JP2010534199A - 抗菌複合治療 - Google Patents
抗菌複合治療 Download PDFInfo
- Publication number
- JP2010534199A JP2010534199A JP2010516586A JP2010516586A JP2010534199A JP 2010534199 A JP2010534199 A JP 2010534199A JP 2010516586 A JP2010516586 A JP 2010516586A JP 2010516586 A JP2010516586 A JP 2010516586A JP 2010534199 A JP2010534199 A JP 2010534199A
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- JP
- Japan
- Prior art keywords
- group
- imidazole
- phenyl
- derivative
- disulfiram
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000000845 anti-microbial effect Effects 0.000 title description 2
- 238000002648 combination therapy Methods 0.000 title 1
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims abstract description 192
- AUZONCFQVSMFAP-UHFFFAOYSA-N disulfiram Chemical compound CCN(CC)C(=S)SSC(=S)N(CC)CC AUZONCFQVSMFAP-UHFFFAOYSA-N 0.000 claims abstract description 100
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- 239000000203 mixture Substances 0.000 claims abstract description 26
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- BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 claims description 20
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0714226.8A GB0714226D0 (en) | 2007-07-20 | 2007-07-20 | anti-bacterial combination therapy |
| US96780107P | 2007-09-07 | 2007-09-07 | |
| PCT/GB2008/002499 WO2009013480A2 (en) | 2007-07-20 | 2008-07-18 | Antibacterial combination therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010534199A true JP2010534199A (ja) | 2010-11-04 |
| JP2010534199A5 JP2010534199A5 (cg-RX-API-DMAC7.html) | 2011-08-25 |
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| JP2010516586A Withdrawn JP2010534199A (ja) | 2007-07-20 | 2008-07-18 | 抗菌複合治療 |
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| Country | Link |
|---|---|
| US (1) | US20110039906A1 (cg-RX-API-DMAC7.html) |
| EP (3) | EP2180900A2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2010534199A (cg-RX-API-DMAC7.html) |
| CN (1) | CN101939026A (cg-RX-API-DMAC7.html) |
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| CA (1) | CA2693544A1 (cg-RX-API-DMAC7.html) |
| GB (1) | GB0714226D0 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009013480A2 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201000919B (cg-RX-API-DMAC7.html) |
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| JP2010527323A (ja) * | 2006-11-16 | 2010-08-12 | イー セラピューティクス ピー エル シー | 多剤耐性細菌感染症の治療 |
| GB0724996D0 (en) * | 2007-12-21 | 2008-01-30 | Therapeutics Ltd E | Antibacterial combination therapy for the treatment of gram positive bacterial infections |
| GB0813211D0 (en) | 2008-07-18 | 2008-08-27 | E Therapeutics Plc | Antibacterial combination therapy for the treatment of gram positive bacterial infections |
| BRPI0904249B1 (pt) * | 2009-08-28 | 2018-03-06 | Biolab Sanus Farmacêutica Ltda. | Compostos éteres aralquil benzílicos, processo de preparação dos mesmos, uso dos referidos compostos, composição farmacêutica |
| CN107184581B (zh) * | 2017-06-02 | 2020-11-20 | 郑州大学 | 胺基二硫代甲酸盐衍生物在抗菌领域的应用 |
| US20240285586A1 (en) * | 2021-06-11 | 2024-08-29 | The Hong Kong Polytechnic University | Methods for treating bacterial cell populations |
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| GB148124A (en) | 1915-12-20 | 1921-09-08 | Valerius Smeu | Improvements relating to apparatus for dissolving materials in or impregnating them with acids or the like |
| GB149428A (en) | 1919-05-13 | 1920-08-13 | James William Mcmyn | Improvements relating to the application of dye stuffs containing the sulphonamide group to dyeing and printing |
| US3249109A (en) | 1963-11-01 | 1966-05-03 | Maeth Harry | Topical dressing |
| US3598122A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US4144317A (en) | 1975-05-30 | 1979-03-13 | Alza Corporation | Device consisting of copolymer having acetoxy groups for delivering drugs |
| US4262003A (en) | 1975-12-08 | 1981-04-14 | Alza Corporation | Method and therapeutic system for administering scopolamine transdermally |
| US4307717A (en) * | 1977-11-07 | 1981-12-29 | Lectec Corporation | Sterile improved bandage containing a medicament |
| NZ210840A (en) * | 1984-01-18 | 1987-05-29 | Johnson & Johnson Baby Prod | Composition comprising synergistic combination of miconazole nitrate and zinc oxide |
| US4725439A (en) | 1984-06-29 | 1988-02-16 | Alza Corporation | Transdermal drug delivery device |
| FR2843302B1 (fr) * | 2002-08-09 | 2004-10-22 | Centre Nat Rech Scient | Forme galenique pour la delivrance colique de principes actifs |
| US20040157837A1 (en) * | 2002-11-07 | 2004-08-12 | Serbedzija George N. | Combinations for the treatment of fungal infections |
| JP2010527323A (ja) * | 2006-11-16 | 2010-08-12 | イー セラピューティクス ピー エル シー | 多剤耐性細菌感染症の治療 |
| GB0813211D0 (en) * | 2008-07-18 | 2008-08-27 | E Therapeutics Plc | Antibacterial combination therapy for the treatment of gram positive bacterial infections |
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2007
- 2007-07-20 GB GBGB0714226.8A patent/GB0714226D0/en not_active Ceased
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2008
- 2008-07-18 US US12/669,133 patent/US20110039906A1/en not_active Abandoned
- 2008-07-18 CA CA2693544A patent/CA2693544A1/en not_active Abandoned
- 2008-07-18 JP JP2010516586A patent/JP2010534199A/ja not_active Withdrawn
- 2008-07-18 AU AU2008278827A patent/AU2008278827A1/en not_active Abandoned
- 2008-07-18 EP EP08776019A patent/EP2180900A2/en not_active Withdrawn
- 2008-07-18 EP EP12002256A patent/EP2529737A1/en not_active Withdrawn
- 2008-07-18 WO PCT/GB2008/002499 patent/WO2009013480A2/en not_active Ceased
- 2008-07-18 EP EP12002512A patent/EP2529733A1/en not_active Withdrawn
- 2008-07-18 CN CN200880025459XA patent/CN101939026A/zh active Pending
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2010
- 2010-02-08 ZA ZA2010/00919A patent/ZA201000919B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB0714226D0 (en) | 2007-08-29 |
| CA2693544A1 (en) | 2009-01-29 |
| AU2008278827A1 (en) | 2009-01-29 |
| EP2529737A1 (en) | 2012-12-05 |
| CN101939026A (zh) | 2011-01-05 |
| US20110039906A1 (en) | 2011-02-17 |
| WO2009013480A3 (en) | 2009-06-25 |
| ZA201000919B (en) | 2012-02-29 |
| WO2009013480A8 (en) | 2010-04-08 |
| EP2529733A1 (en) | 2012-12-05 |
| WO2009013480A2 (en) | 2009-01-29 |
| EP2180900A2 (en) | 2010-05-05 |
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