JP2010527906A5 - - Google Patents
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- Publication number
- JP2010527906A5 JP2010527906A5 JP2009536266A JP2009536266A JP2010527906A5 JP 2010527906 A5 JP2010527906 A5 JP 2010527906A5 JP 2009536266 A JP2009536266 A JP 2009536266A JP 2009536266 A JP2009536266 A JP 2009536266A JP 2010527906 A5 JP2010527906 A5 JP 2010527906A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- glucan
- antigen
- cell
- immune response
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 47
- 239000000427 antigen Substances 0.000 claims 12
- 102000036639 antigens Human genes 0.000 claims 12
- 108091007433 antigens Proteins 0.000 claims 12
- 229920002498 Beta-glucan Polymers 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 9
- 230000028993 immune response Effects 0.000 claims 9
- 229920001503 Glucan Polymers 0.000 claims 8
- 239000002245 particle Substances 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- 239000002671 adjuvant Substances 0.000 claims 3
- 229920002988 biodegradable polymer Polymers 0.000 claims 3
- 239000004621 biodegradable polymer Substances 0.000 claims 3
- 230000000973 chemotherapeutic effect Effects 0.000 claims 3
- 230000003308 immunostimulating effect Effects 0.000 claims 3
- 208000015181 infectious disease Diseases 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- 239000000758 substrate Substances 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 2
- 239000011248 coating agent Substances 0.000 claims 2
- 238000000576 coating method Methods 0.000 claims 2
- 230000002519 immonomodulatory effect Effects 0.000 claims 2
- 239000012678 infectious agent Substances 0.000 claims 2
- 230000002458 infectious effect Effects 0.000 claims 2
- 230000003902 lesion Effects 0.000 claims 2
- 210000000440 neutrophil Anatomy 0.000 claims 2
- 244000052769 pathogen Species 0.000 claims 2
- 230000001717 pathogenic effect Effects 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 102000002812 Heat-Shock Proteins Human genes 0.000 claims 1
- 108010004889 Heat-Shock Proteins Proteins 0.000 claims 1
- 108010034145 Helminth Proteins Proteins 0.000 claims 1
- 208000019693 Lung disease Diseases 0.000 claims 1
- 108010033276 Peptide Fragments Proteins 0.000 claims 1
- 102000007079 Peptide Fragments Human genes 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000013566 allergen Substances 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000000840 anti-viral effect Effects 0.000 claims 1
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 239000000919 ceramic Substances 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 230000001934 delay Effects 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 244000000013 helminth Species 0.000 claims 1
- 206010020718 hyperplasia Diseases 0.000 claims 1
- 229960003444 immunosuppressant agent Drugs 0.000 claims 1
- 230000001861 immunosuppressant effect Effects 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 210000002540 macrophage Anatomy 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 239000000693 micelle Substances 0.000 claims 1
- 239000004005 microsphere Substances 0.000 claims 1
- 210000001616 monocyte Anatomy 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 210000005170 neoplastic cell Anatomy 0.000 claims 1
- 230000000399 orthopedic effect Effects 0.000 claims 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims 1
- 244000045947 parasite Species 0.000 claims 1
