when the collected blood comes into contact with the siphon channel 91, the blood is sucked up into the enzyme reaction region 92 by capillary action, and the glucose and the enzyme in the blood react to generate an electron flow. Since the electrode circuit terminal 932 is connected to the blood glucose level measuring device 95, the blood glucose level measuring device 95 measures the current through the electrode circuit terminal 932 and electrically transmits it. The signal is converted into a signal, and finally, the electrical signal is converted into a corresponding blood glucose concentration value.

  Although the conventional blood sugar reaction sheet 90 described above can measure blood sugar levels, its manufacturing method has many drawbacks. The disadvantages are listed below.

  (1) The conventional blood glucose reaction sheet 90 has a single plastic film 100 as a base material, and screen-printing carbon ink on the base material, thereby providing a measurement electrode terminal 931 at the front stage and an electrode circuit terminal 932 at the rear stage. Although formed, the lengths of the measurement electrode terminal 931 and the electrode circuit terminal 932 are increased and the surface area is also increased. Therefore, the measurement electrode terminal 931 and the electrode circuit terminal 932 are unstable during processing, and the electric resistance value tends to be uneven.

  (2) At present, conductive silver ink is often further printed on the bottom of the carbon ink layer in order to reduce the aforementioned unstable condition. However, although the stability can be improved thereby, the material cost of the silver ink is high, and there are many disadvantages that the thickness control is required at the time of printing and the drying process is complicated.

  The negative factors mentioned above are common views that are now well known in the market.

  U.S. Pat. No. 7,465,597 discloses a method of manufacturing a conductive circuit of a blood glucose reaction sheet by “optical lithography”. In short, it is a method of manufacturing a conductive circuit on a substrate by optical lithography, and a photomask on which a pattern of the designed conductive circuit is drawn is accurately transferred onto a substrate. The pattern is projected onto the substrate using the principle of imaging. The light emitted from the light source passes only through the transparent area of the photomask and forms an image on the surface of the substrate. In addition, after the surface of the base material is cleaned in advance and then applied with a photoresist, the photoresist reacts with light transmitted through the photomask (this procedure is generally called exposure). ). The substrate after the exposure is subjected to a development process, and then the metal that has been gasified by metal vapor deposition is applied to a conductive circuit not coated with photoresist and a shadow mask coated with photoresist. Once deposited and further the photoresist is removed by chemical methods (eg, dissolution, acid etching), the metal covering the top surface is also stripped together, and the remaining metal circuit forms the required conductive circuit. Subsequently, subsequent steps, for example, an enzyme reaction region, a step of providing an upper lid, a step of cutting into an appropriate size to obtain a product, and the like are performed.

  Naturally, the above-mentioned method of manufacturing a conductive circuit of a blood glucose reaction sheet by “optical lithography” has a problem that the precision of the conductive circuit is not high and the surface area of the carbon ink material is large and it is difficult to control the impedance. Although there is no such thing, the micro mechatronics and circuit board wiring with high accuracy and precision are used, so the production cost is relatively high. On the other hand, the above-described method removes the photoresist portion with acidic etching, that is, chemicals, so that when the acidic residue destroys enzyme activity and in addition, the manufacturing process cannot be controlled well, the degradation of enzyme and This method is not an ideal manufacturing method because it causes environmental pollution. Therefore, how to improve the shortcomings in the conventional method for producing a blood glucose reaction sheet is an important issue that the industry must strive to solve and overcome.

  Therefore, the present inventor started research and development of a solution for the problem in view of the fact that the conventional method for producing a planar biometric sheet has disadvantages and is not ideal, and has accuracy, stability and economy. We wanted to develop a method for manufacturing a flat biometric sheet and contribute to social contribution and industry development, and spent a long time submitting the present invention.

US Pat. No. 7,465,597

  The present invention uses a plastic film as a placement sheet (this placement sheet is a non-stretchable material), and employs a method of cutting a large amount after printing into a single product, It is possible to produce in a short time, reduce costs economically, further simplify the processing process, and improve the product quality stability and market competitiveness. An object of the present invention is to provide a method for producing a type biometric sheet and a product thereof.

