JP2010527375A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010527375A5 JP2010527375A5 JP2010508596A JP2010508596A JP2010527375A5 JP 2010527375 A5 JP2010527375 A5 JP 2010527375A5 JP 2010508596 A JP2010508596 A JP 2010508596A JP 2010508596 A JP2010508596 A JP 2010508596A JP 2010527375 A5 JP2010527375 A5 JP 2010527375A5
- Authority
- JP
- Japan
- Prior art keywords
- gpr12
- long
- term memory
- memory formation
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 20
- 101150057121 GPR12 gene Proteins 0.000 claims 17
- 230000015572 biosynthetic process Effects 0.000 claims 15
- 239000003814 drug Substances 0.000 claims 15
- 230000007787 long-term memory Effects 0.000 claims 15
- 239000003795 chemical substances by application Substances 0.000 claims 13
- 229940079593 drug Drugs 0.000 claims 9
- 230000001419 dependent effect Effects 0.000 claims 8
- 241000124008 Mammalia Species 0.000 claims 7
- 230000036992 cognitive tasks Effects 0.000 claims 6
- 210000004727 amygdala Anatomy 0.000 claims 4
- 230000006870 function Effects 0.000 claims 4
- 238000001514 detection method Methods 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 230000000971 hippocampal effect Effects 0.000 claims 3
- 108020004459 Small interfering RNA Proteins 0.000 claims 2
- 230000000692 anti-sense effect Effects 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 230000003920 cognitive function Effects 0.000 claims 1
- 210000001320 hippocampus Anatomy 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93816307P | 2007-05-15 | 2007-05-15 | |
| PCT/US2008/063804 WO2008144453A1 (en) | 2007-05-15 | 2008-05-15 | Methods of treating cognitive disorders by inhibition of gpr12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010527375A JP2010527375A (ja) | 2010-08-12 |
| JP2010527375A5 true JP2010527375A5 (enExample) | 2011-06-23 |
Family
ID=40122145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010508596A Pending JP2010527375A (ja) | 2007-05-15 | 2008-05-15 | Ｇｐｒ１２の阻害による認知障害の治療方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7968524B2 (enExample) |
| EP (1) | EP2162137B1 (enExample) |
| JP (1) | JP2010527375A (enExample) |
| KR (1) | KR20100029079A (enExample) |
| CN (1) | CN101808647A (enExample) |
| AU (1) | AU2008254905A1 (enExample) |
| BR (1) | BRPI0811625A2 (enExample) |
| CA (1) | CA2684920A1 (enExample) |
| IL (1) | IL202091A0 (enExample) |
| MX (1) | MX2009012316A (enExample) |
| WO (1) | WO2008144453A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010118055A1 (en) | 2009-04-09 | 2010-10-14 | Cognition Therapeutics, Inc. | Inhibitors of cognitive decline |
| RU2012107457A (ru) | 2009-07-31 | 2013-09-10 | Когнишн Терапьютикс, Инк. | Ингибиторы ухудшения когнитивных способностей |
| US20130071330A1 (en) * | 2010-02-26 | 2013-03-21 | Susan Catalano | Methods of identifying agents effective to treat cognitive decline and diseases associated therewith |
| SG192596A1 (en) | 2011-02-02 | 2013-09-30 | Cognition Therapeutics Inc | Isolated compounds from turmeric oil and methods of use |
| WO2015116923A1 (en) | 2014-01-31 | 2015-08-06 | Cognition Therapeutics, Inc. | Isoindoline compositions and methods for treating neurodegenerative disease |
| ES3063712T3 (en) | 2017-05-15 | 2026-04-20 | Cognition Therapeutics Inc | Compositions for treating neurodegenerative diseases |
| BR102022009685A2 (pt) * | 2022-05-18 | 2023-11-28 | Fundação Oswaldo Cruz | Método para triagem de fármacos ou substâncias com potencial neuroprotetor, kit para triagem de fármacos ou substâncias, e, uso de um painel de genes |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6044994A (en) | 1993-02-19 | 1994-09-14 | Nippon Shinyaku Co. Ltd. | Glycerol derivative, device and pharmaceutical composition |
