JP2010523596A5 - - Google Patents
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- Publication number
- JP2010523596A5 JP2010523596A5 JP2010502341A JP2010502341A JP2010523596A5 JP 2010523596 A5 JP2010523596 A5 JP 2010523596A5 JP 2010502341 A JP2010502341 A JP 2010502341A JP 2010502341 A JP2010502341 A JP 2010502341A JP 2010523596 A5 JP2010523596 A5 JP 2010523596A5
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- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- alkylenyl
- conr
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92193207P | 2007-04-05 | 2007-04-05 | |
| US60/921,932 | 2007-04-05 | ||
| US96425407P | 2007-08-10 | 2007-08-10 | |
| US60/964,254 | 2007-08-10 | ||
| PCT/US2008/059505 WO2008124651A2 (en) | 2007-04-05 | 2008-04-04 | Nitro-imidazole hypoxia imaging agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010523596A JP2010523596A (ja) | 2010-07-15 |
| JP2010523596A5 true JP2010523596A5 (enExample) | 2011-05-12 |
| JP5347164B2 JP5347164B2 (ja) | 2013-11-20 |
Family
ID=39831553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010502341A Expired - Fee Related JP5347164B2 (ja) | 2007-04-05 | 2008-04-04 | ニトロ−イミダゾール低酸素造影剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7807394B2 (enExample) |
| EP (1) | EP2132200B1 (enExample) |
| JP (1) | JP5347164B2 (enExample) |
| KR (1) | KR101523257B1 (enExample) |
| CN (1) | CN101652360B (enExample) |
| CA (1) | CA2683433C (enExample) |
| WO (1) | WO2008124651A2 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2683433C (en) * | 2007-04-05 | 2016-10-11 | Siemens Medical Solutions Usa, Inc. | Nitro-imidazole hypoxia imaging agents |
| CN101709060B (zh) * | 2009-12-02 | 2013-05-01 | 北京师范大学 | 一种f-三唑环-聚乙二醇-甲硝唑化合物及其制备方法 |
| KR101709372B1 (ko) | 2010-02-08 | 2017-02-22 | 랜티우스 메디컬 이메징, 인크. | 조영제 및 이의 중간체를 합성하는 방법 및 장치 |
| US10639608B2 (en) | 2010-04-08 | 2020-05-05 | Siemens Medical Solutions Usa, Inc. | System, device and method for preparing tracers and transferring materials during radiosynthesis |
| EP2556372A1 (en) | 2010-04-08 | 2013-02-13 | Siemens Medical Solutions USA, Inc. | Synthesis of 18f-labeled tracers in hydrous organic solvents |
| CN101921263A (zh) * | 2010-04-16 | 2010-12-22 | 兰州大学 | 2-硝基咪唑衍生物及其用途和制备方法 |
| KR20170042373A (ko) | 2010-05-11 | 2017-04-18 | 랜티우스 메디컬 이메징, 인크. | 영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템 |
| EP3567029A1 (en) | 2011-09-09 | 2019-11-13 | Lantheus Medical Imaging, Inc. | Compositions, methods, and systems for the synthesis and use of imaging agents |
| CN103945901A (zh) | 2011-10-14 | 2014-07-23 | 住友重机械工业株式会社 | 带电粒子束照射系统以及带电粒子束照射计划方法 |
| EP2793871A4 (en) * | 2011-12-23 | 2015-07-22 | Auckland Uniservices Ltd | COMPOUNDS AND METHODS FOR SELECTIVE IMAGING AND / OR ABLATION |
| WO2014062856A1 (en) | 2012-10-16 | 2014-04-24 | Halozyme, Inc. | Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods |
| RU2635557C2 (ru) | 2014-01-13 | 2017-11-14 | Хафид БЕЛХАДЖ-ТАХАР | Дендримерные композиции, способы их синтеза и их применение |
| WO2016047424A1 (ja) * | 2014-09-25 | 2016-03-31 | 日本メジフィジックス株式会社 | 腎イメージング剤 |
| US10695446B2 (en) | 2015-05-01 | 2020-06-30 | Vanderbilt University | Composition and method for detecting hypoxia |
| US10695450B2 (en) | 2016-07-26 | 2020-06-30 | Laboratoires Cyclopharma | Synthesis of a radioactive agent composition |
| CN106977501A (zh) * | 2017-03-20 | 2017-07-25 | 华东师范大学 | 一种基于2‑硝基咪唑‑1‑烷基醇的低氧激活前药 |
| FR3068695B1 (fr) * | 2017-07-05 | 2019-08-16 | Centre National De La Recherche Scientifique | Composes utiles comme agent d'imagerie de l'hypoxie |
| CN111372940A (zh) * | 2017-09-19 | 2020-07-03 | 阿尔伯塔大学理事会 | 生物还原活化的化合物、其前药、放射性药物、组合物及其在包括癌症在内的低氧疾病的多模式治疗控制中的应用 |
| CN111356698B (zh) * | 2017-09-19 | 2025-02-25 | 威奇生物科技公司 | 用于低氧成像、映射和治疗的标记物、缀合物、组合物和方法 |
| US11091447B2 (en) | 2020-01-03 | 2021-08-17 | Berg Llc | UBE2K modulators and methods for their use |
| CN111233821B (zh) * | 2020-01-20 | 2022-12-27 | 上海交通大学医学院附属仁济医院 | 含3-羟基苯甲酸基团的新抗霉素衍生物及其制备方法和应用 |
| CN114478489B (zh) * | 2022-01-18 | 2023-04-28 | 中国科学院精密测量科学与技术创新研究院 | 一种氟-19修饰的硝基咪唑化合物及其衍生物的制备方法和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5674693A (en) * | 1994-03-18 | 1997-10-07 | Natural Pharmacia International Inc. | Derivatives of 2-nitro-imidazoles as hypoxic cell markers |
| US5721265A (en) * | 1994-08-05 | 1998-02-24 | Sri International | Fluorinated 2-nitroimidazole analogs for detecting hypoxic tumor cells |
| ATE302175T1 (de) * | 1999-08-11 | 2005-09-15 | Univ Catholique Louvain | Verfahren zur herstellung von (18f) radiomarkierten nitroimidazol-derivaten zum nachweis zellulärer hypoxie |
| CA2683433C (en) * | 2007-04-05 | 2016-10-11 | Siemens Medical Solutions Usa, Inc. | Nitro-imidazole hypoxia imaging agents |
-
2008
- 2008-04-04 CA CA2683433A patent/CA2683433C/en not_active Expired - Fee Related
- 2008-04-04 US US12/098,390 patent/US7807394B2/en not_active Expired - Fee Related
- 2008-04-04 KR KR1020097023183A patent/KR101523257B1/ko not_active Expired - Fee Related
- 2008-04-04 EP EP08745183.7A patent/EP2132200B1/en not_active Not-in-force
- 2008-04-04 CN CN200880011415.1A patent/CN101652360B/zh not_active Expired - Fee Related
- 2008-04-04 WO PCT/US2008/059505 patent/WO2008124651A2/en not_active Ceased
- 2008-04-04 JP JP2010502341A patent/JP5347164B2/ja not_active Expired - Fee Related
-
2010
- 2010-07-15 US US12/836,926 patent/US7977361B2/en not_active Expired - Fee Related
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