JP2010529958A5 - - Google Patents
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- JP2010529958A5 JP2010529958A5 JP2010510812A JP2010510812A JP2010529958A5 JP 2010529958 A5 JP2010529958 A5 JP 2010529958A5 JP 2010510812 A JP2010510812 A JP 2010510812A JP 2010510812 A JP2010510812 A JP 2010510812A JP 2010529958 A5 JP2010529958 A5 JP 2010529958A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- group
- disease
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 208000015122 neurodegenerative disease Diseases 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 7
- 102000040430 polynucleotide Human genes 0.000 claims 5
- 108091033319 polynucleotide Proteins 0.000 claims 5
- 239000002157 polynucleotide Substances 0.000 claims 5
- 229920001184 polypeptide Polymers 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 230000004770 neurodegeneration Effects 0.000 claims 4
- 101710106007 Nucleoredoxin-like protein 2 Proteins 0.000 claims 3
- 241000282414 Homo sapiens Species 0.000 claims 2
- 208000023105 Huntington disease Diseases 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 210000004102 animal cell Anatomy 0.000 claims 2
- 210000003169 central nervous system Anatomy 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 210000002569 neuron Anatomy 0.000 claims 2
- 108091008695 photoreceptors Proteins 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000034461 Progressive cone dystrophy Diseases 0.000 claims 1
- 108010029485 Protein Isoforms Proteins 0.000 claims 1
- 102000001708 Protein Isoforms Human genes 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 201000008615 cone dystrophy Diseases 0.000 claims 1
- 230000007850 degeneration Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07109652.3 | 2007-06-05 | ||
| EP07109652A EP2027889A1 (en) | 2007-06-05 | 2007-06-05 | New neuronal viability factor and use thereof |
| PCT/EP2008/057031 WO2008148860A1 (en) | 2007-06-05 | 2008-06-05 | New neuronal viability factor and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010529958A JP2010529958A (ja) | 2010-09-02 |
| JP2010529958A5 true JP2010529958A5 (OSRAM) | 2011-07-21 |
| JP5671678B2 JP5671678B2 (ja) | 2015-02-18 |
Family
ID=38573348
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010510812A Active JP5671678B2 (ja) | 2007-06-05 | 2008-06-05 | ニューロン生存因子およびその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (5) | US9575075B2 (OSRAM) |
| EP (2) | EP2027889A1 (OSRAM) |
| JP (1) | JP5671678B2 (OSRAM) |
| ES (1) | ES2623464T3 (OSRAM) |
| WO (1) | WO2008148860A1 (OSRAM) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1625210B1 (en) | 2003-05-21 | 2010-12-01 | Genzyme Corporation | Methods for producing preparations of recombinant aav virions substantially free of empty capsids |
| EP2027889A1 (en) * | 2007-06-05 | 2009-02-25 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | New neuronal viability factor and use thereof |
| US9567382B2 (en) | 2008-04-15 | 2017-02-14 | Genzyme Corporation | Methods to produce rod-derived cone viability factor (RdCVF) |
| EP2383286A1 (en) | 2010-04-30 | 2011-11-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treatment of retinal degenerative diseases |
| JP6293664B2 (ja) * | 2011-10-27 | 2018-03-14 | ウェルスタット オフサルミクス コーポレイション | 桿体由来錐体生存因子をコードするベクター |
| US9265786B1 (en) * | 2012-03-30 | 2016-02-23 | University Of Wyoming | Method for reducing protein misfolding and accumulation in Huntington'S disease cells |
| WO2016185242A1 (en) | 2015-05-21 | 2016-11-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Synergistic combination of neuronal viability factors and uses thereof |
| MX2018015596A (es) * | 2016-10-11 | 2019-03-14 | Wellstat Ophthalmics Corp | Proteina de fusion entre el factor de viabilidad de los conos derivado de bastones de forma corta y un peptido hidrofilo. |
