CA2694091A1 - Self complementary aav-mediated delivery of interfering rna molecules to treat or prevent ocular disorders - Google Patents
Self complementary aav-mediated delivery of interfering rna molecules to treat or prevent ocular disorders Download PDFInfo
- Publication number
- CA2694091A1 CA2694091A1 CA2694091A CA2694091A CA2694091A1 CA 2694091 A1 CA2694091 A1 CA 2694091A1 CA 2694091 A CA2694091 A CA 2694091A CA 2694091 A CA2694091 A CA 2694091A CA 2694091 A1 CA2694091 A1 CA 2694091A1
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- CA
- Canada
- Prior art keywords
- interfering rna
- ocular
- scaav
- vector
- sirna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
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- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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Applications Claiming Priority (3)
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| US60/976,552 | 2007-10-01 | ||
| PCT/US2008/078380 WO2009046059A1 (en) | 2007-10-01 | 2008-10-01 | Self complementary aav-mediated delivery of interfering rna molecules to treat or prevent ocular disorders |
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| CA2694091A1 true CA2694091A1 (en) | 2009-04-09 |
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| CA2694091A Abandoned CA2694091A1 (en) | 2007-10-01 | 2008-10-01 | Self complementary aav-mediated delivery of interfering rna molecules to treat or prevent ocular disorders |
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| EP (1) | EP2192926A1 (enExample) |
| JP (1) | JP2010540564A (enExample) |
| KR (1) | KR20100061792A (enExample) |
| CN (1) | CN101815536A (enExample) |
| AU (1) | AU2008308784B2 (enExample) |
| BR (1) | BRPI0817937A2 (enExample) |
| CA (1) | CA2694091A1 (enExample) |
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| RU (1) | RU2010117178A (enExample) |
| WO (1) | WO2009046059A1 (enExample) |
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| EP2019143A1 (en) | 2007-07-23 | 2009-01-28 | Genethon | CNS gene delivery using peripheral administration of AAV vectors |
| EP2058401A1 (en) | 2007-10-05 | 2009-05-13 | Genethon | Widespread gene delivery to motor neurons using peripheral injection of AAV vectors |
| EP2287323A1 (en) * | 2009-07-31 | 2011-02-23 | Association Institut de Myologie | Widespread gene delivery to the retina using systemic administration of AAV vectors |
| EA202091105A1 (ru) * | 2010-04-23 | 2020-12-30 | Юниверсити Оф Флорида Рисерч Фаундейшн, Инк. | Композиции гуанилатциклазы и способы лечения врожденного амавроза лебера типа 1 (lca1) |
| CN103505743A (zh) * | 2012-06-21 | 2014-01-15 | 北京命码生科科技有限公司 | 含功能性microRNA/siRNA的细胞微粒子及其应用 |
| EP4012035B1 (en) * | 2014-09-16 | 2024-11-06 | Genzyme Corporation | Adeno-associated viral vectors for treating myocilin (myoc) glaucoma |
| KR102612871B1 (ko) | 2014-09-16 | 2023-12-13 | 젠자임 코포레이션 | 마이오실린(myoc) 녹내장을 치료하기 위한 아데노-관련 바이러스 벡터 |
| CA2961523A1 (en) * | 2014-09-16 | 2016-03-24 | Genzyme Corporation | Adeno-associated viral vectors for treating myocilin (myoc) glaucoma |
| GB201809588D0 (en) * | 2018-06-12 | 2018-07-25 | Univ Bristol | Materials and methods for modulating intraocular and intracranial pressure |
| US20220403438A1 (en) | 2019-10-08 | 2022-12-22 | Trustees Of Boston College | Proteins containing multiple, different unnatural amino acids and methods of making and using such proteins |
| MX2022010936A (es) | 2020-03-05 | 2022-11-16 | Neotx Therapeutics Ltd | ³métodos y composiciones para el tratamiento del cáncer con células inmunológicas. |
| EP4161583A1 (en) * | 2020-06-05 | 2023-04-12 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods and pharmaceutical compositions for treating ocular diseases |
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| US20040209832A1 (en) * | 2001-11-30 | 2004-10-21 | Mcswiggen James | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
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| US20050048529A1 (en) * | 2002-02-20 | 2005-03-03 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of intercellular adhesion molecule (ICAM) gene expression using short interfering nucleic acid (siNA) |
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| US7947267B2 (en) * | 2004-10-08 | 2011-05-24 | Potentia Pharmaceuticals, Inc. | Viral complement control proteins for eye disorders |
| TWI386225B (zh) * | 2004-12-23 | 2013-02-21 | Alcon Inc | 用於治療眼睛病症的結締組織生長因子（ＣＴＧＦ）ＲＮＡ干擾（ＲＮＡｉ）抑制技術 |
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-
2008
- 2008-10-01 WO PCT/US2008/078380 patent/WO2009046059A1/en not_active Ceased
- 2008-10-01 CN CN200880110028A patent/CN101815536A/zh active Pending
- 2008-10-01 KR KR1020107003620A patent/KR20100061792A/ko not_active Withdrawn
- 2008-10-01 EP EP08835867A patent/EP2192926A1/en not_active Withdrawn
- 2008-10-01 RU RU2010117178/15A patent/RU2010117178A/ru not_active Application Discontinuation
- 2008-10-01 BR BRPI0817937 patent/BRPI0817937A2/pt not_active IP Right Cessation
- 2008-10-01 CA CA2694091A patent/CA2694091A1/en not_active Abandoned
- 2008-10-01 JP JP2010527251A patent/JP2010540564A/ja active Pending
- 2008-10-01 MX MX2010001608A patent/MX2010001608A/es not_active Application Discontinuation
- 2008-10-01 AU AU2008308784A patent/AU2008308784B2/en not_active Ceased
- 2008-10-01 US US12/243,100 patent/US20090087413A1/en not_active Abandoned
-
2010
- 2010-01-20 ZA ZA2010/00423A patent/ZA201000423B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2008308784B2 (en) | 2013-07-18 |
| ZA201000423B (en) | 2011-03-30 |
| JP2010540564A (ja) | 2010-12-24 |
| BRPI0817937A2 (pt) | 2015-04-07 |
| MX2010001608A (es) | 2010-03-15 |
| US20090087413A1 (en) | 2009-04-02 |
| WO2009046059A1 (en) | 2009-04-09 |
| KR20100061792A (ko) | 2010-06-09 |
| RU2010117178A (ru) | 2011-11-10 |
| AU2008308784A1 (en) | 2009-04-09 |
| CN101815536A (zh) | 2010-08-25 |
| EP2192926A1 (en) | 2010-06-09 |
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