IN2009DN07390A - - Google Patents

Download PDF

Info

Publication number
IN2009DN07390A
IN2009DN07390A IN7390DEN2009A IN2009DN07390A IN 2009DN07390 A IN2009DN07390 A IN 2009DN07390A IN 7390DEN2009 A IN7390DEN2009 A IN 7390DEN2009A IN 2009DN07390 A IN2009DN07390 A IN 2009DN07390A
Authority
IN
India
Prior art keywords
human
tissues
derived therefrom
cells derived
relates
Prior art date
Application number
Inventor
Charles Roland Wolf
Nico Scheer
Original Assignee
Iti Scotland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iti Scotland Ltd filed Critical Iti Scotland Ltd
Publication of IN2009DN07390A publication Critical patent/IN2009DN07390A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/80—Cytochromes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Environmental Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Husbandry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention relates to transgenic non-human animals, tissues or cells derived therefrom and methods of producing them. The transgenic non-human animals or tissues or cells derived therefrom provide a system capable of expressing human proteins responsible for drug metabolism in place of the homologous endogenous non-human animal proteins and for the controlled expression of human genes introduced into the animal so that the expression of the human genes is regulated in a manner more closely analogous to that seen in vivo in humans. One aspect of the invention relates to the use of a human DNA sequence comprising at least part of introns 6 and/or 7 of the human PXR gene.
IN7390DEN2009 2007-06-04 2008-06-04 IN2009DN07390A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/757,972 US7759541B2 (en) 2004-12-13 2007-06-04 Transgenic animals for assessing drug metabolism and toxicity
PCT/GB2008/001897 WO2008149080A1 (en) 2007-06-04 2008-06-04 Transgenic animals for assessing drug metabolism and toxicity

Publications (1)

Publication Number Publication Date
IN2009DN07390A true IN2009DN07390A (en) 2015-07-24

Family

ID=39698732

Family Applications (1)

Application Number Title Priority Date Filing Date
IN7390DEN2009 IN2009DN07390A (en) 2007-06-04 2008-06-04

Country Status (8)

Country Link
US (3) US7759541B2 (en)
EP (1) EP2173160A1 (en)
JP (1) JP2010528644A (en)
AU (1) AU2008259618A1 (en)
CA (1) CA2688438A1 (en)
IL (1) IL202127A0 (en)
IN (1) IN2009DN07390A (en)
WO (1) WO2008149080A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7759541B2 (en) 2004-12-13 2010-07-20 Iti Life Sciences Transgenic animals for assessing drug metabolism and toxicity
JP4997544B2 (en) * 2007-11-14 2012-08-08 国立大学法人鳥取大学 Mammalian artificial chromosome vector containing human cytochrome P450 gene (cluster) and non-human mammal having the same
US8541646B2 (en) 2009-10-06 2013-09-24 Regeneron Pharmaceuticals, Inc. Genetically modified mice and engraftment
CN102286398B (en) * 2010-06-21 2014-06-04 中国科学院上海生命科学研究院 Method for producing high-activity and high-purity rifamycin SV
US20120023599A1 (en) * 2010-07-23 2012-01-26 Sigma-Aldrich Co. Genome editing of cytochrome p450 in animals
RU2577978C2 (en) 2011-02-15 2016-03-20 Ридженерон Фармасьютикалз, Инк. Humanised mouse m-csf
FR2979453B1 (en) * 2011-08-26 2016-01-08 Olea Medical SYSTEM AND METHOD FOR ESTIMATING A QUANTITY OF INTEREST IN AN ARTERY / FABRIC / VEIN DYNAMIC SYSTEM
JP6120451B2 (en) 2011-10-28 2017-04-26 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Humanized IL-6 and / or IL-6 receptor
US8962913B2 (en) 2012-06-18 2015-02-24 Regeneron Pharmaceuticals, Inc. Humanized IL-7 rodents
KR102594390B1 (en) 2012-09-07 2023-10-27 예일 유니버시티 Genetically modified non-human animals and methods of use thereof
EP4389764A2 (en) * 2012-11-05 2024-06-26 Regeneron Pharmaceuticals, Inc. Genetically modified non-human animals and methods of use thereof
US20140273031A1 (en) * 2013-03-15 2014-09-18 The Cleveland Clinic Foundation In-vitro method for monoclonal antibody production
EP3461331A1 (en) 2013-10-15 2019-04-03 Regeneron Pharmaceuticals, Inc. Humanized il-15 animals
BR112016011003A2 (en) * 2013-11-19 2017-12-05 Regeneron Pharma genetically modified rodent animal, mouse embryonic stem cell, mouse embryo, and methods for making a rodent animal and grafting human cells into a mouse
AU2014353347B2 (en) * 2013-11-19 2020-07-02 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized a proliferation-inducing ligand gene
US9665718B2 (en) 2014-03-14 2017-05-30 International Business Machines Corporation Correlating a task with commands to perform a change ticket in an IT system
KR102627332B1 (en) 2014-05-19 2024-01-26 리제너론 파마슈티칼스 인코포레이티드 Genetically modified non-human animals expressing human epo
PT3282835T (en) 2015-04-13 2023-07-25 Univ Yale Humanized sirpa-il15 knockin mice and methods of use thereof
CA3027752A1 (en) 2016-06-27 2018-01-04 Baylor College Of Medicine Human liver chimeric non-human animal with deficient p450 oxidoreductase and methods of using same
CN109182292B (en) * 2018-09-25 2022-02-08 安徽农业大学 Strawberry glutathione transferase FaGST gene and expression protein and application thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1206906A4 (en) 1999-08-13 2004-12-29 Kirin Brewery Mouse having human cytochrome p450 transferred therein
EP1088900A1 (en) 1999-09-10 2001-04-04 Epidauros Biotechnologie AG Polymorphisms in the human CYP3A4, CYP3A7 and hPXR genes and their use in diagnostic and therapeutic applications
AU2002213660A1 (en) 2000-11-01 2002-05-15 The University Of Sydney Transgenic animals for analysing CYP3A4 cytochrome P450 gene regulation
AUPR446701A0 (en) 2001-04-18 2001-05-17 Gene Stream Pty Ltd Transgenic mammals for pharmacological and toxicological studies
JP2003304896A (en) 2002-04-15 2003-10-28 Yasushi Yamazoe Method of assaying human cyp3a induction potency
GB0216203D0 (en) 2002-07-12 2002-08-21 Imp Cancer Res Tech Mondulation of cytochrome P450 reductase activity
CA2496233A1 (en) * 2002-09-09 2004-03-18 California Institute Of Technology Methods and compositions for the generation of humanized mice
US7759541B2 (en) * 2004-12-13 2010-07-20 Iti Life Sciences Transgenic animals for assessing drug metabolism and toxicity
EP1827087B8 (en) * 2004-12-13 2012-09-12 ITI Scotland Limited Transgenic animals for assessing drug metabolism and toxicity

