JP2011031064A - 脈管用ステント - Google Patents
脈管用ステント Download PDFInfo
- Publication number
- JP2011031064A JP2011031064A JP2010249935A JP2010249935A JP2011031064A JP 2011031064 A JP2011031064 A JP 2011031064A JP 2010249935 A JP2010249935 A JP 2010249935A JP 2010249935 A JP2010249935 A JP 2010249935A JP 2011031064 A JP2011031064 A JP 2011031064A
- Authority
- JP
- Japan
- Prior art keywords
- stent
- human body
- polylactic acid
- plla
- vascular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000002792 vascular Effects 0.000 title claims abstract description 42
- 230000003287 optical effect Effects 0.000 claims abstract description 16
- 239000002685 polymerization catalyst Substances 0.000 claims abstract description 7
- JJTUDXZGHPGLLC-IMJSIDKUSA-N 4511-42-6 Chemical compound C[C@@H]1OC(=O)[C@H](C)OC1=O JJTUDXZGHPGLLC-IMJSIDKUSA-N 0.000 claims abstract description 4
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 70
- 239000004626 polylactic acid Substances 0.000 claims description 70
- 239000000463 material Substances 0.000 claims description 20
- 238000001479 atomic absorption spectroscopy Methods 0.000 claims description 6
- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 claims description 4
- 238000006116 polymerization reaction Methods 0.000 abstract description 10
- 238000000034 method Methods 0.000 abstract description 5
- 238000010521 absorption reaction Methods 0.000 abstract description 3
- 229920001432 poly(L-lactide) Polymers 0.000 abstract 3
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 abstract 2
- 210000004204 blood vessel Anatomy 0.000 description 25
- 238000002844 melting Methods 0.000 description 10
- 230000008018 melting Effects 0.000 description 10
- 238000002074 melt spinning Methods 0.000 description 9
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 8
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 7
- 230000002411 adverse Effects 0.000 description 7
- 229910001385 heavy metal Inorganic materials 0.000 description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- 238000005452 bending Methods 0.000 description 6
- 239000003054 catalyst Substances 0.000 description 6
- 239000012535 impurity Substances 0.000 description 6
- 238000002399 angioplasty Methods 0.000 description 5
- 239000004310 lactic acid Substances 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- 208000037803 restenosis Diseases 0.000 description 5
- 206010061218 Inflammation Diseases 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 230000009477 glass transition Effects 0.000 description 4
- 230000004054 inflammatory process Effects 0.000 description 4
- 235000014655 lactic acid Nutrition 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 239000000178 monomer Substances 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 229920002988 biodegradable polymer Polymers 0.000 description 3
- 239000004621 biodegradable polymer Substances 0.000 description 3
- 238000012423 maintenance Methods 0.000 description 3
- 229910052698 phosphorus Inorganic materials 0.000 description 3
- 239000011574 phosphorus Substances 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 208000031481 Pathologic Constriction Diseases 0.000 description 2
- 238000006073 displacement reaction Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000005304 joining Methods 0.000 description 2
- 239000000155 melt Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000002861 polymer material Substances 0.000 description 2
- 230000000379 polymerizing effect Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000036262 stenosis Effects 0.000 description 2
