JP2010526319A5 - - Google Patents

Info

Publication number

JP2010526319A5

JP2010526319A5 JP2010507552A JP2010507552A JP2010526319A5 JP 2010526319 A5 JP2010526319 A5 JP 2010526319A5 JP 2010507552 A JP2010507552 A JP 2010507552A JP 2010507552 A JP2010507552 A JP 2010507552A JP 2010526319 A5 JP2010526319 A5 JP 2010526319A5

Authority

JP

Japan

Prior art keywords

thrombin receptor

platelet

thrombin

blood sample

trap

Prior art date

2008-05-02

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 238000000034 method Methods 0.000 claims 25
• 102000003790 Thrombin receptors Human genes 0.000 claims 22
• 210000004369 blood Anatomy 0.000 claims 15
• 239000008280 blood Substances 0.000 claims 15
• 108090000166 Thrombin receptors Proteins 0.000 claims 14
• FHZSIZRTNHGLSX-FLMSMKGQSA-N (2s)-1-[(2s)-4-amino-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-amino-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-oxobutanoyl]pyrrolidine-2-carboxyl Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N1[C@@H](CCC1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=CC=C1 FHZSIZRTNHGLSX-FLMSMKGQSA-N 0.000 claims 12
• 239000012190 activator Substances 0.000 claims 12
• 239000002245 particle Substances 0.000 claims 12
• 239000003856 thrombin receptor antagonist Substances 0.000 claims 12
• 239000003446 ligand Substances 0.000 claims 10
• 208000010110 spontaneous platelet aggregation Diseases 0.000 claims 10
• 102100025306 Integrin alpha-IIb Human genes 0.000 claims 8
• 101710149643 Integrin alpha-IIb Proteins 0.000 claims 8
• 102000005962 receptors Human genes 0.000 claims 8
• 108020003175 receptors Proteins 0.000 claims 8
• 108010093640 thrombin receptor peptide SFLLRNP Proteins 0.000 claims 8
• 238000003556 assay Methods 0.000 claims 6
• 108090000765 processed proteins & peptides Proteins 0.000 claims 6
• 239000000126 substance Substances 0.000 claims 5
• CPYVQXAASIFAMD-KNIFDHDWSA-N (2s)-2-aminobutanedioic acid;(2s)-2,6-diaminohexanoic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O.NCCCC[C@H](N)C(O)=O CPYVQXAASIFAMD-KNIFDHDWSA-N 0.000 claims 4
• 108010049003 Fibrinogen Proteins 0.000 claims 4
• 102000008946 Fibrinogen Human genes 0.000 claims 4
• 108090000190 Thrombin Proteins 0.000 claims 4
• 230000002776 aggregation Effects 0.000 claims 4
• 238000004220 aggregation Methods 0.000 claims 4
• 229940012952 fibrinogen Drugs 0.000 claims 4
• 230000005764 inhibitory process Effects 0.000 claims 4
• 229960004072 thrombin Drugs 0.000 claims 4
• 102100037136 Proteinase-activated receptor 1 Human genes 0.000 claims 3
• 102100023710 Proteinase-activated receptor 4 Human genes 0.000 claims 3
• 239000000203 mixture Substances 0.000 claims 3
• UNMBLVOFOAGGCG-UHFFFAOYSA-N 1-(3-tert-butyl-4-methoxy-5-morpholin-4-ylphenyl)-2-(5,6-diethoxy-4-fluoro-3-imino-1h-isoindol-2-yl)ethanone;hydrobromide Chemical compound Br.N=C1C=2C(F)=C(OCC)C(OCC)=CC=2CN1CC(=O)C(C=C(C=1OC)C(C)(C)C)=CC=1N1CCOCC1 UNMBLVOFOAGGCG-UHFFFAOYSA-N 0.000 claims 2
• 239000004475 Arginine Substances 0.000 claims 2
• 102100037362 Fibronectin Human genes 0.000 claims 2
• 108010067306 Fibronectins Proteins 0.000 claims 2
• 239000004793 Polystyrene Substances 0.000 claims 2
• 102100035140 Vitronectin Human genes 0.000 claims 2
• 108010031318 Vitronectin Proteins 0.000 claims 2
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 2
• 230000003247 decreasing effect Effects 0.000 claims 2
• 229920000126 latex Polymers 0.000 claims 2
• 239000004816 latex Substances 0.000 claims 2
• 230000001404 mediated effect Effects 0.000 claims 2
• 239000000816 peptidomimetic Substances 0.000 claims 2
• 210000002381 plasma Anatomy 0.000 claims 2
• 210000004623 platelet-rich plasma Anatomy 0.000 claims 2
• 229920002223 polystyrene Polymers 0.000 claims 2
• 108010047303 von Willebrand Factor Proteins 0.000 claims 2
• 102100036537 von Willebrand factor Human genes 0.000 claims 2
• 229960001134 von willebrand factor Drugs 0.000 claims 2
• ZBGXUVOIWDMMJE-QHNZEKIYSA-N vorapaxar Chemical compound C(/[C@@H]1[C@H]2[C@H](C(O[C@@H]2C)=O)C[C@H]2[C@H]1CC[C@H](C2)NC(=O)OCC)=C\C(N=C1)=CC=C1C1=CC=CC(F)=C1 ZBGXUVOIWDMMJE-QHNZEKIYSA-N 0.000 claims 2
• 229960005044 vorapaxar Drugs 0.000 claims 2
• 206010050661 Platelet aggregation inhibition Diseases 0.000 claims 1
• 101710121440 Proteinase-activated receptor 1 Proteins 0.000 claims 1
• 101710121439 Proteinase-activated receptor 4 Proteins 0.000 claims 1
• 238000010521 absorption reaction Methods 0.000 claims 1
• 230000003213 activating effect Effects 0.000 claims 1
• 239000003146 anticoagulant agent Substances 0.000 claims 1
• 229940127219 anticoagulant drug Drugs 0.000 claims 1
• 239000012911 assay medium Substances 0.000 claims 1
• 230000005540 biological transmission Effects 0.000 claims 1
• 239000012928 buffer substance Substances 0.000 claims 1
• 238000002329 infrared spectrum Methods 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1