JP2010535814A5 - - Google Patents
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- Publication number
- JP2010535814A5 JP2010535814A5 JP2010520325A JP2010520325A JP2010535814A5 JP 2010535814 A5 JP2010535814 A5 JP 2010535814A5 JP 2010520325 A JP2010520325 A JP 2010520325A JP 2010520325 A JP2010520325 A JP 2010520325A JP 2010535814 A5 JP2010535814 A5 JP 2010535814A5
- Authority
- JP
- Japan
- Prior art keywords
- motomeko
- opiate
- active ingredient
- side effects
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000004480 active ingredient Substances 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 229940127240 opiate Drugs 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 238000001356 surgical procedure Methods 0.000 claims 2
- 206010010774 Constipation Diseases 0.000 claims 1
- 206010011224 Cough Diseases 0.000 claims 1
- 206010028817 Nausea and vomiting symptoms Diseases 0.000 claims 1
- 208000003251 Pruritus Diseases 0.000 claims 1
- 206010046555 Urinary retention Diseases 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 230000003871 intestinal function Effects 0.000 claims 1
- 230000007803 itching Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95496007P | 2007-08-09 | 2007-08-09 | |
| US60/954,960 | 2007-08-09 | ||
| PCT/US2008/072632 WO2009023567A1 (en) | 2007-08-09 | 2008-08-08 | Quaternary opioid carboxamides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010535814A JP2010535814A (ja) | 2010-11-25 |
| JP2010535814A5 true JP2010535814A5 (show.php) | 2011-09-22 |
| JP5581211B2 JP5581211B2 (ja) | 2014-08-27 |
Family
ID=39941437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010520325A Active JP5581211B2 (ja) | 2007-08-09 | 2008-08-08 | 第四級オピオイドカルボキサミド |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US8263807B2 (show.php) |
| EP (1) | EP2190819B1 (show.php) |
| JP (1) | JP5581211B2 (show.php) |
| KR (1) | KR101519682B1 (show.php) |
| CN (1) | CN101827819B (show.php) |
| AU (1) | AU2008286979B2 (show.php) |
| BR (1) | BRPI0815020A2 (show.php) |
| CA (1) | CA2694497C (show.php) |
| EA (1) | EA020658B1 (show.php) |
| ES (1) | ES2586245T3 (show.php) |
| IL (1) | IL203459A (show.php) |
| MX (1) | MX2010001371A (show.php) |
| NO (1) | NO341089B1 (show.php) |
| WO (1) | WO2009023567A1 (show.php) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101274107B1 (ko) | 2007-11-30 | 2013-06-13 | 퍼듀 퍼머 엘피 | 벤조모르판 화합물 |
| JP5555890B2 (ja) * | 2009-03-19 | 2014-07-23 | アルカーメス ファーマ アイルランド リミテッド | 高い経口バイオアベイラビリティを有するモルフィナン誘導体 |
| US9119848B2 (en) | 2009-12-04 | 2015-09-01 | Alkermes Pharma Ireland Limited | Morphinan derivatives for the treatment of drug overdose |
| EP2550253B9 (en) | 2010-03-22 | 2016-09-21 | Rensselaer Polytechnic Institute | Morphinane derivatives containing a carboxamide group as opioid receptor ligands |
| NZ605234A (en) * | 2010-07-08 | 2015-02-27 | Alkermes Pharma Ireland Ltd | Process for the synthesis of substituted morphinans |
| EP2407469A1 (en) * | 2010-07-13 | 2012-01-18 | Chemo Ibérica, S.A. | Salt of sitagliptin |
| NZ606730A (en) | 2010-08-23 | 2015-05-29 | Alkermes Pharma Ireland Ltd | Methods for treating antipsychotic-induced weight gain |