| US6291438B1 (en) | 1993-02-24 | 2001-09-18 | Jui H. Wang | Antiviral anticancer poly-substituted phenyl derivatized oligoribonucleotides and methods for their use |
| US5858988A (en) | 1993-02-24 | 1999-01-12 | Wang; Jui H. | Poly-substituted-phenyl-oligoribo nucleotides having enhanced stability and membrane permeability and methods of use |
| US5877399A (en) * | 1994-01-27 | 1999-03-02 | Johns Hopkins University | Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease |
| JPH10501686A (ja) | 1994-04-13 | 1998-02-17 | ザ ロックフェラー ユニヴァーシティ | 神経系の細胞へのｄｎａのａａｖ仲介送達 |
| US5684143A (en) | 1996-02-21 | 1997-11-04 | Lynx Therapeutics, Inc. | Oligo-2'-fluoronucleotide N3'->P5' phosphoramidates |
| US6653086B1 (en) * | 1998-04-14 | 2003-11-25 | Arena Pharmaceuticals, Inc. | Endogenous constitutively activated G protein-coupled orphan receptors |
| JP2003518628A (ja) * | 1999-12-10 | 2003-06-10 | アストラゼネカ アクチボラグ | 化合物 |
| US20040224316A1 (en) * | 2000-08-10 | 2004-11-11 | Tully Timothy P. | Augmented cognitive training |
| US20060247194A1 (en) | 2000-08-30 | 2006-11-02 | Sirna Therapeutics , Inc. | Rna interference mediated treatment of alzheimer's disease using short interfering nucleic acid (sina) |
| CN100523215C (zh) * | 2000-12-01 | 2009-08-05 | 马普科技促进协会 | 介导rna干涉的小rna分子 |
| US6586524B2 (en) | 2001-07-19 | 2003-07-01 | Expression Genetics, Inc. | Cellular targeting poly(ethylene glycol)-grafted polymeric gene carrier |
| US20040023384A1 (en) * | 2002-07-31 | 2004-02-05 | Isis Pharmaceuticals Inc. | Antisense modulation of G protein-coupled receptor 12 expression |
| US20050106731A1 (en) | 2002-08-05 | 2005-05-19 | Davidson Beverly L. | siRNA-mediated gene silencing with viral vectors |
| AU2003261449A1 (en) | 2002-08-07 | 2004-02-25 | Compositions for rna interference and methods of use thereof | |
| WO2004038407A2 (en) * | 2002-10-24 | 2004-05-06 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with human g-protein coupled receptor 12 (gpr12) |
| US7829694B2 (en) * | 2002-11-26 | 2010-11-09 | Medtronic, Inc. | Treatment of neurodegenerative disease through intracranial delivery of siRNA |
| US20070104688A1 (en) | 2003-02-13 | 2007-05-10 | City Of Hope | Small interfering RNA mediated transcriptional gene silencing in mammalian cells |
| EP1662862A1 (en) * | 2003-09-19 | 2006-06-07 | Paradigm Therapeutics Limited | Receptor |
| DK1745295T3 (da) * | 2004-04-20 | 2011-01-31 | Galapagos Nv | Fremgangsmåder, sammensætninger og forbindelsesanalyser til hæmning af produktionen af amyloid beta-protein |
-
2008
- 2008-05-15 US US12/121,731 patent/US7968524B2/en not_active Expired - Fee Related
- 2008-05-15 JP JP2010508596A patent/JP2010527375A/ja active Pending
- 2008-05-15 BR BRPI0811625-3A2A patent/BRPI0811625A2/pt not_active IP Right Cessation
- 2008-05-15 CN CN200880023965A patent/CN101808647A/zh active Pending
- 2008-05-15 CA CA002684920A patent/CA2684920A1/en not_active Abandoned
- 2008-05-15 AU AU2008254905A patent/AU2008254905A1/en not_active Abandoned
- 2008-05-15 EP EP08755619.7A patent/EP2162137B1/en not_active Not-in-force
- 2008-05-15 WO PCT/US2008/063804 patent/WO2008144453A1/en not_active Ceased
- 2008-05-15 KR KR1020097024747A patent/KR20100029079A/ko not_active Withdrawn
- 2008-05-15 MX MX2009012316A patent/MX2009012316A/es unknown
-
2009
- 2009-11-12 IL IL202091A patent/IL202091A0/en unknown
-
2011