  In addition, the present invention treats a shadow mask by printing (for example, using a non-toxic water-based ink), covers the entire surface of a metal conductive plating layer by a vapor deposition process, and further performs a physical method (for example, water washing). ) To remove the conductive plating layer covering the shadow mask and to expose the conductive circuit not covered by the shadow mask. Since the entire manufacturing process is performed by physical methods, A method for producing a planar biometric sheet and its product, which satisfies the requirements, and can improve the accuracy and sensitivity of measurement of a minute current with respect to an electrochemical reaction because the impedance is easily controlled and the conductivity is stable. The purpose is to provide.

  In order to achieve the above-described object, one embodiment of the present invention includes a placement sheet, an enzyme reaction region, and an upper lid film. The mounting sheet is made of a plastic film, and the mounting sheet is provided with a conductive circuit formed by a vapor deposition process. At the front end and the rear end of the conductive circuit, a measurement electrode terminal and an electrode circuit terminal are connected to each other. Provide. The enzyme reaction region is connected to the front end of the measurement electrode terminal. The top cover film covers the placement sheet and exposes the electrode circuit terminals for convenient measurement.

  In order to achieve the above object, in another embodiment of the present invention, first, a measurement electrode terminal of a conductive circuit of a mounting sheet is formed on a conductive material (for example, carbon ink, conductive silver ink) that hardly undergoes a chemical change with an enzyme. Etc.), and then vapor deposition is performed, and the conductive metal is covered with the electrode circuit terminals and the measurement electrode terminals separated from the enzyme reaction region, thereby forming the electrode circuit terminals. The measurement electrode terminal is electrically connected, and upper and lower coupling electrodes are formed on the measurement electrode terminal separated from the enzyme reaction region. The measurement electrode terminal that is in contact with the enzyme reaction region is a conductive material that is unlikely to undergo chemical changes with the enzyme, so its measurement stability is high, it does not change with changes in the environment or the storage period, and its coefficient of variation. (CV) is also easy to control.

  In order to achieve the above-mentioned object, in another embodiment of the present invention, the mounting sheet is made of a sheet-like plastic film, and is formed by a method in which a large amount is printed and then cut into a single product. The

  In order to achieve the above object, in another embodiment of the present invention, the mounting sheet is made of a roll-shaped plastic film, and is continuously cut by roll-to-roll and then cut. To form a single product.

In order to achieve the above object, the method for producing a planar biometric sheet of the present invention comprises the following procedures.
(1) A procedure in which at least one plastic film is used as a mounting sheet, a shadow mask is formed by printing, and the shadow mask exposes the measurement electrode terminal pattern and the electrode circuit terminal pattern.
(2) A procedure for forming a conductive circuit by a vapor deposition process. A deposition process is performed on the mounting sheet on which the shadow mask is printed, and one continuous conductive plating layer is covered on the entire surface of the mounting sheet.
(3) A procedure for removing the conductive plating layer covering the shadow mask. In other words, the conductive plating layer covering the shadow mask is removed by a physical method, and the conductive circuit is completely exposed, whereby the conductive circuit is provided with the measurement electrode terminal and the electrode circuit terminal.
(4) A procedure for providing the enzyme in the enzyme reaction region of the mounting sheet.
(5) A procedure in which the upper lid film is bonded onto the placing sheet to expose the electrode circuit terminals.

In order to achieve the above object, another method for producing the planar biometric sheet of the present invention comprises the following procedures.
(1) Using at least one layer of plastic film as a mounting sheet, first, a measurement electrode terminal is formed by printing or applying a conductive material (for example, carbon ink, conductive silver ink, etc.) that is less likely to cause chemical changes with the enzyme. procedure.
(2) A procedure in which a shadow mask is formed by printing, and the shadow mask exposes the electrode circuit terminal pattern.
(3) A procedure for forming a conductive circuit by a vapor deposition process. Vapor deposition is performed on the mounting sheet on which the shadow mask is printed, and the conductive metal is covered on the measurement electrode terminal separated from the enzyme reaction region and on the electrode circuit terminal, so that the entire surface of the mounting sheet is continuous. By covering the conductive plating layer, the electrode circuit terminal and the measurement electrode terminal are electrically connected, and upper and lower coupling electrodes are formed on the measurement electrode terminal.
(4) A procedure for removing the conductive plating layer covering the shadow mask. That is, the conductive plating layer covering the shadow mask is removed by a physical method, the conductive circuit is completely exposed, and the conductive circuit is provided with the measurement electrode terminal and the electrode circuit terminal.
(5) A procedure for providing the enzyme in the enzyme reaction region of the mounting sheet. (6) A procedure in which the upper lid film is bonded onto the placing sheet to expose the electrode circuit terminals.

