JP2010532978A5 - - Google Patents

Download PDF

Info

Publication number
JP2010532978A5
JP2010532978A5 JP2010515417A JP2010515417A JP2010532978A5 JP 2010532978 A5 JP2010532978 A5 JP 2010532978A5 JP 2010515417 A JP2010515417 A JP 2010515417A JP 2010515417 A JP2010515417 A JP 2010515417A JP 2010532978 A5 JP2010532978 A5 JP 2010532978A5
Authority
JP
Japan
Prior art keywords
seq
amino acids
fusion protein
human surfactant
protein according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010515417A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010532978A (ja
JP6002903B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2008/005644 external-priority patent/WO2009007120A2/en
Publication of JP2010532978A publication Critical patent/JP2010532978A/ja
Publication of JP2010532978A5 publication Critical patent/JP2010532978A5/ja
Application granted granted Critical
Publication of JP6002903B2 publication Critical patent/JP6002903B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2010515417A 2007-07-10 2008-07-10 Tnfスーパーファミリーコレクチン融合タンパク質 Expired - Fee Related JP6002903B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07013506.6 2007-07-10
EP07013506 2007-07-10
PCT/EP2008/005644 WO2009007120A2 (en) 2007-07-10 2008-07-10 Tnf superfamily collectin fusion proteins

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014258068A Division JP6029646B2 (ja) 2007-07-10 2014-12-19 Tnfスーパーファミリーコレクチン融合タンパク質

Publications (3)

Publication Number Publication Date
JP2010532978A JP2010532978A (ja) 2010-10-21
JP2010532978A5 true JP2010532978A5 (show.php) 2011-08-25
JP6002903B2 JP6002903B2 (ja) 2016-10-05

Family

ID=39865190

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2010515417A Expired - Fee Related JP6002903B2 (ja) 2007-07-10 2008-07-10 Tnfスーパーファミリーコレクチン融合タンパク質
JP2014258068A Expired - Fee Related JP6029646B2 (ja) 2007-07-10 2014-12-19 Tnfスーパーファミリーコレクチン融合タンパク質

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2014258068A Expired - Fee Related JP6029646B2 (ja) 2007-07-10 2014-12-19 Tnfスーパーファミリーコレクチン融合タンパク質

Country Status (7)

