JP2010528644A5 - - Google Patents
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- JP2010528644A5 JP2010528644A5 JP2010510871A JP2010510871A JP2010528644A5 JP 2010528644 A5 JP2010528644 A5 JP 2010528644A5 JP 2010510871 A JP2010510871 A JP 2010510871A JP 2010510871 A JP2010510871 A JP 2010510871A JP 2010528644 A5 JP2010528644 A5 JP 2010528644A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- tissue
- dna sequence
- cell according
- human animal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 14
- 101100187477 Homo sapiens NR1I2 gene Proteins 0.000 claims 6
- 229940079593 drug Drugs 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 108010081668 Cytochrome P-450 CYP3A Proteins 0.000 claims 3
- 102100029363 Cytochrome P450 2C19 Human genes 0.000 claims 3
- 102000004190 Enzymes Human genes 0.000 claims 3
- 108090000790 Enzymes Proteins 0.000 claims 3
- 102000005720 Glutathione transferase Human genes 0.000 claims 3
- 108010070675 Glutathione transferase Proteins 0.000 claims 3
- 241001465754 Metazoa Species 0.000 claims 3
- 102000000804 Pregnane X Receptor Human genes 0.000 claims 3
- 108010001511 Pregnane X Receptor Proteins 0.000 claims 3
- 101100114686 Rattus norvegicus Cyp3a9 gene Proteins 0.000 claims 3
- 101150055214 cyp1a1 gene Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- -1 CYP2B10 Proteins 0.000 claims 2
- 108010078791 Carrier Proteins Proteins 0.000 claims 2
- 102000004328 Cytochrome P-450 CYP3A Human genes 0.000 claims 2
- 102100038739 Cytochrome P450 2B6 Human genes 0.000 claims 2
- 102100024889 Cytochrome P450 2E1 Human genes 0.000 claims 2
- 101000896586 Homo sapiens Cytochrome P450 2D6 Proteins 0.000 claims 2
- 101000896576 Homo sapiens Putative cytochrome P450 2D7 Proteins 0.000 claims 2
- 101000841498 Homo sapiens UDP-glucuronosyltransferase 1A1 Proteins 0.000 claims 2
- 102000004855 Multi drug resistance-associated proteins Human genes 0.000 claims 2
- 108090001099 Multi drug resistance-associated proteins Proteins 0.000 claims 2
- 102000014842 Multidrug resistance proteins Human genes 0.000 claims 2
- 108050005144 Multidrug resistance proteins Proteins 0.000 claims 2
- 101100187479 Mus musculus Nr1i2 gene Proteins 0.000 claims 2
- 108010089503 Organic Anion Transporters Proteins 0.000 claims 2
- 102000007990 Organic Anion Transporters Human genes 0.000 claims 2
- 108010029485 Protein Isoforms Proteins 0.000 claims 2
- 102000001708 Protein Isoforms Human genes 0.000 claims 2
- 102100021702 Putative cytochrome P450 2D7 Human genes 0.000 claims 2
- 102000040945 Transcription factor Human genes 0.000 claims 2
- 108091023040 Transcription factor Proteins 0.000 claims 2
- 108010012052 cytochrome P-450 CYP2C subfamily Proteins 0.000 claims 2
- 108091008053 gene clusters Proteins 0.000 claims 2
- 102100033350 ATP-dependent translocase ABCB1 Human genes 0.000 claims 1
- 102100022595 Broad substrate specificity ATP-binding cassette transporter ABCG2 Human genes 0.000 claims 1
- 108010074918 Cytochrome P-450 CYP1A1 Proteins 0.000 claims 1
- 108010074922 Cytochrome P-450 CYP1A2 Proteins 0.000 claims 1
- 108010020070 Cytochrome P-450 CYP2B6 Proteins 0.000 claims 1
- 108010026925 Cytochrome P-450 CYP2C19 Proteins 0.000 claims 1
- 108010000561 Cytochrome P-450 CYP2C8 Proteins 0.000 claims 1
- 108010000543 Cytochrome P-450 CYP2C9 Proteins 0.000 claims 1
- 108010001237 Cytochrome P-450 CYP2D6 Proteins 0.000 claims 1
- 108010001202 Cytochrome P-450 CYP2E1 Proteins 0.000 claims 1
- 102000002004 Cytochrome P-450 Enzyme System Human genes 0.000 claims 1
- 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 claims 1
- 102100031476 Cytochrome P450 1A1 Human genes 0.000 claims 1
