JP2010540541A5 - - Google Patents
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- Publication number
- JP2010540541A5 JP2010540541A5 JP2010527024A JP2010527024A JP2010540541A5 JP 2010540541 A5 JP2010540541 A5 JP 2010540541A5 JP 2010527024 A JP2010527024 A JP 2010527024A JP 2010527024 A JP2010527024 A JP 2010527024A JP 2010540541 A5 JP2010540541 A5 JP 2010540541A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- nhr
- formula
- halogen
- butyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 4
- -1 methylenecyclopropyl Chemical group 0.000 claims 3
- 101150009274 nhr-1 gene Proteins 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000004366 heterocycloalkenyl group Chemical group 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97576507P | 2007-09-27 | 2007-09-27 | |
| US98132207P | 2007-10-19 | 2007-10-19 | |
| PCT/US2008/076499 WO2009042444A2 (en) | 2007-09-27 | 2008-09-16 | Methods and compounds for treating retinol-related diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010540541A JP2010540541A (ja) | 2010-12-24 |
| JP2010540541A5 true JP2010540541A5 (OSRAM) | 2011-11-04 |
Family
ID=40512081
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527024A Pending JP2010540541A (ja) | 2007-09-27 | 2008-09-16 | レチノール関連疾患を治療するための方法及び化合物 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP2205234A4 (OSRAM) |
| JP (1) | JP2010540541A (OSRAM) |
| KR (1) | KR20100097098A (OSRAM) |
| CN (1) | CN101873852A (OSRAM) |
| AU (1) | AU2008305303A1 (OSRAM) |
| CA (1) | CA2699773A1 (OSRAM) |
| IL (1) | IL204728A0 (OSRAM) |
| WO (1) | WO2009042444A2 (OSRAM) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5374377B2 (ja) | 2007-10-18 | 2013-12-25 | 武田薬品工業株式会社 | 複素環化合物 |
| KR20120006545A (ko) * | 2009-04-16 | 2012-01-18 | 다케다 야쿠힌 고교 가부시키가이샤 | 당뇨병의 예방 또는 치료에 특히 유용한 ｎ―아실―ｎ’―페닐피페라진의 유도체 |
| EP2642998B1 (en) | 2010-11-24 | 2020-09-16 | The Trustees of Columbia University in the City of New York | A non-retinoid rbp4 antagonist for treatment of age-related macular degeneration and stargardt disease |
| CN103370416A (zh) * | 2010-12-02 | 2013-10-23 | 第一三共株式会社 | 修饰的单链多核苷酸 |
| WO2013166037A1 (en) | 2012-05-01 | 2013-11-07 | The Trustees Of Columbia University In The City Of New York | Non-retinoid antagonists for treatment of eye disorders |
| WO2014151959A1 (en) | 2013-03-14 | 2014-09-25 | The Trustees Of Columbia University In The City Of New York | N-alkyl-2-phenoxyethanamines, their preparation and use |
| US10273243B2 (en) | 2013-03-14 | 2019-04-30 | The Trustees Of Columbia University In The City Of New York | 4-phenylpiperidines, their preparation and use |
| WO2014151936A1 (en) | 2013-03-14 | 2014-09-25 | The Trustees Of Columbia University In The City Of New York | Octahydropyrrolopyrroles, their preparation and use |
| EP2968303B1 (en) | 2013-03-14 | 2018-07-04 | The Trustees of Columbia University in the City of New York | Octahydrocyclopentapyrroles, their preparation and use |
| WO2015168286A1 (en) | 2014-04-30 | 2015-11-05 | The Trustees Of Columbia University In The City Of New York | Substituted 4-phenylpiperidines, their preparaiton and use |
| ES2848999T3 (es) | 2014-10-24 | 2021-08-13 | Takeda Pharmaceuticals Co | Compuestos heteroarilo para el tratamiento de enfermedades oftálmicas |
| JP6646586B2 (ja) * | 2014-10-24 | 2020-02-14 | 武田薬品工業株式会社 | 複素環化合物 |
| CA3175197A1 (en) * | 2020-04-29 | 2021-11-04 | Joseph J. HIGGINS | Compositions and methods for treatment of inherited macular degeneration |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2526534A (en) * | 1948-07-03 | 1950-10-17 | Dow Chemical Co | Di-(aryloxy)-methanes |
| US4255152A (en) * | 1978-09-05 | 1981-03-10 | Ciba-Geigy Corporation | Process for the dyeing of hydrophobic fibres |
| JPS577480A (en) * | 1980-06-16 | 1982-01-14 | Sankyo Co Ltd | 4-alkoxy-6-phenoxymethyl-2-pyrone derivative |
| US7510710B2 (en) * | 2004-01-08 | 2009-03-31 | The Regents Of The University Of Colorado | Compositions of UCP inhibitors, Fas antibody, a fatty acid metabolism inhibitor and/or a glucose metabolism inhibitor |
| WO2005092062A2 (en) * | 2004-03-19 | 2005-10-06 | Myriad Genetics, Inc. | Compounds for neurodegenerative disorders |
| WO2005116010A1 (en) * | 2004-05-26 | 2005-12-08 | Merck Frosst Canada Ltd. | Ep4 receptor agonist, compositions and methods thereof |
-
2008
- 2008-09-16 AU AU2008305303A patent/AU2008305303A1/en not_active Abandoned
- 2008-09-16 WO PCT/US2008/076499 patent/WO2009042444A2/en not_active Ceased
- 2008-09-16 CA CA2699773A patent/CA2699773A1/en not_active Abandoned
- 2008-09-16 KR KR1020107009129A patent/KR20100097098A/ko not_active Withdrawn
- 2008-09-16 EP EP08834564A patent/EP2205234A4/en not_active Withdrawn
- 2008-09-16 CN CN200880107835A patent/CN101873852A/zh active Pending
- 2008-09-16 JP JP2010527024A patent/JP2010540541A/ja active Pending
-
2010
- 2010-03-25 IL IL204728A patent/IL204728A0/en unknown