| JP2014505113A (ja) * | 2011-02-14 | 2014-02-27 | アルカーメス，インコーポレイテッド | 末梢作用性μオピオイドアンタゴニスト |
| SG10201405403QA (en) * | 2011-03-03 | 2014-11-27 | Cadila Healthcare Ltd | Novel salts of dpp-iv inhibitor |
| US9029543B2 (en) | 2011-04-05 | 2015-05-12 | Alkermes, Inc. | Process for the synthesis of quaternary amine compounds |
| CA2840643C (en) * | 2011-06-29 | 2017-11-21 | Alkermes, Inc. | Peripherally acting opioid compounds |
| US9096606B2 (en) | 2011-12-08 | 2015-08-04 | Purdue Pharma, L.P. | Quarternized buprenorphine analogs |
| TR201815154T4 (tr) | 2011-12-15 | 2018-11-21 | Alkermes Pharma Ireland Ltd | Depresi̇f bozukluklarin tedavi̇si̇ne yöneli̇k buprenorfi̇n i̇le kombi̇nasyon hali̇nde sami̇dorfan (alks 33). |
| US9211293B2 (en) | 2011-12-15 | 2015-12-15 | Alkermes Pharma Ireland Limited | Opioid agonist antagonist combinations |
| US20140066475A1 (en) | 2012-09-04 | 2014-03-06 | Euro-Celtique S.A. | Method For Treating Pruritus |
| JP2016519161A (ja) | 2013-05-24 | 2016-06-30 | アルカームス ファーマ アイルランド リミテッド | モルファン及びモルフィナン類似物及び使用の方法 |
| WO2014190271A2 (en) | 2013-05-24 | 2014-11-27 | Alkermes Pharma Ireland Limted | Methods for treating depressive symptoms |
| US20160243112A1 (en) * | 2015-02-25 | 2016-08-25 | Alkermes, Inc. | Treatments for alzheimer's related diseases and disorders |
| TW202140009A (zh) * | 2020-02-13 | 2021-11-01 | 大陸商上海翰森生物醫藥科技有限公司 | ３－甲醯胺基－４－羥基納曲酮氘代衍生物、其製備方法及其在醫藥上的應用 |
| WO2022101444A1 (en) | 2020-11-12 | 2022-05-19 | Alkermes Pharma Ireland Limited | Immediate release multilayer tablet |
| CN115521317B (zh) * | 2021-02-02 | 2025-07-25 | 山东新时代药业有限公司 | 一种制备纳呋拉啡中间体的方法 |
| WO2025104754A1 (en) * | 2023-11-17 | 2025-05-22 | Msn Laboratories Private Limited, R&D Center | A process for the preparation of samidorphan and its intermediates |
| CN118598813B (zh) * | 2024-08-08 | 2024-10-29 | 山东齐都药业有限公司 | L-苹果酸萨米多芬及其制备方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB874217A (en) * | 1958-10-30 | 1961-08-02 | Albert Boehringer | Normorphine derivatives |
| DE2254298A1 (de) * | 1972-11-06 | 1974-05-16 | Boehringer Sohn Ingelheim | Neue (heteroarylmethyl)-normorphine, deren saeureadditionssalze, verfahren zu deren herstellung sowie deren verwendung als arzneimittel |
| GB1511319A (en) * | 1974-09-20 | 1978-05-17 | Sterling Drug Inc | 2,6-methane-3-benzazocine derivatives and their preparation |
| US4032529A (en) * | 1974-09-20 | 1977-06-28 | Sterling Drug Inc. | Aminomethanobenzazocine intermediates |
| US4176186A (en) * | 1978-07-28 | 1979-11-27 | Boehringer Ingelheim Gmbh | Quaternary derivatives of noroxymorphone which relieve intestinal immobility |
| FR2514644A1 (fr) * | 1981-10-19 | 1983-04-22 | Sanofi Sa | Composition pharmaceutique a action antagoniste peripherique des opiaces |
| CA1315689C (en) * | 1987-09-03 | 1993-04-06 | Leon I. Goldberg | Quarternary derivatives of noroxymorphone which relieve nausea and emesis |
| KR19990077125A (ko) * | 1996-01-10 | 1999-10-25 | 파올로 비지, 엔리꼬 카쭐라니 | 헤테로고리-축합 모르핀 유도체 (ⅱ) |
