JP2010534664A - Ｉｌ−１７拮抗薬を用いた線維症関連疾患治療の方法及び組成物 - Google Patents
Ｉｌ−１７拮抗薬を用いた線維症関連疾患治療の方法及び組成物 Download PDFInfo
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| ES2109945T3 (es) | 1990-06-01 | 1998-02-01 | Chiron Corp | Composiciones y procedimientos para identificar moleculas biologicamente activas. |
| US5723286A (en) | 1990-06-20 | 1998-03-03 | Affymax Technologies N.V. | Peptide library and screening systems |
| US5580734A (en) | 1990-07-13 | 1996-12-03 | Transkaryotic Therapies, Inc. | Method of producing a physical map contigous DNA sequences |
| WO1992005258A1 (en) | 1990-09-20 | 1992-04-02 | La Trobe University | Gene encoding barley enzyme |
| AU1435492A (en) | 1991-02-21 | 1992-09-15 | Gilead Sciences, Inc. | Aptamer specific for biomolecules and method of making |
| US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| US5641670A (en) | 1991-11-05 | 1997-06-24 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| US5733761A (en) | 1991-11-05 | 1998-03-31 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| US5885793A (en) | 1991-12-02 | 1999-03-23 | Medical Research Council | Production of anti-self antibodies from antibody segment repertoires and displayed on phage |
| WO1994012520A1 (en) | 1992-11-20 | 1994-06-09 | Enzon, Inc. | Linker for linked fusion polypeptides |
| US5763733A (en) | 1994-10-13 | 1998-06-09 | Enzon, Inc. | Antigen-binding fusion proteins |
| US5549551A (en) | 1994-12-22 | 1996-08-27 | Advanced Cardiovascular Systems, Inc. | Adjustable length balloon catheter |
| EP0817847B2 (en) * | 1995-03-23 | 2009-09-09 | Immunex Corporation | Il-17 receptor |
| US5656730A (en) | 1995-04-07 | 1997-08-12 | Enzon, Inc. | Stabilized monomeric protein compositions |
| DE69830065T2 (de) | 1997-09-16 | 2006-01-19 | Egea Biosciences, LLC, San Diego | Methoden zur kompletten chemischen synthese und zusammensetzung von genen und genomen |
| US6670127B2 (en) | 1997-09-16 | 2003-12-30 | Egea Biosciences, Inc. | Method for assembly of a polynucleotide encoding a target polypeptide |
| US20070160576A1 (en) * | 2001-06-05 | 2007-07-12 | Genentech, Inc. | IL-17A/F heterologous polypeptides and therapeutic uses thereof |
| US20070053877A1 (en) * | 2003-08-21 | 2007-03-08 | Intermune, Inc. | Methods of treating idiopathic pulmonary fibrosis |
| JP2008500338A (ja) * | 2004-05-25 | 2008-01-10 | イコス・コーポレイション | 造血細胞の異常増殖を治療及び／又は予防する方法 |
| EP1765865A2 (en) * | 2004-06-10 | 2007-03-28 | ZymoGenetics, Inc. | Soluble zcytor14, anti-zcytor14 antibodies and binding partners and methods of using in inflammation |
| GT200600148A (es) * | 2005-04-14 | 2006-11-22 | Metodos para el tratamiento y la prevencion de fibrosis | |
| CA2660463C (en) * | 2006-08-11 | 2013-07-16 | Schering Corporation | Antibodies to il-17a |
-
2008
- 2008-07-21 JP JP2010518314A patent/JP2010534664A/ja active Pending
- 2008-07-21 US US12/670,179 patent/US20110091378A1/en not_active Abandoned
- 2008-07-21 WO PCT/US2008/070588 patent/WO2009015063A2/en not_active Ceased
- 2008-07-21 EP EP08782121.1A patent/EP2182943B1/en active Active
- 2008-07-21 ES ES08782121.1T patent/ES2614735T3/es active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006013107A1 (en) * | 2004-08-05 | 2006-02-09 | Novartis Ag | Il-17 antagonistic antibodies |
| WO2006088833A2 (en) * | 2005-02-14 | 2006-08-24 | Wyeth | Interleukin-17f antibodies and other il-17f signaling antagonists and uses therefor |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2182943B1 (en) | 2016-10-26 |
| EP2182943A4 (en) | 2010-10-06 |
| WO2009015063A8 (en) | 2009-07-23 |
| WO2009015063A2 (en) | 2009-01-29 |
| US20110091378A1 (en) | 2011-04-21 |
| ES2614735T3 (es) | 2017-06-01 |
| WO2009015063A3 (en) | 2009-03-19 |
| EP2182943A2 (en) | 2010-05-12 |
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