JP2010529997A5 - - Google Patents
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- Publication number
- JP2010529997A5 JP2010529997A5 JP2010512373A JP2010512373A JP2010529997A5 JP 2010529997 A5 JP2010529997 A5 JP 2010529997A5 JP 2010512373 A JP2010512373 A JP 2010512373A JP 2010512373 A JP2010512373 A JP 2010512373A JP 2010529997 A5 JP2010529997 A5 JP 2010529997A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- thrombin
- sucrose
- concentration
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 75
- 239000000203 mixture Substances 0.000 claims description 75
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 45
- 229930006000 Sucrose Natural products 0.000 claims description 45
- 239000005720 sucrose Substances 0.000 claims description 45
- 108090000190 Thrombin Proteins 0.000 claims description 43
- 229960004072 thrombin Drugs 0.000 claims description 43
- OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 claims description 26
- 235000019445 benzyl alcohol Nutrition 0.000 claims description 25
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 24
- 229930195725 Mannitol Natural products 0.000 claims description 24
- 239000003085 diluting agent Substances 0.000 claims description 24
- 239000000594 mannitol Substances 0.000 claims description 24
- 235000010355 mannitol Nutrition 0.000 claims description 24
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 16
- 239000000243 solution Substances 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 15
- 239000003755 preservative agent Substances 0.000 claims description 15
- 230000002335 preservative effect Effects 0.000 claims description 15
- 239000000872 buffer Substances 0.000 claims description 14
- 229960004926 chlorobutanol Drugs 0.000 claims description 13
- 239000011780 sodium chloride Substances 0.000 claims description 10
- 229960003766 thrombin (human) Drugs 0.000 claims description 10
- 239000007864 aqueous solution Substances 0.000 claims description 6
- 241000283690 Bos taurus Species 0.000 claims description 4
- 230000003385 bacteriostatic effect Effects 0.000 claims description 4
- 229920005862 polyol Polymers 0.000 claims description 4
- 150000003077 polyols Chemical class 0.000 claims description 4
- 108010015680 recombinant human thrombin Proteins 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 239000004094 surface-active agent Substances 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 239000004705 High-molecular-weight polyethylene Substances 0.000 claims description 2
- 239000007983 Tris buffer Substances 0.000 claims description 2
- 239000008351 acetate buffer Substances 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 150000001720 carbohydrates Chemical class 0.000 claims description 2
- 239000007979 citrate buffer Substances 0.000 claims description 2
- 239000011248 coating agent Substances 0.000 claims description 2
- 238000000576 coating method Methods 0.000 claims description 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 239000008363 phosphate buffer Substances 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 239000008362 succinate buffer Substances 0.000 claims description 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 2
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims 1
- 239000006199 nebulizer Substances 0.000 claims 1
- 239000012190 activator Substances 0.000 description 4
- 241000124008 Mammalia Species 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 108010014173 Factor X Proteins 0.000 description 1
- 241000272112 Oxyuranus scutellatus Species 0.000 description 1
- 108010094028 Prothrombin Proteins 0.000 description 1
- 102100027378 Prothrombin Human genes 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 108010085662 ecarin Proteins 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 108010071286 prethrombins Proteins 0.000 description 1
- 229940039716 prothrombin Drugs 0.000 description 1
- 238000003998 size exclusion chromatography high performance liquid chromatography Methods 0.000 description 1
- 239000003998 snake venom Substances 0.000 description 1
- 239000002435 venom Substances 0.000 description 1
- 210000001048 venom Anatomy 0.000 description 1
- 231100000611 venom Toxicity 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94422407P | 2007-06-15 | 2007-06-15 | |
| US60/944,224 | 2007-06-15 | ||
