JP2011098946A - Skin cosmetic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an excellent skin cosmetic which can display an excellent whitening effect in the inhibition of the deposition of coloring matter especially on a skin, and also which is excellent in the safety side because of little irritation to the skin. <P>SOLUTION: This skin cosmetic is one in which the extract from roasted rice bran, publicly known as a food additive, is allowed to be applied to a skin cosmetic. This skin cosmetic is one which contains an extract from roasted rice bran. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to a skin cosmetic.

  Rice bran obtained at the time of milling brown rice (ie, milled rice) is effectively used in various fields. The effective use of rice bran in the field of cosmetics is described in Patent Documents 1 to 13, for example. More specifically, regarding application to cosmetics, an extract obtained by extracting rice bran with a neutral medium (Patent Documents 1 and 2); a decomposition product obtained by further treating the extract obtained by extracting rice bran with a solvent with an enzyme (Patent Document 3): Extract obtained by extracting rice bran with an acidic aqueous medium (Patent Document 4); For example, by the method described in Patent Document 13, the pH of rice bran or brown rice was adjusted to acidic or alkaline as desired. Extracted with water or a mixed solvent of water and a water-miscible solvent, etc., and obtained by subjecting to proteolytic enzyme treatment if necessary (patent documents 5 and 12); rice bran extract by the method described in patent document 13 What is obtained by hydrolysis treatment (Patent Document 6); Extract from ginger, defatted rice bran or fermented rice bran with a polar solvent (Patent Document 7); Rice bran that has been roasted at low temperature and sieved (Patent Document 8) ; Finely divided rice bran (special Reference 9); extract obtained by digesting rice bran in water or 1,3-butylene glycol and filtering (Patent Document 10); rice bran extract (Patent Document 11); and alkali extraction of rice and / or rice bran A degradation product (Patent Document 13) obtained by treating a liquid with two or more enzymes has been reported.

  An extract of roasted defatted rice bran obtained by removing rice oil (or also called “rice bran oil”) from rice bran (also referred to as “roasted rice bran” in the present specification) (It is also called “roasted rice bran extract”). Roasted rice bran extract is known as a food additive and is recognized as an existing additive (Non-patent Document 1). The roasted rice bran extract has an unpleasant odor of livestock and fish meat (Non-patent Document 1), as well as an unpleasant taste caused by trimethylamine (fish odor), ammonia, diallyl disulfide (garlic odor) and methyl mercaptan (roty odor of onions). It is known to mitigate or suppress odor (Non-Patent Document 2). In patent document 14, the composition for oral cavity using the deodorizing effect of roasted rice bran extract is reported.

JP-A-7-304648 JP 2004-83594 A JP 2000-119160 A JP 2000-264834 A JP 2000-351722 A JP 2002-128654 A JP 2002-255784 A JP 2002-265349 A JP 2004-131458 A JP 2005-15450 A JP 2005-139070 A JP 2005-154375 A JP-A-5-221844 JP 2006-22053 A

“Existing Additives and Natural Fragrances, Food Materials, Natural Products Handbook” 15th edition, page 318, Food and Science Co., Ltd., issued on November 30, 2003 Okuno Pharmaceutical Co., Ltd. Food Research Dept. Technical data, released on April 1, 2003

  An object of this invention is to provide the outstanding skin cosmetics.

  The present invention provides a skin cosmetic comprising a roasted rice bran extract.

  According to the present invention, the roasted rice bran extract known as a food additive can be used for skin cosmetics. Skin cosmetics containing a roasted rice bran extract can exhibit a whitening effect that is particularly excellent in suppressing pigmentation on the skin. There is little irritation to the skin and it is excellent in terms of safety.

It is the figure which showed the total evaluation score for every elapsed days of this test about water, a defatted rice bran extract, and a roasted rice bran extract as a bar graph.