  In order to achieve the above-described object, in the method for producing a planar biometric sheet of the present invention, the mounting sheet is made of a roll-shaped plastic film, and is continuously printed in large quantities by a roll-to-roll. Since the flat biometric sheet is formed by cutting into a single product, it can be produced in large quantities and in a short time, and the cost can be reduced and the processing process can be simplified. As a result, product quality stability and market competitiveness can be improved.

It is explanatory drawing which shows the structure of the conventional blood glucose reaction sheet. It is explanatory drawing which shows the manufacturing process of the conventional blood glucose reaction sheet. It is explanatory drawing which shows the structure of Example 1 of this invention. It is explanatory drawing which shows the structure of Example 1 of this invention. It is explanatory drawing which shows the structure of Example 1 of this invention. It is explanatory drawing which shows the structure of Example 1 of this invention. It is a flowchart which shows the manufacturing method of Example 1 of this invention. It is explanatory drawing which shows the flow of the manufacture process of Example 1 of this invention. It is explanatory drawing which shows the arrangement | sequence in the manufacture process of Example 1 of this invention. It is explanatory drawing which shows the structure of Example 2 of this invention. It is explanatory drawing which shows the structure of Example 2 of this invention. It is explanatory drawing which shows the structure of Example 2 of this invention. It is explanatory drawing which shows the structure of Example 2 of this invention. It is explanatory drawing which shows the structure of Example 2 of this invention. It is a flowchart which shows the manufacturing method of Example 2 of this invention.

  In order that the features of the technology of the present invention and the effects that can be achieved will be further understood and recognized, a detailed description will be given below with reference to preferred embodiments and drawings.

3C and 3D show the configuration of the planar biometric sheet according to Example 1 of the present invention. The biometric sheet 10A has a placement sheet 11A. The mounting sheet 11A is a continuous plastic film (for example, a PET film, a PC film, a PTFE film, a nylon film (Nylon), which is a single layer or a plurality of layers or a roll (this example is a roll). It is a non-stretchable material such as a polycarbonate film, a polystyrene film (Polystyrenes), an acrylonitrile butadiene styrene copolymer film (Acrylonitrile butadiene styrene). Other materials may be substituted).
The mounting sheet 11A is provided with a conductive circuit 13A formed by a vapor deposition process. At the front end and the rear end of the conductive circuit 13A, a measurement electrode terminal 131A and an electrode circuit terminal 132A that are electrically connected to each other are provided, respectively. An enzyme reaction region 16A is connected to the front end of the measurement electrode terminal 131A, and an enzyme is provided in the enzyme reaction region 16A. The placement sheet 11A is provided with an upper cover film 15A, and the electrode circuit terminal 132A is exposed for convenience of measurement.

  3A and 3B showing the configuration of the planar biometric sheet 10A are also referred to at the same time. First, a shadow mask 12A is printed on the mounting sheet 11A, and the shadow mask 12A exposes the conductive circuit 13A pattern (in this embodiment, it is performed in a negative manner. That is, the measurement electrode terminal pattern region and The area of the electrode circuit terminal pattern is not applied or printed). Subsequently, the conductive plating layer 17A is formed by performing a vapor deposition process, and the conductive plating layer 17A covering the shadow mask 12A is removed by a physical method (for example, water washing), and the measurement electrode terminal 131A and the electrode circuit terminal 132A are removed. To expose. In a preferred embodiment, the shadow mask 12A is formed by printing with a non-toxic aqueous ink.

  As shown in FIGS. 4 to 6, the method for manufacturing the planar biometric sheet 10 </ b> A of the present invention includes the following procedure.

