|
US5453566A
(en)
|
1986-03-28 |
1995-09-26 |
Calgene, Inc. |
Antisense regulation of gene expression in plant/cells
|
|
US4987071A
(en)
|
1986-12-03 |
1991-01-22 |
University Patents, Inc. |
RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
|
|
ATE115999T1
(de)
|
1987-12-15 |
1995-01-15 |
Gene Shears Pty Ltd |
Ribozyme.
|
|
GB8822492D0
(en)
|
1988-09-24 |
1988-10-26 |
Considine J |
Apparatus for removing tumours from hollow organs of body
|
|
US5789573A
(en)
|
1990-08-14 |
1998-08-04 |
Isis Pharmaceuticals, Inc. |
Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2
|
|
IL108367A0
(en)
|
1993-01-27 |
1994-04-12 |
Hektoen Inst For Medical Resea |
Antisense polynzcleotide inhibition of human growth factor-sensitive cancer cells
|
|
US5801154A
(en)
|
1993-10-18 |
1998-09-01 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of multidrug resistance-associated protein
|
|
US5739119A
(en)
|
1996-11-15 |
1998-04-14 |
Galli; Rachel L. |
Antisense oligonucleotides specific for the muscarinic type 2 acetylcholine receptor MRNA
|
|
US5932465A
(en)
*
|
1997-10-16 |
1999-08-03 |
Icos Corporation |
Phosphodiesterase 8A
|
|
AU3307999A
(en)
*
|
1998-02-23 |
1999-09-06 |
Icos Corporation |
Phosphodiesterase 10
|
|
DK1018559T3
(da)
*
|
1998-12-23 |
2007-12-03 |
Pfizer |
Phosphodiesteraser
|
|
WO2000068230A1
(en)
|
1999-05-05 |
2000-11-16 |
Darwin Discovery Limited |
9-(1,2,3,4-tetrahydronaphthalen-1-yl)-1,9-dihydropurin-6-one derivatives as pde7 inhibitors
|
|
AU4145200A
(en)
|
1999-05-07 |
2000-11-21 |
Takeda Chemical Industries Ltd. |
Cyclic compounds and uses thereof
|
|
US6146876A
(en)
|
1999-06-11 |
2000-11-14 |
Millennium Pharmaceuticals, Inc. |
22025, a novel human cyclic nucleotide phosphodiesterase
|
|
DE19950647A1
(de)
|
1999-10-21 |
2001-04-26 |
Merck Patent Gmbh |
Imidazolderivate als Phosphodiesterase VII-Hemmer
|
|
US7491742B2
(en)
*
|
1999-10-21 |
2009-02-17 |
Merck Patent Gmbh |
Imidazole derivatives as phosphodiesterase VII inhibitors
|
|
DE19953024A1
(de)
*
|
1999-11-04 |
2001-05-10 |
Merck Patent Gmbh |
Isoxazolderivate als Phosphodiesterase VII-Hemmer
|
|
DE19953025A1
(de)
*
|
1999-11-04 |
2001-05-10 |
Merck Patent Gmbh |
Pyrrolderivate als Phosphodiesterase VII-Hemmer
|
|
DE19953414A1
(de)
*
|
1999-11-06 |
2001-05-10 |
Merck Patent Gmbh |
Imidazopyridinderivate als Phospodiesterase VII-Hemmer
|
|
DE19954707A1
(de)
*
|
1999-11-13 |
2001-05-17 |
Merck Patent Gmbh |
Imidazolverbindungen als Phosphodiesterase VII-Hemmer
|
|
US6649592B1
(en)
|
2000-01-14 |
2003-11-18 |
Science & Technology Corporation @ Unm |
Peptide inhibitors of LFA-1/ICAM-1 interaction
|
|
CA2400708A1
(en)
*
|
2000-02-22 |
2001-08-30 |
Cellegy Canada Inc. |
Methods and compositions for improving sleep
|
|
WO2001062904A1
(en)
|
2000-02-24 |
2001-08-30 |
Bayer Aktiengesellschaft |
Regulation of human gelatinase b-like enzyme 1
|
|
GB0007934D0
(en)
|
2000-03-31 |
2000-05-17 |
Darwin Discovery Ltd |
Chemical compounds
|
|
US7345031B2
(en)
*
|
2000-04-12 |
2008-03-18 |
International Medical Innovations, Inc. |