- 230000003071 parasitic effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 229960004889 salicylic acid Drugs 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 239000013589 supplement Substances 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85683406P | 2006-11-06 | 2006-11-06 | |
| US60/856,834 | 2006-11-06 | ||
| US88038407P | 2007-01-16 | 2007-01-16 | |
| US60/880,384 | 2007-01-16 | ||
| US92975507P | 2007-07-11 | 2007-07-11 | |
| US60/929,755 | 2007-07-11 | ||
| PCT/US2007/023307 WO2008057501A2 (en) | 2006-11-06 | 2007-11-06 | Immunomodulating compositions and methods of use thereof |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014022905A Division JP2014129366A (ja) | 2006-11-06 | 2014-02-08 | 免疫調節組成物及びその使用方法 |
| JP2016112724A Division JP2016188230A (ja) | 2006-11-06 | 2016-06-06 | 免疫調節組成物及びその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010527906A JP2010527906A (ja) | 2010-08-19 |
| JP2010527906A5 true JP2010527906A5 (enExample) | 2011-04-14 |
| JP6082174B2 JP6082174B2 (ja) | 2017-02-15 |
Family
ID=39365102
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009536266A Expired - Fee Related JP6082174B2 (ja) | 2006-11-06 | 2007-11-06 | 免疫調節組成物及びその使用方法 |
| JP2014022905A Pending JP2014129366A (ja) | 2006-11-06 | 2014-02-08 | 免疫調節組成物及びその使用方法 |
| JP2016112724A Pending JP2016188230A (ja) | 2006-11-06 | 2016-06-06 | 免疫調節組成物及びその使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014022905A Pending JP2014129366A (ja) | 2006-11-06 | 2014-02-08 | 免疫調節組成物及びその使用方法 |
| JP2016112724A Pending JP2016188230A (ja) | 2006-11-06 | 2016-06-06 | 免疫調節組成物及びその使用方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8580253B2 (enExample) |
| EP (1) | EP2066294B9 (enExample) |
| JP (3) | JP6082174B2 (enExample) |
| ES (1) | ES2397186T3 (enExample) |
| WO (1) | WO2008057501A2 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009134891A2 (en) | 2008-04-29 | 2009-11-05 | Immunexcite, Inc. | Immunomodulating compositions and methods of use thereof |
| US9457047B2 (en) * | 2006-11-06 | 2016-10-04 | Whitehead Institute | Immunomodulating compositions and methods of use thereof |
| US9850296B2 (en) | 2010-08-10 | 2017-12-26 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| US9517257B2 (en) | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| AU2011289579B2 (en) | 2010-08-10 | 2016-11-17 | Ecole Polytechnique Federale De Lausanne | Erythrocyte-binding therapeutics |
| JP2012205656A (ja) * | 2011-03-29 | 2012-10-25 | Kyocera Medical Corp | 生体インプラント用被覆材料、およびインプラント |
| WO2012139089A2 (en) | 2011-04-08 | 2012-10-11 | The General Hospital Corporation | Fungal-derived carbohydrate-conjugated scaffold |
| WO2012154818A1 (en) * | 2011-05-09 | 2012-11-15 | Biothera, Inc. | B-glucan compounds, compositions, and methods |
| US10092657B2 (en) * | 2011-06-03 | 2018-10-09 | Biothera, Inc. | Opsonized β-glucan preparations and methods |
| ES2887367T3 (es) * | 2013-10-09 | 2021-12-22 | Toray Industries | Inmunopotenciador |
| US10046056B2 (en) | 2014-02-21 | 2018-08-14 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| US10953101B2 (en) | 2014-02-21 | 2021-03-23 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| US10946079B2 (en) | 2014-02-21 | 2021-03-16 | Ecole Polytechnique Federale De Lausanne | Glycotargeting therapeutics |
| LT3107563T (lt) | 2014-02-21 | 2021-07-12 | Ecole Polytechnique Fédérale De Lausanne (Epfl) Epfl-Tto | Gliko-nukreipiantys terapiniai agenai |
| WO2015172040A2 (en) * | 2014-05-08 | 2015-11-12 | Immunexcite, Inc. | IMMUNOMODULATING β-1,6-D-GLUCANS |
| US9480656B1 (en) | 2015-09-28 | 2016-11-01 | King Saud University | Method of preparing rosemary nanoparticles and encapsulated rosemary nanoparticles |