  (1) The shadow mask 12A (21A) is formed by continuous mass printing in sheet form or roll form (in this embodiment, roll to roll is taken as an example) (the printing method is Screen printing and intaglio roller printing employed in this embodiment). That is, a rolled plastic film 31 (for example, a material having no elasticity such as PET film, PC film, PTFE film, nylon film, polycarbonate film, polystyrene film, acrylonitrile butadiene styrene copolymer film). As a material for the placement sheet 11A (shown in FIG. 3A), continuous printing of the intaglio plate by the intaglio printing roller 32 (or screen printing and other techniques that are well-known in the art) (It may be carried out by the printing method). The intaglio printing roller 32 is provided with a plurality of mesh patterns 321 to which non-toxic aqueous ink can be applied, and the shadow mask 12A is printed on the placement sheet 11A.

  (2) A conductive plating layer is formed by vapor deposition (22A). That is, the mounting sheet 11 </ b> A on which the shadow mask 12 </ b> A is printed is dried by the drying device 33, and then the deposition process is performed by the vacuum deposition device 34. In the vapor deposition process, the mounting sheet 11A is wound around a winding roll via a cooling roll (not shown), a vacuum is generated by a vacuum pump, and a high-purity conductive material (for example, gold) is heated by heating an evaporation source. , Silver, copper, aluminum, etc.) are melted at high temperature and evaporated to gas, then the film winding system is started, and after the film traveling speed reaches a certain value, the baffle plate is opened, When gaseous conductive fine particles are deposited on the surface of the moving mounting sheet 11A and cooled, a continuous conductive plating layer 17A is formed on the mounting sheet 11A.

  In this vapor deposition process, it is formed by vapor deposition by controlling the evaporation speed of conductive materials (for example, metals such as gold, silver, copper, and aluminum), the moving speed of the mounting sheet 11A, and the degree of vacuum in the vapor deposition chamber. The thickness of the conductive plating layer 17A applied can be adjusted, and the manufacturing quality of the measurement electrode terminal 131A and the electrode circuit terminal 132A can be accurately controlled.

  (3) The conductive plating layer 17A covering the shadow mask 12A is removed (23A). That is, the mounting sheet 11A after the vapor deposition process is removed by cleaning the conductive plating layer 17A covering the shadow mask 12A (Mask) with a cleaning device 35 (for example, water cleaning), and the measurement electrode terminal 131A and the electrode circuit terminal 132A is exposed.

  (4) An enzyme is provided in the enzyme reaction region of the placement sheet (24A). That is, the enzyme is installed on the placement sheet 11A (enzyme reaction region 16A) by the enzyme printing device 36. The enzyme can be installed by a method such as intaglio printing, screen printing, ink jet printing, or drip.

  In addition, when the present invention is performed by intaglio printing, the thickness of the enzyme can be set according to the difference in the depth of the intaglio, thereby further improving the enzyme reaction and making the measurement more accurate.

  (5) The upper lid film 15A is bonded to the placement sheet 11A (25A). That is, an adhesive material (for example, water glue or acrylic glue) is used to bond the upper lid film 15A on the placement sheet 11A, and the electrode circuit terminal 132A is exposed for convenience of measurement.

  It should be noted that the enzyme reaction region 16A (measurement electrode terminal 131A) of the plastic film 31 is provided two by two as shown in FIG. By bonding, the installation of a plurality of upper lid films 15A in two rows can be completed at the same time, and the manufacturing efficiency is further improved.

  (6) Cut into a single product (26A). That is, when the plastic film 31 that has undergone a series of steps is set in the cutting machine 37 and cut, a plurality of planar biometric sheet 10A (blood glucose level measuring device) products are completed.

  7A to 7E show a planar biometric sheet of Example 2 of the present invention. The biometric sheet 10C includes a mounting sheet 11C (the configuration of the mounting sheet is the same as that of the first embodiment). The mounting sheet 11C is provided with a conductive circuit 13C. The conductive circuit 13C includes a measurement electrode terminal 131C and an electrode. It has a circuit terminal 132C. The measurement electrode terminal 131C is formed by applying or printing using a conductive material (for example, carbon ink, conductive silver ink, or the like) that hardly causes a chemical change with an enzyme. Further, by performing vapor deposition and covering a conductive metal (for example, a metal such as gold, silver, copper, and aluminum) on the electrode circuit terminal 132C and the measurement electrode terminal 131C separated from the enzyme reaction region 16C, The electrode circuit terminal 132C and the measurement electrode terminal 131C are electrically connected, and upper and lower coupling electrodes are formed on the measurement electrode terminal 131C. The measurement electrode terminal 131C that is in contact with the enzyme reaction region 16C is a stable conductive material and does not cause a chemical change with the enzyme in the enzyme reaction region 16C. It does not change over time, and the coefficient of variation (CV) is easy to control.

