JP2010539895A5 - - Google Patents
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- Publication number
- JP2010539895A5 JP2010539895A5 JP2010525439A JP2010525439A JP2010539895A5 JP 2010539895 A5 JP2010539895 A5 JP 2010539895A5 JP 2010525439 A JP2010525439 A JP 2010525439A JP 2010525439 A JP2010525439 A JP 2010525439A JP 2010539895 A5 JP2010539895 A5 JP 2010539895A5
- Authority
- JP
- Japan
- Prior art keywords
- snorna
- nucleic acid
- sequence
- modified
- genbank accession
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108020003224 Small Nucleolar RNA Proteins 0.000 claims 77
- 102000042773 Small Nucleolar RNA Human genes 0.000 claims 77
- 150000007523 nucleic acids Chemical class 0.000 claims 49
- 102000039446 nucleic acids Human genes 0.000 claims 40
- 108020004707 nucleic acids Proteins 0.000 claims 40
- 210000004027 cell Anatomy 0.000 claims 17
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 15
- 241000616464 Wallacemonas collosoma Species 0.000 claims 15
- 238000000034 method Methods 0.000 claims 15
- 230000000295 complement effect Effects 0.000 claims 9
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 239000013598 vector Substances 0.000 claims 6
- 241000223105 Trypanosoma brucei Species 0.000 claims 5
- 238000010367 cloning Methods 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 238000012545 processing Methods 0.000 claims 4
- 230000001105 regulatory effect Effects 0.000 claims 4
- 108020004999 messenger RNA Proteins 0.000 claims 3
- 101100444344 Caenorhabditis elegans eat-17 gene Proteins 0.000 claims 2
- 108091026890 Coding region Proteins 0.000 claims 2
- 108091026898 Leader sequence (mRNA) Proteins 0.000 claims 2
- 241000222702 Leishmania tarentolae Species 0.000 claims 2
- 108091036066 Three prime untranslated region Proteins 0.000 claims 2
- 108020004566 Transfer RNA Proteins 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 108091070501 miRNA Proteins 0.000 claims 2
- 239000002679 microRNA Substances 0.000 claims 2
- 238000012986 modification Methods 0.000 claims 2
- 230000004048 modification Effects 0.000 claims 2
- 238000013518 transcription Methods 0.000 claims 2
- 230000035897 transcription Effects 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 240000005528 Arctium lappa Species 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 102000008300 Mutant Proteins Human genes 0.000 claims 1
- 108010021466 Mutant Proteins Proteins 0.000 claims 1
- 241000223104 Trypanosoma Species 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 230000001276 controlling effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000007877 drug screening Methods 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 230000010354 integration Effects 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000037361 pathway Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000013600 plasmid vector Substances 0.000 claims 1
- 230000006798 recombination Effects 0.000 claims 1
- 238000005215 recombination Methods 0.000 claims 1
- 238000011160 research Methods 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0718542.4 | 2007-09-22 | ||
| GBGB0718542.4A GB0718542D0 (en) | 2007-09-22 | 2007-09-22 | Targeted modulation of gene expression |
| PCT/GB2008/003211 WO2009037490A1 (en) | 2007-09-22 | 2008-09-22 | Targeted modulation of gene expression |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010539895A JP2010539895A (ja) | 2010-12-24 |
| JP2010539895A5 true JP2010539895A5 (OSRAM) | 2011-11-10 |
| JP5756631B2 JP5756631B2 (ja) | 2015-07-29 |
Family
ID=38670367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010525439A Expired - Fee Related JP5756631B2 (ja) | 2007-09-22 | 2008-09-22 | 遺伝子発現の標的調節 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20110212058A1 (OSRAM) |
| EP (1) | EP2205739B1 (OSRAM) |
| JP (1) | JP5756631B2 (OSRAM) |
| CN (1) | CN101868543A (OSRAM) |
| GB (1) | GB0718542D0 (OSRAM) |
| WO (1) | WO2009037490A1 (OSRAM) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5959522B2 (ja) * | 2011-08-11 | 2016-08-02 | 学校法人 新潟科学技術学園 新潟薬科大学 | ヒト血液がん細胞のアポトーシスを誘導するヘプタマー型スモールガイド核酸 |
| GB201117482D0 (en) | 2011-10-11 | 2011-11-23 | Univ Dundee | Targetiing of miRNA precursors |
| CN113957146A (zh) | 2014-09-26 | 2022-01-21 | 詹森药业有限公司 | 使用fgfr突变基因组鉴定将对用fgfr抑制剂进行治疗有反应的癌症患者 |
| CA3006305A1 (en) | 2015-12-09 | 2017-06-15 | Excision Biotherapeutics, Inc. | Gene editing methods and compositions for eliminating risk of jc virus activation and pml (progressive multifocal leukoencephalopathy) during immunosuppressive therapy |
| US12018255B2 (en) * | 2017-12-08 | 2024-06-25 | University Of Connecticut | Compositions and methods for treating disorders of genomic imprinting |
| CN112020557B (zh) * | 2018-03-27 | 2025-02-11 | 罗切斯特大学 | 用于假尿苷化的核酸分子 |
| WO2024102659A1 (en) * | 2022-11-08 | 2024-05-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Directed acetylation of mrna through engineered snorna adapters |
| CN116694759B (zh) * | 2023-02-17 | 2023-12-15 | 中国人民解放军军事科学院军事医学研究院 | Scarna12基因调节细胞增殖与存活中的应用 |
| CN116525001A (zh) * | 2023-04-27 | 2023-08-01 | 西安交通大学 | 一种基于深度学习的rna修饰位点预测模型的构建方法 |
-
2007
- 2007-09-22 GB GBGB0718542.4A patent/GB0718542D0/en not_active Ceased
-
2008
- 2008-09-22 CN CN200880117264A patent/CN101868543A/zh active Pending
- 2008-09-22 WO PCT/GB2008/003211 patent/WO2009037490A1/en not_active Ceased
- 2008-09-22 JP JP2010525439A patent/JP5756631B2/ja not_active Expired - Fee Related
- 2008-09-22 US US12/679,208 patent/US20110212058A1/en not_active Abandoned
- 2008-09-22 EP EP08806365.6A patent/EP2205739B1/en not_active Not-in-force
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