JP2010524963A5 - - Google Patents

Download PDF

Info

Publication number
JP2010524963A5
JP2010524963A5 JP2010504247A JP2010504247A JP2010524963A5 JP 2010524963 A5 JP2010524963 A5 JP 2010524963A5 JP 2010504247 A JP2010504247 A JP 2010504247A JP 2010504247 A JP2010504247 A JP 2010504247A JP 2010524963 A5 JP2010524963 A5 JP 2010524963A5
Authority
JP
Japan
Prior art keywords
ion
pairing agent
lipoic acid
pharmaceutical formulation
item
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010504247A
Other languages
English (en)
Japanese (ja)
Other versions
JP5480804B2 (ja
JP2010524963A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2008/060650 external-priority patent/WO2008131114A2/en
Publication of JP2010524963A publication Critical patent/JP2010524963A/ja
Publication of JP2010524963A5 publication Critical patent/JP2010524963A5/ja
Application granted granted Critical
Publication of JP5480804B2 publication Critical patent/JP5480804B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2010504247A 2007-04-18 2008-04-17 リポ酸誘導体を含有する医薬製剤 Expired - Fee Related JP5480804B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91260507P 2007-04-18 2007-04-18
US60/912,605 2007-04-18
PCT/US2008/060650 WO2008131114A2 (en) 2007-04-18 2008-04-17 Pharmaceutical formulations containing lipoic acid derivatives

Publications (3)

Publication Number Publication Date
JP2010524963A JP2010524963A (ja) 2010-07-22
JP2010524963A5 true JP2010524963A5 (OSRAM) 2012-05-31
JP5480804B2 JP5480804B2 (ja) 2014-04-23

Family

ID=39872894

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010504247A Expired - Fee Related JP5480804B2 (ja) 2007-04-18 2008-04-17 リポ酸誘導体を含有する医薬製剤

Country Status (19)

