JP2010540564A - 自己相補的なａａｖが媒介する眼の障害を処置または予防するための干渉ｒｎａ分子の送達 - Google Patents
自己相補的なａａｖが媒介する眼の障害を処置または予防するための干渉ｒｎａ分子の送達 Download PDFInfo
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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| EP (1) | EP2192926A1 (enExample) |
| JP (1) | JP2010540564A (enExample) |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170054493A (ko) * | 2014-09-16 | 2017-05-17 | 젠자임 코포레이션 | 마이오실린(myoc) 녹내장을 치료하기 위한 아데노-관련 바이러스 벡터 |
| JP2021526839A (ja) * | 2018-06-12 | 2021-10-11 | ザ ユニバーシティ オブ ブリストル | 眼圧及び頭蓋内圧を調節するための材料及び方法 |
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| EP2019143A1 (en) | 2007-07-23 | 2009-01-28 | Genethon | CNS gene delivery using peripheral administration of AAV vectors |
| EP2058401A1 (en) | 2007-10-05 | 2009-05-13 | Genethon | Widespread gene delivery to motor neurons using peripheral injection of AAV vectors |
| EP2287323A1 (en) * | 2009-07-31 | 2011-02-23 | Association Institut de Myologie | Widespread gene delivery to the retina using systemic administration of AAV vectors |
| EA202091105A1 (ru) * | 2010-04-23 | 2020-12-30 | Юниверсити Оф Флорида Рисерч Фаундейшн, Инк. | Композиции гуанилатциклазы и способы лечения врожденного амавроза лебера типа 1 (lca1) |
| CN103505743A (zh) * | 2012-06-21 | 2014-01-15 | 北京命码生科科技有限公司 | 含功能性microRNA/siRNA的细胞微粒子及其应用 |
| EP4012035B1 (en) * | 2014-09-16 | 2024-11-06 | Genzyme Corporation | Adeno-associated viral vectors for treating myocilin (myoc) glaucoma |
| CA2961523A1 (en) * | 2014-09-16 | 2016-03-24 | Genzyme Corporation | Adeno-associated viral vectors for treating myocilin (myoc) glaucoma |
| US20220403438A1 (en) | 2019-10-08 | 2022-12-22 | Trustees Of Boston College | Proteins containing multiple, different unnatural amino acids and methods of making and using such proteins |
| MX2022010936A (es) | 2020-03-05 | 2022-11-16 | Neotx Therapeutics Ltd | ³métodos y composiciones para el tratamiento del cáncer con células inmunológicas. |
| EP4161583A1 (en) * | 2020-06-05 | 2023-04-12 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods and pharmaceutical compositions for treating ocular diseases |
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| ES2256265T3 (es) * | 2000-06-01 | 2006-07-16 | University Of North Carolina At Chapel Hill | Vectores de parvovirus duplicados. |
