JP2010529994A5 - - Google Patents
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- Publication number
- JP2010529994A5 JP2010529994A5 JP2010512352A JP2010512352A JP2010529994A5 JP 2010529994 A5 JP2010529994 A5 JP 2010529994A5 JP 2010512352 A JP2010512352 A JP 2010512352A JP 2010512352 A JP2010512352 A JP 2010512352A JP 2010529994 A5 JP2010529994 A5 JP 2010529994A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- deuterium
- hydrogen
- independently
- enantiomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims description 43
- 229910052805 deuterium Inorganic materials 0.000 claims description 43
- 150000001875 compounds Chemical class 0.000 claims description 21
- 229910052739 hydrogen Inorganic materials 0.000 claims description 13
- 239000001257 hydrogen Substances 0.000 claims description 13
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 11
- 150000003839 salts Chemical class 0.000 claims description 5
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94373107P | 2007-06-13 | 2007-06-13 | |
| PCT/US2008/066730 WO2008157240A1 (en) | 2007-06-13 | 2008-06-12 | Substituted piperazines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010529994A JP2010529994A (ja) | 2010-09-02 |
| JP2010529994A5 true JP2010529994A5 (show.php) | 2011-07-28 |
Family
ID=39609397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010512352A Pending JP2010529994A (ja) | 2007-06-13 | 2008-06-12 | 置換ピペラジン |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20080312247A1 (show.php) |
| EP (1) | EP2155697B1 (show.php) |
| JP (1) | JP2010529994A (show.php) |
| KR (1) | KR20100047190A (show.php) |
| CN (1) | CN101835761A (show.php) |
| AU (1) | AU2008266124A1 (show.php) |
| CA (1) | CA2690379A1 (show.php) |
| IL (1) | IL202666A0 (show.php) |
| WO (1) | WO2008157240A1 (show.php) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2139877B1 (en) * | 2007-03-07 | 2011-05-11 | Concert Pharmaceuticals Inc. | Deuterated piperazine derivatives as anti-anginal compounds |
| US20110053968A1 (en) * | 2009-06-09 | 2011-03-03 | Auspex Pharmaceuticals, Inc. | Aminopyrimidine inhibitors of tyrosine kinase |
| US20120301463A1 (en) | 2009-09-30 | 2012-11-29 | President And Fellows Of Harvard College | Methods for Modulation of Autophagy Through the Modulation of Autophagy-Enhancing Gene Products |
| CN101811941A (zh) * | 2010-03-12 | 2010-08-25 | 重庆欣欣向荣精细化工有限公司 | 邻羟基苯基烷基醚的制备方法 |
| CN102295622A (zh) | 2010-06-25 | 2011-12-28 | 上海冠杰生物医药科技有限公司 | 一种雷诺嗪的制备方法 |
| ES2414384T3 (es) * | 2011-05-11 | 2013-07-19 | Ratiopharm Gmbh | Composición de liberación modificada que comprende ranolazina |
| EP2717860A4 (en) * | 2011-06-08 | 2014-11-05 | Sti Pharma Llc | FORMULATION FROM A WATER SOLUBLE AND PHARMACEUTICALLY ACTIVE ORGANIC COMPOUND WITH CONTROLLED ABSORPTION FOR ONLY DAILY APPLICATION |
| WO2014164749A1 (en) | 2013-03-13 | 2014-10-09 | Forma Therapeutics, Inc. | Novel compounds and compositions for inhibition of fasn |
| US20160030426A1 (en) * | 2013-03-14 | 2016-02-04 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| EP3049084A4 (en) * | 2013-09-25 | 2017-03-15 | Cortendo AB (publ) | Novel functionalized 5-(phenoxymethyl)-1,3-dioxane analogs exhibitng cytochrome p450 inhibition |
| US10166183B2 (en) | 2014-02-07 | 2019-01-01 | Auspex Pharmaceuticals, Inc. | Pharmaceutical formulations |
| US10793554B2 (en) | 2018-10-29 | 2020-10-06 | Forma Therapeutics, Inc. | Solid forms of 4-(2-fluoro-4-(1-methyl-1H-benzo[d]imidazol-5-yl)benzoyl)piperazin-1-yl)(1-hydroxycyclopropyl)methanone |
| CN116251072B (zh) * | 2023-03-14 | 2023-09-15 | 郑州大学第一附属医院 | 一种吲哚布芬片及其制备方法、用途 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4567264A (en) * | 1983-05-18 | 1986-01-28 | Syntex (U.S.A.) Inc. | Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry |
