JP2010534676A - 心的外傷後ストレス障害の治療 - Google Patents

心的外傷後ストレス障害の治療 Download PDF

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Publication number
JP2010534676A
JP2010534676A JP2010518369A JP2010518369A JP2010534676A JP 2010534676 A JP2010534676 A JP 2010534676A JP 2010518369 A JP2010518369 A JP 2010518369A JP 2010518369 A JP2010518369 A JP 2010518369A JP 2010534676 A JP2010534676 A JP 2010534676A
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JP
Japan
Prior art keywords
nepicastat
dopamine
post
patient
compound
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JP2010518369A
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English (en)
Japanese (ja)
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JP2010534676A5 (https=
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トム・ヴォイヴォーデ
マルク・モラン
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Synosia Therapeutics Inc
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Synosia Therapeutics Inc
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Publication of JP2010534676A publication Critical patent/JP2010534676A/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP2010518369A 2007-07-23 2008-07-23 心的外傷後ストレス障害の治療 Pending JP2010534676A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93503607P 2007-07-23 2007-07-23
PCT/US2008/070948 WO2009015248A1 (en) 2007-07-23 2008-07-23 Treatment of post-traumatic stress disorder

Publications (2)

Publication Number Publication Date
JP2010534676A true JP2010534676A (ja) 2010-11-11
JP2010534676A5 JP2010534676A5 (https=) 2011-08-18

Family

ID=40281815

Family Applications (1)

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JP2010518369A Pending JP2010534676A (ja) 2007-07-23 2008-07-23 心的外傷後ストレス障害の治療

Country Status (12)

Country Link
US (1) US20090054403A1 (https=)
EP (1) EP2182952A4 (https=)
JP (1) JP2010534676A (https=)
CN (1) CN101951912A (https=)
AU (1) AU2008279091A1 (https=)
CA (1) CA2707858A1 (https=)
CO (1) CO6260078A2 (https=)
MX (1) MX2010000937A (https=)
NZ (1) NZ583193A (https=)
RU (1) RU2458691C2 (https=)
SG (1) SG183069A1 (https=)
WO (1) WO2009015248A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021015300A1 (ja) * 2019-07-25 2021-01-28 学校法人東京理科大学 精神・神経系の疾患又は症状を治療し、予防し又は改善する剤

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008279169A1 (en) * 2007-07-23 2009-01-29 Biotie Therapies, Inc 4-hydroxy-4-methyl-piperidine-1-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide for the treatment of post-traumatic stress disorder
EP3251670A1 (en) * 2007-08-06 2017-12-06 Biotie Therapies, Inc. Methods for treating dependence
AU2016208412A1 (en) * 2007-08-06 2016-08-18 Biotie Therapies, Inc. Methods for treating dependence
SMT201700578T1 (it) * 2009-11-20 2018-01-11 Tonix Pharma Holdings Ltd Metodo e composizioni per trattare i sintomi associati al disturbo da stress post-traumatico usando ciclobenzaprina
US20110319389A1 (en) 2010-06-24 2011-12-29 Tonix Pharmaceuticals, Inc. Methods and compositions for treating fatigue associated with disordered sleep using very low dose cyclobenzaprine
US11998516B2 (en) 2011-03-07 2024-06-04 Tonix Pharma Holdings Limited Methods and compositions for treating depression using cyclobenzaprine
SMT202400324T1 (it) 2013-03-15 2024-11-15 Tonix Pharma Ltd Formulazioni eutettiche di ciclobenzaprina cloridrato e mannitolo
AU2014354808A1 (en) * 2013-11-26 2016-06-02 University Of North Texas Health Science Center At Fort Worth Personalized medicine approach for treating cognitive loss
MY186047A (en) 2014-09-18 2021-06-17 Tonix Pharma Holdings Ltd Eutectic formulations of cyclobenzaprine hydrochloride
RU2614697C1 (ru) * 2016-04-12 2017-03-28 Общество с ограниченной ответственностью "Нормофарм" Нейропротекторное средство
JOP20190049A1 (ar) 2016-09-23 2019-03-20 Bial Portela & C? S A مثبطات دوبامين-b-هيدروكسيلاز
WO2018222781A2 (en) * 2017-05-30 2018-12-06 Emerson Paul G Compositions and methods to regulate hormonal cascades in stress disorders
AU2018204843B2 (en) * 2017-07-05 2023-07-27 Medtronic Ardian Luxembourg S.A.R.L. Methods for treating anxiety disorders in patients via renal neuromodulation
EP3720856A1 (en) 2017-12-04 2020-10-14 BIAL - PORTELA & Cª, S.A. Dopamine-& x392;-hydroxylase inhibitors
MX2020006140A (es) 2017-12-11 2020-08-13 Tonix Pharma Holdings Ltd Tratamiento con ciclobenzaprina para la agitacion, psicosis y deterioro cognitivo en la demencia y enfermedades neurodegenerativas.
CN109966281B (zh) * 2019-04-11 2021-04-27 北京大学 PAO作为Pi4KIIα抑制剂在制备治疗创伤后应激障碍药物中的应用
CN120882371A (zh) * 2022-11-30 2025-10-31 闪烁实验室有限公司 使用眼睑跟踪的精神药理学系统和方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005517036A (ja) * 2002-02-14 2005-06-09 ソルベイ・フアーマシユーチカルズ・ベー・ブイ セロトニンおよび/またはノルアドレナリン阻害活性を持つドーパミン−d2受容体部分アゴニスト
JP2005523334A (ja) * 2002-04-24 2005-08-04 サイプレス バイオサイエンス, インコーポレイテッド ストレス関連障害を含む機能的身体障害の予防および処置
WO2006096434A2 (en) * 2005-03-04 2006-09-14 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for the treatment and/or prevention of anxiety disorders
WO2007005962A2 (en) * 2005-07-06 2007-01-11 Sepracor Inc. Combinations of eszopiclone and an antidepressant

