JP2010540541A5 - - Google Patents
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- Publication number
- JP2010540541A5 JP2010540541A5 JP2010527024A JP2010527024A JP2010540541A5 JP 2010540541 A5 JP2010540541 A5 JP 2010540541A5 JP 2010527024 A JP2010527024 A JP 2010527024A JP 2010527024 A JP2010527024 A JP 2010527024A JP 2010540541 A5 JP2010540541 A5 JP 2010540541A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- nhr
- formula
- halogen
- butyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 4
- -1 methylenecyclopropyl Chemical group 0.000 claims 3
- 101150009274 nhr-1 gene Proteins 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000004366 heterocycloalkenyl group Chemical group 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97576507P | 2007-09-27 | 2007-09-27 | |
| US98132207P | 2007-10-19 | 2007-10-19 | |
| PCT/US2008/076499 WO2009042444A2 (en) | 2007-09-27 | 2008-09-16 | Methods and compounds for treating retinol-related diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010540541A JP2010540541A (ja) | 2010-12-24 |
| JP2010540541A5 true JP2010540541A5 (enrdf_load_stackoverflow) | 2011-11-04 |
Family
ID=40512081
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527024A Pending JP2010540541A (ja) | 2007-09-27 | 2008-09-16 | レチノール関連疾患を治療するための方法及び化合物 |
Country Status (8)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5374377B2 (ja) * | 2007-10-18 | 2013-12-25 | 武田薬品工業株式会社 | 複素環化合物 |
| MX2011010694A (es) | 2009-04-16 | 2011-10-21 | Takeda Pharmaceutical | Derivados de n-acil-n'-fenilpiperazina utiles (inter alia) para la profilaxis o tratamiento de diabetes. |
| WO2012071369A2 (en) * | 2010-11-24 | 2012-05-31 | The Trustees Of Columbia University In The City Of New York | A non-retinoid rbp4 antagonist for treatment of age-related macular degeneration and stargardt disease |
| WO2012074038A1 (ja) * | 2010-12-02 | 2012-06-07 | 第一三共株式会社 | 修飾１本鎖ポリヌクレオチド |
| US9333202B2 (en) | 2012-05-01 | 2016-05-10 | The Trustees Of Columbia University In The City Of New York | Non-retinoid antagonists for treatment of age-related macular degeneration and stargardt disease |
| WO2014151936A1 (en) | 2013-03-14 | 2014-09-25 | The Trustees Of Columbia University In The City Of New York | Octahydropyrrolopyrroles, their preparation and use |
| WO2014151959A1 (en) | 2013-03-14 | 2014-09-25 | The Trustees Of Columbia University In The City Of New York | N-alkyl-2-phenoxyethanamines, their preparation and use |
| ES2705247T3 (es) | 2013-03-14 | 2019-03-22 | Univ Columbia | 4-fenilpiperidinas, su preparación y uso |
| ES2700541T3 (es) | 2013-03-14 | 2019-02-18 | Univ Columbia | Octahidrociclopentapirroles, su preparación y uso |
| BR112016025356B1 (pt) | 2014-04-30 | 2023-04-18 | The Trustees Of Columbia University In The City Of New York | Compostos de 4-fenilpiperidinas substituídas, composições e seus usos |
| US9944596B2 (en) * | 2014-10-24 | 2018-04-17 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| MA53568A (fr) * | 2014-10-24 | 2022-02-23 | Takeda Pharmaceuticals Co | Médicaments pour le traitement de maladies ophtalmiques |
| EP4142796A4 (en) * | 2020-04-29 | 2024-06-26 | Saliogen Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR TREATMENT OF HEREDITARY MACULAR DEGENERATION |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2526534A (en) * | 1948-07-03 | 1950-10-17 | Dow Chemical Co | Di-(aryloxy)-methanes |
| US4255152A (en) * | 1978-09-05 | 1981-03-10 | Ciba-Geigy Corporation | Process for the dyeing of hydrophobic fibres |
| JPS577480A (en) * | 1980-06-16 | 1982-01-14 | Sankyo Co Ltd | 4-alkoxy-6-phenoxymethyl-2-pyrone derivative |
| US7510710B2 (en) * | 2004-01-08 | 2009-03-31 | The Regents Of The University Of Colorado | Compositions of UCP inhibitors, Fas antibody, a fatty acid metabolism inhibitor and/or a glucose metabolism inhibitor |
| US20090155903A1 (en) * | 2004-03-19 | 2009-06-18 | Myriad Genetics, Incorporated | Pharmaceutical composition and method |
| WO2005116010A1 (en) * | 2004-05-26 | 2005-12-08 | Merck Frosst Canada Ltd. | Ep4 receptor agonist, compositions and methods thereof |
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2008
- 2008-09-16 EP EP08834564A patent/EP2205234A4/en not_active Withdrawn
- 2008-09-16 WO PCT/US2008/076499 patent/WO2009042444A2/en active Application Filing
- 2008-09-16 CN CN200880107835A patent/CN101873852A/zh active Pending
- 2008-09-16 KR KR1020107009129A patent/KR20100097098A/ko not_active Withdrawn
- 2008-09-16 AU AU2008305303A patent/AU2008305303A1/en not_active Abandoned
- 2008-09-16 JP JP2010527024A patent/JP2010540541A/ja active Pending
- 2008-09-16 CA CA2699773A patent/CA2699773A1/en not_active Abandoned
-
2010
- 2010-03-25 IL IL204728A patent/IL204728A0/en unknown