Country Link
US (6) US8383774B2 (show.php)
EP (4) EP3321277B1 (show.php)
JP (2) JP6002903B2 (show.php)
AU (1) AU2008274490B2 (show.php)
CA (3) CA2860950C (show.php)
ES (3) ES2560871T3 (show.php)
WO (1) WO2009007120A2 (show.php)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2704422C (en) * 2007-11-01 2019-09-24 The Board Of Trustees Of The University Of Arkansas Compositions and methods of enhancing immune responses to eimeria
ES2524553T3 (es) 2008-06-17 2014-12-10 Apogenix Gmbh Receptores multiméricos de TNF
HUE025236T2 (en) 2008-07-21 2016-03-29 Apogenix Gmbh TNFSF single chain molecules
WO2010068754A2 (en) 2008-12-10 2010-06-17 Paka Pulmonary Pharmaceuticals, Inc. Methods and compositions for delivery of medicaments to the lungs
EP2382236B1 (en) * 2009-01-09 2016-08-17 Apogenix AG Fusion proteins forming trimers
CN101698852B (zh) * 2009-10-23 2014-08-13 江苏先声药物研究有限公司 具有cd137l功能的蛋白或多肽及其基因和应用
WO2011105537A1 (ja) * 2010-02-26 2011-09-01 積水メディカル株式会社 偽陽性反応を抑制する検体抽出液
WO2012040101A1 (en) 2010-09-21 2012-03-29 University Of Miami Compositions and methods for inducing migration by dendritic cells and an immune response
WO2012040266A2 (en) * 2010-09-24 2012-03-29 University Of Miami Gene-based adjuvants and compositions thereof to increase antibody production in response to gene-based vaccines
SG189370A1 (en) * 2010-12-03 2013-05-31 Adamed Sp Zoo Anticancer fusion protein
EP2586793A1 (en) 2011-10-27 2013-05-01 Centre National de la Recherche Scientifique Chimeric molecule involving oligomerized FasL extracellular domain
US20150191506A1 (en) * 2012-06-29 2015-07-09 Asahi Kasei Medical Co., Ltd. Adsorbent consisting of carrier which bound with polypeptide comprising b-domain mutant derived from protein a
NO2776305T3 (show.php) 2014-04-23 2018-01-27
WO2016079527A1 (en) 2014-11-19 2016-05-26 Tetralogic Birinapant Uk Ltd Combination therapy
WO2016097773A1 (en) 2014-12-19 2016-06-23 Children's Cancer Institute Therapeutic iap antagonists for treating proliferative disorders
MA41460A (fr) 2015-02-03 2017-12-12 Oncomed Pharm Inc Agents de liaison à la tnfrsf et leurs utilisations
WO2017053170A1 (en) * 2015-09-24 2017-03-30 The University Of North Carolina At Chapel Hill Methods and compositions for reducing metastases
AU2016341402B2 (en) 2015-10-23 2020-08-27 Apogenix Ag Single-chain GITR-receptor agonist proteins
CA3003511A1 (en) * 2015-10-28 2017-05-04 Apogenix Ag Single-chain tl1a receptor agonist proteins
TWI788307B (zh) 2016-10-31 2023-01-01 美商艾歐凡斯生物治療公司 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞
WO2018129332A1 (en) 2017-01-06 2018-07-12 Iovance Biotherapeutics, Inc. Expansion of tumor infiltrating lymphocytes (tils) with tumor necrosis factor receptor superfamily (tnfrsf) agonists and therapeutic combinations of tils and tnfrsf agonists
EP3565586B1 (en) 2017-01-06 2025-10-08 Iovance Biotherapeutics, Inc. Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof
WO2018185247A1 (en) * 2017-04-06 2018-10-11 Universität Stuttgart Tumor necrosis factor receptor (tnfr) binding protein complex with improved binding and bioactivity
TW201904578A (zh) 2017-05-10 2019-02-01 美商艾歐凡斯生物治療公司 源自液體腫瘤之腫瘤浸潤性淋巴細胞的擴增和該經擴增腫瘤浸潤性淋巴細胞之治療用途
WO2018226714A1 (en) 2017-06-05 2018-12-13 Iovance Biotherapeutics, Inc. Methods of using tumor infiltrating lymphocytes in double-refractory melanoma
EP3703723A4 (en) 2017-10-31 2021-12-15 KaliVir Immunotherapeutics, Inc. ONCOLYTIC PLATFORM VECTOR FOR SYSTEMS ADMINISTRATION
DK3710576T3 (da) 2017-11-17 2025-01-02 Iovance Biotherapeutics Inc Til-ekspansion fra finnålsaspirater og små biopsier
EP3714041A1 (en) 2017-11-22 2020-09-30 Iovance Biotherapeutics, Inc. Expansion of peripheral blood lymphocytes (pbls) from peripheral blood
