JP2010531638A5 - - Google Patents

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Publication number
JP2010531638A5
JP2010531638A5 JP2010512360A JP2010512360A JP2010531638A5 JP 2010531638 A5 JP2010531638 A5 JP 2010531638A5 JP 2010512360 A JP2010512360 A JP 2010512360A JP 2010512360 A JP2010512360 A JP 2010512360A JP 2010531638 A5 JP2010531638 A5 JP 2010531638A5
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JP
Japan
Prior art keywords
cell
cells
protein
caspase
nucleic acid
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JP2010512360A
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English (en)
Japanese (ja)
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JP2010531638A (ja
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Priority claimed from PCT/US2008/066774 external-priority patent/WO2008154644A1/en
Publication of JP2010531638A publication Critical patent/JP2010531638A/ja
Publication of JP2010531638A5 publication Critical patent/JP2010531638A5/ja
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JP2010512360A 2007-06-12 2008-06-12 標的化された細胞死 Pending JP2010531638A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94344807P 2007-06-12 2007-06-12
PCT/US2008/066774 WO2008154644A1 (en) 2007-06-12 2008-06-12 Targeted cell death

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013015116A Division JP2013081480A (ja) 2007-06-12 2013-01-30 標的化された細胞死

Publications (2)

Publication Number Publication Date
JP2010531638A JP2010531638A (ja) 2010-09-30
JP2010531638A5 true JP2010531638A5 (enExample) 2012-08-16

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ID=40130220

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2010512360A Pending JP2010531638A (ja) 2007-06-12 2008-06-12 標的化された細胞死
JP2013015116A Pending JP2013081480A (ja) 2007-06-12 2013-01-30 標的化された細胞死

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2013015116A Pending JP2013081480A (ja) 2007-06-12 2013-01-30 標的化された細胞死

Country Status (7)

Country Link
US (4) US8124749B2 (enExample)
EP (1) EP2167688A4 (enExample)
JP (2) JP2010531638A (enExample)
AU (1) AU2008261644B2 (enExample)
CA (1) CA2690815A1 (enExample)
IL (4) IL202701A (enExample)
WO (1) WO2008154644A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8124749B2 (en) * 2007-06-12 2012-02-28 Case Western Reserve University Targeted cell death
EP2473031A4 (en) * 2009-09-02 2013-12-04 Univ Chicago METHOD AND SYSTEMS FOR THE INDUCIBLE ABERMENTATION OF NERVE CELLS
US8269827B2 (en) * 2009-09-29 2012-09-18 General Electric Company System and methods for mapping fluorescent images into a bright field color space
WO2012177927A1 (en) 2011-06-21 2012-12-27 Mayo Foundation For Medical Education And Research Transgenic animals capable of being induced to delete senescent cells
WO2013070079A2 (en) * 2011-11-10 2013-05-16 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk, miRNA IN BLOOD BRAIN BARRIER OF MS PATIENTS
WO2013158664A2 (en) 2012-04-17 2013-10-24 Kythera Biopharmaceuticals, Inc. Use of engineered viruses to specifically kill senescent cells
US9901080B2 (en) 2012-08-23 2018-02-27 Buck Institute For Research On Aging Transgenic mouse having a transgene that converts a prodrug into a cytotoxic compound in senescent cells
US9901081B2 (en) 2012-08-23 2018-02-27 Buck Institute For Research On Aging Transgenic mouse for determining the role of senescent cells in cancer
AU2013204922B2 (en) 2012-12-20 2015-05-14 Celgene Corporation Chimeric antigen receptors
CN105518018B (zh) * 2013-03-15 2020-04-03 细胞基因公司 修饰的t淋巴细胞
EP2978854A4 (en) 2013-03-24 2017-01-11 Oisin Biotechnologies Systems and methods for the targeted production of a therapeutic protein within a target cell
RU2022105597A (ru) 2016-11-14 2022-04-04 Тулджен Инкорпорейтед Искусственно созданная система управления функцией шк
CA3047140A1 (en) 2017-01-09 2018-07-12 Oisin Biotechnologies Constructs for expression of therapeutic proteins in target cells
CN112312918A (zh) 2018-04-18 2021-02-02 奥依信生物技术公司 促融合脂质纳米粒和制备其的方法以及其用于靶细胞特异性产生治疗蛋白和治疗与靶细胞有关的疾病、病况或障碍的用途
CN115197989A (zh) * 2021-04-09 2022-10-18 中国科学院分子细胞科学卓越创新中心 基于细胞死活表型的药物靶点拮抗剂的新型筛选系统

