JP2010532312A - １−ｈ−ピラゾロ（３，４ｂ）ピリミジン誘導体および有糸分裂キナーゼの調節剤としてのその使用 - Google Patents

１−ｈ−ピラゾロ（３，４ｂ）ピリミジン誘導体および有糸分裂キナーゼの調節剤としてのその使用 Download PDF

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Publication number
JP2010532312A
JP2010532312A JP2009548293A JP2009548293A JP2010532312A JP 2010532312 A JP2010532312 A JP 2010532312A JP 2009548293 A JP2009548293 A JP 2009548293A JP 2009548293 A JP2009548293 A JP 2009548293A JP 2010532312 A JP2010532312 A JP 2010532312A
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Prior art keywords
group
pyrazolo
pyrimidin
phenyl
ylamino
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JP2009548293A
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Japanese (ja)
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JP2010532312A5 (https=
Inventor
スリニバス ラオ カシバトラ，
ケビン ホン，
リン チャン，
マーカス エフ． ベーム，
チュンホア ファン，
ブラジィデック， ジャン−イブ ル
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biogen Inc
Biogen MA Inc
Original Assignee
Biogen Inc
Biogen Idec Inc
Biogen Idec MA Inc
Biogen MA Inc
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Publication of JP2010532312A publication Critical patent/JP2010532312A/ja
Publication of JP2010532312A5 publication Critical patent/JP2010532312A5/ja
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2009548293A 2007-01-30 2008-01-30 １−ｈ−ピラゾロ（３，４ｂ）ピリミジン誘導体および有糸分裂キナーゼの調節剤としてのその使用 Withdrawn JP2010532312A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89838207P 2007-01-30 2007-01-30
US89830007P 2007-01-30 2007-01-30
PCT/US2008/001230 WO2008094602A2 (en) 2007-01-30 2008-01-30 1-h-pyrazolo (3,4b) pyrimidine derivatives and their use as modulators of mitotic kinases

Publications (2)

Publication Number Publication Date
JP2010532312A true JP2010532312A (ja) 2010-10-07
JP2010532312A5 JP2010532312A5 (https=) 2012-04-05

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JP2009548293A Withdrawn JP2010532312A (ja) 2007-01-30 2008-01-30 １−ｈ−ピラゾロ（３，４ｂ）ピリミジン誘導体および有糸分裂キナーゼの調節剤としてのその使用
JP2009548286A Withdrawn JP2010516812A (ja) 2007-01-30 2008-01-30 有糸分裂キナーゼの調節剤

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JP2009548286A Withdrawn JP2010516812A (ja) 2007-01-30 2008-01-30 有糸分裂キナーゼの調節剤

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US (2) US20110281821A9 (https=)
EP (2) EP2108020A2 (https=)
JP (2) JP2010532312A (https=)
AU (2) AU2008211172A1 (https=)
CA (2) CA2676665A1 (https=)
WO (2) WO2008094575A2 (https=)

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Publication number Priority date Publication date Assignee Title
JP2013542966A (ja) * 2010-11-19 2013-11-28 エフ．ホフマン−ラ ロシュ アーゲー ピラゾロピリジンならびにｔｙｋ２阻害剤としてのピラゾロピリジン及びそれらの使用
JP2015516445A (ja) * 2012-05-14 2015-06-11 イースト チャイナ ユニバーシティ オブ サイエンス アンド テクノロジー プテリジノン誘導体およびｅｇｆｒ、ｂｌｋ、ｆｌｔ３の阻害剤としての応用
JP2015518863A (ja) * 2012-05-22 2015-07-06 ジェネンテック， インコーポレイテッド Ｎ−置換ベンズアミドおよび疼痛の処置におけるそれらの使用
JP2021527051A (ja) * 2018-06-05 2021-10-11 ラプト・セラピューティクス・インコーポレイテッド ピラゾロ−ピリミジン−アミノ−シクロアルキル化合物及びその治療的使用