  As shown in FIG. 8, the manufacturing method of Example 2 mentioned above consists of the following procedures.

  (1) A measurement electrode is previously formed on a plastic film by printing or coating (20C). That is, a measurement electrode terminal is formed by using a sheet-shaped or roll-shaped plastic film as a material for the mounting sheet and printing or applying a conductive material that hardly undergoes a chemical change with an enzyme on the plastic film.

  (2) A shadow mask is formed on the placement sheet by printing (21C). That is, the shadow mask 12C is printed on the placement sheet 11C, and the shadow mask is connected to the measurement electrode terminal 131C.

  (3) A conductive plating layer is formed by vapor deposition (22C). That is, after the mounting sheet 11C on which the shadow mask 12C is printed is dried, a deposition process is performed, and the conductive metal is covered with the electrode circuit terminal 12C and the measurement electrode terminal 131C separated from the enzyme reaction region 16C. As a result, the electrode circuit terminal 132C and the measurement electrode terminal 131C are electrically connected, and the upper and lower coupling electrodes are formed on the measurement electrode terminal 131C.

  (4) The conductive plating layer covering the shadow mask 12C is cleaned and removed (23C). That is, the mounting sheet 11C after the deposition process is put into a cleaning device, and the conductive plating layer 17C covering the shadow mask 12C (Mask) is cleaned and removed by a physical method (for example, water cleaning), and the measurement electrode terminal 131C is removed. Only the electrode circuit terminal 132C is exposed.

  (5) An enzyme is provided in the enzyme reaction region of the placement sheet (24C). That is, the enzyme is installed on the placement sheet 11C (on the enzyme reaction region) by the enzyme printing device 36. The enzyme can be installed by a method such as intaglio printing, screen printing, ink jet printing, or drip.

  (6) The upper lid film 15C is bonded to the placement sheet 11C (25C). That is, an adhesive material (for example, water glue or acrylic glue) is used to bond the upper lid film 15C on the placement sheet 11C, and the electrode circuit terminal 132C is exposed for convenience of measurement.

  (7) Cut into a single product (26C). That is, when the plastic film 31 that has undergone a series of steps is set in a cutting machine and cut, a product of a plurality of planar biological measurement sheets 10C (blood glucose level measuring devices) is completed.

  As described above, since the planar biometric sheet according to the present invention is manufactured by printing (for example, intaglio printing or screen printing) on a sheet-like or roll-to-roll plastic film, In addition, the production cost can be reduced in a short time, the cost can be reduced, the processing process can be further simplified, and the stability of the product quality and the market competitiveness can be improved. Since the characteristics of conductivity are formed by the method, the requirements for environmental protection of the earth are satisfied, the impedance is easily controlled, the conductivity is stable, and the accuracy and sensitivity of measurement of physiological state can be greatly enhanced. .

  As described above, the present invention meets the requirements of the patent, and the present invention is filed in accordance with the law. Although the embodiments of the present invention have been described in detail with reference to the drawings, all are merely preferred examples, and the specific configuration is not limited to this embodiment, and the shape does not depart from the gist of the present invention. Further, structures, features, design changes, and the like are included in the scope of the claims.

10A, 10C... Biometric sheet 11A, 11C... Mounting sheet 12A, 12C... Shadow mask 13A, 13C .. conductive circuit 131A, 131C. Terminals 132A, 132C ... Electrode circuit terminals 15A, 15C ... Upper lid films 17A, 17C ... Conductive plating layers 16A, 16C ... Enzyme reaction region 31 ... ... Plastic film 32 ... Intaglio printing roller 321 ... Net pattern 33 ... Drying device 34 ...・ ・ ・ ・ ・ Vacuum vapor deposition device 35 ・ ・ ・ ・ ・ Cleaning device 36 ・ ・ ・ ・ ・ Enzyme printing device 37 ・ ・ ・ ・ ・ Cutting machine

Claims (14)