- 102100026533 Cytochrome P450 1A2 Human genes 0.000 claims 1
- 102100029359 Cytochrome P450 2C8 Human genes 0.000 claims 1
- 102100029358 Cytochrome P450 2C9 Human genes 0.000 claims 1
- 102100021704 Cytochrome P450 2D6 Human genes 0.000 claims 1
- 102100039205 Cytochrome P450 3A4 Human genes 0.000 claims 1
- 102000016354 Glucuronosyltransferase Human genes 0.000 claims 1
- 108010092364 Glucuronosyltransferase Proteins 0.000 claims 1
- 101000823298 Homo sapiens Broad substrate specificity ATP-binding cassette transporter ABCG2 Proteins 0.000 claims 1
- 101000957383 Homo sapiens Cytochrome P450 2B6 Proteins 0.000 claims 1
- 101000909131 Homo sapiens Cytochrome P450 2E1 Proteins 0.000 claims 1
- 108091092195 Intron Proteins 0.000 claims 1
- 108010047230 Member 1 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 claims 1
- 108010090306 Member 2 Subfamily G ATP Binding Cassette Transporter Proteins 0.000 claims 1
- 102100021339 Multidrug resistance-associated protein 1 Human genes 0.000 claims 1
- 102000023984 PPAR alpha Human genes 0.000 claims 1
- 102000004357 Transferases Human genes 0.000 claims 1
- 108090000992 Transferases Proteins 0.000 claims 1
- 102100029152 UDP-glucuronosyltransferase 1A1 Human genes 0.000 claims 1
- 102000005421 acetyltransferase Human genes 0.000 claims 1
- 108020002494 acetyltransferase Proteins 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000010348 incorporation Methods 0.000 claims 1
- 108010066052 multidrug resistance-associated protein 1 Proteins 0.000 claims 1
- 108091008725 peroxisome proliferator-activated receptors alpha Proteins 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/757,972 US7759541B2 (en) | 2004-12-13 | 2007-06-04 | Transgenic animals for assessing drug metabolism and toxicity |
| PCT/GB2008/001897 WO2008149080A1 (en) | 2007-06-04 | 2008-06-04 | Transgenic animals for assessing drug metabolism and toxicity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010528644A JP2010528644A (ja) | 2010-08-26 |
| JP2010528644A5 true JP2010528644A5 (enExample) | 2011-07-14 |
Family
ID=39698732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010510871A Pending JP2010528644A (ja) | 2007-06-04 | 2008-06-04 | 薬物の代謝及び毒性を評価するためのトランスジェニック動物 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US7759541B2 (enExample) |
| EP (1) | EP2173160A1 (enExample) |
| JP (1) | JP2010528644A (enExample) |
| AU (1) | AU2008259618A1 (enExample) |
| CA (1) | CA2688438A1 (enExample) |
| IL (1) | IL202127A0 (enExample) |
| IN (1) | IN2009DN07390A (enExample) |
| WO (1) | WO2008149080A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7759541B2 (en) * | 2004-12-13 | 2010-07-20 | Iti Life Sciences | Transgenic animals for assessing drug metabolism and toxicity |
| AU2008322038B2 (en) * | 2007-11-14 | 2012-02-23 | National University Corporation Tottori University | Mammalian artificial chromosome vector comprising human cytochrome P450 gene (cluster) and non-human mammalian animal retaining the same |
| EP4049535B1 (en) | 2009-10-06 | 2024-11-27 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice and engraftment |
| WO2011160573A1 (zh) * | 2010-06-21 | 2011-12-29 | 中国科学院上海生命科学研究院 | 一种生产高活性和高纯度利福霉素sv的方法 |
| US20120023599A1 (en) * | 2010-07-23 | 2012-01-26 | Sigma-Aldrich Co. | Genome editing of cytochrome p450 in animals |
| RU2730643C2 (ru) | 2011-02-15 | 2020-08-24 | Ридженерон Фармасьютикалз, Инк. | Гуманизированные m-csf мыши |
| FR2979453B1 (fr) * | 2011-08-26 | 2016-01-08 | Olea Medical | Systeme et procede pour estimer une quantite d'interet d'un systeme dynamique artere/tissu/veine |
| ES2624605T3 (es) * | 2011-10-28 | 2017-07-17 | Regeneron Pharmaceuticals, Inc. | IL-6 y receptor de IL-6 humanizados |
