JP2010520284A5 - - Google Patents
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- Publication number
- JP2010520284A5 JP2010520284A5 JP2009552711A JP2009552711A JP2010520284A5 JP 2010520284 A5 JP2010520284 A5 JP 2010520284A5 JP 2009552711 A JP2009552711 A JP 2009552711A JP 2009552711 A JP2009552711 A JP 2009552711A JP 2010520284 A5 JP2010520284 A5 JP 2010520284A5
- Authority
- JP
- Japan
- Prior art keywords
- virus
- pharmaceutical composition
- poly
- tumor
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000700605 Viruses Species 0.000 claims 19
- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- 206010028980 Neoplasm Diseases 0.000 claims 11
- 102000008230 Toll-like receptor 3 Human genes 0.000 claims 11
- 108010060885 Toll-like receptor 3 Proteins 0.000 claims 11
- 239000000427 antigen Substances 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 229960005486 vaccine Drugs 0.000 claims 5
- 230000028993 immune response Effects 0.000 claims 4
- 241000713112 Orthobunyavirus Species 0.000 claims 2
- 239000000556 agonist Substances 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 238000011065 in-situ storage Methods 0.000 claims 2
- 238000001802 infusion Methods 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- 229920002477 rna polymer Polymers 0.000 claims 2
- 210000004881 tumor cell Anatomy 0.000 claims 2
- 108090000944 RNA Helicases Proteins 0.000 claims 1
- 102000004409 RNA Helicases Human genes 0.000 claims 1
- 102000002689 Toll-like receptor Human genes 0.000 claims 1
- 108020000411 Toll-like receptor Proteins 0.000 claims 1
- 210000002865 immune cell Anatomy 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000015788 innate immune response Effects 0.000 claims 1
- 238000010255 intramuscular injection Methods 0.000 claims 1
- 239000007927 intramuscular injection Substances 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 238000010254 subcutaneous injection Methods 0.000 claims 1
- 239000007929 subcutaneous injection Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90479207P | 2007-03-05 | 2007-03-05 | |
| PCT/US2008/002874 WO2008109083A2 (en) | 2007-03-05 | 2008-03-05 | Restrictive agonist of toll-like receptor 3 (tlr3) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010520284A JP2010520284A (ja) | 2010-06-10 |
| JP2010520284A5 true JP2010520284A5 (https=) | 2011-06-02 |
Family
ID=39738981
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009552711A Pending JP2010520284A (ja) | 2007-03-05 | 2008-03-05 | Ｔｏｌｌ様受容体３（ＴＬＲ３）の限定アゴニスト |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20100183638A1 (https=) |
| EP (1) | EP2134172A4 (https=) |
| JP (1) | JP2010520284A (https=) |
| KR (1) | KR20090130019A (https=) |
| CN (1) | CN101652062A (https=) |
| AU (1) | AU2008223446B2 (https=) |
| BR (1) | BRPI0808637A2 (https=) |
| CA (1) | CA2680134A1 (https=) |
| NZ (1) | NZ579433A (https=) |
| WO (1) | WO2008109083A2 (https=) |
| ZA (1) | ZA200905954B (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007067517A2 (en) | 2005-12-07 | 2007-06-14 | Hemispherx Biopharma | Dsrnas as influenza virus vaccine adjuvants or immuno-stimulants |
| WO2009102496A2 (en) * | 2008-02-15 | 2009-08-20 | Hemispherx Biopharma, Inc. | Selective agonist of toll-like receptor 3 |
| US8722874B2 (en) | 2008-10-23 | 2014-05-13 | Hemispherx Biopharma, Inc. | Double-stranded ribonucleic acids with rugged physico-chemical structure and highly specific biologic activity |
| AU2009308105B2 (en) * | 2008-10-23 | 2016-07-07 | Aim Immunotech Inc. | Double-stranded ribonucleic acids with rugged physico-chemical structure and highly specific biologic activity |