| US11253579B2 (en) | 2017-06-16 | 2022-02-22 | The University Of Chicago | Compositions and methods for inducing immune tolerance |
| EA202092723A1 (ru) | 2018-05-09 | 2021-04-09 | Зе Юниверсити Оф Чикаго | Композиции и способы, касающиеся иммунной толерантности |
| JP7534312B2 (ja) | 2019-02-15 | 2024-08-14 | ザ クリーブランド クリニック ファウンデーション | ワクチンアジュバント及び製剤 |
| WO2020236626A1 (en) * | 2019-05-17 | 2020-11-26 | Herzlinger George A | Methods and systems for treating microbial disease |
| EP3858362A1 (en) * | 2020-01-29 | 2021-08-04 | Pleuran, s.r.o. | Beta-glucan for use in enhancement of anti-tumor immunity in remission |
| WO2021152497A1 (en) * | 2020-01-29 | 2021-08-05 | Pleuran, S.R.O. | Beta-glucan for use in modulation of an immune response in a remission |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4036945A (en) * | 1976-05-03 | 1977-07-19 | The Massachusetts General Hospital | Composition and method for determining the size and location of myocardial infarcts |
| US4331647A (en) * | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
| US4590181A (en) * | 1982-12-20 | 1986-05-20 | Board Of Regents Of The University Of Nebraska | Synthetic immunoregulators and methods of use and preparation |
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4992540A (en) * | 1984-11-28 | 1991-02-12 | Massachusetts Institute Of Technology | Glucan composition and process for preparation thereof |
| US4739046A (en) * | 1985-08-19 | 1988-04-19 | Luzio Nicholas R Di | Soluble phosphorylated glucan |
| US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| GB8823869D0 (en) * | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5032401A (en) * | 1989-06-15 | 1991-07-16 | Alpha Beta Technology | Glucan drug delivery system and adjuvant |
| JPH05503952A (ja) * | 1989-09-08 | 1993-06-24 | アルファ ベータ テクノロジー,インコーポレイティッド | 可溶性グルカン類の製造方法 |
| US5811542A (en) * | 1989-09-08 | 1998-09-22 | Alpha-Beta Technology, Inc. | Method for producing soluble glucans |
| US5622939A (en) * | 1992-08-21 | 1997-04-22 | Alpha-Beta Technology, Inc. | Glucan preparation |
| US5488040A (en) * | 1989-09-08 | 1996-01-30 | Alpha-Beta Technology, Inc. | Use of neutral soluble glucan preparations to stimulate platelet production |
| ATE153856T1 (de) * | 1989-09-08 | 1997-06-15 | Alpha Beta Technology | Zusammensetzung zur stimulierung des immunsystems |
| US5625126A (en) * | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| KR100272077B1 (ko) * | 1990-08-29 | 2000-11-15 | 젠팜인터내셔날,인코포레이티드 | 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물 |
| US5661016A (en) * | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5545806A (en) * | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5633425A (en) * | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| EP0640348A1 (en) | 1993-07-26 | 1995-03-01 | Akzo Nobel N.V. | Oil-based and water-based adjuvant mixture |
| NO300692B1 (no) * | 1994-04-29 | 1997-07-07 | Biotec Mackzymal As | Solubilisert forgrenet ß-1,3-glukan og anvendelse derav samt anvendelse av usolubilisert forgrenet ß-1,3-glukan |
| US5622940A (en) * | 1994-07-14 | 1997-04-22 | Alpha-Beta Technology | Inhibition of infection-stimulated oral tissue destruction by β(1,3)-glucan |
| AUPN166195A0 (en) * | 1995-03-13 | 1995-04-06 | Norvet Research Pty Limited | Process for glucan extraction |
| US6048551A (en) * | 1997-03-27 | 2000-04-11 | Hilfinger; John M. | Microsphere encapsulation of gene transfer vectors |