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CA2676665A1 (en) * 2007-01-30 2008-08-07 Biogen Idec Ma Inc. Modulators of mitotic kinases
TWI490214B (zh) 2008-05-30 2015-07-01 艾德克 上野股份有限公司 苯或噻吩衍生物及該等作為ｖａｐ－１抑制劑之用途
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RU2711869C3 (ru) 2009-12-01 2022-02-02 Эббви Инк. Имидазопирролопиразиновые производные, полезные для лечения заболеваний, вызванных аномальной активностью протеинкиназ Jak1, Jak3 или Syk
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WO2011156698A2 (en) * 2010-06-11 2011-12-15 Abbott Laboratories NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS
US9040545B2 (en) 2010-08-20 2015-05-26 Cellzome Limited Heterocyclyl pyrazolopyrimidine analogues as selective JAK inhibitors
EP2646448B1 (en) 2010-11-29 2017-08-30 OSI Pharmaceuticals, LLC Macrocyclic kinase inhibitors
WO2012143320A1 (en) 2011-04-18 2012-10-26 Cellzome Limited (7h-pyrrolo[2,3-d]pyrimidin-2-yl)amine compounds as jak3 inhibitors
WO2013017480A1 (en) * 2011-07-29 2013-02-07 Cellzome Limited Pyrazolo[4,3-c]pyridine derivatives as jak inhibitors
WO2013017479A1 (en) * 2011-07-29 2013-02-07 Cellzome Limited Pyrazolo[4,3-c]pyridine derivatives as jak inhibitors
JP6014155B2 (ja) 2011-10-31 2016-10-25 ゼノン・ファーマシューティカルズ・インコーポレイテッドＸｅｎｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． ビアリールエーテルスルホンアミドおよび治療剤としてのそれらの使用
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US10934291B2 (en) 2014-09-25 2021-03-02 Duke University Kinase inhibitors and related methods of use
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TWI726861B (zh) 2015-01-23 2021-05-11 英商葛蘭素史克智慧財產發展有限公司 吡唑并-嘧啶化合物、其鹽及其用途
JP2018520107A (ja) 2015-05-22 2018-07-26 ジェネンテック， インコーポレイテッド 置換ベンズアミド及びその使用方法
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CN108290881B (zh) 2015-09-28 2021-12-07 健泰科生物技术公司 治疗性化合物和其使用方法
SG10201913990RA (en) 2015-10-16 2020-03-30 Abbvie Inc PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-a]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2,2,2-TRIFLUOROETHYL)PYRROLIDINE-1-CARBOXAMIDE AND SOLID STATE FORMS THEREOF
US11512092B2 (en) 2015-10-16 2022-11-29 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
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US11773106B2 (en) 2015-10-16 2023-10-03 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US10899732B2 (en) 2015-11-25 2021-01-26 Genentech, Inc. Substituted benzamides useful as sodium channel blockers
EP3854782A1 (en) 2016-03-30 2021-07-28 Genentech, Inc. Substituted benzamides and methods of use thereof
US20190152992A1 (en) 2016-06-29 2019-05-23 Orion Corporation Benzodioxane derivatives and their pharmaceutical use
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JP2020511511A (ja) 2017-03-24 2020-04-16 ジェネンテック， インコーポレイテッド ナトリウムチャネル阻害剤としての４−ピペリジン−ｎ−（ピリミジン−４−イル）クロマン−７−スルホンアミド誘導体
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TW202003490A (zh) 2018-05-22 2020-01-16 瑞士商赫孚孟拉羅股份公司 治療性化合物及其使用方法
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CA2676665A1 (en) * 2007-01-30 2008-08-07 Biogen Idec Ma Inc. Modulators of mitotic kinases

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013542966A (ja) * 2010-11-19 2013-11-28 エフ．ホフマン−ラ ロシュ アーゲー ピラゾロピリジンならびにｔｙｋ２阻害剤としてのピラゾロピリジン及びそれらの使用
JP2015516445A (ja) * 2012-05-14 2015-06-11 イースト チャイナ ユニバーシティ オブ サイエンス アンド テクノロジー プテリジノン誘導体およびｅｇｆｒ、ｂｌｋ、ｆｌｔ３の阻害剤としての応用
JP2015518863A (ja) * 2012-05-22 2015-07-06 ジェネンテック， インコーポレイテッド Ｎ−置換ベンズアミドおよび疼痛の処置におけるそれらの使用
JP2021527051A (ja) * 2018-06-05 2021-10-11 ラプト・セラピューティクス・インコーポレイテッド ピラゾロ−ピリミジン−アミノ−シクロアルキル化合物及びその治療的使用

Also Published As

Publication number Publication date
AU2008211172A1 (en) 2008-08-07
WO2008094575A3 (en) 2008-12-18
WO2008094602A3 (en) 2008-11-13
US20100190787A1 (en) 2010-07-29
EP2108019A2 (en) 2009-10-14
CA2676658A1 (en) 2008-08-07
AU2008211172A2 (en) 2009-12-17
CA2676665A1 (en) 2008-08-07
JP2010516812A (ja) 2010-05-20
AU2008211108A1 (en) 2008-08-07
EP2108020A2 (en) 2009-10-14
WO2008094575A2 (en) 2008-08-07
US20110281821A9 (en) 2011-11-17
US20100249067A1 (en) 2010-09-30
WO2008094602A2 (en) 2008-08-07
AU2008211108A2 (en) 2010-02-18

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