| US20040209832A1 (en) * | 2001-11-30 | 2004-10-21 | Mcswiggen James | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| US20040198682A1 (en) * | 2001-11-30 | 2004-10-07 | Mcswiggen James | RNA interference mediated inhibition of placental growth factor gene expression using short interfering nucleic acid (siNA) |
| US20050048529A1 (en) * | 2002-02-20 | 2005-03-03 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of intercellular adhesion molecule (ICAM) gene expression using short interfering nucleic acid (siNA) |
| WO2005019422A2 (en) * | 2003-08-13 | 2005-03-03 | The Board Of Trustees Of The University Of Illinois | Silencing of tgf-beta receptor type ii expression by sirna |
| US7947267B2 (en) * | 2004-10-08 | 2011-05-24 | Potentia Pharmaceuticals, Inc. | Viral complement control proteins for eye disorders |
| TWI386225B (zh) * | 2004-12-23 | 2013-02-21 | Alcon Inc | 用於治療眼睛病症的結締組織生長因子（ＣＴＧＦ）ＲＮＡ干擾（ＲＮＡｉ）抑制技術 |
| TWI401316B (zh) * | 2004-12-23 | 2013-07-11 | Alcon Inc | 用於治療青光眼之血清澱粉樣蛋白Ａ的ＲＮＡｉ抑制作用 |
| TW200639253A (en) * | 2005-02-01 | 2006-11-16 | Alcon Inc | RNAi-mediated inhibition of ocular targets |
| BRPI0609206A2 (pt) * | 2005-03-11 | 2010-03-02 | Alcon Inc | inibiÇço mediada por rnai de proteÍna relacionada frizzled-1 para tratamento de glaucoma |
| GB0521351D0 (en) * | 2005-10-20 | 2005-11-30 | Genomica Sau | Modulation of TRPV expression levels |
| AR057252A1 (es) * | 2005-12-27 | 2007-11-21 | Alcon Mfg Ltd | Inhibicion de rho quinasa mediada por arni para el tratamiento de trastornos oculares |
| TW200731980A (en) * | 2005-12-29 | 2007-09-01 | Alcon Mfg Ltd | RNAi-mediated inhibition of HIF1A for treatment of ocular angiogenesis |
| TW200808360A (en) * | 2006-04-13 | 2008-02-16 | Alcon Mfg Ltd | RNAi-mediated inhibition of spleen tyrosine kinase-related inflammatory conditions |
| US8298818B2 (en) * | 2006-04-28 | 2012-10-30 | University Of Florida Research Foundation, Inc. | Self-complementary adeno-associated virus having a truncated CMV-chicken β-actin promoter |
| AU2007253776B2 (en) * | 2006-05-19 | 2012-04-26 | Arrowhead Research Corporation | RNAi-mediated inhibition of tumor necrosis factor alpha-related conditions |
| BRPI0715821A2 (pt) * | 2006-08-24 | 2013-07-23 | Alcon Res Ltd | inibiÇço de gremlina mediada por rnai para tratamento de condiÇÕes relacionadas À iop |
| EP2137205A2 (en) * | 2007-02-26 | 2009-12-30 | Quark Pharmaceuticals, Inc. | Inhibitors of rtp801 and their use in disease treatment |