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6391922B1 (en) * 1998-01-13 2002-05-21 Synchroneuron, Llc Treatment of posttraumatic stress disorder, obsessive-compulsive disorder and related neuropsychiatric disorders
CA2459304A1 (en) * 2001-09-13 2003-03-20 Schering Corporation Combination of an adenosine a2a receptor antagonist and an antidepressant or anxiolytic
WO2005079756A2 (en) * 2004-02-13 2005-09-01 Neuromolecular, Inc. Combination of a nmda receptor antagonist and an anti-depressive drug mao-inhibitor or a gadph-inhibitor for the treatment of psychiatric conditions
WO2008115706A1 (en) * 2007-03-16 2008-09-25 Emory University Methods and compositions for treatment of drug addiction
WO2009015244A1 (en) * 2007-07-23 2009-01-29 Synosia Therapeutics Rufinamide for the treatment of post-traumatic stress disorder

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005517036A (ja) * 2002-02-14 2005-06-09 ソルベイ・フアーマシユーチカルズ・ベー・ブイ セロトニンおよび/またはノルアドレナリン阻害活性を持つドーパミン−d2受容体部分アゴニスト
JP2005523334A (ja) * 2002-04-24 2005-08-04 サイプレス バイオサイエンス, インコーポレイテッド ストレス関連障害を含む機能的身体障害の予防および処置
WO2006096434A2 (en) * 2005-03-04 2006-09-14 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for the treatment and/or prevention of anxiety disorders
WO2007005962A2 (en) * 2005-07-06 2007-01-11 Sepracor Inc. Combinations of eszopiclone and an antidepressant

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JPN6013012692; British Journal of Pharmacology Vol.121, No.8, 1997, p.1803-1809 *
JPN6013012695; Biology and Psychiatry Vol.60, 2006, p.777-783 *
JPN6013012696; Psychiatry Research Vol.77, 1998, p.175-181 *
JPN6013012698; 精神科 Vol.6 No.3, 2005, p.215-221 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021015300A1 (ja) * 2019-07-25 2021-01-28 学校法人東京理科大学 精神・神経系の疾患又は症状を治療し、予防し又は改善する剤

Also Published As

Publication number Publication date
EP2182952A1 (en) 2010-05-12
AU2008279091A1 (en) 2009-01-29
CN101951912A (zh) 2011-01-19
SG183069A1 (en) 2012-08-30
EP2182952A4 (en) 2010-09-08
CO6260078A2 (es) 2011-03-22
NZ583193A (en) 2012-05-25
CA2707858A1 (en) 2009-01-29
US20090054403A1 (en) 2009-02-26
WO2009015248A1 (en) 2009-01-29
RU2010106014A (ru) 2011-08-27
MX2010000937A (es) 2010-06-25
RU2458691C2 (ru) 2012-08-20

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