JP2010533166A5 - - Google Patents
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- Publication number
- JP2010533166A5 JP2010533166A5 JP2010515728A JP2010515728A JP2010533166A5 JP 2010533166 A5 JP2010533166 A5 JP 2010533166A5 JP 2010515728 A JP2010515728 A JP 2010515728A JP 2010515728 A JP2010515728 A JP 2010515728A JP 2010533166 A5 JP2010533166 A5 JP 2010533166A5
- Authority
- JP
- Japan
- Prior art keywords
- salt
- prophylactic
- active ingredient
- therapeutic agent
- fatty liver
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 208000004930 Fatty Liver Diseases 0.000 claims 2
- 206010019708 Hepatic steatosis Diseases 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 208000010706 fatty liver disease Diseases 0.000 claims 2
- 230000000069 prophylactic effect Effects 0.000 claims 2
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 claims 2
- 231100000240 steatosis hepatitis Toxicity 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000005606 carbostyryl group Chemical group 0.000 claims 1
- RRGUKTPIGVIEKM-UHFFFAOYSA-N cilostazol Chemical group C=1C=C2NC(=O)CCC2=CC=1OCCCCC1=NN=NN1C1CCCCC1 RRGUKTPIGVIEKM-UHFFFAOYSA-N 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010515728A JP5558348B2 (ja) | 2007-07-11 | 2008-07-09 | シロスタゾールを含むカルボスチリル誘導体の脂肪肝治療剤 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007181760 | 2007-07-11 | ||
| JP2007181760 | 2007-07-11 | ||
| JP2010515728A JP5558348B2 (ja) | 2007-07-11 | 2008-07-09 | シロスタゾールを含むカルボスチリル誘導体の脂肪肝治療剤 |
| PCT/JP2008/062771 WO2009008539A1 (en) | 2007-07-11 | 2008-07-09 | Carbostyril derivatives including cilostazol for treating fatty liver |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014115759A Division JP2014185161A (ja) | 2007-07-11 | 2014-06-04 | シロスタゾールを含むカルボスチリル誘導体の脂肪肝治療剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010533166A JP2010533166A (ja) | 2010-10-21 |
| JP2010533166A5 true JP2010533166A5 (enExample) | 2011-05-19 |
| JP5558348B2 JP5558348B2 (ja) | 2014-07-23 |
Family
ID=39689465
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010515728A Expired - Fee Related JP5558348B2 (ja) | 2007-07-11 | 2008-07-09 | シロスタゾールを含むカルボスチリル誘導体の脂肪肝治療剤 |
| JP2014115759A Withdrawn JP2014185161A (ja) | 2007-07-11 | 2014-06-04 | シロスタゾールを含むカルボスチリル誘導体の脂肪肝治療剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014115759A Withdrawn JP2014185161A (ja) | 2007-07-11 | 2014-06-04 | シロスタゾールを含むカルボスチリル誘導体の脂肪肝治療剤 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8642618B2 (enExample) |
| EP (1) | EP2162134A1 (enExample) |
| JP (2) | JP5558348B2 (enExample) |
| KR (2) | KR20100046188A (enExample) |
| CN (1) | CN101778630A (enExample) |
| AR (1) | AR067446A1 (enExample) |
| CA (1) | CA2691632A1 (enExample) |
| TW (1) | TW200908973A (enExample) |
| WO (1) | WO2009008539A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101094934B1 (ko) * | 2010-10-22 | 2011-12-15 | 영남대학교 산학협력단 | 실로스타졸을 유효성분으로 함유하는 알코올성 간질환 치료 또는 예방용 약학조성물 |
| EP3263705A1 (en) * | 2016-06-28 | 2018-01-03 | DKFZ Deutsches Krebsforschungszentrum | Treatments of non-alcoholic steatohepatitis (nash) |
| TW201829448A (zh) | 2016-12-15 | 2018-08-16 | 大陸商深圳瑞健生命科學硏究院有限公司 | 纖溶酶原在製備預防或治療肥胖症及疾病倂發的肥胖的藥物中的用途 |
| TW201822805A (zh) | 2016-12-15 | 2018-07-01 | 深圳瑞健生命科學硏究院有限公司 | 一種預防和治療脂肪異常沉積導致的組織損傷的方法 |
| EP3556385A4 (en) | 2016-12-15 | 2020-12-30 | Talengen International Limited | PROCESS FOR ALLEGING HEART DISEASE |
| EP4337314A1 (en) * | 2021-05-11 | 2024-03-20 | Regeneron Pharmaceuticals, Inc. | Methods of treating liver diseases with phosphodiesterase 3b (pde3b) inhibitors |
| US20230160012A1 (en) * | 2021-08-31 | 2023-05-25 | Regeneron Pharmaceuticals, Inc. | Treatment of Liver Diseases With CAMP Responsive Element Binding Protein 3 Like 3 (CREB3L3) Inhibitors |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3944257B2 (ja) | 1995-12-07 | 2007-07-11 | 大塚製薬株式会社 | 肝実質細胞増殖因子産生増加剤 |
-
2008
- 2008-07-03 AR ARP080102879A patent/AR067446A1/es unknown
- 2008-07-09 WO PCT/JP2008/062771 patent/WO2009008539A1/en not_active Ceased
- 2008-07-09 JP JP2010515728A patent/JP5558348B2/ja not_active Expired - Fee Related
- 2008-07-09 EP EP08791177A patent/EP2162134A1/en not_active Withdrawn
- 2008-07-09 KR KR1020107002982A patent/KR20100046188A/ko not_active Abandoned
- 2008-07-09 KR KR20157007589A patent/KR20150038739A/ko not_active Ceased
- 2008-07-09 CN CN200880024072A patent/CN101778630A/zh active Pending
- 2008-07-09 CA CA002691632A patent/CA2691632A1/en not_active Abandoned
- 2008-07-09 US US12/667,875 patent/US8642618B2/en not_active Expired - Fee Related
- 2008-07-10 TW TW097126022A patent/TW200908973A/zh unknown
-
2013
- 2013-12-24 US US14/140,179 patent/US20140121241A1/en not_active Abandoned
-
2014
- 2014-06-04 JP JP2014115759A patent/JP2014185161A/ja not_active Withdrawn