| US7973019B1 (en) * | 2007-10-03 | 2011-07-05 | Alcon Research, Ltd. | Transferrin/transferrin receptor-mediated siRNA delivery |
| TW200932274A (en) * | 2007-12-18 | 2009-08-01 | Alcon Res Ltd | Interfering RNA delivery system and uses thereof |
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2008
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2010
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| JPN6013023940; 'Ｓｕｐｐｒｅｓｓｉｏｎ ｏｆ ｍｏｕｓｅ ｒｈｏｄｏｐｓｉｎ ｅｘｐｒｅｓｓｉｏｎ ｉｎ ｖｉｖｏ ｂｙ ＡＡＶ ｍｅｄｉａｔｅｄ ｓｉＲＮＡ ｄｅｌｉｖｅｒｙ．' Ｖｉｓｉｏｎ Ｒｅｓ． ４７（９）, 2007, １２０２-１２０８ * |
| JPN6013023942; 'Ｏｃｕｌａｒ ｇｅｎｅ ｔｒａｎｓｆｅｒ ｗｉｔｈ ｓｅｌｆ-ｃｏｍｐｌｅｍｅｎｔａｒｙ ＡＡＶ ｖｅｃｔｏｒｓ．' Ｉｎｖｅｓｔ Ｏｐｈｔｈａｌｍｏｌ Ｖｉｓ Ｓｃｉ． ４８（７）, 2007, ３３２４-３３２８ * |
| JPN6013023944; 'Ｍｅｃｈａｎｉｓｍｓ ｏｆ ＡＡＶ ｔｒａｎｓｄｕｃｔｉｏｎ ｉｎ ｇｌａｕｃｏｍａ-ａｓｓｏｃｉａｔｅｄ ｈｕｍａｎ ｔｒａｂｅｃｕｌａｒ ｍｅｓｈｗｏｒｋ ｃｅｌｌｓ．' Ｊ Ｇｅｎｅ Ｍｅｄ． ８（５）, 2006, ５８９-６０２ * |
| JPN6013023945; 'ＡＡＶ ｈｙｂｒｉｄ ｓｅｒｏｔｙｐｅｓ： ｉｍｐｒｏｖｅｄ ｖｅｃｔｏｒｓ ｆｏｒ ｇｅｎｅ ｄｅｌｉｖｅｒｙ．' Ｃｕｒｒ Ｇｅｎｅ Ｔｈｅｒ． ５（３）, 2005, ２９９-３１０ * |
| JPN6013023948; 'Ｉｎｈｉｂｉｔｉｏｎ ｏｆ Ｏｃｕｌａｒ Ａｎｇｉｏｇｅｎｅｓｉｓ ｂｙ ｓｉＲＮＡ Ｔａｒｇｅｔｉｎｇ Ｖａｓｃｕｌａｒ Ｅｎｄｏｔｈｅｌｉａｌ Ｇｒｏｗｔｈ Ｆａｃｔｏｒ Ｐａｔｈｗａｙ Ｇｅｎｅ' Ａｍ Ｊ Ｐａｔｈｏｌ． １６５（６）, 2004, ２１７７-２１８５ * |
| JPN6013023949; 'Ｐｏｔｅｎｔｉａｌ ａｐｐｌｉｃａｔｉｏｎｓ ｆｏｒ ＲＮＡｉ ｔｏ ｐｒｏｂｅ ｐａｔｈｏｇｅｎｅｓｉｓ ａｎｄ ｄｅｖｅｌｏｐ ｎｅｗ ｔｒｅａｔｍｅｎｔｓ ｆｏｒ ｏｃｕｌａｒ ｄｉｓｏｒｄｅｒ' Ｇｅｎｅ Ｔｈｅｒａｐｙ １３（６）, 2006, ５５９-５６２ * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170054493A (ko) * | 2014-09-16 | 2017-05-17 | 젠자임 코포레이션 | 마이오실린(myoc) 녹내장을 치료하기 위한 아데노-관련 바이러스 벡터 |
| JP2017529395A (ja) * | 2014-09-16 | 2017-10-05 | ジェンザイム・コーポレーション | ミオシリン（ｍｙｏｃ）緑内障を処置するためのアデノ随伴ウイルスベクター |
| KR102612871B1 (ko) | 2014-09-16 | 2023-12-13 | 젠자임 코포레이션 | 마이오실린(myoc) 녹내장을 치료하기 위한 아데노-관련 바이러스 벡터 |
| JP2021526839A (ja) * | 2018-06-12 | 2021-10-11 | ザ ユニバーシティ オブ ブリストル | 眼圧及び頭蓋内圧を調節するための材料及び方法 |
| JP7430917B2 (ja) | 2018-06-12 | 2024-02-14 | ザ ユニバーシティ オブ ブリストル | 眼圧及び頭蓋内圧を調節するための材料及び方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2694091A1 (en) | 2009-04-09 |
| AU2008308784B2 (en) | 2013-07-18 |
| ZA201000423B (en) | 2011-03-30 |
| BRPI0817937A2 (pt) | 2015-04-07 |
| MX2010001608A (es) | 2010-03-15 |
| US20090087413A1 (en) | 2009-04-02 |
| WO2009046059A1 (en) | 2009-04-09 |
| KR20100061792A (ko) | 2010-06-09 |
| RU2010117178A (ru) | 2011-11-10 |
| AU2008308784A1 (en) | 2009-04-09 |
| CN101815536A (zh) | 2010-08-25 |
| EP2192926A1 (en) | 2010-06-09 |
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