| US6046323A (en) * | 1997-07-29 | 2000-04-04 | The Collaborative Group, Ltd. | Conformations of PPG-glucan |
| US6468519B1 (en) * | 1997-09-10 | 2002-10-22 | Rutgers, The State University Of New Jersey | Polyanhydrides with biologically active degradation products |
| US6486214B1 (en) * | 1997-09-10 | 2002-11-26 | Rutgers, The State University Of New Jersey | Polyanhydride linkers for production of drug polymers and drug polymer compositions produced thereby |
| US5965714A (en) * | 1997-10-02 | 1999-10-12 | Connaught Laboratories, Inc. | Method for the covalent attachment of polysaccharides to protein molecules |
| US6369216B1 (en) * | 1998-09-25 | 2002-04-09 | Biopolymer Engineering Pharmaceutical, Inc. | Very high molecular weight β-glucans |
| AU6261999A (en) * | 1998-09-25 | 2000-04-17 | Collaborative Group, Ltd., The | Very high molecular weight beta-glucans |
| US6328988B1 (en) * | 1999-04-23 | 2001-12-11 | Rutgers, The State University Of New Jersey | Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules |
| US7011845B2 (en) * | 2000-05-09 | 2006-03-14 | Mcp Hahnemann University | β-glucans encapsulated in liposomes |
| US6998115B2 (en) * | 2000-10-10 | 2006-02-14 | Massachusetts Institute Of Technology | Biodegradable poly(β-amino esters) and uses thereof |
| US20040127458A1 (en) * | 2000-11-06 | 2004-07-01 | Hunter Kenneth W. | Beta-glucan containing compositions, methods for manufacturing beta-glucans, and for manufacturing and using beta-glucans and conjugates thereof as vaccine adjuvants |
| US6476003B1 (en) * | 2000-11-06 | 2002-11-05 | Immusonic, Inc. | Method for preparing small particle size glucan in a dry material |
| US7507724B2 (en) * | 2001-01-16 | 2009-03-24 | Sloan-Kettering Institute For Cancer Research | Therapy-enhancing glucan |
| US20050191361A1 (en) * | 2001-08-03 | 2005-09-01 | Powederject Research Ltd. | Hydrogel particle formation |
| GB0211118D0 (en) * | 2002-05-15 | 2002-06-26 | Polonelli Luciano | Vaccines |
| US20060165700A1 (en) * | 2002-09-04 | 2006-07-27 | Ostroff Gary R | Cancer therapy using whole glucan particles and antibodies |
| WO2004021994A2 (en) * | 2002-09-04 | 2004-03-18 | Biopolymer Engineering, Inc. | Cancer therapy using whole glucan particles and antibodies |
| US7060299B2 (en) * | 2002-12-31 | 2006-06-13 | Battelle Memorial Institute | Biodegradable microparticles that stabilize and control the release of proteins |
| US8048432B2 (en) * | 2003-08-06 | 2011-11-01 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Polysaccharide-protein conjugate vaccines |
| WO2007033315A1 (en) * | 2005-09-14 | 2007-03-22 | Whitehead Institute For Biomedical Research | Drug induced exposure of the fungal pro-inflammatory molecule beta-glucan |
| WO2008027580A2 (en) * | 2006-09-01 | 2008-03-06 | University Of Louisville | PARTICULATE β-GLUCAN COMPOSITIONS FOR REGULATING DENDRITIC CELLS |
| WO2009134891A2 (en) | 2008-04-29 | 2009-11-05 | Immunexcite, Inc. | Immunomodulating compositions and methods of use thereof |
-
2007
- 2007-11-06 ES ES07861719T patent/ES2397186T3/es active Active
- 2007-11-06 JP JP2009536266A patent/JP6082174B2/ja not_active Expired - Fee Related
- 2007-11-06 US US12/513,830 patent/US8580253B2/en not_active Expired - Fee Related
- 2007-11-06 EP EP07861719.8A patent/EP2066294B9/en active Active
- 2007-11-06 WO PCT/US2007/023307 patent/WO2008057501A2/en not_active Ceased
-
2014
- 2014-02-08 JP JP2014022905A patent/JP2014129366A/ja active Pending
-
2016
- 2016-06-06 JP JP2016112724A patent/JP2016188230A/ja active Pending
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