Pharmaceutical dopamine glycoconjugate compositions and methods of their preparation and use
|
|
GB0015095D0
(en)
|
2000-06-20 |
2000-08-09 |
Celltech Chiroscience Ltd |
Chemical compounds
|
|
EP1313478A2
(en)
|
2000-08-30 |
2003-05-28 |
Lilly Icos LLC |
Method for treatment of migraine using pde5 inhibitors
|
|
EP1193261A1
(en)
|
2000-10-02 |
2002-04-03 |
Warner-Lambert Company |
New thiadiazoles and their use as phosphodiesterase-7 inhibitors
|
|
AU2002224835A1
(en)
|
2000-11-14 |
2002-05-27 |
Byk Gulden Lomberg Chemische Fabrik G.M.B.H. |
Dihydroisoquinolines as novel phosphodiesterase inhibitors
|
|
CA2428527A1
(en)
|
2000-11-14 |
2002-05-23 |
Altana Pharma Ag |
(dihydro)isoquinoline derivatives as phosphodiesterase inhibitors
|
|
IL140844A0
(en)
*
|
2001-01-10 |
2002-02-10 |
Polygene Ltd |
Cationic polysaccharide compositions
|
|
JP2005506286A
(ja)
*
|
2001-03-02 |
2005-03-03 |
ブリストル−マイヤーズ スクイブ カンパニー |
サイクリック−amp関連疾患の治療を目的としたメラノコルチン受容体アゴニストおよびホスホジエステラーゼ阻害剤の併用投与
|
|
US6617357B2
(en)
|
2001-03-06 |
2003-09-09 |
Smithkline Beecham Corporation |
Compounds and their use as PDE inhibitors
|
|
WO2002076953A1
(en)
*
|
2001-03-21 |
2002-10-03 |
Warner-Lambert Company Llc |
New spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors
|
|
US6903109B2
(en)
*
|
2001-04-18 |
2005-06-07 |
Ortho-Muniel Pharmaceutical, Inc. |
Arylindenopyridines and related therapeutic and prophylactic methods
|
|
US6958328B2
(en)
|
2001-04-18 |
2005-10-25 |
Ortho-Mcneil Pharmaceutical, Inc |
Arylindenopyridines and related therapeutic and prophylactic methods
|
|
EP1385843A1
(en)
|
2001-04-18 |
2004-02-04 |
Ortho-Mcneil Pharmaceutical, Inc. |
Arylindenopyridines with pde inhibiting activity
|
|
US20030032579A1
(en)
*
|
2001-04-20 |
2003-02-13 |
Pfizer Inc. |
Therapeutic use of selective PDE10 inhibitors
|
|
NZ529221A
(en)
|
2001-04-25 |
2005-04-29 |
Altana Pharma Ag |
Phthalazinones with PDE-inhibiting properties for treatment of airway disorders and other inflammatory conditions
|
|
US6849638B2
(en)
|
2001-04-30 |
2005-02-01 |
Bayer Pharmaceuticals Corporation |
4-amino-5,6-substituted thiopheno [2,3-d] pyrimidines, pharmaceutical compositions containing the same, and their use in the treatment or prevention of pde7b-mediated diseases and conditions
|
|
US20030053980A1
(en)
|
2001-04-30 |
2003-03-20 |
The Gillette Company |
Shaving compositions containing highly lubricious water soluble polymers
|
|
WO2002088079A2
(en)
|
2001-05-01 |
2002-11-07 |
Bristol-Myers Squibb Company |
Dual inhibitors of pde 7 and pde 4
|
|
KR20040010713A
(ko)
*
|
2001-06-15 |
2004-01-31 |
야마노우치세이야쿠 가부시키가이샤 |
페닐피리딘 카보닐 피페라진 유도체
|
|
JP2005500294A
(ja)
|
2001-06-19 |
2005-01-06 |
ブリストル−マイヤーズ スクイブ カンパニー |
ホスホジエステラーゼ7に対するピリミジン阻害剤
|
|
PE20030008A1
(es)
|
2001-06-19 |
2003-01-22 |
Bristol Myers Squibb Co |
Inhibidores duales de pde 7 y pde 4
|
|
DE10130167A1
(de)
|
2001-06-22 |
2003-01-02 |
Bayer Ag |
Imidazotriazine
|
|
EP1575916B1
(en)
*
|
2001-08-31 |
2013-05-22 |
The Rockefeller University |