| US6221335B1 (en) * | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| US6884429B2 (en) * | 1997-09-05 | 2005-04-26 | Isotechnika International Inc. | Medical devices incorporating deuterated rapamycin for controlled delivery thereof |
| US6479496B1 (en) * | 1998-09-10 | 2002-11-12 | Cv Therapeutics, Inc. | Methods for treating angina with ranolazine |
| US6303607B1 (en) * | 1998-09-10 | 2001-10-16 | Cv Therapeutics, Inc. | Method for administering a sustained release ranolanolazine formulation |
| US6440710B1 (en) * | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
| DE60001623T2 (de) * | 1999-12-03 | 2003-12-18 | Pfizer Products Inc., Groton | Sulfamoylheteroarylpyrazolverbindungen zur Verwendung als analgetisches/entzündungshemmendes Mittel |
| US6396062B1 (en) * | 1999-12-03 | 2002-05-28 | Cymer, Inc. | Portable laser beam monitor |
| EP1134290A3 (en) * | 2000-03-14 | 2004-01-02 | Pfizer Products Inc. | Pharmacophore models for the identification of the CYP2D6 inhibitory potency of selective serotonin reuptake inhibitors |
| TW200413273A (en) * | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
| WO2006008753A1 (en) * | 2004-07-19 | 2006-01-26 | Unichem Laboratories Limited | Crystalline and amorphous form of ranolazine and the process for manufacturing them |
| CA2615678C (en) * | 2005-07-26 | 2015-01-20 | Nycomed Gmbh | Isotopically substituted pantoprazole |
| KR101380190B1 (ko) * | 2005-07-29 | 2014-04-11 | 콘서트 파마슈티컬즈, 인크. | 벤조 〔ｄ〕〔１,３〕―디옥솔 유도체 |
| US20080033011A1 (en) * | 2005-07-29 | 2008-02-07 | Concert Pharmaceuticals Inc. | Novel benzo[d][1,3]-dioxol derivatives |
| BRPI0617987A2 (pt) * | 2005-10-06 | 2011-08-16 | Auspex Pharmaceuticals Inc | composição, composição farmacêutica, forma de dosagem efervescente, composição farmacêutica oral de comprimidos unitários múltiplos, forma de dosagem farmacêutica de liberação prolongada, forma de dosagem farmacêutica revestida entérica, forma de dosagem farmacêutica estável para administração oral a sujeitos mamìferos, método para tratamento de doenças relacionadas a ácido gástrico pela inibição de secreção de ácido gástrico, método para tratamento de uma infecção bacteriana provocada ou mediada por helicobacter pylori, processo para preparar um composto da fórmula 3, processo para preparar um composto da fórmula 5, uso de um composto da fórmula 1 para a preparação de um medicamento para tratamento de doenças relacionadas a ácido gástrico, pela inibição de secreção de ácido gástrico, uso de um composto da fórmula 1 para a preparação de um medicamento para tratamento de uma infecção bacteriana provocada ou mediada por helicobacter pylori uso de um composto da fórmula 1 para a preparação de um medicamento para tratamento de doenças relecionadas a ácido gástrico pela inibição de secreção de ácido gástrico |
| US7750168B2 (en) * | 2006-02-10 | 2010-07-06 | Sigma-Aldrich Co. | Stabilized deuteroborane-tetrahydrofuran complex |
| EP2139877B1 (en) * | 2007-03-07 | 2011-05-11 | Concert Pharmaceuticals Inc. | Deuterated piperazine derivatives as anti-anginal compounds |
-
2008
- 2008-06-12 KR KR1020097025972A patent/KR20100047190A/ko not_active Withdrawn
- 2008-06-12 US US12/138,169 patent/US20080312247A1/en not_active Abandoned
- 2008-06-12 EP EP08770860A patent/EP2155697B1/en not_active Not-in-force
- 2008-06-12 AU AU2008266124A patent/AU2008266124A1/en not_active Abandoned
- 2008-06-12 CN CN200880101588A patent/CN101835761A/zh active Pending
- 2008-06-12 CA CA2690379A patent/CA2690379A1/en not_active Abandoned
- 2008-06-12 JP JP2010512352A patent/JP2010529994A/ja active Pending
- 2008-06-12 WO PCT/US2008/066730 patent/WO2008157240A1/en not_active Ceased
-
2009
- 2009-12-10 IL IL202666A patent/IL202666A0/en unknown
-
2011
- 2011-01-06 US US12/985,709 patent/US20110160154A1/en not_active Abandoned
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