JP2010524486A - β−カテニンを調節するためのＲＮＡアンタゴニスト化合物 - Google Patents

β−カテニンを調節するためのＲＮＡアンタゴニスト化合物 Download PDF

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JP2010524486A
JP2010524486A JP2010504745A JP2010504745A JP2010524486A JP 2010524486 A JP2010524486 A JP 2010524486A JP 2010504745 A JP2010504745 A JP 2010504745A JP 2010504745 A JP2010504745 A JP 2010504745A JP 2010524486 A JP2010524486 A JP 2010524486A
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oligomer
catenin
seq
nucleotide
sequence
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JP2010524486A5 (OSRAM
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ヴォルム，イェスペル
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Roche Innovation Center Copenhagen AS
Enzon Pharmaceuticals Inc
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Santaris Pharma AS
Enzon Pharmaceuticals Inc
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate

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  • Health & Medical Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2010504745A 2007-05-01 2008-04-30 β−カテニンを調節するためのＲＮＡアンタゴニスト化合物 Pending JP2010524486A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91537107P 2007-05-01 2007-05-01
US2324408P 2008-01-24 2008-01-24
PCT/EP2008/055365 WO2008132234A2 (en) 2007-05-01 2008-04-30 Rna antagonist compounds for the modulation of beta-catenin

Related Child Applications (1)

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JP2014125205A Division JP2014209915A (ja) 2007-05-01 2014-06-18 β−カテニンを調節するためのＲＮＡアンタゴニスト化合物

Publications (2)

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JP2010524486A true JP2010524486A (ja) 2010-07-22
JP2010524486A5 JP2010524486A5 (OSRAM) 2011-07-14

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JP2010504745A Pending JP2010524486A (ja) 2007-05-01 2008-04-30 β−カテニンを調節するためのＲＮＡアンタゴニスト化合物
JP2014125205A Abandoned JP2014209915A (ja) 2007-05-01 2014-06-18 β−カテニンを調節するためのＲＮＡアンタゴニスト化合物

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JP2014125205A Abandoned JP2014209915A (ja) 2007-05-01 2014-06-18 β−カテニンを調節するためのＲＮＡアンタゴニスト化合物

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US (4) US20090005335A1 (OSRAM)
EP (1) EP2152879B1 (OSRAM)
JP (2) JP2010524486A (OSRAM)
KR (1) KR20100024399A (OSRAM)
CN (1) CN101842483A (OSRAM)
AU (1) AU2008244211B2 (OSRAM)
CA (1) CA2685444A1 (OSRAM)
DK (1) DK2152879T3 (OSRAM)
EA (1) EA018986B1 (OSRAM)
ES (1) ES2399371T3 (OSRAM)
IL (1) IL201865A0 (OSRAM)
MX (1) MX2009011878A (OSRAM)
NZ (1) NZ581200A (OSRAM)
TW (1) TW200848077A (OSRAM)
WO (1) WO2008132234A2 (OSRAM)

Cited By (1)

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JP2015503608A (ja) * 2012-01-09 2015-02-02 ノバルティス アーゲー ベータ−カテニン関連疾患を処置するための有機組成物

