JP2010526300A5 - - Google Patents
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- Publication number
- JP2010526300A5 JP2010526300A5 JP2010506656A JP2010506656A JP2010526300A5 JP 2010526300 A5 JP2010526300 A5 JP 2010526300A5 JP 2010506656 A JP2010506656 A JP 2010506656A JP 2010506656 A JP2010506656 A JP 2010506656A JP 2010526300 A5 JP2010526300 A5 JP 2010526300A5
- Authority
- JP
- Japan
- Prior art keywords
- platelet
- particles
- blood sample
- antagonist
- individual
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims 20
- 239000002245 particle Substances 0.000 claims 13
- 210000004369 blood Anatomy 0.000 claims 11
- 239000008280 blood Substances 0.000 claims 11
- XTWYTFMLZFPYCI-KQYNXXCUSA-N 5'-adenylphosphoric acid Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O XTWYTFMLZFPYCI-KQYNXXCUSA-N 0.000 claims 10
- XTWYTFMLZFPYCI-UHFFFAOYSA-N Adenosine diphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(O)=O)C(O)C1O XTWYTFMLZFPYCI-UHFFFAOYSA-N 0.000 claims 10
- 239000003446 ligand Substances 0.000 claims 10
- GMVPRGQOIOIIMI-UHFFFAOYSA-N (8R,11R,12R,13E,15S)-11,15-Dihydroxy-9-oxo-13-prostenoic acid Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CCCCCCC(O)=O GMVPRGQOIOIIMI-UHFFFAOYSA-N 0.000 claims 9
- 229960000711 alprostadil Drugs 0.000 claims 9
- 239000005557 antagonist Substances 0.000 claims 9
- GMVPRGQOIOIIMI-DWKJAMRDSA-N prostaglandin E1 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O GMVPRGQOIOIIMI-DWKJAMRDSA-N 0.000 claims 9
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 claims 9
- 102100025306 Integrin alpha-IIb Human genes 0.000 claims 8
- 101710149643 Integrin alpha-IIb Proteins 0.000 claims 8
- 102000005962 receptors Human genes 0.000 claims 8
- 108020003175 receptors Proteins 0.000 claims 8
- 230000004520 agglutination Effects 0.000 claims 7
- 238000006243 chemical reaction Methods 0.000 claims 7
- IYMAXBFPHPZYIK-BQBZGAKWSA-N Arg-Gly-Asp Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O IYMAXBFPHPZYIK-BQBZGAKWSA-N 0.000 claims 6
- 108010049003 Fibrinogen Proteins 0.000 claims 4
- 102000008946 Fibrinogen Human genes 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 229940012952 fibrinogen Drugs 0.000 claims 4
- 230000005764 inhibitory process Effects 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 208000010110 spontaneous platelet aggregation Diseases 0.000 claims 4
- 238000003556 assay Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 230000009257 reactivity Effects 0.000 claims 3
- DBDCNCCRPKTRSD-UHFFFAOYSA-N thieno[3,2-b]pyridine Chemical group C1=CC=C2SC=CC2=N1 DBDCNCCRPKTRSD-UHFFFAOYSA-N 0.000 claims 3
- 229940125670 thienopyridine Drugs 0.000 claims 3
- 239000002175 thienopyridine Substances 0.000 claims 3
- 102100037362 Fibronectin Human genes 0.000 claims 2
- 108010067306 Fibronectins Proteins 0.000 claims 2
- 239000004793 Polystyrene Substances 0.000 claims 2
- 208000007536 Thrombosis Diseases 0.000 claims 2
- 102100035140 Vitronectin Human genes 0.000 claims 2
- 108010031318 Vitronectin Proteins 0.000 claims 2
- 230000002776 aggregation Effects 0.000 claims 2
- 238000004220 aggregation Methods 0.000 claims 2
- 239000012911 assay medium Substances 0.000 claims 2
- 230000003247 decreasing effect Effects 0.000 claims 2
- 229920000126 latex Polymers 0.000 claims 2
- 239000004816 latex Substances 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 210000002381 plasma Anatomy 0.000 claims 2
- 210000004623 platelet-rich plasma Anatomy 0.000 claims 2
- 229920002223 polystyrene Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 230000004044 response Effects 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 108010047303 von Willebrand Factor Proteins 0.000 claims 2
- 102100036537 von Willebrand factor Human genes 0.000 claims 2