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4873191A (en) * 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
US5071773A (en) * 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
US5175385A (en) * 1987-09-03 1992-12-29 Ohio University/Edison Animal Biotechnolgy Center Virus-resistant transgenic mice
US6677311B1 (en) * 1988-07-20 2004-01-13 The Salk Institute For Biological Studies Inducible HSV-TK in transformed cell populations
FR2637803B1 (fr) * 1988-10-19 1993-07-09 Ire Celltarg Sa Ligands specifiques de recepteurs d'hormones steroides estrogenes et progestagenes, application et produits intermediaires de synthese
US5175384A (en) * 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
WO1994029442A2 (en) * 1993-06-14 1994-12-22 Basf Aktiengesellschaft Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters
US5464758A (en) * 1993-06-14 1995-11-07 Gossen; Manfred Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters
US5589362A (en) * 1993-06-14 1996-12-31 Basf Aktiengesellschaft Tetracycline regulated transcriptional modulators with altered DNA binding specificities
FR2717824B1 (fr) * 1994-03-25 1996-04-26 Rhone Poulenc Rorer Sa Virus recombinants, préparation et utilisation en thérapie génique.
AU5103996A (en) * 1995-03-09 1996-10-02 Bavarian Nordic Research Institute A/S Vectors carrying therapeutic genes encoding antimicrobial peptides for gene therapy
US6143557A (en) * 1995-06-07 2000-11-07 Life Technologies, Inc. Recombination cloning using engineered recombination sites
US5837837A (en) * 1997-02-27 1998-11-17 Millennium Pharmaceuticals, Inc. Nucleic acids molecules encoding Caspase-8h and Caspase-8i
US6472520B2 (en) * 1997-03-21 2002-10-29 The Trustees Of Columbia University In The City Of New York Rat PEG-3 promoter
US20030110524A1 (en) * 1997-07-28 2003-06-12 Bradley Michael John Stringer Transgenic organisms and their uses
US6982082B1 (en) * 1997-08-27 2006-01-03 President And Fellows Of Harvard College Gene therapy by cell specific targeting
US6984635B1 (en) * 1998-02-13 2006-01-10 Board Of Trustees Of The Leland Stanford Jr. University Dimerizing agents, their production and use
US6235872B1 (en) * 1998-03-12 2001-05-22 The Burnham Institute Proapoptotic peptides dependence polypeptides and methods of use
US7033595B1 (en) * 1998-08-04 2006-04-25 Purdue Research Foundation Pseudotyped retroviruses and stable cell lines for their production
JP5213202B2 (ja) * 1998-10-28 2013-06-19 バイシス・インコーポレーテツド 細胞アレイならびに遺伝障害マーカーの検出および使用方法
US6313373B1 (en) * 1998-10-30 2001-11-06 Case Western Reserve University Tissue specific promoters and transgenic mouse for the screening of pharmaceuticals
US7109317B1 (en) 1998-11-06 2006-09-19 President And Fellows Of Harvard College FK506-based regulation of biological events
US6903244B1 (en) * 1999-02-26 2005-06-07 University Of Utah Research Foundation Mice which are +/− or −/− for the elastin gene as models for vascular disease
US6881555B2 (en) 1999-03-19 2005-04-19 Aventis Pharmaceuticals Inc. AKT nucleic acids, polypeptides, and uses thereof