| WO2018134168A1 (en) | 2017-01-17 | 2018-07-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of expressing a polynucleotide of interest in the cone photoreceptors |
| US11723988B2 (en) | 2017-10-20 | 2023-08-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of expressing a polynucleotide of interest in the cone photoreceptors of a subject comprising the subretinal delivery of a therapeutically effective amount of a recombinant AAV9-derived vector |
| DK3728610T5 (da) | 2017-12-22 | 2024-08-26 | Sparingvision | Konstrukter omfattende neuronale viabilitetsfaktorer og anvendelser heraf |
| EP4326339B1 (en) | 2021-04-20 | 2025-04-02 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Compositions and methods for treating retinal degenerative disorders |
| US20250276088A1 (en) * | 2021-07-07 | 2025-09-04 | Institut National de la Santé et de la Recherche Médicale | Synergistic combination of rdcfv2 and rdcvf2l for the treatment of tauopathies |
| CN120303405A (zh) | 2022-10-20 | 2025-07-11 | 节约视觉公司 | 用于治疗视网膜退行性疾病的组合物和方法 |
| WO2024206928A1 (en) | 2023-03-30 | 2024-10-03 | Pharma Cinq, Llc | VECTOR ENCODING ROD-DERIVED CONE VIABILITY FACTOR AND HUMAN IgK SIGNAL SEQUENCE |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1242443A4 (en) | 1999-12-23 | 2005-06-22 | Nuvelo Inc | NEW NUCLEIC ACIDS AND POLYPEPTIDES |
| FR2823221B1 (fr) * | 2001-04-06 | 2004-04-02 | Univ Pasteur | Sequences associees a la degenerescence retinienne et applications |
| FR2870241B1 (fr) * | 2004-05-13 | 2015-02-27 | Novartis Ag | Facteur de viabilite des cones derive des batonnets ou rdcvf et applications |
| US20090011040A1 (en) * | 2007-05-02 | 2009-01-08 | Naash Muna I | Use of compacted nucleic acid nanoparticles in non-viral treatments of ocular diseases |
| EP2027889A1 (en) * | 2007-06-05 | 2009-02-25 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | New neuronal viability factor and use thereof |
| ES2582559T3 (es) * | 2007-12-06 | 2016-09-13 | Inserm - Institut National De La Santé Et De La Recherche Médicale | Factor trófico para el tratamiento de las enfermedades degenerativas de la retina |
| WO2010029130A1 (en) * | 2008-09-10 | 2010-03-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Neuronal viability factor and use thereof |
| JP6293664B2 (ja) * | 2011-10-27 | 2018-03-14 | ウェルスタット オフサルミクス コーポレイション | 桿体由来錐体生存因子をコードするベクター |
| WO2016185242A1 (en) * | 2015-05-21 | 2016-11-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Synergistic combination of neuronal viability factors and uses thereof |
| US11723988B2 (en) * | 2017-10-20 | 2023-08-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of expressing a polynucleotide of interest in the cone photoreceptors of a subject comprising the subretinal delivery of a therapeutically effective amount of a recombinant AAV9-derived vector |
| DK3728610T5 (da) * | 2017-12-22 | 2024-08-26 | Sparingvision | Konstrukter omfattende neuronale viabilitetsfaktorer og anvendelser heraf |
-
2007
- 2007-06-05 EP EP07109652A patent/EP2027889A1/en not_active Withdrawn
-
2008
- 2008-06-05 ES ES08760606.7T patent/ES2623464T3/es active Active
- 2008-06-05 WO PCT/EP2008/057031 patent/WO2008148860A1/en not_active Ceased
- 2008-06-05 JP JP2010510812A patent/JP5671678B2/ja active Active
- 2008-06-05 EP EP08760606.7A patent/EP2175932B1/en active Active
- 2008-06-05 US US12/602,736 patent/US9575075B2/en active Active
-
2016
- 2016-07-08 US US15/205,797 patent/US20170014478A1/en not_active Abandoned
-
2018
- 2018-10-02 US US16/149,420 patent/US20190064189A1/en not_active Abandoned
-
2019
- 2019-12-12 US US16/711,492 patent/US11428698B2/en active Active
-
2022
- 2022-07-18 US US17/866,900 patent/US20220404376A1/en not_active Abandoned
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