- 229960001134 von willebrand factor Drugs 0.000 claims 2
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims 1
- 239000005552 B01AC04 - Clopidogrel Substances 0.000 claims 1
- 239000005528 B01AC05 - Ticlopidine Substances 0.000 claims 1
- 229940127424 P2Y12 Receptor Antagonists Drugs 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- 229960001138 acetylsalicylic acid Drugs 0.000 claims 1
- 230000009471 action Effects 0.000 claims 1
- 230000001464 adherent effect Effects 0.000 claims 1
- 239000003146 anticoagulant agent Substances 0.000 claims 1
- 229940127219 anticoagulant drug Drugs 0.000 claims 1
- 229960003009 clopidogrel Drugs 0.000 claims 1
- GKTWGGQPFAXNFI-HNNXBMFYSA-N clopidogrel Chemical compound C1([C@H](N2CC=3C=CSC=3CC2)C(=O)OC)=CC=CC=C1Cl GKTWGGQPFAXNFI-HNNXBMFYSA-N 0.000 claims 1
- 238000002329 infrared spectrum Methods 0.000 claims 1
- 230000009467 reduction Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229960005001 ticlopidine Drugs 0.000 claims 1
- PHWBOXQYWZNQIN-UHFFFAOYSA-N ticlopidine Chemical group ClC1=CC=CC=C1CN1CC(C=CS2)=C2CC1 PHWBOXQYWZNQIN-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/742,684 | 2007-05-01 | ||
| US11/742,684 US20070243632A1 (en) | 2003-07-08 | 2007-05-01 | Methods for measuring platelet reactivity of patients that have received drug eluting stents |
| PCT/US2008/062297 WO2008137600A1 (en) | 2007-05-01 | 2008-05-01 | Methods for measuring platelet reactivity of individuals treated with drug eluting stents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010526300A JP2010526300A (ja) | 2010-07-29 |
| JP2010526300A5 true JP2010526300A5 (enExample) | 2011-06-23 |
| JP5687055B2 JP5687055B2 (ja) | 2015-03-18 |
Family
ID=39615637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010506656A Active JP5687055B2 (ja) | 2007-05-01 | 2008-05-01 | 薬剤溶出性ステントで処理された個体の血小板反応性を評価する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20070243632A1 (enExample) |
| EP (1) | EP2145192A1 (enExample) |
| JP (1) | JP5687055B2 (enExample) |
| KR (1) | KR20100017510A (enExample) |
| CN (1) | CN101688871A (enExample) |
| WO (1) | WO2008137600A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE536889T1 (de) * | 2003-07-08 | 2011-12-15 | Accumetrics Inc | Kontrollierte thrombozyten-aktivierung zur überwachung der behandlung von adp-antagonisten |
| US20070243632A1 (en) | 2003-07-08 | 2007-10-18 | Coller Barry S | Methods for measuring platelet reactivity of patients that have received drug eluting stents |
| US7595169B2 (en) * | 2005-04-27 | 2009-09-29 | Accumetrics, Inc. | Method for determining percent platelet aggregation |
| US20080299587A1 (en) * | 2007-05-03 | 2008-12-04 | Dennis Durbin | Methods of measuring inhibition of platelet aggregation by thrombin receptor antagonists |
| US8448499B2 (en) | 2008-12-23 | 2013-05-28 | C A Casyso Ag | Cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method |
| EP2371284A1 (en) * | 2010-03-24 | 2011-10-05 | C A Casyso AG | Method and apparatus for determining at least one evaluation parameter of a blood sample |
| RU2442167C1 (ru) * | 2010-07-21 | 2012-02-10 | Государственное образовательное учреждение высшего профессионального образования "Санкт-Петербургская государственная медицинская академия им. И.И. Мечникова Федерального агентства по здравоохранению и социальному развитию" | Способ оценки эффективности действия антиагрегантных препаратов, влияющих на метаболизм арахидоновой кислоты путем ингибирования циклооксигеназы-1 как в отдельности, так и совместно с антагонистом рецептора адф p2y12 на тромбоцитарных мембранах, на состояния тромбоцитов крови пациента, принимающего антиагрегантные препараты указанной группы |
| JP5768422B2 (ja) * | 2011-03-17 | 2015-08-26 | ソニー株式会社 | 血液凝固系解析方法および血液凝固系解析装置 |
