JP2010529262A - 持続効果の消毒洗浄剤 - Google Patents
持続効果の消毒洗浄剤 Download PDFInfo
- Publication number
- JP2010529262A JP2010529262A JP2010511369A JP2010511369A JP2010529262A JP 2010529262 A JP2010529262 A JP 2010529262A JP 2010511369 A JP2010511369 A JP 2010511369A JP 2010511369 A JP2010511369 A JP 2010511369A JP 2010529262 A JP2010529262 A JP 2010529262A
- Authority
- JP
- Japan
- Prior art keywords
- cationic
- skin
- compound
- soap
- detergent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
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- XLKZJJVNBQCVIX-UHFFFAOYSA-N tetradecane-1,14-diol Chemical compound OCCCCCCCCCCCCCCO XLKZJJVNBQCVIX-UHFFFAOYSA-N 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 229940100617 topical lotion Drugs 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 229960000306 zinc gluconate Drugs 0.000 description 1
- 235000011478 zinc gluconate Nutrition 0.000 description 1
- 239000011670 zinc gluconate Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
- A01N31/16—Oxygen or sulfur directly attached to an aromatic ring system with two or more oxygen or sulfur atoms directly attached to the same aromatic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Detergent Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94261007P | 2007-06-07 | 2007-06-07 | |
| PCT/US2008/066142 WO2008154395A1 (en) | 2007-06-07 | 2008-06-06 | Prolonged effect disinfectant cleanser |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010529262A true JP2010529262A (ja) | 2010-08-26 |
| JP2010529262A5 JP2010529262A5 (https=) | 2011-07-21 |
Family
ID=40130153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010511369A Pending JP2010529262A (ja) | 2007-06-07 | 2008-06-06 | 持続効果の消毒洗浄剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20100216889A1 (https=) |
| EP (1) | EP2152071A4 (https=) |
| JP (1) | JP2010529262A (https=) |
| BR (1) | BRPI0812214A2 (https=) |
| CA (1) | CA2690860A1 (https=) |
| IL (1) | IL202546A0 (https=) |
| MX (1) | MX2009013317A (https=) |
| WO (1) | WO2008154395A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015501816A (ja) * | 2011-12-07 | 2015-01-19 | ロチャル インダストリーズ エルエルピーRochal Industries,Llp | 殺菌組成物及び該殺菌組成物の使用方法 |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0104153D0 (en) | 2001-02-20 | 2001-04-11 | Reckitt Benckiser Inc | Improvements in or relating to organic compositions |
| EP2166840B1 (en) * | 2007-06-20 | 2017-01-11 | The Trustees of Columbia University in the City of New York | Bio-film resistant surfaces |
| US9511040B2 (en) | 2007-06-20 | 2016-12-06 | The Trustees Of Columbia University In The City Of New York | Skin and surface disinfectant compositions containing botanicals |
| US9687429B2 (en) | 2007-06-20 | 2017-06-27 | The Trustees Of Columbia University In The City Of New York | Antimicrobial compositions containing low concentrations of botanicals |
| US9981069B2 (en) | 2007-06-20 | 2018-05-29 | The Trustees Of Columbia University In The City Of New York | Bio-film resistant surfaces |
| JP5663181B2 (ja) * | 2010-03-30 | 2015-02-04 | 小林製薬株式会社 | トイレ洗浄用組成物 |
| FR2968942B1 (fr) * | 2010-12-21 | 2016-02-12 | Oreal | Composition cosmetique comprenant un sel de zinc et du 1,2-octanediol |
| AU2012332495B2 (en) | 2011-11-03 | 2017-06-08 | The Trustees Of Columbia University In The City Of New York | Composition with sustained antimicrobial activity |
| US9968101B2 (en) | 2011-11-03 | 2018-05-15 | The Trustees Of Columbia University In The City Of New York | Botanical antimicrobial compositions |
| TW201330856A (zh) | 2011-12-06 | 2013-08-01 | Univ Columbia | 廣效性的天然防腐組成物 |
| US8481480B1 (en) * | 2012-04-30 | 2013-07-09 | Uyen T. Lam | Anti-adherent formulation including a quaternary ammonium compound and a fatty alcohol |
| DE102012208291A1 (de) | 2012-05-16 | 2013-11-21 | Schülke & Mayr GmbH | Antimikrobiell wirksame Zusammensetzungen auf Basis von Zinkverbindung, Glycerinmonoalkylether und Antioxidans |
| GB201211702D0 (en) * | 2012-07-02 | 2012-08-15 | Reckitt Benckiser Llc | Sprayable aqueous alcoholic microbicidal compostions comprising zinc ions |
| GB201211701D0 (en) | 2012-07-02 | 2012-08-15 | Reckitt Benckiser Llc | Aqueous alcoholic microbicidal compositions comprising zinc ions |
| GB201211691D0 (en) | 2012-07-05 | 2012-08-15 | Reckitt Benckiser Llc | Sprayable aqueous alcoholic microbicidal compositions comprising zinc ions |