EP3724885A2 (en) 2017-12-15 2020-10-21 Iovance Biotherapeutics, Inc. Systems and methods for determining the beneficial administration of tumor infiltrating lymphocytes, and methods of use thereof and beneficial administration of tumor infiltrating lymphocytes, and methods of use thereof
US11713446B2 (en) 2018-01-08 2023-08-01 Iovance Biotherapeutics, Inc. Processes for generating TIL products enriched for tumor antigen-specific T-cells
WO2019136459A1 (en) 2018-01-08 2019-07-11 Iovance Biotherapeutics, Inc. Processes for generating til products enriched for tumor antigen-specific t-cells
SG11202006541UA (en) 2018-01-08 2020-08-28 Iovance Biotherapeutics Inc Processes for generating til products enriched for tumor antigen-specific t-cells
MA51875A (fr) 2018-02-13 2020-12-23 Iovance Biotherapeutics Inc Expansion de lymphocytes infiltrant les tumeurs (til) avec des antagonistes du récepteur a2a de l'adénosine et combinaisons thérapeutiques de til et d'antagonistes du récepteur a2a de l'adénosine
EA202092319A1 (ru) 2018-03-29 2021-03-04 Айовэнс Байотерапьютикс, Инк. Способы получения опухоль-инфильтрирующих лимфоцитов и применения их в иммунотерапии
US20210130779A1 (en) 2018-04-27 2021-05-06 Iovance Biotherapeutics, Inc. Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy
WO2019217753A1 (en) 2018-05-10 2019-11-14 Iovance Biotherapeutics, Inc. Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy
CA3098498A1 (en) * 2018-06-14 2019-12-19 Nantbio, Inc. Tnf-type receptor-ligand fusion proteins and methods
TW202031273A (zh) 2018-08-31 2020-09-01 美商艾歐凡斯生物治療公司 抗pd-1抗體難治療性之非小細胞肺癌(nsclc)病患的治療
WO2020061429A1 (en) 2018-09-20 2020-03-26 Iovance Biotherapeutics, Inc. Expansion of tils from cryopreserved tumor samples
US12343380B2 (en) 2018-11-05 2025-07-01 Iovance Biotherapeutics, Inc. Expansion of TILs utilizing AKT pathways inhibitors
CN113272421B (zh) 2018-11-05 2025-02-18 艾欧凡斯生物治疗公司 用于产生肿瘤浸润性淋巴细胞的方法及其在免疫疗法中的用途
MX2021004953A (es) 2018-11-05 2021-08-11 Iovance Biotherapeutics Inc Seleccion de celulas t reactivas al tumor mejoradas.
SG11202104663PA (en) 2018-11-05 2021-06-29 Iovance Biotherapeutics Inc Treatment of nsclc patients refractory for anti-pd-1 antibody
JP7710372B2 (ja) 2018-12-19 2025-07-18 アイオバンス バイオセラピューティクス,インコーポレイテッド 操作されたサイトカイン受容体対を使用して腫瘍浸潤リンパ球を拡大培養する方法及びその使用
US20220135649A1 (en) * 2019-02-06 2022-05-05 The Regents Of The University Of California Dominant negative cd40l polypeptides
WO2020168151A2 (en) * 2019-02-15 2020-08-20 Epicypher, Inc. Quantitative mapping of chromatin associated proteins
WO2020180733A1 (en) 2019-03-01 2020-09-10 Iovance Biotherapeutics, Inc. Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof
US20220177547A1 (en) * 2019-03-07 2022-06-09 Kyungpook National University Industry-Academic Cooperation Foundation Ferritin nanocage for multi-displaying trail trimer and cancer-targeting peptide and use thereof as anticancer agent
CA3134144A1 (en) 2019-03-29 2020-10-08 Myst Therapeutics, Llc Ex vivo methods for producing a t cell therapeutic and related compositions and methods
US20220249559A1 (en) 2019-05-13 2022-08-11 Iovance Biotherapeutics, Inc. Methods and compositions for selecting tumor infiltrating lymphocytes and uses of the same in immunotherapy
WO2020260368A1 (en) 2019-06-24 2020-12-30 Universität Stuttgart Tnfr2 agonists with improved stability
US20220389381A1 (en) 2019-10-25 2022-12-08 Iovance Biotherapeutics, Inc. Gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy
AU2020391231A1 (en) 2019-11-27 2022-07-14 Turnstone Biologics Corp. Method of producing tumor-reactive T cell composition using modulatory agents