(Roasted rice bran extract)
Roasted rice bran extract is known as a food additive and is recognized as an existing additive (Non-patent Document 1). In Non-Patent Document 1, the base of the roasted rice bran extract is obtained by degreasing and roasting rice bran rice and extracting the protein with hot ethanol after extraction with hot water. , It describes that it contains maltol as a component. The roasted rice bran extract used in the following examples can be an example of the roasted rice bran extract defined in Non-Patent Document 1, but the method for producing the roasted rice bran extract used in the present invention is obtained. As long as the product exhibits the desired effect (especially suppression of pigmentation in the skin), there is no limitation as described below. Food additives (for example, products manufactured by Okuno Seiyaku Kogyo Co., Ltd .: trade names “Desmy R” and “Desmy R Powder”) available as “Baisen rice bran extract” (additive label) are also included in the present invention. Can be used.

  “Roasted rice bran” is prepared by roasting defatted rice bran obtained by removing rice oil from rice bran. As rice bran, it is possible to use the skin and embryo part discarded at the time of milling. Rice bran is also available commercially. For the production of defatted rice bran by extracting rice oil from rice bran, any method commonly used by those skilled in the art can be used, and as such methods, compression extraction and solvent extraction (for example, using hexane) are known. . The defatted rice bran may be a residue after rice oil extraction from the rice bran. Degreased rice bran is also commercially available. “Roasting” refers to a process of heating rice bran contained in a container to a high temperature from the outside without adding moisture. The roasting is performed at a temperature of 120 to 210 ° C., preferably 130 to 190 ° C., more preferably about 170 ° C., for example, for 20 to 90 minutes, preferably 30 to 60 minutes, more preferably about 40 minutes. However, it is not particularly limited to these conditions.

  A “roasted rice bran extract” can be prepared by extracting roasted rice bran with water or an organic solvent, or a combination of water and an organic solvent. Examples of water include tap water, distilled water, and pure water. Examples of the organic solvent include alcohols such as methanol, ethanol, propanol, and 1,3-butylene glycol. Extraction with a combination of water and an organic solvent is performed by sequentially separating water and an organic solvent (which may be an aqueous solution containing an organic solvent at a high concentration (about 50 v / v% or more)) (for example, with water) The extraction may be performed with an organic solvent after the extraction) or with a mixed solvent of water and an organic solvent (that is, an aqueous solution of an organic solvent).

  The method for preparing a roasted rice bran extract will be further described below with examples, but is not limited to these examples. Throughout this specification, materials that are usually available to those skilled in the art can be used unless otherwise described, and techniques or devices that are commonly used by those skilled in the art can be used unless otherwise described in terms of processing or operation. .

  As an example, the roasted rice bran is subjected to extraction with hot water, the extract obtained by filtration is concentrated and then powdered (for example, by spray drying), and then the powder is alcohol (preferably ethanol) The extract obtained by filtration and concentrated by filtration is obtained to obtain the final extract. The hot water extraction is performed at a temperature of, for example, 80 ° C. to 100 ° C., preferably 90 ° C. to 99 ° C., more preferably about 98 ° C., for example, 5 minutes or more, preferably 90 minutes or more, more preferably 120 minutes or more. Can be done over time. For the alcohol extraction, an aqueous solution containing a high concentration of alcohol, for example, 50 to 99.5 v / v%, preferably 70 to 95 v / v%, more preferably about 90 v / v%, in consideration of its handling aspect. An aqueous solution containing alcohol can be used as the extraction solvent. In consideration of the boiling point of the extraction solvent to be used, the extraction is performed at a temperature of, for example, 50 to 78 ° C, preferably 60 to 70 ° C, more preferably about 65 ° C, for example, for 60 minutes or more, preferably 90 minutes or more. More preferably, it can be performed over 120 minutes.

  As another example, roasted rice bran can be subjected to extraction with a solution containing alcohol and water (alcohol aqueous solution), and the extract obtained by filtration can be subjected to concentration. The alcohol aqueous solution is preferably an ethanol aqueous solution. The alcohol concentration of the aqueous alcohol solution used as the extraction solvent is preferably 30-70 v / v%, more preferably 40-60 v / v%, even more preferably about 50 v / v%. In consideration of the boiling point of the extraction solvent to be used, the extraction is performed at a temperature of, for example, 60 ° C. to 80 ° C., preferably 65 ° C. to 75 ° C., more preferably about 70 ° C., for example, 5 minutes or more, preferably 90 minutes. As described above, it can be carried out more preferably over about 120 minutes.