| GB201211688D0 (en) | 2012-07-02 | 2012-08-15 | Reckitt Benckiser Llc | Aqueous alcoholic microbicidal compositions comprising zinc ions |
| EP2874616B1 (en) | 2012-07-23 | 2026-01-21 | Innovative Biodefense Inc. | Topical sanitizing formulations and uses thereof |
| WO2014083330A1 (en) | 2012-11-30 | 2014-06-05 | Reckitt & Colman (Overseas) Limited | Microbicidal personal care compositions comprising metal ions |
| US8603550B1 (en) | 2013-05-15 | 2013-12-10 | Normajean Fusco | Compositions for topical treatment |
| US10842147B2 (en) | 2014-11-26 | 2020-11-24 | Microban Products Company | Surface disinfectant with residual biocidal property |
| US10834922B2 (en) | 2014-11-26 | 2020-11-17 | Microban Products Company | Surface disinfectant with residual biocidal property |
| US10925281B2 (en) | 2014-11-26 | 2021-02-23 | Microban Products Company | Surface disinfectant with residual biocidal property |
| US11033023B2 (en) | 2014-11-26 | 2021-06-15 | Microban Products Company | Surface disinfectant with residual biocidal property |
| US11634666B2 (en) * | 2015-12-22 | 2023-04-25 | 3M Innovative Properties Company | Methods for spore removal comprising a polysorbate surfactant and cationic antimicrobial mixture |
| US10799433B2 (en) | 2016-04-20 | 2020-10-13 | S. C. Johnson & Son, Inc. | Foaming antimicrobial compositions |
| US11503824B2 (en) | 2016-05-23 | 2022-11-22 | Microban Products Company | Touch screen cleaning and protectant composition |
| CN111514175A (zh) * | 2020-04-24 | 2020-08-11 | 嘉兴力山明朗生物医药科技有限公司 | 一种免洗抗菌喷剂及其制备方法 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004182673A (ja) * | 2002-12-05 | 2004-07-02 | Mandom Corp | 皮膚洗浄剤組成物 |
| JP2004307568A (ja) * | 2003-04-02 | 2004-11-04 | Kose Corp | 洗浄料組成物 |
| JP2006143621A (ja) * | 2004-11-17 | 2006-06-08 | Kao Corp | 抗菌剤 |
| JP2006160822A (ja) * | 2004-12-03 | 2006-06-22 | Kao Corp | 衣料用液体洗浄剤 |
| WO2006074359A2 (en) * | 2005-01-07 | 2006-07-13 | The Trustees Of Columbia University In The City Of New York | Non-irritating compositions containing zinc salts |
| JP2007126581A (ja) * | 2005-11-04 | 2007-05-24 | Diversey Ip Internatl Bv | 硬表面用除菌洗浄剤組成物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6017561A (en) * | 1997-04-04 | 2000-01-25 | The Clorox Company | Antimicrobial cleaning composition |
| JP3724988B2 (ja) * | 1999-07-30 | 2005-12-07 | 信越化学工業株式会社 | 新規シリコーン化合物及びそれを含有してなる化粧料 |
| EP1898952B1 (en) * | 2005-06-17 | 2012-09-12 | Symrise AG | Synergistic mixtures of aromatic alcohols and derivatives thereof with tropolone |
| EP1948236B1 (en) * | 2005-09-27 | 2021-03-03 | Special Water Patents B.V. | Methods and compositions for treatment of skin |
-
2008
- 2008-06-06 US US12/663,231 patent/US20100216889A1/en not_active Abandoned
- 2008-06-06 MX MX2009013317A patent/MX2009013317A/es unknown
- 2008-06-06 WO PCT/US2008/066142 patent/WO2008154395A1/en not_active Ceased
- 2008-06-06 JP JP2010511369A patent/JP2010529262A/ja active Pending
- 2008-06-06 BR BRPI0812214A patent/BRPI0812214A2/pt not_active IP Right Cessation
- 2008-06-06 CA CA2690860A patent/CA2690860A1/en not_active Abandoned
- 2008-06-06 EP EP08770357A patent/EP2152071A4/en not_active Withdrawn
-
2009
- 2009-12-06 IL IL202546A patent/IL202546A0/en unknown
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004182673A (ja) * | 2002-12-05 | 2004-07-02 | Mandom Corp | 皮膚洗浄剤組成物 |
| JP2004307568A (ja) * | 2003-04-02 | 2004-11-04 | Kose Corp | 洗浄料組成物 |
| JP2006143621A (ja) * | 2004-11-17 | 2006-06-08 | Kao Corp | 抗菌剤 |
| JP2006160822A (ja) * | 2004-12-03 | 2006-06-22 | Kao Corp | 衣料用液体洗浄剤 |
| WO2006074359A2 (en) * | 2005-01-07 | 2006-07-13 | The Trustees Of Columbia University In The City Of New York | Non-irritating compositions containing zinc salts |
| JP2007126581A (ja) * | 2005-11-04 | 2007-05-24 | Diversey Ip Internatl Bv | 硬表面用除菌洗浄剤組成物 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015501816A (ja) * | 2011-12-07 | 2015-01-19 | ロチャル インダストリーズ エルエルピーRochal Industries,Llp | 殺菌組成物及び該殺菌組成物の使用方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| MX2009013317A (es) | 2010-01-29 |
| US20100216889A1 (en) | 2010-08-26 |
| IL202546A0 (en) | 2010-06-30 |
| WO2008154395A1 (en) | 2008-12-18 |
| CA2690860A1 (en) | 2008-12-18 |
| BRPI0812214A2 (pt) | 2016-08-02 |
| EP2152071A4 (en) | 2012-08-15 |
| EP2152071A1 (en) | 2010-02-17 |
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