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WO2008132234A2 (en) * 2007-05-01 2008-11-06 Santaris Pharma A/S Rna antagonist compounds for the modulation of beta-catenin
EP2490767A4 (en) * 2009-07-15 2013-02-13 Santaris Pharma As GLI2 TARGETING TARGET ANTAGONIST FOR THE TREATMENT OF LEUKEMIA
ES2734743T3 (es) 2010-07-06 2019-12-11 Dicerna Pharmaceuticals Inc Métodos y composiciones para la inhibición específica de beta-catenina por RNA bicatenario
US9920317B2 (en) 2010-11-12 2018-03-20 The General Hospital Corporation Polycomb-associated non-coding RNAs
EP2638163B1 (en) 2010-11-12 2017-05-17 The General Hospital Corporation Polycomb-associated non-coding rnas
WO2013071161A1 (en) * 2011-11-11 2013-05-16 Enzon Pharmaceuticals, Inc. Compounds for the modulation of beta-catenin expression and uses thereof
US10837014B2 (en) 2012-05-16 2020-11-17 Translate Bio Ma, Inc. Compositions and methods for modulating SMN gene family expression
AU2013262709A1 (en) 2012-05-16 2015-01-22 Rana Therapeutics, Inc. Compositions and methods for modulating MECP2 expression
CN104583398A (zh) 2012-05-16 2015-04-29 Rana医疗有限公司 用于调节基因表达的组合物和方法
CA2889044A1 (en) 2012-11-15 2014-05-22 Roche Innovation Center Copenhagen A/S Anti apob antisense conjugate compounds
MX2015009056A (es) * 2013-01-30 2015-10-05 Hoffmann La Roche Conjugados de oligonucleotidos de acido nucleico bloqueado y carbohidratos.
SG10201803157XA (en) 2013-05-01 2018-05-30 Regulus Therapeutics Inc Microrna compounds and methods for modulating mir-122
CA2909868C (en) 2013-05-01 2021-10-19 Regulus Therapeutics Inc. Compounds and methods for enhanced cellular uptake
KR101800981B1 (ko) 2013-08-22 2017-11-23 휴렛-팩커드 디벨롭먼트 컴퍼니, 엘.피. 투사 컴퓨팅 시스템
TWI657755B (zh) * 2013-12-30 2019-05-01 Philip Morris Products S. A. 包含隔熱可燃熱源之煙品
CN106470699A (zh) 2014-02-03 2017-03-01 耶路撒冷希伯来大学的益生研究开发有限公司 使用酪蛋白激酶i抑制剂以消耗干细胞的用途
WO2016070060A1 (en) 2014-10-30 2016-05-06 The General Hospital Corporation Methods for modulating atrx-dependent gene repression
WO2016149455A2 (en) 2015-03-17 2016-09-22 The General Hospital Corporation The rna interactome of polycomb repressive complex 1 (prc1)
WO2018093919A1 (en) * 2016-11-15 2018-05-24 City Of Hope Methods for intracellular delivery and enhanced gene targeting
JP7279081B2 (ja) 2018-05-08 2023-05-22 レグルス セラピューティクス インコーポレイテッド Ｍｉｒ－１２２を調節するためのマイクロｒｎａ化合物及び方法

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Publication number Priority date Publication date Assignee Title
JP2015503608A (ja) * 2012-01-09 2015-02-02 ノバルティス アーゲー ベータ−カテニン関連疾患を処置するための有機組成物

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Publication number Publication date
WO2008132234A2 (en) 2008-11-06
WO2008132234A4 (en) 2009-07-09
EP2152879A2 (en) 2010-02-17
IL201865A0 (en) 2011-08-01
US20110086902A1 (en) 2011-04-14
KR20100024399A (ko) 2010-03-05
US7915401B2 (en) 2011-03-29
TW200848077A (en) 2008-12-16
DK2152879T3 (da) 2013-02-18
AU2008244211A1 (en) 2008-11-06
MX2009011878A (es) 2010-01-25
US20090203137A1 (en) 2009-08-13
ES2399371T3 (es) 2013-03-27
EA018986B1 (ru) 2013-12-30
US20090005335A1 (en) 2009-01-01
AU2008244211B2 (en) 2014-08-21
EA200971013A1 (ru) 2010-04-30
US8039446B2 (en) 2011-10-18
WO2008132234A3 (en) 2009-05-07
JP2014209915A (ja) 2014-11-13
NZ581200A (en) 2012-04-27
US20120004288A1 (en) 2012-01-05
EP2152879B1 (en) 2012-11-14
CN101842483A (zh) 2010-09-22
CA2685444A1 (en) 2008-11-06

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