At least in the planar biometric sheet consisting of a placement sheet and an enzyme reaction region,
The mounting sheet is made of a plastic film, and a shadow mask is printed on the mounting sheet.
On the shadow mask, a conductive circuit is formed by depositing a conductive metal,
The conductive circuit has a measurement electrode terminal and an electrode circuit terminal that are electrically connected to each other, and the enzyme reaction region is connected to a front end of the measurement electrode terminal,
Planar biometric sheet. At least in the planar biometric sheet consisting of a mounting sheet, a conductive circuit, and an enzyme reaction region,
The mounting sheet is made of plastic film,
The conductive circuit is provided on the placement sheet, and
The conductive circuit includes a measurement electrode terminal formed by applying or printing a conductive material;
An electrode formed by conducting a mutual connection with the measurement electrode terminal, printing a shadow mask on the mounting sheet, and depositing a conductive metal on the shadow mask after the measurement electrode terminal is formed. With circuit terminals,
The enzyme reaction region is connected to a front end of the measurement electrode terminal,
Planar biometric sheet.   3. The planar biometric sheet according to claim 2, wherein one end of the measurement electrode terminal away from the enzyme reaction region forms a deposited conductive metal and upper and lower coupling electrodes.   The planar biometric sheet according to claim 2, wherein the conductive material forming the measurement electrode terminal is carbon ink or conductive silver ink.   The planar biometric sheet according to claim 1 or 2, wherein the placement sheet is formed by laminating a single layer or a plurality of layers of plastic films.   The said installation sheet | seat consists of a PET film, PC film, PTFE film, a nylon film, a polycarbonate film, a polystyrene film, or an acrylonitrile butadiene styrene copolymer film, It is characterized by the above-mentioned. Planar biometric sheet.   The planar biometric sheet according to claim 1 or 2, wherein the conductive material of the vapor deposition metal forming the conductive circuit is gold, silver, copper, or aluminum. (1) Using a roll-shaped plastic film as a mounting sheet, forming a shadow mask by printing, the shadow mask exposing a measurement electrode terminal pattern and an electrode circuit terminal pattern;
(2) The entire surface of the mounting sheet on which the shadow mask is printed is covered with a continuous conductive plating layer by a vapor deposition process to form a conductive circuit;
(3) Procedure for removing the conductive plating layer covering the shadow mask by a physical method and completely exposing the conductive circuit, thereby providing the conductive circuit with a measurement electrode terminal and an electrode circuit terminal that are electrically connected to each other. When,
(4) A procedure for providing an enzyme in the enzyme reaction region on the mounting sheet,
It is characterized by consisting of
A method for producing a planar biometric sheet. (1) A procedure in which a measurement electrode terminal is formed by printing or applying a conductive material that hardly causes a chemical change with an enzyme on the plastic film, using a roll-shaped plastic film as a mounting sheet;
(2) On the placement sheet, a shadow mask is formed by printing, and the shadow mask is connected to one end of the measurement electrode terminal;
(3) A vapor deposition process is performed on the mounting sheet on which the shadow mask is printed, and the conductive metal is covered with the electrode circuit terminal and the measurement electrode terminal separated from the enzyme reaction region, thereby A procedure for electrically connecting the electrode circuit terminal and the measurement electrode terminal, and forming upper and lower coupling electrodes on the measurement electrode terminal;
(4) After the vapor deposition step is completed, the conductive plating layer covering the shadow mask is removed by washing on the placement sheet, and the measurement electrode terminal and the electrode circuit terminal are exposed.
(5) a procedure for providing an enzyme in the enzyme reaction region on the mounting sheet,
It is characterized by consisting of
A method for producing a planar biometric sheet.   The method for producing a planar biometric sheet according to claim 8 or 9, wherein the shadow mask is formed by intaglio printing or screen printing using a non-toxic aqueous ink.   The method for manufacturing a planar biometric sheet according to claim 8 or 9, wherein the conductive material of the deposited metal forming the conductive circuit is gold, silver, copper, or aluminum.   The planar biometric sheet according to claim 8 or 9, wherein the enzyme is continuously provided on the placing sheet by intaglio printing, screen printing, ink jet printing, or drip. Production method.   The method for producing a planar biometric sheet according to claim 8 or 9, wherein an upper lid film is bonded onto the placement sheet and then cut into a single product.   The method for producing a planar biometric sheet according to claim 9, wherein the conductive material forming the measurement electrode terminal is carbon ink or conductive silver ink.

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