- 2011-06-27 US US13/169,739 patent/US20110281936A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Jeong et al. | Activation of temperature-sensitive TRPV1-like receptors in ARC POMC neurons reduces food intake | |
| Davis et al. | Ghrelin signaling affects feeding behavior, metabolism, and memory through the vagus nerve | |
| Ng et al. | Indoxyl sulfate downregulates expression of Mas receptor via OAT3/AhR/Stat3 pathway in proximal tubular cells | |
| Meyer et al. | A ghrelin–growth hormone axis drives stress-induced vulnerability to enhanced fear | |
| Lan et al. | Deficiency of NOX1 or NOX4 prevents liver inflammation and fibrosis in mice through inhibition of hepatic stellate cell activation | |
| Kilduff et al. | Activation of cortical interneurons during sleep: an anatomical link to homeostatic sleep regulation? | |
| Crossland et al. | Focal adhesion kinase is required for IGF-I-mediated growth of skeletal muscle cells via a TSC2/mTOR/S6K1-associated pathway | |
| Thomas et al. | Adolescent nicotine exposure alters GABAA receptor signaling in the ventral tegmental area and increases adult ethanol self-administration | |
| Troca-Marín et al. | An increase in basal BDNF provokes hyperactivation of the Akt-mammalian target of rapamycin pathway and deregulation of local dendritic translation in a mouse model of Down's syndrome | |
| Ren et al. | Neuropeptide S: a novel regulator of pain-related amygdala plasticity and behaviors | |
| Li et al. | The paraventricular thalamus mediates visceral pain and anxiety-like behaviors via two distinct pathways | |
| Moaddab et al. | Oxytocin receptor neurotransmission in the dorsolateral bed nucleus of the stria terminalis facilitates the acquisition of cued fear in the fear-potentiated startle paradigm in rats | |
| Aceto et al. | Chronic mild stress alters synaptic plasticity in the nucleus accumbens through GSK3β-dependent modulation of Kv4. 2 channels | |
| Munari et al. | Selective brain region activation by histamine H3 receptor antagonist/inverse agonist ABT-239 enhances acetylcholine and histamine release and increases c-Fos expression | |
| Forsberg et al. | CO2-evoked release of PGE2 modulates sighs and inspiration as demonstrated in brainstem organotypic culture | |
| Roberts et al. | Dopamine release in nucleus accumbens is under tonic inhibition by adenosine A1 receptors regulated by astrocytic ENT1 and dysregulated by ethanol | |
| John et al. | Caffeine promotes glutamate and histamine release in the posterior hypothalamus | |
| WO2010093872A3 (en) | Molecular-based method of cancer diagnosis and prognosis | |
| Sane et al. | The effect of ABCG2 and ABCC4 on the pharmacokinetics of methotrexate in the brain | |
| Fricke et al. | Glutamine uptake by System A transporters maintains neurotransmitter GABA synthesis and inhibitory synaptic transmission | |
| Bancroft et al. | Extracellular S100B inhibits A‐type voltage‐gated potassium currents and increases L‐type voltage‐gated calcium channel activity in dopaminergic neurons | |
| UA116871C2 (uk) | СПОСІБ ЛІКУВАННЯ МІЄЛОДИСПЛАСТИЧНОГО СИНДРОМУ, ТАЛАСЕМІЇ ТА СЕРПОПОДІБНО-КЛІТИННОЇ АНЕМІЇ ЗА ДОПОМОГОЮ ЗАСТОСУВАННЯ АНТАГОНІСТА АКТИВІНУ ПОЛІПЕПТИДУ ActRII | |
| Li et al. | Experimental colitis modulates the functional properties of NMDA receptors in dorsal root ganglia neurons | |
| Xing et al. | Acid‐sensing ion channel subtype 3 function and immunolabelling increases in skeletal muscle sensory neurons following femoral artery occlusion | |
| Tanaka et al. | Antihyperalgesic effects of ProTx-II, a Nav1. 7 antagonist, and A803467, a Nav1. 8 antagonist, in diabetic mice |