| PCT/US2008/066850 WO2008157304A2 (en) | 2007-06-15 | 2008-06-13 | Stabilized thrombin compositions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010529997A JP2010529997A (ja) | 2010-09-02 |
| JP2010529997A5 true JP2010529997A5 (cg-RX-API-DMAC7.html) | 2012-05-17 |
| JP5253501B2 JP5253501B2 (ja) | 2013-07-31 |
Family
ID=40132545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010512373A Expired - Fee Related JP5253501B2 (ja) | 2007-06-15 | 2008-06-13 | 安定化トロンビン組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8071090B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2167041B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5253501B2 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008266094B2 (cg-RX-API-DMAC7.html) |
| CA (2) | CA2937487C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2397234T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL202306A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008157304A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101558310B (zh) * | 2006-12-21 | 2013-05-08 | 积水医疗株式会社 | 含凝血酶的溶液中的α-凝血酶的稳定化方法 |
| EP2822474B1 (en) | 2012-03-06 | 2018-05-02 | Ferrosan Medical Devices A/S | Pressurized container containing haemostatic paste |
| EP2977066A3 (en) | 2012-06-12 | 2016-07-27 | Ferrosan Medical Devices A/S | Dry haemostatic composition |
| US9149529B2 (en) | 2012-10-24 | 2015-10-06 | Orthovita, Inc. | Stable compositions containing thrombin and methods for preparation and use thereof |
| EP3010419B1 (en) | 2013-06-21 | 2020-05-20 | Ferrosan Medical Devices A/S | Vacuum expanded dry composition and syringe for retaining same |
| IL229134A0 (en) | 2013-10-29 | 2014-03-31 | Omrix Biopharmaceuticals Ltd | Compounds and methods for stabilizing thrombin activity |
| JP6489485B2 (ja) | 2013-12-11 | 2019-03-27 | フェロサン メディカル デバイシーズ エイ／エス | 押し出し増強因子を含んでいる乾燥組成物 |
| IL234246A0 (en) | 2014-08-21 | 2014-11-30 | Omrix Biopharmaceuticals Ltd | Stabilized thrombin |
| CN106999621B (zh) | 2014-10-13 | 2020-07-03 | 弗罗桑医疗设备公司 | 用于止血和伤口愈合的干组合物 |
| BR112017013565B1 (pt) | 2014-12-24 | 2021-12-28 | Ferrosan Medical Devices A/S | Seringa para retenção e mistura de primeira e segunda substâncias |
| US20160264954A1 (en) * | 2015-03-13 | 2016-09-15 | Vitrum Biologies Inc. | Method of stabilizing thrombin and composition thereof |
| CA2986981A1 (en) | 2015-07-03 | 2017-01-12 | Ferrosan Medical Devices A/S | Syringe for mixing two components and for retaining a vacuum in a storage condition |
| AU2019266529B2 (en) | 2018-05-09 | 2024-05-23 | Ethicon Inc. | Method for preparing a haemostatic composition |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3879369A (en) * | 1972-05-12 | 1975-04-22 | Abbott Lab | Anti-coagulant isolation from malayan pit viper using affinity chromatography |
| US4696812A (en) | 1985-10-28 | 1987-09-29 | Warner-Lambert Company | Thrombin preparations |
| JPS6440433A (en) * | 1987-08-05 | 1989-02-10 | Green Cross Corp | Aqueous liquid composition of thrombin |
| US5707996A (en) * | 1995-11-06 | 1998-01-13 | Macleod Pharmaceuticals, Inc. | Pharmaceutical solution and methods for preparation thereof |
| US20060083733A1 (en) * | 2002-01-18 | 2006-04-20 | Fumihide Nishio | High-concentration preparation of soluble thrombomodulin |
| US7928147B2 (en) * | 2002-04-11 | 2011-04-19 | Teva Animal Health, Inc. | Antimicrobial wash and carrier solutions, and uses thereof |
| AU2005265251B2 (en) | 2004-06-22 | 2009-09-10 | Baxter International Inc. | Thrombin compositions |
| US20060270015A1 (en) * | 2005-05-26 | 2006-11-30 | Dan Pawlak | Thrombin purification |
| JP2006160760A (ja) * | 2006-02-03 | 2006-06-22 | Tobishi Pharmaceut Co Ltd | 血管壁内膜肥厚抑制剤 |
-
2008
- 2008-06-13 JP JP2010512373A patent/JP5253501B2/ja not_active Expired - Fee Related
- 2008-06-13 CA CA2937487A patent/CA2937487C/en active Active
- 2008-06-13 EP EP08780809A patent/EP2167041B1/en not_active Not-in-force
- 2008-06-13 ES ES08780809T patent/ES2397234T3/es active Active
- 2008-06-13 AU AU2008266094A patent/AU2008266094B2/en not_active Ceased
- 2008-06-13 WO PCT/US2008/066850 patent/WO2008157304A2/en not_active Ceased
- 2008-06-13 CA CA2687968A patent/CA2687968C/en active Active
- 2008-06-13 US US12/138,922 patent/US8071090B2/en active Active
-
2009
- 2009-11-24 IL IL202306A patent/IL202306A/en not_active IP Right Cessation
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