Phosphodiesterase activity and regulation of phosphodiesterase 1-b-mediated signaling in brain
|
|
US20060286622A1
(en)
*
|
2001-09-28 |
2006-12-21 |
Patricia Soulard |
Polypeptides exhibiting PDE7 activity and their use for selecting compounds which inhibit PDE 7 enzyme activity
|
|
DE60222931T2
(de)
*
|
2001-12-13 |
2008-07-10 |
Asubio Pharma Co., Ltd. |
Pyrazolopyrimidinonderivate mit pde7-hemmender wirkung
|
|
DE10163991A1
(de)
*
|
2001-12-24 |
2003-07-03 |
Merck Patent Gmbh |
Pyrrolo-pyrimidine
|
|
WO2003057149A2
(en)
|
2001-12-28 |
2003-07-17 |
Bayer Corporation |
4-substituted fused heteropyrimidines and fused hetero-4-pyrimidones
|
|
US7378428B2
(en)
|
2002-01-31 |
2008-05-27 |
Ono Pharmaceutical Co., Ltd. |
Nitrogen-containing bicyclic compounds and drugs containing the same as the active ingredient
|
|
US20040082061A1
(en)
*
|
2002-02-14 |
2004-04-29 |
Anna Astromoff |
Drug metabolizing enzymes
|
|
EP1348701A1
(en)
|
2002-03-28 |
2003-10-01 |
Warner-Lambert Company LLC |
(2,4-disubstituted-thiazol-5-yl) amine compounds as PDE7 inhibitors
|
|
EP1348433A1
(en)
*
|
2002-03-28 |
2003-10-01 |
Warner-Lambert Company LLC |
Thiazol-2-yl-imine compounds as PDE-7 inhibitors
|
|
EP1400244A1
(en)
|
2002-09-17 |
2004-03-24 |
Warner-Lambert Company LLC |
New spirocondensed quinazolinones and their use as phosphodiesterase inhibitors
|
|
EP1608742A1
(en)
|
2002-11-13 |
2005-12-28 |
Bayer HealthCare AG |
DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH HUMAN PHOSPHODIESTERASE 7B (PDE7b)
|
|
ES2217956B1
(es)
|
2003-01-23 |
2006-04-01 |
Almirall Prodesfarma, S.A. |
Nuevos derivados de 4-aminotieno(2,3-d)pirimidin-6-carbonitrilo.
|
|
US7217527B2
(en)
*
|
2003-04-15 |
2007-05-15 |
Vanderbilt University |
Assay for phosphodiesterase function
|
|
JP2006219374A
(ja)
|
2003-06-13 |
2006-08-24 |
Daiichi Asubio Pharma Co Ltd |
Pde7阻害作用を有するイミダゾトリアジノン誘導体
|
|
JP2006219373A
(ja)
*
|
2003-06-13 |
2006-08-24 |
Daiichi Asubio Pharma Co Ltd |
Pde7阻害作用を有するピリジニルピラゾロピリミジノン誘導体
|
|
WO2005018563A2
(en)
*
|
2003-08-22 |
2005-03-03 |
Pharmacia Corporation |
Compositions of a cyclooxygenase-2 selective inhibitor and a phosphodiesterase inhibitor for the treatment of ischemic mediated central nervous system disorders or injury
|
|
MX2007000214A
(es)
|
2004-07-01 |
2007-05-10 |
Asubio Pharma Co Ltd |
Derivado de tienopirazol que tiene actividad inhibidora de pde 7.
|
|
EP1855686A1
(en)
*
|
2005-03-01 |
2007-11-21 |
Pfizer Limited |
Use of pde7 inhibitors for the treatment of neuropathic pain
|
|
WO2006092692A1
(en)
|
2005-03-01 |
2006-09-08 |
Pfizer Limited |
Use of combinations of pde7 inhibitors and alpha-2-delty ligands for the treatment of neuropathic pain
|
|
EP1940389A2
(en)
*
|
2005-10-21 |
2008-07-09 |
Braincells, Inc. |
Modulation of neurogenesis by pde inhibition
|
|
BRPI0619126A2
(pt)
*
|
2005-12-02 |
2011-09-13 |
Pfizer Ltd |
derivados espirocìclicos, composição farmacêutica e usos dos mesmos
|
|
US8637528B2
(en)
*
|
2007-03-27 |
2014-01-28 |
Omeros Corporation |
Use of PDE7 inhibitors for the treatment of movement disorders
|