| US8962913B2 (en) | 2012-06-18 | 2015-02-24 | Regeneron Pharmaceuticals, Inc. | Humanized IL-7 rodents |
| JP6283031B2 (ja) | 2012-09-07 | 2018-02-21 | イエール ユニバーシティ | 遺伝学的に修飾された非ヒト動物およびその使用法 |
| EP3308641B1 (en) * | 2012-11-05 | 2019-07-03 | Regeneron Pharmaceuticals, Inc. | Immunodeficient, genetically modified rodent and methods of use thereof |
| US20140273031A1 (en) * | 2013-03-15 | 2014-09-18 | The Cleveland Clinic Foundation | In-vitro method for monoclonal antibody production |
| HRP20170380T1 (hr) | 2013-10-15 | 2017-05-19 | Regeneron Pharmaceuticals, Inc. | Životinje s humaniziranim il-5 |
| ES2700972T3 (es) * | 2013-11-19 | 2019-02-20 | Regeneron Pharma | Animales no humanos que tienen un gen de factor activador de células B humanizado |
| CA2929774C (en) * | 2013-11-19 | 2020-09-15 | Regeneron Pharmaceuticals, Inc. | Non-human animal cells having a humanized proliferation-inducing ligand gene |
| US9665718B2 (en) | 2014-03-14 | 2017-05-30 | International Business Machines Corporation | Correlating a task with commands to perform a change ticket in an IT system |
| CA2947309A1 (en) | 2014-05-19 | 2015-11-26 | Regeneron Pharmaceuticals, Inc. | Genetically modified non-human animals expressing human epo |
| ES2950399T3 (es) | 2015-04-13 | 2023-10-09 | Regeneron Pharma | Ratones humanizados Sirpa-IL15 insertados y métodos de uso de los mismos |
| JP2019524077A (ja) | 2016-06-27 | 2019-09-05 | ベイラー カレッジ オブ メディスンＢａｙｌｏｒ Ｃｏｌｌｅｇｅ Ｏｆ Ｍｅｄｉｃｉｎｅ | Ｐ４５０オキシドレダクターゼ欠損を有するヒト肝臓キメラ非ヒト動物およびそれを使用する方法 |
| CN109182292B (zh) * | 2018-09-25 | 2022-02-08 | 安徽农业大学 | 一种草莓谷胱甘肽转移酶FaGST基因及其表达蛋白和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6476000A (en) | 1999-08-13 | 2001-03-13 | Kirin Beer Kabushiki Kaisha | Mouse having human cytochrome p450 transferred therein |
| EP1088900A1 (en) | 1999-09-10 | 2001-04-04 | Epidauros Biotechnologie AG | Polymorphisms in the human CYP3A4, CYP3A7 and hPXR genes and their use in diagnostic and therapeutic applications |
| AU2002213660A1 (en) | 2000-11-01 | 2002-05-15 | The University Of Sydney | Transgenic animals for analysing CYP3A4 cytochrome P450 gene regulation |
| AUPR446701A0 (en) | 2001-04-18 | 2001-05-17 | Gene Stream Pty Ltd | Transgenic mammals for pharmacological and toxicological studies |
| JP2003304896A (ja) | 2002-04-15 | 2003-10-28 | Yasushi Yamazoe | ヒトｃｙｐ３ａ誘導能の測定法 |
| GB0216203D0 (en) | 2002-07-12 | 2002-08-21 | Imp Cancer Res Tech | Mondulation of cytochrome P450 reductase activity |
| WO2004022738A1 (en) | 2002-09-09 | 2004-03-18 | California Institute Of Technology | Methods and compositions for the generation of humanized mice |
| WO2006064197A2 (en) | 2004-12-13 | 2006-06-22 | Iti Scotland Limited | Transgenic animals for assessing drug metabolism and toxicity |
| US7759541B2 (en) * | 2004-12-13 | 2010-07-20 | Iti Life Sciences | Transgenic animals for assessing drug metabolism and toxicity |
-
2007
- 2007-06-04 US US11/757,972 patent/US7759541B2/en not_active Expired - Fee Related
-
2008
- 2008-06-04 CA CA002688438A patent/CA2688438A1/en not_active Abandoned
- 2008-06-04 AU AU2008259618A patent/AU2008259618A1/en not_active Abandoned
- 2008-06-04 JP JP2010510871A patent/JP2010528644A/ja active Pending
- 2008-06-04 EP EP08762250A patent/EP2173160A1/en not_active Withdrawn
- 2008-06-04 WO PCT/GB2008/001897 patent/WO2008149080A1/en not_active Ceased
- 2008-06-04 IN IN7390DEN2009 patent/IN2009DN07390A/en unknown
- 2008-06-04 US US12/602,723 patent/US8624079B2/en not_active Expired - Fee Related
-
2009
- 2009-11-15 IL IL202127A patent/IL202127A0/en unknown
-
2010
- 2010-05-26 US US12/787,816 patent/US8212105B2/en not_active Expired - Lifetime
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