US12516291B2 (en) 2019-12-11 2026-01-06 Iovance Biotherapeutics, Inc. Processes for the production of tumor infiltrating lymphocytes (TILs) and methods of using the same
KR20220158727A (ko) 2020-02-27 2022-12-01 미스트 쎄라퓨틱스, 엘엘씨 종양 반응성 t 세포의 생체외 농축 및 확장 방법 및 이의 관련 조성물
CA3177413A1 (en) 2020-05-04 2021-11-11 Michelle SIMPSON-ABELSON Selection of improved tumor reactive t-cells
EP4146794A1 (en) 2020-05-04 2023-03-15 Iovance Biotherapeutics, Inc. Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy
WO2022076606A1 (en) 2020-10-06 2022-04-14 Iovance Biotherapeutics, Inc. Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
EP4225330A1 (en) 2020-10-06 2023-08-16 Iovance Biotherapeutics, Inc. Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
WO2022079308A1 (en) * 2020-10-16 2022-04-21 Institut Pasteur Chimeric constructs useful in vaccination and cancer therapy
CN116801899A (zh) 2020-11-19 2023-09-22 卡利威尔免疫治疗公司 通过肿瘤微环境重塑的溶瘤免疫疗法
US20240131064A1 (en) 2020-12-11 2024-04-25 Iovance Biotherapeutics, Inc. Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with braf inhibitors and/or mek inhibitors
US20240123067A1 (en) 2020-12-17 2024-04-18 Iovance Biotherapeutics, Inc. Treatment of cancers with tumor infiltrating lymphocyte therapies
WO2022133140A1 (en) 2020-12-17 2022-06-23 Iovance Biotherapeutics, Inc. Treatment with tumor infiltrating lymphocyte therapies in combination with ctla-4 and pd-1 inhibitors
US20240299540A1 (en) 2021-02-05 2024-09-12 Iovance Biotherapeutics, Inc. Adjuvant therapy for cancer
CN117279506A (zh) 2021-03-05 2023-12-22 艾欧凡斯生物治疗公司 肿瘤储存及细胞培养组合物
AU2022263418A1 (en) 2021-04-19 2023-10-26 Iovance Biotherapeutics, Inc. Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies
MX2023012608A (es) 2021-04-30 2023-11-03 Kalivir Immunotherapeutics Inc Virus oncoliticos para la expresion modificada del mhc.
US20240269180A1 (en) 2021-05-17 2024-08-15 Iovance Biotherapeutics, Inc. Pd-1 gene-edited tumor infiltrating lymphocytes and uses of same in immunotherapy
BR112023026235A2 (pt) * 2021-06-17 2024-03-05 Kalivir Immunotherapeutics Inc Proteínas de fusão tnfsf-l e seus usos
WO2023009716A1 (en) 2021-07-28 2023-02-02 Iovance Biotherapeutics, Inc. Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with kras inhibitors
CA3232700A1 (en) 2021-09-24 2023-03-30 Rafael CUBAS Expansion processes and agents for tumor infiltrating lymphocytes
CA3235824A1 (en) 2021-10-27 2023-05-04 Frederick G. Vogt Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy
CA3237410A1 (en) 2021-11-10 2023-05-19 Friedrich Graf Finck VON FINCKENSTEIN Methods of expansion treatment utilizing cd8 tumor infiltrating lymphocytes
WO2023088889A1 (en) 2021-11-16 2023-05-25 Apogenix Ag CD137 ligands
JP2025503987A (ja) 2022-01-28 2025-02-06 アイオバンス バイオセラピューティクス,インコーポレイテッド ペイロードを発現するように操作された腫瘍浸潤リンパ球
CA3248034A1 (en) 2022-04-15 2023-10-19 Iovance Biotherapeutics, Inc. METHODS FOR EXPANSION OF TIL CELLS BY MEANS OF SPECIFIC CYTOKINE COMBINATIONS AND/OR AKT INHIBITOR TREATMENT
CN119654339A (zh) 2022-07-01 2025-03-18 特兰斯吉恩股份有限公司 包含表面活性蛋白-d和tnfsf成员的融合蛋白
EP4565683A1 (en) 2022-08-01 2025-06-11 Iovance Biotherapeutics, Inc. Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies
WO2024098024A1 (en) 2022-11-04 2024-05-10 Iovance Biotherapeutics, Inc. Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof
WO2024151885A1 (en) 2023-01-13 2024-07-18 Iovance Biotherapeutics, Inc. Use of til as maintenance therapy for nsclc patients who achieved pr/cr after prior therapy
WO2025101484A1 (en) 2023-11-06 2025-05-15 Iovance Biotherapeutics, Inc. Treatment of endometrial cancers with tumor infiltrating lymphocyte therapies