Country Link
US (4) US20080262077A1 (OSRAM)
EP (1) EP2144609B1 (OSRAM)
JP (1) JP5480804B2 (OSRAM)
KR (1) KR101539785B1 (OSRAM)
CN (1) CN101820875B (OSRAM)
AR (1) AR067309A1 (OSRAM)
AU (1) AU2008242827B2 (OSRAM)
BR (1) BRPI0810439B1 (OSRAM)
CA (1) CA2684479C (OSRAM)
CL (1) CL2008001124A1 (OSRAM)
ES (1) ES2528414T3 (OSRAM)
IL (1) IL201581A (OSRAM)
MX (1) MX2009011165A (OSRAM)
NZ (1) NZ580973A (OSRAM)
PL (1) PL2144609T3 (OSRAM)
PT (1) PT2144609E (OSRAM)
SA (1) SA08290240B1 (OSRAM)
TW (1) TWI459944B (OSRAM)
WO (1) WO2008131114A2 (OSRAM)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008131114A2 (en) 2007-04-18 2008-10-30 Cornerstone Pharmaceuticals, Inc. Pharmaceutical formulations containing lipoic acid derivatives
US8263653B2 (en) * 2007-04-18 2012-09-11 Cornerstone Pharmaceuticals, Inc. Pharmaceutical formulations containing lipoic acid derivatives
CN101765370B (zh) * 2007-04-18 2014-06-25 基石制药公司 硫辛酸衍生物
CN102089276A (zh) * 2008-03-04 2011-06-08 罗伯特·绍尔 酶结构、活性和/或表达水平的调节
CA2720396A1 (en) * 2008-04-04 2009-10-08 Robert Shorr Pharmaceutical composition
JP2012510511A (ja) * 2008-12-01 2012-05-10 インヴアスク セラピューテイックス インコーポレイテッド レニン−アンジオテンシン−アルドステロン系阻害剤及びリポ酸化合物を含有する組成物、並びに、レニン−アンジオテンシン−アルドステロン系に関連した疾患の治療のためのそれらの使用
WO2010110771A2 (en) * 2009-03-25 2010-09-30 Frank Gibson Substituted thiol-containing alkyl fatty acids and process for synthesizing derivatives thereof
RS58405B1 (sr) 2009-12-01 2019-04-30 Translate Bio Inc Stereoidni derivati za isporuku irnk u humanim genetskim oboljenjima
WO2011143590A1 (en) * 2010-05-14 2011-11-17 Cornerstone Pharmaceuticals, Inc. Combination therapy compositions and methods using lipoic acid derivatives and an anti-proliferation agent
WO2011143593A1 (en) * 2010-05-14 2011-11-17 Cornerstone Pharmaceuticals, Inc. Conjugates of a lipoic acid derivative and anti-proliferation agent and medical uses thereof
JP6184945B2 (ja) 2011-06-08 2017-08-23 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド ｍＲＮＡ送達のための脂質ナノ粒子組成物および方法
CN102657606B (zh) * 2012-05-25 2014-01-01 江苏神龙药业有限公司 一种供静脉给药用的硫辛酸注射液
US20150267192A1 (en) 2012-06-08 2015-09-24 Shire Human Genetic Therapies, Inc. Nuclease resistant polynucleotides and uses thereof
CA2895029A1 (en) * 2012-12-19 2014-06-26 Robert Shorr Metal complexes of lipoic acid derivatives
WO2014153052A2 (en) 2013-03-14 2014-09-25 Shire Human Genetic Therapies, Inc. Cftr mrna compositions and related methods and uses
EP2970955B1 (en) 2013-03-14 2018-11-14 Translate Bio, Inc. Methods for purification of messenger rna
CN103360437B (zh) * 2013-04-27 2015-10-21 江苏教育学院 一种硫辛酸糖类衍生物及其制备方法和在制备抗肿瘤药物中的应用
CN103497344B (zh) * 2013-09-25 2015-09-23 深圳先进技术研究院 用于负载贵金属颗粒的纳米凝胶及其制备方法与应用
BR112016009014B1 (pt) 2013-10-22 2024-02-06 Translate Bio, Inc USO DE COMPOSIÇÃO COMPREENDENDO mRNA PARA DEFICIÊNCIA DE ARGININOSSUCINATO SINTETASE
MX2016005239A (es) 2013-10-22 2016-08-12 Shire Human Genetic Therapies Tratamiento con acido ribonucleico mensajero para la fenilcetonuria.
SG11201608725YA (en) 2014-04-25 2016-11-29 Shire Human Genetic Therapies Methods for purification of messenger rna
EP3188726B1 (en) * 2014-06-19 2019-08-07 Rafael Pharmaceuticals, Inc. Pharmaceutical compounds
EP3189033B1 (en) * 2014-06-19 2020-08-05 Rafael Pharmaceuticals, Inc. Pharmaceutical compounds
AU2018224326B2 (en) 2017-02-27 2024-01-04 Translate Bio, Inc. Novel codon-optimized CFTR mRNA
IL270631B2 (en) 2017-05-16 2024-03-01 Translate Bio Inc Treatment of cystic fibrosis through the administration of mRNA with an optimal codon encoding ctfr
CN112930396B (zh) 2018-08-24 2024-05-24 川斯勒佰尔公司 用于纯化信使rna的方法
US20200157157A1 (en) 2018-11-21 2020-05-21 Translate Bio, Inc. TREATMENT OF CYSTIC FIBROSIS BY DELIVERY OF NEBULIZED mRNA ENCODING CFTR
TW202114651A (zh) * 2019-08-16 2021-04-16 美商拉斐爾製藥公司 用於治療癌症之方法及含有４，６—雙（苄硫基）己酸之藥物組成物
EP4110308A4 (en) * 2020-02-28 2024-03-20 University Of Florida Research Foundation, Incorporated ANTI-TUMOR IMMUNITY MODULATING COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
US20240115591A1 (en) * 2020-11-03 2024-04-11 Cornerstone Pharmaceuticals, Inc. Therapeutic methods and compositions for treating biliary tract cancer using devimistat
CN119770650A (zh) * 2025-01-09 2025-04-08 华中科技大学 一种硫辛酸-胆碱离子液体溶液及其制备方法和应用