| EP2508892A1 (de) | 2011-04-04 | 2012-10-10 | Siemens Healthcare Diagnostics Products GmbH | Kontrollen und Kit für Thrombozytenaktivitätsteste |
| DE102014112270B3 (de) * | 2014-08-27 | 2015-04-23 | Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V. | Verfahren zur Messung der Thrombozytenfunktion |
| US10539579B2 (en) | 2014-09-29 | 2020-01-21 | C A Casyso Gmbh | Blood testing system and method |
| GB201503425D0 (en) * | 2015-02-27 | 2015-04-15 | Randox Lab Ltd | Prognosis in patients with acute coronary syndrome undergoing percutaneous coronary intervention |
| MX2017012732A (es) * | 2015-04-08 | 2017-11-30 | Koninklijke Philips Nv | Sistema para analisis automatizado de valores de laboratorio y notificacion de riesgo en unidad de cuidados intensivos. |
| CN105203752A (zh) * | 2015-11-05 | 2015-12-30 | 上海中山医疗科技发展公司 | 一种磁性血小板吸附颗粒及其制备方法 |
| CN105717263B (zh) * | 2016-03-04 | 2018-01-26 | 北京乐普医疗科技有限责任公司 | 一种检测噻吩并吡啶类抗血小板药物疗效的试剂卡及其使用方法和应用 |
| AU2022205600A1 (en) * | 2021-01-07 | 2023-07-06 | Baxter Healthcare Sa | Thrombin-free hemostatic materials, methods of manufacture, and uses thereof |
| WO2023238136A1 (en) * | 2022-06-08 | 2023-12-14 | Ichilov Tech Ltd. | Methods of assessing platelet aggregation |
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| US409758A (en) * | 1889-08-27 | Velocipede | ||
| US3518057A (en) * | 1966-04-22 | 1970-06-30 | Huron Road Hospital | Method and apparatus for thrombus formation time determinations |
| US3694161A (en) * | 1971-04-14 | 1972-09-26 | Armour Pharma | Method for measuring platelet aggregation |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US4051236A (en) * | 1973-02-15 | 1977-09-27 | E. R. Squibb & Sons, Inc. | Inhibition of blood platelet aggregation |
| FI58700C (fi) * | 1974-02-21 | 1981-03-10 | Braun Melsungen Ag | Foerfarande foer maetning av blodplaettars spontanaaggregation i blodplaettsrik citratplasma |
| US4529561A (en) | 1978-03-24 | 1985-07-16 | The Regents Of The University Of California | Method for producing liposomes in selected size range |
| JPS5697226A (en) | 1979-12-28 | 1981-08-05 | Mitsubishi Chem Ind Ltd | Blood platelet coagulation inhibitor |
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| US20070243632A1 (en) | 2003-07-08 | 2007-10-18 | Coller Barry S | Methods for measuring platelet reactivity of patients that have received drug eluting stents |
| ATE536889T1 (de) | 2003-07-08 | 2011-12-15 | Accumetrics Inc | Kontrollierte thrombozyten-aktivierung zur überwachung der behandlung von adp-antagonisten |
| US7595169B2 (en) * | 2005-04-27 | 2009-09-29 | Accumetrics, Inc. | Method for determining percent platelet aggregation |
| US7205115B2 (en) * | 2005-04-28 | 2007-04-17 | Accumetrics, Inc. | Method and system for stabilization of arachidonic acid for use in platelet function assay |
| WO2007007588A1 (ja) | 2005-07-08 | 2007-01-18 | Ono Pharmaceutical Co., Ltd. | 平面性を有する環状基を母核とする化合物 |
| US20080299587A1 (en) * | 2007-05-03 | 2008-12-04 | Dennis Durbin | Methods of measuring inhibition of platelet aggregation by thrombin receptor antagonists |
| CA2697635C (en) | 2007-11-30 | 2016-06-28 | Corbett Research Pty Ltd | Thermal cycling device |
-
2007
- 2007-05-01 US US11/742,684 patent/US20070243632A1/en not_active Abandoned
-
2008
- 2008-05-01 JP JP2010506656A patent/JP5687055B2/ja active Active
- 2008-05-01 WO PCT/US2008/062297 patent/WO2008137600A1/en not_active Ceased
- 2008-05-01 KR KR1020097024975A patent/KR20100017510A/ko not_active Ceased
- 2008-05-01 CN CN200880022878A patent/CN101688871A/zh active Pending
- 2008-05-01 EP EP08754988A patent/EP2145192A1/en not_active Withdrawn
- 2008-05-01 US US12/598,581 patent/US9506938B2/en active Active
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