| ES2121553B1 (es) * | 1996-12-23 | 1999-06-16 | Univ Santiago Compostela | Nuevos endoperoxidos morfinicos funcionalizados en posiciones c-6 y c-14 del anillo c y procedimiento para su obtencion. |
| WO2001014382A1 (en) * | 1999-08-23 | 2001-03-01 | Toray Industries, Inc. | Analgesics containing as the active ingredient quaternary ammonium salt derivatives of morphinan |
| EP1206264A2 (en) * | 1999-08-25 | 2002-05-22 | Barrett R. Cooper | Compositions and methods for treating opiate intolerance |
| JP2003528819A (ja) | 1999-11-29 | 2003-09-30 | アドラー コーポレーション | オピオイドおよびそのアンタゴニストに関する新規方法および組成物 |
| AU2002227135B2 (en) | 2000-10-31 | 2008-01-03 | Rensselaer Polytechnic Institute | 8- substituted-2, 6-methano-3-benzazocines and 3-substituted morphinanes as opioid receptor binding agents |
| US7375082B2 (en) * | 2002-02-22 | 2008-05-20 | Shire Llc | Abuse-resistant hydrocodone compounds |
| DE10229842A1 (de) | 2002-07-03 | 2004-02-05 | Helmut Prof. Dr. Schmidhammer | Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung |
| EP1803724A1 (en) * | 2002-09-25 | 2007-07-04 | Euro-Celtique S.A. | N-substituted hydromorphones and the use thereof |
| US7285665B2 (en) * | 2002-11-08 | 2007-10-23 | Mallinckrodt Inc. | Process for the preparation of quaternary N-alkyl morphinan alkaloid salts |
| WO2006052710A1 (en) | 2004-11-05 | 2006-05-18 | Rensselaer Polytechnic Institute | 4-hydroxybenzomorphans |
| MX2007010833A (es) | 2005-03-07 | 2009-02-17 | Univ Chicago | Uso de antagonistas opioides para atenuar proliferacion y migracion de células endoteliales. |
| EP2266959B1 (en) | 2005-07-21 | 2013-05-01 | Rensselaer Polytechnic Institute | 8-carboxamido-substituted-2, 6-methano-3-benzazocines and 3-carboxamido-substituted morphanes as opioid receptor binding agents |
| WO2007022535A2 (en) | 2005-08-19 | 2007-02-22 | Pharmacofore, Inc. | Prodrugs of active agents |
-
2008
- 2008-08-08 JP JP2010520325A patent/JP5581211B2/ja active Active
- 2008-08-08 BR BRPI0815020-6A2A patent/BRPI0815020A2/pt not_active Application Discontinuation
- 2008-08-08 CN CN2008801024294A patent/CN101827819B/zh active Active
- 2008-08-08 WO PCT/US2008/072632 patent/WO2009023567A1/en not_active Ceased
- 2008-08-08 US US12/188,814 patent/US8263807B2/en active Active
- 2008-08-08 ES ES08797495.2T patent/ES2586245T3/es active Active
- 2008-08-08 EA EA201070237A patent/EA020658B1/ru active IP Right Revival
- 2008-08-08 KR KR1020107005151A patent/KR101519682B1/ko active Active
- 2008-08-08 MX MX2010001371A patent/MX2010001371A/es active IP Right Grant
- 2008-08-08 AU AU2008286979A patent/AU2008286979B2/en active Active
- 2008-08-08 EP EP08797495.2A patent/EP2190819B1/en active Active
- 2008-08-08 CA CA2694497A patent/CA2694497C/en active Active
-
2010
- 2010-03-02 NO NO20100289A patent/NO341089B1/no unknown
-
2012
- 2012-08-09 US US13/570,925 patent/US8563572B2/en active Active
-
2013
- 2013-04-02 IL IL203459A patent/IL203459A/en active IP Right Grant
- 2013-09-27 US US14/039,175 patent/US20140107143A1/en not_active Abandoned
-
2016
- 2016-05-09 US US15/149,594 patent/US20170095469A1/en not_active Abandoned
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