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9409768D0 (en) 1994-05-16 1994-07-06 Medical Res Council Trimerising polypeptides
EP1666591B1 (en) 1995-06-29 2011-03-23 Immunex Corporation Cytokine that induces apoptosis
US7300774B1 (en) 1999-12-09 2007-11-27 The Regents Of The University Of California Multimeric fusion proteins of the TNF superfamily ligands
DE19963859A1 (de) 1999-12-30 2001-07-12 Apotech Res & Dev Ltd Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen
GB0015426D0 (en) * 2000-06-24 2000-08-16 Univ Southampton Method for generating soluble highly multimeric proteins
US20040247563A1 (en) * 2000-11-02 2004-12-09 Lynch David H. Method of enhancing lymphocyte-mediated immune responses
DE10122140A1 (de) * 2001-05-08 2002-11-28 Apotech Res & Dev Ltd Rekombinante Fusionsproteine und deren Trimere
US7238499B2 (en) 2001-12-21 2007-07-03 Immunex Corporation Trimeric macrophage scavenger receptor fusion proteins and encoding nucleic acids
AU2003228483A1 (en) * 2002-04-12 2003-10-27 Human Genome Sciences, Inc. Antibodies that specifically bind to tr2
PT1539964E (pt) 2002-09-10 2007-04-30 Natlmmune As Quimeras colectina-proteína activadora do complemento
GB0524316D0 (en) * 2005-11-29 2006-01-04 Medical Res Council Tumour necrosis factor-related apoptosis-inducing ligands (TRAILs)
AU2007239095B2 (en) * 2006-01-09 2012-05-03 The Regents Of The University Of California Immunostimulatory combinations for vaccine adjuvants
WO2007102690A1 (en) * 2006-03-06 2007-09-13 Postech Foundation Vector including the codon-optimized dna cassette for producing secretory recombinant dodecamer trail
EP1894940A1 (en) 2006-08-28 2008-03-05 Apogenix GmbH TNF superfamily fusion proteins
ES2523992T3 (es) * 2006-12-28 2014-12-03 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts La neutralización de la actividad de CD95 bloquea la invasión de células de glioblastoma in vivo
EP2382236B1 (en) 2009-01-09 2016-08-17 Apogenix AG Fusion proteins forming trimers

Similar Documents

Publication Publication Date Title
JP2010532978A5 (show.php)
JP2010065037A5 (show.php)
JP2010088434A5 (show.php)
RU2016146198A (ru) Терапевтические dll4-связывающие белки
JP2017048194A5 (show.php)
JP2020022459A5 (show.php)
JP2010227108A5 (show.php)
JP2014501510A5 (show.php)
JP2012095652A5 (show.php)
JP2010011868A5 (show.php)
JP2013510581A5 (show.php)
JP2018033454A5 (show.php)
JP2013507132A5 (show.php)
JP2009524429A5 (show.php)
HRP20090245T1 (en) Pyy agonists and uses thereof
WO2010138263A3 (en) Novel aav 's and uses thereof
CA2760924A1 (en) Synthetic, defined fibronectin mimetic peptides and surfaces modified with the same
WO2009133462A3 (en) Proteins
JP2014525439A5 (show.php)
JP2007510403A5 (show.php)
WO2008103819A3 (en) Chimeric newcastle disease virus vlps
DE602007004110D1 (de) Hausstaubmilbenallergen
JP2004532624A5 (show.php)
JP2008521795A5 (show.php)
WO2010057242A3 (de) Vakzin