Also Published As

Publication number Publication date
US20100235928A1 (en) 2010-09-16
IL202127A0 (en) 2010-06-16
AU2008259618A1 (en) 2008-12-11
US8212105B2 (en) 2012-07-03
JP2010528644A (en) 2010-08-26
US8624079B2 (en) 2014-01-07
WO2008149080A1 (en) 2008-12-11
US20080148416A1 (en) 2008-06-19
US20100257620A1 (en) 2010-10-07
EP2173160A1 (en) 2010-04-14
US7759541B2 (en) 2010-07-20
CA2688438A1 (en) 2008-12-11

Similar Documents

Publication Publication Date Title
IN2009DN07390A (en)
WO2006064197A3 (en) Transgenic animals for assessing drug metabolism and toxicity
HK1118577A1 (en) Rnai expression constructs rnai
WO2007035213A3 (en) Transgenic ungulates expressing ctla4-ig and uses thereof
WO2008155133A3 (en) Fusion protein comprising a caspase domain and a nuclear hormone receptor binding domain and methods and uses thereof
WO2006001021A3 (en) Chimeric avian-based screening system containing mammalian grafts
WO2009007855A3 (en) Reversible sirna-based silencing of mutant and endogenous wild-type huntingtin gene and its application for the treatment of huntington's disease
MX2007007602A (en) Glp-1 agonists, compositions, methods and uses.
EP2302034A3 (en) Improved methods of reprogramming animal somatic cells
BR112016029650A2 (en) rodent, pd-1 polypeptide, isolated cell or rodent tissue, rodent embryonic stem cell, methods of producing a rodent, reducing tumor growth in a rodent, killing tumor cells in a rodent, and evaluating pharmacokinetic properties of a drug that targets human pd-1, and, rodent tumor model?
SG151315A1 (en) Human glp-1 mimetibodies, compositions, methods and uses
BRPI0510206A (en) phenotype identification method, single cell, agent identification methods, agents, therapeutic agents, therapeutic agent evaluation method, pharmaceutical composition, treatment methods, dysfunction prevention or amelioration and modulation methods
MY150595A (en) Nutritional composition to promote healthy development and growth
NZ598769A (en) Transgenic chickens
WO2005111204A3 (en) Porcine forssman synthetase cdna and polypeptide
WO2006074012A3 (en) Facilitated cellular reconstitution of organs and tissues
MX2012000918A (en) System and method of feeding beneficial insects.
WO2004108904A3 (en) Porcine cmp-n-acetylneuraminic acid hydroxylase gene
IL274740B1 (en) Non-human animals comprising a humanized trkb locus
WO2008099280A3 (en) Regulation of expression of pi3kb protein in tumors
WO2005047469A3 (en) PORCINE ISOGLOBOSIDE 3 SYNTHASE PROTEIN, cDNA, GENOMIC ORGANIZATION, AND REGULATORY REGION
WO2005117576A3 (en) Modification of sugar metabolic process in transgenic cells, tissues and animals
HK1204651A1 (en) Expression vector for producing protein derived from foreign gene in large quantity using animal cells, and use thereof
EP1799709A4 (en) Myostatin isoform
MX2007015127A (en) Uses of oligonucleotides stimulatory of the mesenchymal stem cell proliferation.