  The roasted rice bran extract is preferably obtained by extracting roasted rice bran obtained by roasting defatted rice bran at about 170 ° C. for about 40 minutes with hot water (about 98 ° C.) over about 120 minutes, and filtering. After concentrating the extract obtained in this manner, it was pulverized by spray drying, and then this powder was extracted with about 90 v / v% aqueous ethanol (about 65 ° C.) over about 120 minutes and filtered. The resulting extract can be prepared by concentration. Alternatively, the roasted rice bran extract is obtained by extracting the roasted rice bran with about 50 v / v% ethanol aqueous solution (about 70 ° C.) over about 120 minutes and concentrating the extract obtained by filtration. Can also be prepared.

(Skin cosmetic)
The skin cosmetic of the present invention contains roasted rice bran extract. The roasted rice bran extract can be used in any form such as powder, granule, liquid, emulsion, paste and the like. For example, a liquid form such as a final product produced based on the above-described procedure may be used as it is or diluted with a solvent (for example, water, fat, alcohol, etc.) as necessary, or a powder form may be used. You may use it, melt | dissolving or suspending or emulsifying in a solvent (for example, water, alcohol, etc.). The powder form can be prepared by drying the final liquid product produced based on the procedure as described above to a powder, such as by spray drying or freeze drying. For example, a liquid roasted rice bran extract can be dissolved in water together with dextrin as a powder base material and powdered by spray drying.

  The content of the roasted rice bran extract in the skin cosmetic may vary depending on the type of the intended skin cosmetic, but is suitable for exhibiting the desired effect (especially pigmentation suppression) of the roasted rice bran extract. In general, it can be 1 to 90% by weight, preferably 5 to 60% by weight, more preferably 20 to 30% by weight.

  In addition to roasted rice bran extract, skin cosmetics are usually used in cosmetics and pharmaceuticals, such as anionic surfactants, amphoteric surfactants, nonionic surfactants, cationic surfactants. , Adhesives, oils, powders (pigments, dyes, resins, etc.), preservatives, antioxidants, fragrances, salts, solvents, chelating agents, pearlizing agents, neutralizing agents, moisturizers, emulsifiers, pH adjusters, Insect repellents, enzymes and the like can be appropriately contained within a range not impairing the object of the present invention.

  The skin cosmetic of the present invention can be produced according to a conventional method. The skin cosmetic of the present invention is not limited to general cosmetics, and can also include skin external preparations such as quasi drugs, designated quasi drugs, and external drugs. The dosage form can be arbitrarily selected according to the purpose, and can be, for example, a lotion, emulsion, gel, cream, ointment and the like. Specifically, basic cosmetics such as milky lotion, cream, lotion, essence, pack, face wash, makeup cosmetics such as lipstick, foundation, liquid foundation, makeup press powder, face wash, body shampoo, soap, etc. Examples include, but are not limited to, cleaning cosmetics and bath preparations.

  EXAMPLES Hereinafter, although an Example demonstrates this invention more concretely, this invention is not limited by these Examples.

(Example 1: Application test to skin)
(Preparation of defatted rice bran extract and roasted rice bran extract)
A defatted rice bran extract and a roasted rice bran extract were prepared as described below. A rice oil was extracted from the rice bran obtained at the time of milling with hexane according to a procedure commonly used by those skilled in the art to obtain defatted rice bran. Further, the defatted rice bran was roasted at about 170 ° C. over 40 minutes to obtain roasted rice bran. The roasted rice bran was extracted with hot water at 98 ° C. for 120 minutes, and the extract obtained by filtration through a 150 mesh filter was concentrated with a global concentrator (manufactured by Nisaka Manufacturing Co., Ltd.), and then spray dried. Powdered. The obtained powder was extracted with a 90 v / v% ethanol aqueous solution at 65 ° C. over 2 hours, and the extract obtained by filtering in the same manner was concentrated in the same manner to obtain a liquid with a solid content of 70 w / v%. Got. This was used as a roasted rice bran extract in the following tests. The defatted rice bran extract was prepared in the same manner as described above except that defatted rice bran was used as a starting material for extraction instead of roasted rice bran.