US6890726B1 (en) * 1999-04-06 2005-05-10 Oklahoma Medical Research Foundation Method for selecting recombinase variants with altered specificity
JP2004500197A (ja) * 2000-02-08 2004-01-08 コーネル リサーチ ファンデーション インコーポレーテッド 光ファイバーを通じた蛍光分光用の多光子励起
US7196182B2 (en) * 2000-05-24 2007-03-27 The Burnham Institute Card domain containing polypeptides, encoding nucleic acids, and methods of use
US6781029B2 (en) * 2000-07-13 2004-08-24 University Of South Florida Transgenic animal and methods
US6891081B1 (en) * 2000-08-14 2005-05-10 The Trustees Of Columbia University In The City Of New York Transgenic mice over-expressing amyloid-beta alcohol dehydrogenase (ABAD) in brain as model of alzheimer's disease and uses thereof
US6753456B2 (en) * 2000-09-07 2004-06-22 California Institute Of Technology Point mutant mice with hypersensitive alpha 4 nicotinic receptors: dopaminergic pathology and increased anxiety
US6967725B2 (en) * 2000-10-13 2005-11-22 Lucent Technologies Inc. System and method for optical scanning
AU2002239538A1 (en) * 2000-12-06 2002-06-18 Deltagen, Inc. Transgenic mice containing glucagon receptor gene disruptions
EP1360173A2 (en) * 2001-01-25 2003-11-12 Guilford Pharmaceuticals Inc. Trisubstituted carbocyclic cyclophilin binding compounds and their use
US7169564B1 (en) * 2001-06-26 2007-01-30 Anaderm Research Corporation FKBP51/52 and CyP40-mediated mammalian hair growth
JP2005516732A (ja) * 2002-02-14 2005-06-09 ザ プロクター アンド ギャンブル カンパニー 使い捨て排泄物収集器
US7153685B2 (en) 2002-03-11 2006-12-26 The Board Of Trustees Of The University Of Illinois Tamoxifen and 4-hydroxytamoxifen-activated system for regulated production of proteins in eukaryotic cells
US20060030541A1 (en) * 2002-04-05 2006-02-09 Proskelia Genes involved in osteogenesis, and methods of use
US20060034767A1 (en) * 2002-07-05 2006-02-16 Roger Williams Medical Center Targeting and tracking of cells to specific organs and tissues in vivo
US20050143330A1 (en) * 2002-09-30 2005-06-30 Ron Mandel Method for the treatment of Parkinson's Disease
US7638331B2 (en) * 2004-01-02 2009-12-29 The Administration of the Tulane Rducation Fund Directed apoptosis in COX-2 overexpressing cancer cells through expression targeted gene delivery
EP1711597B1 (en) * 2004-01-14 2012-03-07 Novahep AB Human hepatic progenitor cells and methods of use thereof
US20060052327A1 (en) * 2004-09-07 2006-03-09 Lin Liu Cell specific gene silencing using cell-specific promoters in vitro and in vivo
US20090010873A1 (en) * 2004-11-29 2009-01-08 Yeda Research And Development Co. Ltd. Methods of Cell Therapy, Neurogenesis and Oligodendrogenesis
EP1710316A1 (en) * 2005-04-08 2006-10-11 Max-Delbrück-Centrum Für Molekulare Medizin Reconstructed human mariner transposon capable of stable gene transfer into chromosomes in vertebrates
US7423194B2 (en) * 2005-06-14 2008-09-09 University Of Chicago Animal models for demyelination disorders
EP1909562A4 (en) * 2005-06-14 2015-04-08 Univ Chicago METHOD FOR TREATING MYELIN LOSS STATES
US8124749B2 (en) * 2007-06-12 2012-02-28 Case Western Reserve University Targeted cell death

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