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2805251A (en) * 1953-07-22 1957-09-03 Ethyl Corp Preparation of aryloxyaliphatic acids and salts thereof
GB758897A (en) 1953-10-19 1956-10-10 Merck & Co Inc Thio-substituted aliphatic carboxylic acids and their preparation
US3002011A (en) * 1953-12-04 1961-09-26 Merck & Co Inc Intermediates and processes for producing alpha-lipoic acid
US2809978A (en) * 1953-12-04 1957-10-15 Merck & Co Inc Intermediates useful in the synthesis of alpha-lipoic acid
US2980716A (en) * 1954-06-11 1961-04-18 Research Corp Method for preparing 6, 8-dihalooctanoic esters
US2975198A (en) * 1954-07-08 1961-03-14 Research Corp Lipoic acid intermediates
US2852531A (en) * 1954-09-24 1958-09-16 Merck & Co Inc Tris-(2-tetrahydropyranyl) esters of 6, 8-bis (hydrocarbonmercapto)-4, 4-dicarboxy-5-ocaprylic acid and preparation thereof
US2875238A (en) * 1957-02-19 1959-02-24 Merck & Co Inc Intermediates useful in the synthesis of alpha-lipoic acid
US2875239A (en) * 1957-02-19 1959-02-24 Merck & Co Inc Intermediates useful in the synthesis of alpha-lipoic acid
US2985685A (en) * 1959-01-26 1961-05-23 American Cyanamid Co Alkanolamine aluminates as catalysts for ester redistribution
US3453312A (en) * 1966-04-27 1969-07-01 Merck & Co Inc (beta - (substituted-thio) - acylphenoxy)-alkanoic acids and (beta-(substitutedthio) acylphenylmercapto) alkanoic acids and derivatives thereof
US3345368A (en) * 1967-02-15 1967-10-03 American Cyanamid Co Substituted 7-acetylamino cephalosporanic acids
US3881017A (en) * 1973-05-18 1975-04-29 Ciba Geigy Corp 9-Thiaprostaglandin compositions
DE2422498A1 (de) * 1973-05-18 1974-12-05 Ciba Geigy Ag Neue thiaprostaglandine und verfahren zu ihrer herstellung
JPS5323539Y2 (OSRAM) * 1973-11-30 1978-06-17
DE3512911A1 (de) * 1985-04-11 1986-10-16 Degussa Ag, 6000 Frankfurt Verfahren zur herstellung von 1,2-dithiolan-3-pentansaeure (thioctsaeure)
US5344941A (en) * 1986-09-03 1994-09-06 Samour Carlos M Water soluble salts of thionaphthene-2-carboxylic acid
DE4000397A1 (de) * 1990-01-09 1991-07-11 Hoechst Ag Lipidselektive antioxidantien sowie deren herstellung und verwendung
US5569670A (en) * 1992-06-05 1996-10-29 Asta Medica Aktiengesellschaft Combination medications containing alpha-lipoic acid and related
WO1994023748A1 (en) * 1993-04-08 1994-10-27 The University Of Queensland Administration of vaso-active agent and therapeutic agent
US5463093A (en) * 1993-11-26 1995-10-31 Garnett; Merrill Palladium complexes and methods for using same in the treatment of tumors or Psoriasis
FR2777001B1 (fr) * 1998-04-01 2000-06-09 Cird Galderma Derives de l'acide 6,8-dimercaptooctanoique substitues en 6-s et/ou en 8-s par le radical (3-methylthiopropanoyl) et compositions pharmaceutiques destinees au traitement des tumeurs cancereuses
EP2145883A1 (en) * 1998-10-26 2010-01-20 The Research Foundation Of The State University Of New York Dibenzyl lipoic acid derivatives and their use in treatment of disease
US7320797B2 (en) * 2003-08-29 2008-01-22 Bioderm Research Antiaging cosmetic delivery systems
JP2007077066A (ja) * 2005-09-14 2007-03-29 Shiseido Co Ltd 不全角化抑制剤、毛穴縮小剤
US20090036356A1 (en) * 2006-03-06 2009-02-05 Avestha Gengraine Technologies Pvt. Ltd. Octanoic acid derivatives as dipeptidyl peptidase inhibitors
WO2008131114A2 (en) 2007-04-18 2008-10-30 Cornerstone Pharmaceuticals, Inc. Pharmaceutical formulations containing lipoic acid derivatives
CN101765370B (zh) * 2007-04-18 2014-06-25 基石制药公司 硫辛酸衍生物
US8263653B2 (en) * 2007-04-18 2012-09-11 Cornerstone Pharmaceuticals, Inc. Pharmaceutical formulations containing lipoic acid derivatives

Similar Documents

Publication Publication Date Title
JP2010524963A5 (OSRAM)
KR101539785B1 (ko) 리포산 유도체를 함유하는 약제학적 제형
JPWO2020081938A5 (OSRAM)
ES2381672T3 (es) Preparación en solución acuosa que comprende un antibiótico aminoglicósido y bromfenaco
JP7764041B2 (ja) 脳腫瘍における改善された血液脳関門浸透性及び滞留性を備えた、スケーラブルなチロインテグリンアンタゴニストの組成物
JP2020508985A (ja) 治療用デンドリマー
JP2015512413A5 (OSRAM)
JP2010505865A5 (OSRAM)
JP2003306481A5 (OSRAM)
JP2007505044A5 (OSRAM)
TW201139421A (en) Novel ep4 agonist
KR20090040354A (ko) 방사선 보호 α,β 불포화 아릴설폰 제형
MX2022011242A (es) Inmunomodulación de o-het/aril azálidos.
RU2010124422A (ru) Производные диоксоантрацен сульфоната
US10358454B2 (en) Marinopyrrole derivatives and methods of making and using same
WO2011136631A1 (es) N6 -(ferrocenmetil)quinazolin-2,4,6-triamina (h2), sus derivados y profarmacos, como agentes antimicrobianos antiparasitarios, antiprotozoarios y antileishmanias
CN109152750B (zh) 用于增殖性疾病的组合疗法
CN104981245B (zh) 无副作用的抗癌剂
US20080293648A1 (en) Compositions and Methods for Cancer Treatment
CN110958998B (zh) 毛兰素衍生物和使用毛兰素衍生物的方法
WO2019195207A1 (en) Light-activated cannabinoid compounds and methods of use thereof
TWI694838B (zh) 用於疏水性藥物傳送的新穎以聚合物爲基礎的增溶物
ES2965179T3 (es) Derivado polimérico soluble en agua de venetoclax
JP2018525353A5 (OSRAM)
KR20170091610A (ko) 신규 peg 유도체