(Test method)
<Preliminary test>
Ten randomly selected males and 10 females of age 40 to 40 were used as subjects, and three 1 × 1 cm ultraviolet irradiation portions were set on both arms on the side of the upper arm. The periphery of the ultraviolet irradiation part was covered with aluminum foil. Ultraviolet rays (UVB) are irradiated to the ultraviolet irradiation part from a position 30 cm away by a fluorescent lamp FL20-SE for health rays manufactured by Toshiba Lighting & Technology Corporation, and the appearance of erythema is visually observed 24 hours after irradiation in the ultraviolet irradiation part. Observed. For each subject, the amount of ultraviolet light necessary for the appearance of the lightest erythema was determined, and this was defined as the minimum erythema amount (MED).

<Main test>
The amount of ultraviolet rays corresponding to the MED of each subject obtained in advance in the preliminary test was irradiated once a day (morning) for five consecutive days in the same manner as in the preliminary test on the ultraviolet irradiation part of each subject. Furthermore, 20 days after the start date of UV irradiation, one day immediately after UV irradiation (after irradiation treatment (after the sixth day) is the same as when irradiation was performed; that is, in the morning) and 8 hours after that Two times, 50 mg of water, defatted rice bran extract or roasted rice bran extract was applied to each of the three UV-irradiated portions, and the pigmentation state was visually observed.

<Evaluation method>
The subject's pigmentation state was observed on the 5th, 10th, and 20th days and evaluated as follows in comparison with water application.

Evaluation points and criteria:
0: Little pigmentation is observed;
1: Less pigmentation than water application;
2: Slightly less pigmentation than water application;
3: Pigmentation similar to water application is observed.

  The evaluation score of each subject was summed up about application | coating of a defatted rice bran extract and a roasted rice bran extract. The total number of water applications is 60, and the lower the score, the less pigmentation.

(Test results)
The evaluation results of this test are shown in Table 1 below and FIG.

  FIG. 1 is a graph showing the total evaluation score for each elapsed day of this test for water, defatted rice bran extract and roasted rice bran extract as a bar graph. The vertical axis represents the total evaluation points (points), and the horizontal axis represents the number of days elapsed (5 days, 10 days, and 20 days). In each elapsed day, water, defatted rice bran extract, and roasted rice bran extract are shown in order from the left.

  From Table 1 and FIG. 1, it was observed that the defatted rice bran extract or the roasted rice bran extract applied to the skin showed less pigmentation compared to the water application on the fifth day after the start of the ultraviolet irradiation. As the number of days passed, the degree of pigmentation was reduced by applying the defatted rice bran extract or roasted rice bran extract to the skin, and the pigmentation inhibitory effect increased. Furthermore, pigmentation was more greatly inhibited by roasted rice bran extract than defatted rice bran extract.

  As described above, it has been found that when roasted rice bran extract is applied to the skin exposed to ultraviolet rays, the effect of suppressing pigmentation in the skin is exhibited. Furthermore, the effect was also found to be superior to the defatted rice bran extract. In addition, there was no subject who had an abnormality on the skin due to the application of roasted rice bran extract during this test.

  The roasted rice bran extract can exert an effect of suppressing pigmentation in the skin when applied to the skin. According to the present invention, it is possible to use a roasted rice bran extract, which has been known to be used as a food additive, for cosmetics. According to the skin cosmetic containing the roasted rice bran extract of the present invention, the application to the skin suppresses the expression of stains, buckwheat, etc., and white and beautiful skin can be maintained. In addition, a cosmetic with little irritation to the skin and high safety can be obtained.

Claims (1)

  Skin cosmetic containing roasted rice bran extract.

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