| US20100160413A1 (en) * | 2008-10-23 | 2010-06-24 | Hemispherx Biopharma, Inc. | Double-stranded ribonucleic acids with rugged physico-chemical structure and highly specific biologic activity |
| RS55861B1 (sr) * | 2008-10-31 | 2017-08-31 | Janssen Biotech Inc | Antagonisti toll-like receptora 3 |
| US9090897B2 (en) * | 2009-12-18 | 2015-07-28 | Bavarian Nordic A/S | Production of IFN-lambda by conventional dendritic cells |
| CN101780279B (zh) * | 2009-12-22 | 2012-07-11 | 中山大学中山眼科中心 | Toll-like receptor-3激动剂在制备促进伤口愈合的药物中的应用 |
| EP2558069A1 (en) | 2010-04-13 | 2013-02-20 | Novartis AG | Benzonapthyridine compositions and uses thereof |
| CA2802721C (en) * | 2010-06-25 | 2015-08-18 | Idera Pharmaceuticals, Inc. | Novel agonists of toll-like receptor 3 and methods of their use |
| US10105305B2 (en) | 2014-02-19 | 2018-10-23 | The Johns Hopkins University | Compositions and methods for promoting skin regeneration and hair growth |
| EP3321362A1 (en) | 2016-11-10 | 2018-05-16 | Centre Leon Berard | Tlr3 agonist for use for inducing apoptosis in senescent cancer cells |
| EP3558350A1 (en) | 2016-12-22 | 2019-10-30 | Intervet International B.V. | Eimeria vaccine with improved efficacy |
| CN112703011A (zh) | 2018-08-06 | 2021-04-23 | 国家医疗保健研究所 | 用于治疗癌症的方法和组合物 |
| WO2020232226A1 (en) | 2019-05-16 | 2020-11-19 | The Johns Hopkins University | Compositions and methods for skin rejuvenation |
| CN117320722A (zh) | 2021-04-28 | 2023-12-29 | 埃尼奥制药公司 | 使用fxr激动剂作为联合治疗强烈增强tlr3激动剂的作用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6080726A (en) * | 1985-08-12 | 2000-06-27 | University Of Maryland | Anti-viral and immuno stimulator polynucleotide duplex and use thereof |
| US5063209A (en) * | 1985-08-26 | 1991-11-05 | Hem Research, Inc. | Modulation of aids virus-related events by double-stranded RNAs |
| IE72103B1 (en) * | 1987-08-12 | 1997-03-12 | Hem Res Inc | Promotion of host defense by systemic dsRNA treatment |
| US5683986A (en) * | 1987-08-12 | 1997-11-04 | Hemispherx Biopharma Inc. | Elaboration of host defense mediators into biological fluids by systemic dsRNA treatment |
| US5976800A (en) * | 1996-06-28 | 1999-11-02 | The Regents Of The University Of California | Enhancement of cancer cell death |
| GB0119346D0 (en) * | 2001-08-08 | 2001-10-03 | Bioclones Proprietary Ltd | Process for the maturation of dendritic cells |
| US20060211752A1 (en) * | 2004-03-16 | 2006-09-21 | Kohn Leonard D | Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression |
| CA2587676A1 (en) * | 2004-11-19 | 2006-05-26 | Institut Gustave Roussy | Improved treatment of cancer by double-stranded rna |
-
2008
- 2008-03-05 EP EP08726414A patent/EP2134172A4/en not_active Withdrawn
- 2008-03-05 NZ NZ579433A patent/NZ579433A/en not_active IP Right Cessation
- 2008-03-05 CA CA002680134A patent/CA2680134A1/en not_active Abandoned
- 2008-03-05 AU AU2008223446A patent/AU2008223446B2/en not_active Ceased
- 2008-03-05 US US12/530,148 patent/US20100183638A1/en not_active Abandoned
- 2008-03-05 JP JP2009552711A patent/JP2010520284A/ja active Pending
- 2008-03-05 CN CN200880007263A patent/CN101652062A/zh active Pending
- 2008-03-05 KR KR1020097020751A patent/KR20090130019A/ko not_active Ceased
- 2008-03-05 WO PCT/US2008/002874 patent/WO2008109083A2/en not_active Ceased
- 2008-03-05 BR BRPI0808637-0A patent/BRPI0808637A2/pt not_active IP Right Cessation
-
2009
- 2009-08-27 ZA ZA2009/05954A patent/ZA200905954B/en unknown
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