- 208000037804 stenosis Diseases 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- FBYFHODQAUBIOO-UHFFFAOYSA-N 2-(1-carboxyethoxy)propanoic acid Chemical compound OC(=O)C(C)OC(C)C(O)=O FBYFHODQAUBIOO-UHFFFAOYSA-N 0.000 description 1
- 208000005422 Foreign-Body reaction Diseases 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 210000000013 bile duct Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 1
- 229960003957 dexamethasone Drugs 0.000 description 1
- 238000000113 differential scanning calorimetry Methods 0.000 description 1
- 238000009998 heat setting Methods 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000002966 stenotic effect Effects 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000005979 thermal decomposition reaction Methods 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
【解決手段】 生体内に植え込まれた後、生体内で分解され消失する脈管用ステントであって、L−体の光学純度が99.8%以上であって、重量平均分子量が80,000〜300,000の範囲にあるポリ乳酸(PLLA)により形成されている。ここで用いるポリ乳酸(PLLA)は、L−ラクタイドを溶融重合する際に用いられた重合触媒の残存料が原子吸光法により検出されない範囲まで除去されている。
【選択図】 図1
Description
Claims (2)
- 生体内に植え込まれた後、生体内で分解され消失する脈管用ステントであって、
当該ステントは、L−体の光学純度が99.8%以上であって、重量平均分子量が80,000〜300,000の範囲にあるポリ乳酸(PLLA)により形成されていることを特徴とする脈管用ステント。 - 上記ポリ乳酸(PLLA)は、L−ラクタイドを溶融重合する際に用いられた重合触媒の残存料が原子吸光法により検出されない範囲まで除去されていることを特徴とする請求項1記載の脈管用ステント。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010249935A JP5170474B2 (ja) | 2010-11-08 | 2010-11-08 | 脈管用ステント |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010249935A JP5170474B2 (ja) | 2010-11-08 | 2010-11-08 | 脈管用ステント |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005163139A Division JP4791085B2 (ja) | 2005-06-02 | 2005-06-02 | 医療用脈管ステント用ポリマー材料及び脈管用ステントの糸 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2011031064A true JP2011031064A (ja) | 2011-02-17 |
JP5170474B2 JP5170474B2 (ja) | 2013-03-27 |
Family
ID=43760684
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010249935A Active JP5170474B2 (ja) | 2010-11-08 | 2010-11-08 | 脈管用ステント |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP5170474B2 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014184939A1 (ja) | 2013-05-16 | 2014-11-20 | 株式会社ソフセラ | 生分解性材料 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07165896A (ja) * | 1993-09-09 | 1995-06-27 | Kanebo Ltd | 生分解性ポリエステル共重合体、その製法および該共重合体からの成形品 |
JPH07300520A (ja) * | 1994-05-06 | 1995-11-14 | Kanebo Ltd | 改良された生分解性ポリエステル共重合体、その成形体及びその製造方法 |
JPH07305228A (ja) * | 1994-05-06 | 1995-11-21 | Kanebo Ltd | 高分子量ポリ乳酸成形品の製造方法 |
JPH1033657A (ja) * | 1996-07-23 | 1998-02-10 | Dainippon Ink & Chem Inc | 生体内分解性材料及びその製造方法 |
JP2006262960A (ja) * | 2005-03-22 | 2006-10-05 | Terumo Corp | ステント |
-
2010
- 2010-11-08 JP JP2010249935A patent/JP5170474B2/ja active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07165896A (ja) * | 1993-09-09 | 1995-06-27 | Kanebo Ltd | 生分解性ポリエステル共重合体、その製法および該共重合体からの成形品 |
JPH07300520A (ja) * | 1994-05-06 | 1995-11-14 | Kanebo Ltd | 改良された生分解性ポリエステル共重合体、その成形体及びその製造方法 |
JPH07305228A (ja) * | 1994-05-06 | 1995-11-21 | Kanebo Ltd | 高分子量ポリ乳酸成形品の製造方法 |
JPH1033657A (ja) * | 1996-07-23 | 1998-02-10 | Dainippon Ink & Chem Inc | 生体内分解性材料及びその製造方法 |
JP2006262960A (ja) * | 2005-03-22 | 2006-10-05 | Terumo Corp | ステント |
Non-Patent Citations (2)
Title |
---|
JPN6011020697; 分子心血管病, 5[1] (2004) p.33-38 * |
JPN6011020701; J Soc Mat Sci Japan., 49[9] (2000) p.1030-1035 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014184939A1 (ja) | 2013-05-16 | 2014-11-20 | 株式会社ソフセラ | 生分解性材料 |
Also Published As
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JP5170474B2 (ja) | 2013-03-27 |
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