JP2010532764A5 - - Google Patents
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- JP2010532764A5 JP2010532764A5 JP2010515288A JP2010515288A JP2010532764A5 JP 2010532764 A5 JP2010532764 A5 JP 2010532764A5 JP 2010515288 A JP2010515288 A JP 2010515288A JP 2010515288 A JP2010515288 A JP 2010515288A JP 2010532764 A5 JP2010532764 A5 JP 2010532764A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- specific binding
- binding protein
- domain
- residues
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000009870 specific binding Effects 0.000 claims 34
- 102000023732 binding proteins Human genes 0.000 claims 27
- 108091008324 binding proteins Proteins 0.000 claims 27
- 208000011380 COVID-19–associated multisystem inflammatory syndrome in children Diseases 0.000 claims 11
- 238000002319 photoionisation mass spectrometry Methods 0.000 claims 11
- 235000018102 proteins Nutrition 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 2
- 230000003013 cytotoxicity Effects 0.000 claims 2
- 231100000135 cytotoxicity Toxicity 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000012636 effector Substances 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 102100025218 B-cell differentiation antigen CD72 Human genes 0.000 claims 1
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 1
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 1
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims 1
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims 1
- 101000934359 Homo sapiens B-cell differentiation antigen CD72 Proteins 0.000 claims 1
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 1
- 101000777628 Homo sapiens Leukocyte antigen CD37 Proteins 0.000 claims 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 1
- 102100031586 Leukocyte antigen CD37 Human genes 0.000 claims 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 1
- 230000027455 binding Effects 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000002523 lectin Substances 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000001575 pathological effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 102220288073 rs151218932 Human genes 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94839707P | 2007-07-06 | 2007-07-06 | |
| PCT/US2008/069378 WO2009023386A2 (en) | 2007-07-06 | 2008-07-07 | Binding peptides having a c-terminally disposed specific binding domain |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010532764A JP2010532764A (ja) | 2010-10-14 |
| JP2010532764A5 true JP2010532764A5 (cg-RX-API-DMAC7.html) | 2011-08-25 |
Family
ID=40351400
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010515288A Pending JP2010532764A (ja) | 2007-07-06 | 2008-07-07 | C末端に配置された特異的結合性ドメインを有する結合性ペプチド |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20090148447A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2167130A2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2010532764A (cg-RX-API-DMAC7.html) |
| CN (1) | CN101990439A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008287195A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0814060A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2691819A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009023386A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (52)
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| DK2298815T3 (en) | 2005-07-25 | 2015-06-15 | Emergent Product Dev Seattle | B-CELL REDUCTION USING CD37 SPECIFIC AND CD20 SPECIFIC BINDING MOLECULES |
| CN105837690A (zh) | 2006-06-12 | 2016-08-10 | 新兴产品开发西雅图有限公司 | 具有效应功能的单链多价结合蛋白 |
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| EP2195341B1 (en) | 2007-09-26 | 2017-03-22 | UCB Biopharma SPRL | Dual specificity antibody fusions |
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| PL3063275T3 (pl) | 2013-10-31 | 2020-03-31 | Resolve Therapeutics, Llc | Terapeutyczne fuzje nukleaza-albumina i sposoby |
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| UA129489C2 (uk) | 2015-08-28 | 2025-05-14 | Дебіофарм Інтернаціонал, С.А. | Антитіло до cd37 |
| EP3352760A4 (en) | 2015-09-21 | 2019-03-06 | Aptevo Research and Development LLC | CD3-BINDING POLYPEPTIDES |
| CA3005136A1 (en) | 2015-11-20 | 2017-05-26 | Oregon Health & Science University | Cmv vectors comprising microrna recognition elements |
| CN119120423A (zh) | 2016-07-01 | 2024-12-13 | 分解治疗有限责任公司 | 优化的二核酸酶融合体和方法 |
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| US11278629B2 (en) | 2016-11-02 | 2022-03-22 | Debiopharm International, S.A. | Methods for improving anti-CD37 immunoconjugate therapy |
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| CN108395482B (zh) | 2017-02-08 | 2021-02-05 | 西比曼生物科技(香港)有限公司 | 一种靶向cd20抗原嵌合抗原受体的构建及其工程化t细胞的活性鉴定 |
| JP7254710B2 (ja) | 2017-03-16 | 2023-04-10 | ザ ジェネラル ホスピタル コーポレイション | Cd37を標的にするキメラ抗原受容体 |
| EP3672986A1 (en) | 2017-08-22 | 2020-07-01 | Sanabio, LLC | Soluble interferon receptors and uses thereof |
| US12144818B2 (en) | 2018-05-30 | 2024-11-19 | Debiopharm International, S.A. | Method for treating cancer in a human patient by administering an anti-CD37 immunoconjugate using various dosing regimens |
| US20210268027A1 (en) * | 2018-06-22 | 2021-09-02 | The General Hospital Corporation | Chimeric antigen receptors targeting cd37 and cd19 |
| WO2021030488A1 (en) | 2019-08-12 | 2021-02-18 | Bienvenue David Leonard | 4-1bb and ox40 binding proteins and related compositions and methods, antibodies against 4-1bb, antibodies against ox40 |
| CN113402612A (zh) | 2020-03-17 | 2021-09-17 | 西比曼生物科技(香港)有限公司 | 靶向cd19和cd20的联合嵌合抗原受体及其应用 |
| WO2022104692A1 (en) * | 2020-11-20 | 2022-05-27 | Bliss Biopharmaceutical (Hangzhou) Co., Ltd. | Engineered antibody, antibody-drug conjugate, and use thereof |
| IL303328A (en) | 2020-12-01 | 2023-07-01 | Aptevo Res & Development Llc | Heterodimeric psma and cd3-binding bispecific antibodies |
| EP4626447A1 (en) | 2023-03-31 | 2025-10-08 | AbelZeta Inc. | Bispecific chimeric antigen receptors targeting cd20 and bcma |
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2008
- 2008-07-07 CN CN2008801052519A patent/CN101990439A/zh active Pending
- 2008-07-07 BR BRPI0814060-0A2A patent/BRPI0814060A2/pt not_active IP Right Cessation
- 2008-07-07 CA CA002691819A patent/CA2691819A1/en not_active Abandoned
- 2008-07-07 AU AU2008287195A patent/AU2008287195A1/en not_active Abandoned
- 2008-07-07 JP JP2010515288A patent/JP2010532764A/ja active Pending
- 2008-07-07 WO PCT/US2008/069378 patent/WO2009023386A2/en not_active Ceased
- 2008-07-07 EP EP08827538A patent/EP2167130A2/en not_active Withdrawn
- 2008-07-07 US US12/168,875 patent/US20090148447A1/en not_active Abandoned
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